TR199501361A2 - Basit terkipli ve yüksek biyo-yararlikli oral verilmek üzere siklosporin'in yeni formülleri ve bunlarin istihsal edilmesi icin proses. - Google Patents

Basit terkipli ve yüksek biyo-yararlikli oral verilmek üzere siklosporin'in yeni formülleri ve bunlarin istihsal edilmesi icin proses.

Info

Publication number: TR199501361A2
Authority: TR; Turkey
Prior art keywords: cyclosporin; weight; oral administration; high bioavailability; cyclosporine
Prior art date: 1994-11-03

Application number

TR95/01361A

Other languages

English (en)

Inventor

Dr Matthias Obricht

Dr Heinrich Potter

Original Assignee

Dresden Arzneimittel

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-03

Filing date

1995-11-02

Publication date

1996-06-21

1995-11-02 Application filed by Dresden Arzneimittel filed Critical Dresden Arzneimittel

1996-06-21 Publication of TR199501361A2 publication Critical patent/TR199501361A2/tr

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 5
108010036949 Cyclosporine Proteins 0.000 title abstract 5
229960001265 ciclosporin Drugs 0.000 title abstract 5
229930182912 cyclosporin Natural products 0.000 title abstract 4
239000000203 mixture Substances 0.000 title abstract 2
229930105110 Cyclosporin A Natural products 0.000 abstract 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
239000006184 cosolvent Substances 0.000 abstract 2
ZMKGDQSIRSGUDJ-VSROPUKISA-N (3s,6s,9s,12r,15s,18s,21s,24s,30s,33s)-33-[(e,1r,2r)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-30-propyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,1 Chemical compound CCC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O ZMKGDQSIRSGUDJ-VSROPUKISA-N 0.000 abstract 1
ZMKGDQSIRSGUDJ-UHFFFAOYSA-N NVa2 cyclosporine Natural products CCCC1NC(=O)C(C(O)C(C)CC=CC)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(C(C)C)NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O ZMKGDQSIRSGUDJ-UHFFFAOYSA-N 0.000 abstract 1
239000002202 Polyethylene glycol Substances 0.000 abstract 1
239000002775 capsule Substances 0.000 abstract 1
108010019249 cyclosporin G Proteins 0.000 abstract 1
235000014113 dietary fatty acids Nutrition 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000000194 fatty acid Substances 0.000 abstract 1
229930195729 fatty acid Natural products 0.000 abstract 1
150000004665 fatty acids Chemical class 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
150000002334 glycols Chemical class 0.000 abstract 1
229920001223 polyethylene glycol Polymers 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
238000003756 stirring Methods 0.000 abstract 1
150000005846 sugar alcohols Polymers 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Oil, Petroleum & Natural Gas (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Dispersion Chemistry (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Transplantation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Peptides Or Proteins (AREA)

TR95/01361A 1994-11-03 1995-11-02 Basit terkipli ve yüksek biyo-yararlikli oral verilmek üzere siklosporin'in yeni formülleri ve bunlarin istihsal edilmesi icin proses. TR199501361A2 (tr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4438861		1994-11-03

Publications (1)

Publication Number	Publication Date
TR199501361A2 true TR199501361A2 (tr)	1996-06-21

Family

ID=6532126

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TR95/01361A TR199501361A2 (tr)	1994-11-03	1995-11-02	Basit terkipli ve yüksek biyo-yararlikli oral verilmek üzere siklosporin'in yeni formülleri ve bunlarin istihsal edilmesi icin proses.

Country Status (27)

Country	Link
US (1)	US6486124B2 (tr)
EP (1)	EP0789580B1 (tr)
JP (1)	JP3833248B2 (tr)
KR (1)	KR970704464A (tr)
CN (1)	CN1121238C (tr)
AT (1)	ATE218359T1 (tr)
AU (1)	AU715165B2 (tr)
BG (1)	BG62955B1 (tr)
BR (1)	BR9509550A (tr)
CA (1)	CA2231404C (tr)
CZ (1)	CZ287806B6 (tr)
DE (2)	DE59510233D1 (tr)
DK (1)	DK0789580T3 (tr)
EE (1)	EE03425B1 (tr)
ES (1)	ES2177652T3 (tr)
FI (1)	FI118722B (tr)
HU (1)	HUT77283A (tr)
LT (1)	LT4306B (tr)
LV (1)	LV11884B (tr)
NO (1)	NO970741D0 (tr)
PL (1)	PL183579B1 (tr)
PT (1)	PT789580E (tr)
RU (1)	RU2158601C2 (tr)
SK (1)	SK164796A3 (tr)
TR (1)	TR199501361A2 (tr)
TW (1)	TW492876B (tr)
WO (1)	WO1996014079A1 (tr)

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BRPI0609071A2 (pt)	2005-04-12	2010-11-16	Elan Pharma Int Ltd	composicão estável de ciclosporina nanoparticulada, método para preparar uma ciclosporina nanoparticulada, uso da composição de ciclosporina nanoparticulada estável, e, composição de liberação controlada
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HU208491B (en)	1990-11-27	1993-11-29	Gyogyszerkutato Intezet	Process for producing oral pharmaceutical composition containing cyclosporin
GB9113872D0 (en)	1991-06-27	1991-08-14	Sandoz Ag	Improvements in or relating to organic compounds
US5206219A (en)	1991-11-25	1993-04-27	Applied Analytical Industries, Inc.	Oral compositions of proteinaceous medicaments
GB9208712D0 (en)	1992-04-22	1992-06-10	Sandoz Ltd	Pharmaceutical compositions containing cyclosporin derivates
DK0589843T3 (da)	1992-09-25	2002-04-02	Novartis Ag	Cyclosporinholdige farmaceutiske præparater
CH686761A5 (de)	1993-05-27	1996-06-28	Sandoz Ag	Galenische Formulierungen.
IL111003A0 (en)	1993-09-30	1994-11-28	American Home Prod	Multi-component oral rapamycin formulation
KR0146671B1 (ko) *	1994-02-25	1998-08-17	김충환	사이클로스포린-함유 분말 조성물
ATE188870T1 (de)	1994-10-04	2000-02-15	Lohmann Rudolf Lomapharm	Lösungen von anthrachinonen zur parenteralen applikation
ES2177652T3 (es)	1994-11-03	2002-12-16	Novartis Ag	Nuevas formas de preparacion de ciclosporina para la aplicacion oral con composicion simple y alta biodisponibilidad, y procedimiento para su obtencion.

1995
- 1995-07-19 ES ES95925707T patent/ES2177652T3/es not_active Expired - Lifetime
- 1995-07-19 RU RU97108682/14A patent/RU2158601C2/ru active
- 1995-07-19 CN CN95196010A patent/CN1121238C/zh not_active Expired - Fee Related
- 1995-07-19 KR KR1019970700361A patent/KR970704464A/ko not_active Ceased
- 1995-07-19 JP JP51493496A patent/JP3833248B2/ja not_active Expired - Fee Related
- 1995-07-19 WO PCT/DE1995/000951 patent/WO1996014079A1/de not_active Ceased
- 1995-07-19 HU HU9702144A patent/HUT77283A/hu unknown
- 1995-07-19 CZ CZ19963616A patent/CZ287806B6/cs not_active IP Right Cessation
- 1995-07-19 EE EE9700112A patent/EE03425B1/xx not_active IP Right Cessation
- 1995-07-19 DK DK95925707T patent/DK0789580T3/da active
- 1995-07-19 CA CA002231404A patent/CA2231404C/en not_active Expired - Fee Related
- 1995-07-19 SK SK1647-96A patent/SK164796A3/sk unknown
- 1995-07-19 BR BR9509550A patent/BR9509550A/pt not_active Application Discontinuation
- 1995-07-19 DE DE59510233T patent/DE59510233D1/de not_active Expired - Fee Related
- 1995-07-19 AU AU29751/95A patent/AU715165B2/en not_active Ceased
- 1995-07-19 EP EP95925707A patent/EP0789580B1/de not_active Expired - Lifetime
- 1995-07-19 PT PT95925707T patent/PT789580E/pt unknown
- 1995-07-19 AT AT95925707T patent/ATE218359T1/de not_active IP Right Cessation
- 1995-08-08 TW TW084108225A patent/TW492876B/zh active
- 1995-10-26 DE DE19539860A patent/DE19539860A1/de not_active Withdrawn
- 1995-11-02 TR TR95/01361A patent/TR199501361A2/tr unknown
1997
- 1997-01-06 BG BG101117A patent/BG62955B1/bg unknown
- 1997-01-09 LT LT97-002A patent/LT4306B/lt not_active IP Right Cessation
- 1997-02-14 FI FI970634A patent/FI118722B/fi active IP Right Grant
- 1997-02-18 NO NO970741A patent/NO970741D0/no not_active Application Discontinuation
- 1997-05-14 LV LVP-97-94A patent/LV11884B/lv unknown
1998
- 1998-03-09 PL PL95318560A patent/PL183579B1/pl unknown
2001
- 2001-10-17 US US09/981,929 patent/US6486124B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
RU2158601C2 (ru)	2000-11-10
PL183579B1 (pl)	2002-06-28
NO970741L (no)	1997-02-18
BR9509550A (pt)	1997-09-16
DK0789580T3 (da)	2002-09-09
BG62955B1 (bg)	2000-12-29
JPH10508306A (ja)	1998-08-18
AU715165B2 (en)	2000-01-20
DE59510233D1 (de)	2002-07-11
EE03425B1 (et)	2001-06-15
CA2231404C (en)	2009-02-17
CZ287806B6 (en)	2001-02-14
FI118722B (fi)	2008-02-29
KR970704464A (ko)	1997-09-06
CN1162265A (zh)	1997-10-15
WO1996014079A1 (de)	1996-05-17
PL318560A1 (en)	1997-06-23
EE9700112A (et)	1997-12-15
FI970634A0 (fi)	1997-02-14
EP0789580B1 (de)	2002-06-05
DE19539860A1 (de)	1996-05-09
LT97002A (en)	1997-11-25
ATE218359T1 (de)	2002-06-15
LV11884B (lv)	1998-03-20
NO970741D0 (no)	1997-02-18
CN1121238C (zh)	2003-09-17
LV11884A (lv)	1997-12-20
PT789580E (pt)	2002-09-30
US20020025927A1 (en)	2002-02-28
SK164796A3 (en)	1997-06-04
TW492876B (en)	2002-07-01
ES2177652T3 (es)	2002-12-16
HUT77283A (hu)	1998-03-30
FI970634L (fi)	1997-02-14
BG101117A (en)	1997-08-29
US6486124B2 (en)	2002-11-26
JP3833248B2 (ja)	2006-10-11
LT4306B (lt)	1998-03-25
AU2975195A (en)	1996-05-31
EP0789580A1 (de)	1997-08-20
CZ361696A3 (en)	1997-07-16
CA2231404A1 (en)	1996-05-17

Publication	Publication Date	Title
LT97002A (en)	1997-11-25	Novel cyclosporine preparation forms for oral administration of simple composition and high bioavailability, and process for producing them
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ATE198833T1 (de)	2001-02-15	Cyclosporin enthaltende flüssige zubereitungen und verfahren zu ihrer herstellung
GB9907715D0 (en)	1999-05-26	Pharmaceutical compositions
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MY111841A (en)	2001-01-31	Injectable liposomal pharmaceutical preparations
ATE407666T1 (de)	2008-09-15	Kaubare weichkapseln mit verbesserten verabreichungseigenschaften sowie verfahren zu deren herstellung
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JPH0570609B2 (tr)	1993-10-05
IT1293835B1 (it)	1999-03-10	Composizioni farmaceutiche orali in forma solida a cessione modulata contenenti nicorandil e procedimento per la loro preparazione
CA2572498A1 (en)	1995-06-22	Biphasic capsule formulation
JPS55130919A (en)	1980-10-11	Gallstone-dissolving agent
RU97120225A (ru)	1999-11-10	Фармацевтическая композиция, содержащая гидрохлорид тиагабина, и способ ее получения