TR199802426T2 - Taksus türünün hücre kültürleriyle taksanlarin arttirilmis üretimi. - Google Patents

Taksus türünün hücre kültürleriyle taksanlarin arttirilmis üretimi.

Info

Publication number
TR199802426T2
TR199802426T2 TR1998/02426T TR9802426T TR199802426T2 TR 199802426 T2 TR199802426 T2 TR 199802426T2 TR 1998/02426 T TR1998/02426 T TR 1998/02426T TR 9802426 T TR9802426 T TR 9802426T TR 199802426 T2 TR199802426 T2 TR 199802426T2
Authority
TR
Turkey
Prior art keywords
taxus
taxol
efficiency
species
enhancing agents
Prior art date
Application number
TR1998/02426T
Other languages
English (en)
Inventor
Bringi Venkataraman
G. Kadkrade Prakash
L. Prince Christopher
L. Roach Braden
Original Assignee
Phyton, Inc..
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24619244&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR199802426(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Phyton, Inc.. filed Critical Phyton, Inc..
Publication of TR199802426T2 publication Critical patent/TR199802426T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0025—Culture media for plant cell or plant tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04—Plant cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)

Abstract

Mevcut bulus; sayesinde brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, media ve chinensis gibi bilinen bütün Taksus (Taxus) türlerinden taksol, baccatin III ve diger taksol benzeri bilesiklerin veya taksanlarin çok yüksek verimde üretilebildigi metotlar saglanmaktadir. Kültür sartlarinin özel modifikasyonlari (yani ortam bilesimi ve isletme modlari) bütün Taksus türlerinin hücre kültüründen çesitli taksanlarin verimini arttirmak için bulunmustur. Özellikle tercih edilen arttirma ajanlari gümüs iyonu veya kompleksi, jasmonik asit (özellikle metil ester), oksinle (auxin) ilgili gelisim düzenleyicileri ve 3,4- metilendioksi-6-nitrosinnamik asit gibi fenilpropanoid kimyasal degisim inhibitörleri içermektedir. Bu arttirma ajanlari tek basina veya bir baska veya diger verim arttici sartlarla kombine olarak kullanilabilmektedir.
TR1998/02426T 1996-05-24 1997-05-27 Taksus türünün hücre kültürleriyle taksanlarin arttirilmis üretimi. TR199802426T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65303696A 1996-05-24 1996-05-24

Publications (1)

Publication Number Publication Date
TR199802426T2 true TR199802426T2 (tr) 2001-01-22

Family

ID=24619244

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/02426T TR199802426T2 (tr) 1996-05-24 1997-05-27 Taksus türünün hücre kültürleriyle taksanlarin arttirilmis üretimi.

Country Status (16)

Country Link
US (2) US8338143B2 (tr)
EP (3) EP1538214A1 (tr)
JP (5) JP4047929B2 (tr)
KR (7) KR20090005241A (tr)
AT (1) ATE315097T1 (tr)
AU (1) AU727425B2 (tr)
BR (1) BR9709361B1 (tr)
CA (2) CA2256357C (tr)
DE (1) DE69735059T2 (tr)
DK (1) DK0954596T3 (tr)
ES (1) ES2256887T3 (tr)
HU (2) HUP9901788A3 (tr)
IL (1) IL127062A (tr)
PT (1) PT954596E (tr)
TR (1) TR199802426T2 (tr)
WO (1) WO1997044476A1 (tr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7264951B1 (en) 1992-02-20 2007-09-04 Phyton, Inc. Enhanced production of taxol and taxanes by cell cultures of Taxus species
HUP9901788A3 (en) * 1996-05-24 2002-07-29 Phyton Inc Ithaca Enhanced production of taxanes by cell cultures of taxus species
KR100287465B1 (ko) 1997-06-25 2001-05-02 나까니시 히로유끼 탁산형 디테르펜의 제조방법
TW200304947A (en) * 2002-02-08 2003-10-16 Bristol Myers Squibb Co Compositions and methods for latering biosynthesis of taxanes and taxane-related compounds
US8936940B2 (en) 2005-06-03 2015-01-20 Samyang Biopharmaceuticals Corporation Mass production of secondary metabolite in plant cell culture by treatment of saccharide mixture in medium
EP2386626B1 (en) * 2005-10-31 2016-10-26 Unhwa Corporation Stability of secondary metabolite mass production through syncronized plant cell cultures
US8053238B2 (en) 2005-10-31 2011-11-08 Unhwa Corporation Isolated population of plant single cells and method of preparing the same
KR101064518B1 (ko) 2007-09-21 2011-09-19 주식회사 운화 저장근을 가지는 초본식물의 형성층 유래 식물줄기세포주 및 이의 분리방법
KR101100867B1 (ko) * 2008-05-14 2012-01-02 주식회사 운화 주목의 형성층 또는 전형성층 유래 식물줄기세포주를 유효성분으로 함유하는 항산화, 항염증 또는 항노화용 조성물
US8877501B2 (en) 2009-06-18 2014-11-04 Phyton Holdings, Llc Production of alkaloids by liliaceae cell culture
FR2952072B1 (fr) 2009-11-05 2013-09-27 Pf Medicament Procede de production de triptolide
WO2013164834A1 (en) * 2012-05-04 2013-11-07 Phyto Biotech Pvt. Ltd. Cost-effective process for commercial production of paclitaxel
CN103570647A (zh) * 2013-11-06 2014-02-12 湖南农业大学 从红豆杉细胞培养液中制备高纯度紫杉醇的方法
DK3077523T3 (da) 2013-12-02 2020-07-20 Phyton Holdings Llc Produktion af thapsigarginer ved hjælp af Thapsia cellesuspensionskultur
US10058542B1 (en) 2014-09-12 2018-08-28 Thioredoxin Systems Ab Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith
EP3270686B1 (en) 2015-03-20 2019-12-18 Phyton Holdings, LLC Production of ingenol, ingenol esters and/or tiglian-3-one derivatives by euphorbiaceae plant cell suspension cultures
CN105349592B (zh) * 2015-12-09 2018-11-27 天津艾赛博生物技术有限公司 代谢互补的植物细胞系混种培养生产次级代谢产物的方法
CN106636242A (zh) * 2016-12-20 2017-05-10 天津艾赛博生物技术有限公司 一种红豆杉细胞长期培养生产紫杉烷的调控方法
JP7359527B2 (ja) * 2017-05-31 2023-10-11 トヨタ自動車株式会社 電池搭載構造
AU2021318553A1 (en) 2020-07-28 2023-03-23 Impello Biosciences Inc. Methods and compositions for altering secondary metabolites in plants
CN113416689B (zh) * 2021-08-04 2023-01-10 海南鑫开源医药科技有限公司 一种利用植物细胞发酵技术生产高丽槐素的方法
CN115948494B (zh) * 2022-09-12 2024-07-16 昆明理工大学 一种利用三七细胞合成齐墩果烷型皂苷的方法
WO2025058703A1 (en) * 2023-09-13 2025-03-20 Bedoukian Research, Inc Method of controlling or reducing senescencein plants and seeds
CN117379425A (zh) * 2023-11-14 2024-01-12 广州日聚商贸发展有限公司 喹啉-4-羧酸在抗衰老产品以及保护肝脏、促进肝脏再生产品制备中的应用

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3270112D1 (en) * 1981-08-11 1986-04-30 Mitsui Petrochemical Ind Method for producing secondary metabolites of plants
WO1986002463A1 (fr) 1984-10-19 1986-04-24 Alain Zarudiansky Systeme de lunettes
JPH0833258B2 (ja) 1987-10-09 1996-03-29 三洋電機株式会社 吸収冷凍装置
DE3801023A1 (de) 1988-01-13 1989-07-27 Schering Ag Verfahren zur steigerung von enzym-aktivitaeten und der syntheseleistung von organismen
EP0378921A3 (en) 1988-12-21 1990-09-19 Idaho Research Foundation, Inc. Enhancement of plant metabolite production by timed elicitation
US5019504A (en) * 1989-03-23 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Production of taxol or taxol-like compounds in cell culture
US5334529A (en) * 1989-06-27 1994-08-02 Escagenetics Corporation Stably transformed coffee plant cells and plantlets
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
ATE142420T1 (de) 1990-05-25 1996-09-15 Univ Washington Verfahren zur auslösung pflanzenschützender mechanismen
EP0529083B1 (en) 1991-02-12 1996-12-18 Nippon Steel Corporation Process for producing taxol by cell culture of taxus species
US5244775A (en) * 1991-03-20 1993-09-14 Hitachi, Ltd. Method of manufacturing an optical disc
EP0580759B1 (en) 1991-04-19 1999-05-26 The University Of Mississippi Methods and compositions for isolating taxanes
US5248625A (en) * 1991-06-06 1993-09-28 Lsi Logic Corporation Techniques for forming isolation structures
KR930702323A (ko) 1991-07-17 1993-09-08 하지메 나까가와 항종양 활성을 가진 화합물(nsc-lsc1) 및 그의 제조방법
US5344775A (en) 1991-11-15 1994-09-06 Escagenetics Corporation Synthesis of taxanes in culture using pseudocalluscells
US5407816A (en) * 1992-02-20 1995-04-18 Phyton Catalytic, Inc. Enhanced production of taxol and taxanes by cell cultures of taxus species
US5451392A (en) * 1992-03-03 1995-09-19 The Research And Development Institute At Montana State University Production of taxol
US5445809A (en) * 1992-03-03 1995-08-29 Research And Development Institute At Montana State University Production of taxol from the yew tree
JPH05244971A (ja) 1992-03-06 1993-09-24 Nippon Oil Co Ltd タキサン類化合物の製造方法
US5850032A (en) * 1992-04-01 1998-12-15 Union Camp Corporation Method for production of plant biological products in precocious neomorphic embryoids
CA2131532A1 (en) * 1992-04-01 1993-10-14 Steven R. Wann Induction of somatic embryogenesis in taxus, and the production of taxane-ring containing alkaloids therefrom
CA2434692A1 (en) * 1992-04-07 1993-10-08 Paul M. Cino Callus cell induction and the preparation of taxanes
US5322779A (en) * 1992-04-16 1994-06-21 The Research And Development Institute, Inc. At Montana State University Taxol production by taxomyces andreanae
JPH08500973A (ja) 1992-05-21 1996-02-06 ザ ペン ステイト リサーチ ファウンデーション タキソール、関連タキサン及び他の新規な抗癌／抗ウイルス性化合物原料としてのイチイ培養組織
JP2967532B2 (ja) 1992-06-11 1999-10-25 日石三菱株式会社 タキサン類化合物の製造方法
US5279953A (en) * 1992-06-24 1994-01-18 Esca Genetics Corporation In vivo production of taxanes
JP3162217B2 (ja) 1992-12-24 2001-04-25 三井化学株式会社 タキサン型ジテルペンの製造方法
JP3144947B2 (ja) 1993-04-08 2001-03-12 三井化学株式会社 タキサン型ジテルペンの製造方法
JPH06296493A (ja) 1993-04-14 1994-10-25 Nippon Steel Corp タキソールの生産方法
KR950005081B1 (ko) 1993-07-06 1995-05-18 산림청임목육종연구소 주목 종자의 씨눈 유래의 체세포배 및 체세포배성세포 혹은 그 배양배지로부터 택솔(Taxol) 및 그 유도체를 생산하는 방법
JPH07308196A (ja) 1994-05-18 1995-11-28 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JPH08116981A (ja) 1994-10-18 1996-05-14 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JPH07308197A (ja) 1994-05-18 1995-11-28 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JPH0856680A (ja) * 1994-08-25 1996-03-05 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JP3434892B2 (ja) 1994-06-28 2003-08-11 三井化学株式会社 タキサン型ジテルペンの製造方法
JPH0856681A (ja) 1994-08-25 1996-03-05 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
DE69431135T2 (de) * 1993-11-15 2003-03-27 Mitsui Chemicals, Inc. Methode zur Herstellung von Taxan-Typ Diterpen und Methode zur Gewinnung von Kulturzellen die Taxan-Typ Diterpen in hohen Ausbeuten herstellen
JP3488492B2 (ja) 1993-11-15 2004-01-19 三井化学株式会社 タキサン型ジテルペン高産生培養細胞の取得方法
JP2967034B2 (ja) 1994-03-07 1999-10-25 三井化学株式会社 タキサン型ジテルペンの製造方法
JPH07255495A (ja) 1994-03-28 1995-10-09 Ishikawajima Harima Heavy Ind Co Ltd タキソールの製造方法
US5547866A (en) * 1994-07-20 1996-08-20 The Regents Of The University Of California Taxane production in haploid-derived cell cultures
JPH0870880A (ja) 1994-09-05 1996-03-19 Osaka Organic Chem Ind Ltd タキソールの培養生産法
JP3549594B2 (ja) 1994-11-25 2004-08-04 三井化学株式会社 タキサン型ジテルペンの製造方法
CA2163614C (en) * 1994-11-25 2002-12-31 Yukihito Yukimune Method of producing a taxane-type diterpene
JPH08163991A (ja) 1994-12-15 1996-06-25 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JPH08149984A (ja) 1994-11-30 1996-06-11 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JPH08154693A (ja) 1994-12-05 1996-06-18 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JP3746550B2 (ja) 1994-12-05 2006-02-15 三井化学株式会社 タキサン型ジテルペンの製造方法
JPH08205881A (ja) * 1994-12-05 1996-08-13 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JP3019736B2 (ja) 1994-12-07 2000-03-13 三井化学株式会社 タキサン型ジテルペンの製造方法
JPH08198863A (ja) * 1995-01-25 1996-08-06 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
US5620875A (en) * 1995-02-17 1997-04-15 University Of Portland Transfer of taxol from yew tree cuttings into a culture medium over time
US6248572B1 (en) * 1995-04-27 2001-06-19 Samyang, Genex, Corporation Production of taxol from taxus plant cell culture adding silver nitrate
KR960037826A (ko) * 1995-04-27 1996-11-19 김경환 택서스속 식물세포의 반연속식 배양방법
US5900367A (en) 1995-04-29 1999-05-04 Samyang Genex Co., Ltd. Method for purifying taxol from taxus biomass
JPH08298993A (ja) 1995-05-02 1996-11-19 Nippon Steel Corp イチイの組織培養によるタキサン化合物の製造法
US5965438A (en) 1995-06-07 1999-10-12 Phyton, Inc. Cryopreservation of plant cells
JPH0928392A (ja) 1995-07-17 1997-02-04 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JPH0956387A (ja) 1995-08-22 1997-03-04 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
US5670663A (en) 1996-02-14 1997-09-23 Regents Of The University Of California Recovery of taxanes from conifers
HUP9901788A3 (en) * 1996-05-24 2002-07-29 Phyton Inc Ithaca Enhanced production of taxanes by cell cultures of taxus species
JPH1042888A (ja) 1996-07-30 1998-02-17 Jumoku Seiri Kinousei Butsushitsu Gijutsu Kenkyu Kumiai タキソールの培養生産方法
JPH1052296A (ja) 1996-08-09 1998-02-24 Nippon Oil Co Ltd タキサン類化合物の製造方法（ｉｉｉ）
JPH1052295A (ja) 1996-08-09 1998-02-24 Nippon Oil Co Ltd タキサン類化合物の製造方法（ｉｉ）
JPH1052294A (ja) 1996-08-09 1998-02-24 Nippon Oil Co Ltd タキサン類化合物の製造方法（ｉ）
DE69821343T2 (de) * 1997-02-19 2004-10-07 Phytobiotech Inc Verfahren zur steigerung des wachstums von pflanzenzellkulturen
KR100287465B1 (ko) * 1997-06-25 2001-05-02 나까니시 히로유끼 탁산형 디테르펜의 제조방법
JPH1146782A (ja) 1997-08-05 1999-02-23 Mitsui Chem Inc ラジカル発生剤処理による植物二次代謝産物の生産促進方法
US6030818A (en) * 1997-12-22 2000-02-29 Bcm Developpement, Inc. Bacterial mass production of taxanes and paclitaxel
JP3897267B2 (ja) 1998-03-26 2007-03-22 三井化学株式会社 タキサン型ジテルペンの製造方法
JP2000106893A (ja) 1998-10-06 2000-04-18 Kobe Tennenbutsu Kagaku Kk タキサン型ジテルペン類の製造方法
JP3815919B2 (ja) 1999-05-26 2006-08-30 三井化学株式会社 タキサン型ジテルペンの製造方法
US6365407B1 (en) * 2001-03-05 2002-04-02 Council Of Scientific & Industrial Research Culture medium composition useful for induction and proliferation of Taxus calli

Also Published As

Publication number Publication date
KR20100070389A (ko) 2010-06-25
US20110086397A1 (en) 2011-04-14
BR9709361A (pt) 1999-08-10
CA2256357A1 (en) 1997-11-27
WO1997044476A1 (en) 1997-11-27
HUP9901788A2 (hu) 1999-09-28
JP4047929B2 (ja) 2008-02-13
PT954596E (pt) 2006-05-31
CA2638292A1 (en) 1997-11-27
JP2007143557A (ja) 2007-06-14
IL127062A0 (en) 1999-09-22
EP0954596B1 (en) 2006-01-04
EP0954596A1 (en) 1999-11-10
JP2013046643A (ja) 2013-03-07
KR20120138251A (ko) 2012-12-24
JP2008167764A (ja) 2008-07-24
KR20090005241A (ko) 2009-01-12
US8338143B2 (en) 2012-12-25
US20130017582A1 (en) 2013-01-17
AU3143097A (en) 1997-12-09
KR20070094867A (ko) 2007-09-21
ATE315097T1 (de) 2006-02-15
ES2256887T3 (es) 2006-07-16
DE69735059D1 (de) 2006-03-30
JP2000511420A (ja) 2000-09-05
IL127062A (en) 2005-09-25
DK0954596T3 (da) 2006-05-15
CA2256357C (en) 2008-08-12
BR9709361B1 (pt) 2009-05-05
DE69735059T2 (de) 2006-08-31
KR20100070388A (ko) 2010-06-25
EP1398384A1 (en) 2004-03-17
KR20140062179A (ko) 2014-05-22
AU727425B2 (en) 2000-12-14
JP2011212029A (ja) 2011-10-27
KR100897457B1 (ko) 2009-12-18
KR20000015952A (ko) 2000-03-25
HU0302357D0 (en) 2003-09-29
HUP9901788A3 (en) 2002-07-29
EP1538214A1 (en) 2005-06-08
HU223267B1 (hu) 2004-04-28

Similar Documents

Publication Publication Date Title
TR199802426T2 (tr) Taksus türünün hücre kültürleriyle taksanlarin arttirilmis üretimi.
Patel Tour de paclitaxel: biocatalysis for semisynthesis
Hibi et al. Characteristics and biotechnology applications of aliphatic amino acid hydroxylases belonging to the Fe (II)/α-ketoglutarate-dependent dioxygenase superfamily
Walker et al. Partial purification and characterization of acetyl coenzyme A: taxa-4 (20), 11 (12)-dien-5α-olO-acetyl transferase that catalyzes the first acylation step of Taxol biosynthesis
Exposito et al. Effect of taxol feeding on taxol and related taxane production in Taxus baccata suspension cultures
Kashani et al. Identification of rate-limiting enzymes involved in paclitaxel biosynthesis pathway affected by coronatine and methyl-β-cyclodextrin in Taxus baccata L. cell suspension cultures
Bamneshin et al. Gene expression pattern and taxane biosynthesis in a cell suspension culture of Taxus baccata L. subjected to light and a phenylalanine ammonia lyase (PAL) inhibitor
Mamadalieva et al. Taxus brevifolia a high-value medicinal plant, as a source of taxol
Oliver et al. Microwave synthesis and evaluation of phenacylhomoserine lactones as anticancer compounds that minimally activate quorum sensing pathways in Pseudomonas aeruginosa
Wang et al. Inhibition of biofilm in Bacillus amyloliquefaciens Q-426 by diketopiperazines
Poveda Analysis of Marchantia polymorpha–microorganism interactions: basis for understanding plant–microbe and plant–pathogen interactions
ATE409694T1 (de) Halbsynthetische darstellung von taxan- zwischenprodukten aus 9-dihydro-13-acetylbaccatin iii
Qi et al. Unveiling the role of tropinone reductase I in biodegradation of oxytetracycline: identifying antibiotic deactivation enzymes to enhance engineering feasibility of microalgae-based biotechnologies
EA200800253A1 (ru) Бессывороточная культуральная среда для получения рекомбинантных гонадотропинов
KR960037826A (ko) 택서스속 식물세포의 반연속식 배양방법
Itose et al. Improved culture conditions for the production of β-thujaplicin by suspension cell cultures of Cupressus lusitanica
CO5271695A1 (es) Proceso para preparar placlitaxel y 13-acetil-9- dihidrobacatin iii
Zhang et al. Effects of different elicitors on 10‐deacetylbaccatin III‐10‐O‐acetyltransferase activity and cytochrome P450 monooxygenase content in suspension cultures of Taxus cuspidata cells
Kuse Chromophores in photoproteins of a glowing squid and mollusk
Nishiyama et al. Organocatalytic activity of granaticin and its involvement in bactericidal function
Ayyamuthu Rajarathinam Uma et al. Pink powerhouses: insights into the multifaceted role of Methylobacterium in climate-resilient farming
Joshi et al. PGPR Consortia: Micro Solution to Major Challenges
Fathali Tehrani et al. Plasma-activated water modulates taxanes production and phenylalanineammonia-lyase activity in Taxus baccata cell culture
Jaziri et al. Bioactive Taxoid Production from Natural Sources
DK1383754T3 (da) Fremgangsmåde til syntetisering af taxanderivater