TR199900531A2 - Pirazolopirimidinler ve pirazolotriazinler. - Google Patents

Pirazolopirimidinler ve pirazolotriazinler.

Info

Publication number
TR199900531A2
TR199900531A2 TR1999/00531A TR9900531A TR199900531A2 TR 199900531 A2 TR199900531 A2 TR 199900531A2 TR 1999/00531 A TR1999/00531 A TR 1999/00531A TR 9900531 A TR9900531 A TR 9900531A TR 199900531 A2 TR199900531 A2 TR 199900531A2
Authority
TR
Turkey
Prior art keywords
disease
compounds
disorders
depressions
pirazolotriazines
Prior art date
Application number
TR1999/00531A
Other languages
English (en)
Other versions
TR199900531A3 (tr
Inventor
B�S Michael
Riemer Claus
Stadler Heinz
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of TR199900531A3 publication Critical patent/TR199900531A3/tr
Publication of TR199900531A2 publication Critical patent/TR199900531A2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Bu bulus asagidaki genel formülleri havi pirazolopirmidinler ve pirazolotriazinler ve bunlarin farmasötik yönden kabul edilebilir tuzlari ile ilgilidir. Sasirtici bir sekilde, bu bilesikler 5HT-6 reseptörlerine karsi selektif bir affiniteye sahiptir. Buna uygun bir sekilde, bu bilisikler örnegin psikozlar, sizofreni, manik depresyonlar, depresyonlar, nörolojik bozukluklar, hafiza bozukluklari, Parkinson hastaligi, amiyotrofik lateral skleroz, Alzheimer hastaligi ve Huntington koreasi gibi merkezi sinir sistemi bozukluklarinin tedavisi ve önlenmesi için uygundur.
TR1999/00531A 1998-03-11 1999-03-11 Pirazolopirimidinler ve pirazolotriazinler. TR199900531A2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98104346 1998-03-11

Publications (2)

Publication Number Publication Date
TR199900531A3 TR199900531A3 (tr) 1999-10-21
TR199900531A2 true TR199900531A2 (tr) 1999-10-21

Family

ID=8231568

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/00531A TR199900531A2 (tr) 1998-03-11 1999-03-11 Pirazolopirimidinler ve pirazolotriazinler.

Country Status (33)

Country Link
US (1) US6194410B1 (tr)
EP (1) EP0941994B1 (tr)
JP (1) JP3231288B2 (tr)
KR (1) KR100313181B1 (tr)
CN (1) CN1118468C (tr)
AR (1) AR016453A1 (tr)
AT (1) ATE240332T1 (tr)
AU (1) AU752408B2 (tr)
BR (1) BR9901095A (tr)
CA (1) CA2265095C (tr)
CZ (1) CZ291514B6 (tr)
DE (1) DE69907784T2 (tr)
DK (1) DK0941994T3 (tr)
ES (1) ES2198095T3 (tr)
HR (1) HRP990077B1 (tr)
HU (1) HUP9900589A1 (tr)
ID (1) ID23575A (tr)
IL (1) IL128869A (tr)
MA (1) MA26612A1 (tr)
MY (1) MY119536A (tr)
NO (1) NO312297B1 (tr)
NZ (1) NZ334526A (tr)
PE (1) PE20000337A1 (tr)
PL (1) PL331875A1 (tr)
PT (1) PT941994E (tr)
RU (1) RU2218340C2 (tr)
SG (1) SG78336A1 (tr)
SI (1) SI0941994T1 (tr)
TR (1) TR199900531A2 (tr)
TW (1) TW585865B (tr)
UY (1) UY25419A1 (tr)
YU (1) YU12099A (tr)
ZA (1) ZA991946B (tr)

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RU2330854C2 (ru) * 2006-03-15 2008-08-10 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию" (ГОУВПО "ПГФА Росздрава") Способ получения конденсированных гем-диметилзамещенных амино-1,3,5-триазинов
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JP5584627B2 (ja) * 2008-01-24 2014-09-03 アンドレイ・アレクサンドロビッチ・イワシェンコ 置換されたシクロアルキル［ｅ又はｄ］ピラゾロ［１，５−ａ］ピリミジン−セロトニン５−ＨＴ６受容体のアンタゴニスト、その調製の方法及び使用
EA017805B1 (ru) * 2008-01-24 2013-03-29 Андрей Александрович ИВАЩЕНКО 2-АЛКИЛАМИНО-3-АРИЛСУЛЬФОНИЛЦИКЛОАЛКАНО[e ИЛИ d]ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-НТРЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
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GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
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RU2443697C1 (ru) 2010-12-21 2012-02-27 Александр Васильевич Иващенко Замещенные метил-амины, антагонисты серотониновых 5-ht6 рецепторов, способы получения и применения
PT2760453T (pt) 2011-09-30 2016-08-02 Ipsen Pharma Sas Inibidores macrocíclicos da cinase lrrk2
DK2834243T3 (en) * 2012-03-09 2018-07-23 Lexicon Pharmaceuticals Inc Pyrazole [1,5-a] pyrimidine-based compounds, compositions comprising them and methods for their use
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Also Published As

Publication number Publication date
PE20000337A1 (es) 2000-05-13
IL128869A (en) 2003-09-17
KR100313181B1 (ko) 2001-11-05
MY119536A (en) 2005-06-30
IL128869A0 (en) 2000-01-31
CZ291514B6 (cs) 2003-03-12
CN1236780A (zh) 1999-12-01
CA2265095A1 (en) 1999-09-11
NO312297B1 (no) 2002-04-22
CN1118468C (zh) 2003-08-20
HRP990077B1 (en) 2003-08-31
US6194410B1 (en) 2001-02-27
HK1023343A1 (en) 2000-09-08
AR016453A1 (es) 2001-07-04
ZA991946B (en) 1999-09-13
MA26612A1 (fr) 2004-12-20
DE69907784D1 (de) 2003-06-18
NZ334526A (en) 2000-07-28
ES2198095T3 (es) 2004-01-16
RU2218340C2 (ru) 2003-12-10
BR9901095A (pt) 2000-05-02
CA2265095C (en) 2008-07-22
JP2000186090A (ja) 2000-07-04
TR199900531A3 (tr) 1999-10-21
HUP9900589A1 (hu) 2000-03-28
HU9900589D0 (en) 1999-05-28
PL331875A1 (en) 1999-09-13
AU2038399A (en) 1999-09-23
TW585865B (en) 2004-05-01
HRP990077A2 (en) 2000-02-29
DE69907784T2 (de) 2004-03-25
PT941994E (pt) 2003-09-30
UY25419A1 (es) 2001-11-30
NO991150D0 (no) 1999-03-10
SI0941994T1 (en) 2003-10-31
JP3231288B2 (ja) 2001-11-19
YU12099A (sh) 2000-10-30
SG78336A1 (en) 2001-02-20
NO991150L (no) 1999-09-13
KR19990077741A (ko) 1999-10-25
AU752408B2 (en) 2002-09-19
ID23575A (id) 2000-05-04
ATE240332T1 (de) 2003-05-15
EP0941994A1 (en) 1999-09-15
CZ82599A3 (cs) 1999-09-15
DK0941994T3 (da) 2003-09-08
EP0941994B1 (en) 2003-05-14

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