TR199903025T2 - 4-Fenilpiperidin bilesimleri. - Google Patents
4-Fenilpiperidin bilesimleri.Info
- Publication number
- TR199903025T2 TR199903025T2 TR1999/03025T TR9903025T TR199903025T2 TR 199903025 T2 TR199903025 T2 TR 199903025T2 TR 1999/03025 T TR1999/03025 T TR 1999/03025T TR 9903025 T TR9903025 T TR 9903025T TR 199903025 T2 TR199903025 T2 TR 199903025T2
- Authority
- TR
- Turkey
- Prior art keywords
- group
- alkyl
- halogen
- alkoxy
- optionally substituted
- Prior art date
Links
- UTBULQCHEUWJNV-UHFFFAOYSA-N 4-phenylpiperidine Chemical compound C1CNCCC1C1=CC=CC=C1 UTBULQCHEUWJNV-UHFFFAOYSA-N 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- -1 methylenedioxy Chemical group 0.000 abstract 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 abstract 1
- 125000004950 trifluoroalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
(Formül (I)): Bu bulus bir bilesime ve ilaç imaline uygun tuzlara iliskin olup, formül I' e sahiptirler; burada R bir alkil ya da alkinil grubunu temsil etmekte olup, 1-4 karbon atomuna sahiptir, ya da bir fenil grubu olup, istege göre C1-4 alkil, alkiltio, alkoksi,halojen,nitro,asilamino,metilsülfonil ya da metilenedioksi ile yerdegisimi yapilmaktadir, ya da tetrahidronaftili temsil etmektedir; R1 hidrojen, trifloro (C1-4) alkil, alkil ya da alkinili temsil etmektedir; X hidrojen, 1-4 karbon atomlu alkil, alkoksi, trifloroalkil, hidroksi, halojen, metiltio ya da aralkoksiyi temsil etmektedir; R2 ise sunlari temsil etmektedir: bir C1-C10 alkil grubu, bir fenil grubu olup, istege göre asagidaki gruplarin bir ya da daha fazlasiyla yerdegisimi yapilmaktadir; bir C1-C10 alkil grubu, bir halojen grubu, bir nitro grubu, hidroksi grubu, ve/veya bir alkoksi grubu.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/872,023 US5874447A (en) | 1997-06-10 | 1997-06-10 | 4-Phenylpiperidine compounds for treating depression |
| PCT/NL1997/000328 WO1998056787A1 (en) | 1997-06-10 | 1997-06-10 | 4-Phenylpiperidine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR199903025T2 true TR199903025T2 (tr) | 2000-07-21 |
Family
ID=26647319
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR1999/03025T TR199903025T2 (tr) | 1997-06-10 | 1997-06-10 | 4-Fenilpiperidin bilesimleri. |
| TR2002/01156T TR200201156T2 (tr) | 1997-06-10 | 1997-06-10 | 4-Fenilpiperidin bileşimleri. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2002/01156T TR200201156T2 (tr) | 1997-06-10 | 1997-06-10 | 4-Fenilpiperidin bileşimleri. |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US5874447A (tr) |
| EP (2) | EP0994872B9 (tr) |
| JP (1) | JP2002503248A (tr) |
| KR (1) | KR100543614B1 (tr) |
| AT (1) | ATE200781T1 (tr) |
| AU (1) | AU3108097A (tr) |
| BG (1) | BG64315B1 (tr) |
| BR (1) | BR9714787A (tr) |
| CA (1) | CA2293247C (tr) |
| CZ (1) | CZ295301B6 (tr) |
| DE (2) | DE29724281U1 (tr) |
| DK (1) | DK0994872T3 (tr) |
| EE (2) | EE03970B1 (tr) |
| ES (1) | ES2155995T3 (tr) |
| GR (1) | GR3035784T3 (tr) |
| HU (1) | HUP0003141A3 (tr) |
| IL (1) | IL133366A (tr) |
| IS (2) | IS1927B (tr) |
| NO (3) | NO317371B1 (tr) |
| PL (1) | PL188450B1 (tr) |
| PT (1) | PT994872E (tr) |
| SI (1) | SI0994872T1 (tr) |
| SK (1) | SK283394B6 (tr) |
| TR (2) | TR199903025T2 (tr) |
| WO (1) | WO1998056787A1 (tr) |
Families Citing this family (53)
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|---|---|---|---|---|
| HU221921B1 (hu) * | 1996-07-08 | 2003-02-28 | Richter Gedeon Vegyészeti Gyár Rt. | N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására |
| SK15032000A3 (sk) * | 1998-04-09 | 2001-04-09 | Smithkline Beecham Plc | Maleínan paroxetínu, spôsob jeho výroby a jeho použitie |
| US20010023252A1 (en) * | 1998-07-02 | 2001-09-20 | Smithkline Beecham Plc | Novel compound |
| AU724845B3 (en) * | 1998-07-02 | 2000-09-28 | Smithkline Beecham Plc | Novel compound |
| CH689805A8 (fr) * | 1998-07-02 | 2000-02-29 | Smithkline Beecham Plc | Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant. |
| GB9814316D0 (en) * | 1998-07-02 | 1998-09-02 | Smithkline Beecham Plc | Novel compounds |
| EP1102764A1 (en) * | 1998-08-08 | 2001-05-30 | Smithkline Beecham Plc | Paroxetine salts |
| GB9827431D0 (en) * | 1998-12-11 | 1999-02-03 | Smithkline Beecham Plc | Novel compound |
| GB9828779D0 (en) * | 1998-12-29 | 1999-02-17 | Smithkline Beecham Plc | Novel process |
| GB9828780D0 (en) * | 1998-12-29 | 1999-02-17 | Smithkline Beecham Plc | Novel process |
| GB9828781D0 (en) * | 1998-12-29 | 1999-02-17 | Smithkline Beecham Plc | Novel process |
| ES2159260B1 (es) * | 1999-06-22 | 2002-05-01 | Smithkline Beechan Plc | Nueva composicion de metanosulfonato de paroxetina |
| GB9914585D0 (en) * | 1999-06-22 | 1999-08-25 | Smithkline Beecham Plc | Novel process |
| AU5078700A (en) * | 1999-06-22 | 2001-01-09 | Smithkline Beecham Plc | Novel composition |
| US6984632B1 (en) * | 1999-07-01 | 2006-01-10 | Italfarmaco S.P.A. | Complexes of paroxetine, with cyclodextrins or cyclodextrin derivatives |
| GB9919052D0 (en) * | 1999-08-12 | 1999-10-13 | Smithkline Beecham Plc | Novel compound composition and process |
| US6503927B1 (en) * | 1999-10-28 | 2003-01-07 | Pentech Pharmaceuticals, Inc. | Amorphous paroxetine composition |
| USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
| CZ20023694A3 (cs) * | 2000-05-12 | 2003-05-14 | Synthon B. V. | Tosylátové soli 4-(p-fluorfenyl)-piperidin-3-methanolů |
| DK1286965T3 (da) * | 2000-05-12 | 2004-05-03 | Synthon Bv | Piperidin-forbindelser og fremgangsmåder til fremstilling af sådanne |
| EP1313474A2 (en) * | 2000-08-28 | 2003-05-28 | Synthon B.V. | Paroxetine compositions and processes for making the same |
| AU2001286232A1 (en) * | 2000-09-14 | 2002-03-26 | Asahi Glass Company, Limited | Process for producing paroxetine salt containing substantially no organic solvent |
| DE20100529U1 (de) * | 2001-01-11 | 2001-05-10 | Synthon Bv | Pharmazeutische Tablette umfassend Paroxetinmesylat |
| US6720003B2 (en) * | 2001-02-16 | 2004-04-13 | Andrx Corporation | Serotonin reuptake inhibitor formulations |
| NL1017421C2 (nl) * | 2001-02-21 | 2002-01-15 | Synthon Bv | Werkwijze voor het vervaardigen van paroxetine. |
| US20030032809A1 (en) * | 2001-04-25 | 2003-02-13 | Subhash P. Upadhyaya | Optimized procedures for the manufacture of paroxetine salts |
| JP2006512278A (ja) * | 2001-06-13 | 2006-04-13 | テバ ファーマシューティカル インダストリーズ リミティド | アルコキシ不純物を実質的に含有しないパロキセチンの製造方法 |
| IL159280A0 (en) * | 2001-06-14 | 2004-06-01 | Teva Pharma | A process for preparing paroxetine hcl which limits formation of pink colored compounds |
| US20040225128A1 (en) * | 2001-08-02 | 2004-11-11 | Callewaert George Leo | Paroxetine isethionate salt, process of preparation and use in the treatment of depression |
| US20030181488A1 (en) | 2002-03-07 | 2003-09-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof |
| EP1485344A1 (en) * | 2002-03-28 | 2004-12-15 | Synthon B.V. | Venlafaxine besylate |
| US20040220153A1 (en) * | 2002-09-24 | 2004-11-04 | Jost-Price Edward Roydon | Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines |
| US7202259B2 (en) * | 2002-11-18 | 2007-04-10 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| PT1691811E (pt) | 2003-12-11 | 2014-10-30 | Sunovion Pharmaceuticals Inc | Combinação de um sedativo e de um modulador de neurotransmissores e métodos para melhorar a qualidade do sono e tratamento da depressão |
| WO2006018318A1 (en) * | 2004-08-18 | 2006-02-23 | Synthon B.V. | Liquid paroxetine compositions |
| WO2006023347A1 (en) * | 2004-08-20 | 2006-03-02 | Alpharma, Inc. | Paroxetine formulations |
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| US20080033011A1 (en) * | 2005-07-29 | 2008-02-07 | Concert Pharmaceuticals Inc. | Novel benzo[d][1,3]-dioxol derivatives |
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| SE529246C2 (sv) | 2005-10-13 | 2007-06-12 | Neurosearch Sweden Ab | Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission |
| US20080033050A1 (en) | 2006-08-04 | 2008-02-07 | Richards Patricia Allison Tewe | Method of treating thermoregulatory disfunction with paroxetine |
| JP5647519B2 (ja) | 2007-09-13 | 2014-12-24 | コンサート ファーマシューティカルズ インコーポレイテッド | 重水素化カテコールおよびベンゾ［ｄ］［１，３］ジオキソールおよびその誘導体の合成 |
| US9138430B2 (en) * | 2007-12-27 | 2015-09-22 | Mylan Specialty L.P. | Formulation and method for the release of paroxetine in the large intestine |
| CA2771403C (en) | 2009-08-19 | 2015-02-24 | Eisai R&D Management Co. Ltd. | Quinoline derivative-containing pharmaceutical composition |
| JP6038128B2 (ja) | 2011-06-03 | 2016-12-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー |
| EP2810942B1 (en) * | 2012-01-31 | 2016-03-30 | Eisai R&D Management Co., Ltd. | Paroxetine derivative |
| BR112014024672A8 (pt) | 2012-04-04 | 2018-04-03 | Ivax Int Gmbh | Composições farmacêuticas para terapia de combinação |
| EP3187491A4 (en) | 2014-08-28 | 2018-08-01 | Eisai R&D Management Co., Ltd. | High-purity quinoline derivative and method for manufacturing same |
| US20180028662A1 (en) | 2015-02-25 | 2018-02-01 | Eisai R&D Management Co., Ltd. | Method for Suppressing Bitterness of Quinoline Derivative |
| CA2988707C (en) | 2015-06-16 | 2023-10-10 | Eisai R&D Management Co., Ltd. | Combination of cbp/catenin inhibitor and immune checkpoint inhibitor for treating cancer |
| CN108135894B (zh) | 2015-08-20 | 2021-02-19 | 卫材R&D管理有限公司 | 肿瘤治疗剂 |
| CN110072528B (zh) | 2017-02-08 | 2022-04-26 | 卫材R&D管理有限公司 | 治疗肿瘤的药物组合物 |
| WO2018212202A1 (en) | 2017-05-16 | 2018-11-22 | Eisai R&D Management Co., Ltd. | Treatment of hepatocellular carcinoma |
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| GB2297550B (en) * | 1995-02-06 | 1997-04-09 | Smithkline Beecham Plc | Paroxetine hydrochloride anhydrate substantially free of bound organic solvent |
| SK283608B6 (sk) * | 1995-02-06 | 2003-10-07 | Smithkline Beecham Plc | Bezvodý hydrochlorid paroxetínu, spôsob jeho výroby a použitie |
| EP0818990A1 (en) * | 1995-04-03 | 1998-01-21 | Abbott Laboratories | Homogeneous mixtures of low temperature-melting drugs and additives for controlled release |
| CA2220963A1 (en) * | 1995-05-17 | 1996-11-21 | Novo Nordisk A/S | Process for preparing 4-aryl-piperidine derivatives |
| JP2813768B2 (ja) * | 1995-05-24 | 1998-10-22 | 農林水産省家畜衛生試験場長 | 口蹄疫診断用ペプチドおよび当該ペプチドを含有する口蹄疫診断用抗原 |
| GB9514842D0 (en) * | 1995-07-20 | 1995-09-20 | Smithkline Beecham Plc | Novel formulation |
| AU701386B2 (en) * | 1995-10-31 | 1999-01-28 | Merck & Co., Inc. | Process for preparing substituted azetidinones |
| IT1276160B1 (it) * | 1995-11-22 | 1997-10-27 | Recordati Chem Pharm | Composizioni farmaceutiche orali a pronto rilascio per sospensioni estemporanee |
| GB9526645D0 (en) * | 1995-12-28 | 1996-02-28 | Chiroscience Ltd | Stereoselective synthesis |
| ES2117557B1 (es) * | 1996-02-29 | 1999-07-01 | Ferrer Int | Nuevo procedimiento de obtencion de (-)-trans -n-p-fluorobenzoilmetil-4-(p-fluorofenil)-3- ((3,4-(metilendioxi)fenoxi ) metil)-piperidina. |
| JP3446468B2 (ja) * | 1996-04-15 | 2003-09-16 | 旭硝子株式会社 | ピペリジンカルビノール類の製造方法 |
| CA2206592A1 (en) * | 1996-05-30 | 1997-11-30 | Shu-Zhong Wang | Method of producing amorphous paroxetine hydrochloride |
| JP3882224B2 (ja) * | 1996-05-31 | 2007-02-14 | 旭硝子株式会社 | パロキセチンの製造方法 |
| EP0812827B1 (en) * | 1996-06-13 | 2009-09-02 | Sumitomo Chemical Company, Limited | Piperidine derivative as intermediates for the preparation of paroxetine and process for their preparation |
| HU221921B1 (hu) * | 1996-07-08 | 2003-02-28 | Richter Gedeon Vegyészeti Gyár Rt. | N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására |
| US5672609A (en) * | 1996-07-18 | 1997-09-30 | Eli Lilly And Company | Pyridine compounds, intermediates compositions and methods of use |
| CA2187128A1 (en) * | 1996-10-04 | 1997-06-26 | K. S. Keshava Murthy | New and useful polymorph of anhydrous paroxetine hydrochloride |
| US5955475A (en) * | 1997-06-30 | 1999-09-21 | Endo Pharmaceuticals Inc. | Process for manufacturing paroxetine solid dispersions |
| CH689805A8 (fr) | 1998-07-02 | 2000-02-29 | Smithkline Beecham Plc | Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant. |
-
1997
- 1997-06-10 JP JP50212699A patent/JP2002503248A/ja not_active Ceased
- 1997-06-10 DK DK97926276T patent/DK0994872T3/da active
- 1997-06-10 PT PT97926276T patent/PT994872E/pt unknown
- 1997-06-10 BR BR9714787-7A patent/BR9714787A/pt unknown
- 1997-06-10 SK SK1619-99A patent/SK283394B6/sk unknown
- 1997-06-10 ES ES97926276T patent/ES2155995T3/es not_active Expired - Lifetime
- 1997-06-10 WO PCT/NL1997/000328 patent/WO1998056787A1/en not_active Ceased
- 1997-06-10 DE DE29724281U patent/DE29724281U1/de not_active Expired - Lifetime
- 1997-06-10 IL IL13336697A patent/IL133366A/xx not_active IP Right Cessation
- 1997-06-10 EE EEP199900570A patent/EE03970B1/xx not_active IP Right Cessation
- 1997-06-10 HU HU0003141A patent/HUP0003141A3/hu unknown
- 1997-06-10 US US08/872,023 patent/US5874447A/en not_active Expired - Lifetime
- 1997-06-10 CZ CZ19994295A patent/CZ295301B6/cs not_active IP Right Cessation
- 1997-06-10 AU AU31080/97A patent/AU3108097A/en not_active Abandoned
- 1997-06-10 DE DE69704679T patent/DE69704679T2/de not_active Expired - Lifetime
- 1997-06-10 AT AT97926276T patent/ATE200781T1/de not_active IP Right Cessation
- 1997-06-10 EE EEP200200633A patent/EE200200633A/xx unknown
- 1997-06-10 KR KR1019997011625A patent/KR100543614B1/ko not_active Expired - Fee Related
- 1997-06-10 CA CA002293247A patent/CA2293247C/en not_active Expired - Lifetime
- 1997-06-10 TR TR1999/03025T patent/TR199903025T2/tr unknown
- 1997-06-10 PL PL97336895A patent/PL188450B1/pl not_active IP Right Cessation
- 1997-06-10 SI SI9730138T patent/SI0994872T1/xx unknown
- 1997-06-10 EP EP97926276A patent/EP0994872B9/en not_active Expired - Lifetime
- 1997-06-10 EP EP00203910A patent/EP1078925A1/en not_active Withdrawn
- 1997-06-10 TR TR2002/01156T patent/TR200201156T2/tr unknown
-
1998
- 1998-11-30 US US09/200,743 patent/US7598271B1/en not_active Expired - Lifetime
-
1999
- 1999-11-08 NO NO19995455A patent/NO317371B1/no unknown
- 1999-11-16 IS IS5249A patent/IS1927B/is unknown
- 1999-12-10 BG BG103980A patent/BG64315B1/bg unknown
-
2001
- 2001-04-26 GR GR20010400220T patent/GR3035784T3/el not_active IP Right Cessation
- 2001-05-16 US US09/855,710 patent/US6900327B2/en not_active Expired - Lifetime
-
2003
- 2003-08-25 NO NO20033766A patent/NO20033766D0/no not_active Application Discontinuation
- 2003-08-25 NO NO20033765A patent/NO20033765D0/no not_active Application Discontinuation
-
2004
- 2004-01-08 IS IS7098A patent/IS7098A/is unknown
-
2009
- 2009-01-23 US US12/358,997 patent/US20090326233A1/en not_active Abandoned
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