TR200101482T2 - WT1'e özgü imünoterapi için bileşimler - Google Patents
WT1'e özgü imünoterapi için bileşimlerInfo
- Publication number
- TR200101482T2 TR200101482T2 TR2001/01482T TR200101482T TR200101482T2 TR 200101482 T2 TR200101482 T2 TR 200101482T2 TR 2001/01482 T TR2001/01482 T TR 2001/01482T TR 200101482 T TR200101482 T TR 200101482T TR 200101482 T2 TR200101482 T2 TR 200101482T2
- Authority
- TR
- Turkey
- Prior art keywords
- compositions
- polypeptide
- specific immunotherapy
- treatment
- cell
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000009169 immunotherapy Methods 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 206010061289 metastatic neoplasm Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4242—Transcription factors, e.g. SOX or c-MYC
- A61K40/4243—Wilms tumor 1 [WT1]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Lösemi ve kanser gibi habis hastaliklarin tedavisi için bilesimler ve yöntemler tarif edilmektedir. Bilesimler bir WT1 polinükleotidi, bir WT1 polipeptidi, bir WT1 polipeptidi olusturan bir antijen olusturucu hücre, bir WT1 polipeptidine özel olarak baglanan bir antikor veya bir WT1 polipeptidi ile özel olarak tepkimeye girebilen bir T hücresinden bir veya daha fazlasini içerir. Bu tip bilesimler örnegin metastatik hastaliklarin önlenmesinde ve tedavi edilmesinde kullanilabilir.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/164,223 US7063854B1 (en) | 1998-09-30 | 1998-09-30 | Composition and methods for WTI specific immunotherapy |
| US27648499A | 1999-03-25 | 1999-03-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200101482T2 true TR200101482T2 (tr) | 2002-01-21 |
Family
ID=26860363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2001/01482T TR200101482T2 (tr) | 1998-09-30 | 1999-09-30 | WT1'e özgü imünoterapi için bileşimler |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1117687B1 (tr) |
| JP (3) | JP4243792B2 (tr) |
| KR (1) | KR100752065B1 (tr) |
| CN (1) | CN100486995C (tr) |
| AR (1) | AR021849A1 (tr) |
| AT (1) | ATE399179T1 (tr) |
| AU (1) | AU6407899A (tr) |
| BR (1) | BR9914116A (tr) |
| CA (1) | CA2349442C (tr) |
| CZ (1) | CZ20011144A3 (tr) |
| DE (1) | DE69938970D1 (tr) |
| ES (1) | ES2310052T3 (tr) |
| HK (1) | HK1039782B (tr) |
| HU (1) | HUP0103598A3 (tr) |
| IL (2) | IL142216A0 (tr) |
| MX (1) | MXPA01003344A (tr) |
| MY (1) | MY139226A (tr) |
| NO (1) | NO325839B1 (tr) |
| NZ (1) | NZ510600A (tr) |
| PL (1) | PL201881B1 (tr) |
| RU (1) | RU2237674C2 (tr) |
| SA (1) | SA00200872B1 (tr) |
| TR (1) | TR200101482T2 (tr) |
| TW (1) | TWI285648B (tr) |
| WO (1) | WO2000018795A2 (tr) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2203782T3 (es) | 1996-01-17 | 2004-04-16 | Imperial College Innovations Limited | Inmunoterapia que utiliza linfocitos t citotoxicos (ctl). |
| CN1560078B (zh) * | 1998-07-31 | 2011-06-22 | 株式会社国际癌症免疫研究所 | 基于癌抑制基因wt1的产物的癌抗原 |
| US7063854B1 (en) | 1998-09-30 | 2006-06-20 | Corixa Corporation | Composition and methods for WTI specific immunotherapy |
| US7901693B2 (en) | 1998-09-30 | 2011-03-08 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US20030072767A1 (en) * | 1998-09-30 | 2003-04-17 | Alexander Gaiger | Compositions and methods for WT1 specific immunotherapy |
| US7655249B2 (en) | 1998-09-30 | 2010-02-02 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US7115272B1 (en) | 1998-09-30 | 2006-10-03 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US20030235557A1 (en) * | 1998-09-30 | 2003-12-25 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US7144581B2 (en) | 2000-10-09 | 2006-12-05 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US7329410B1 (en) | 1998-09-30 | 2008-02-12 | Corixa Corporation | Compositions and method for WT1 specific immunotherapy |
| GB9823897D0 (en) | 1998-11-02 | 1998-12-30 | Imp College Innovations Ltd | Immunotherapeutic methods and molecules |
| AU7859900A (en) * | 1999-10-04 | 2001-05-10 | Corixa Corporation | Compositions and methods for wt1 specific immunotherapy |
| CA2401070A1 (en) * | 2000-02-22 | 2001-08-30 | Corixa Corporation | Compositions and methods for diagnosis and therapy of malignant mesothelioma |
| JP4592641B2 (ja) * | 2000-05-24 | 2010-12-01 | 治夫 杉山 | Wt1関連疾患の検査方法 |
| JP3846199B2 (ja) * | 2000-05-24 | 2006-11-15 | 治夫 杉山 | Wt1関連疾患の検査方法 |
| ES2298353T3 (es) * | 2001-03-22 | 2008-05-16 | International Institute Of Cancer Immunology, Inc. | Peptido wt1 modificado. |
| CN1320923C (zh) * | 2001-06-29 | 2007-06-13 | 中外制药株式会社 | 含有基于癌抑制基因wt1的产物的癌抗原和阳离子脂质体的癌疫苗 |
| US7553494B2 (en) | 2001-08-24 | 2009-06-30 | Corixa Corporation | WT1 fusion proteins |
| US8735357B2 (en) | 2001-09-28 | 2014-05-27 | International Institute Of Cancer Immunology, Inc. | Method of inducing antigen-specific T cells |
| US20050002951A1 (en) * | 2001-09-28 | 2005-01-06 | Haruo Sugiyama | Novel method of inducing antigen-specific t cells |
| WO2003106682A1 (ja) * | 2002-06-12 | 2003-12-24 | 中外製薬株式会社 | Hla−a24拘束性癌抗原ペプチド |
| WO2004024175A1 (ja) * | 2002-09-12 | 2004-03-25 | Haruo Sugiyama | 癌抗原ペプチド製剤 |
| ATE442378T1 (de) | 2002-09-20 | 2009-09-15 | Int Inst Cancer Immunology Inc | Substituierte wt1-peptide |
| EP1584627B1 (en) * | 2003-01-15 | 2009-10-07 | International Institute of Cancer Immunology, Inc. | Dimerized peptide |
| KR101431312B1 (ko) * | 2003-06-27 | 2014-08-20 | 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 | Wt1 백신 적응 환자의 선택 방법 |
| CN101580538B (zh) * | 2003-11-05 | 2013-06-19 | 株式会社国际癌症免疫研究所 | Wt1衍生的hla-dr-结合抗原肽 |
| ES2556232T3 (es) | 2004-03-31 | 2016-01-14 | International Institute Of Cancer Immunology, Inc. | Péptidos antigénicos del cáncer derivados de WT1 |
| EP1657250A1 (en) * | 2004-11-11 | 2006-05-17 | Charité - Universitätsmedizin Berlin | HLA-A *01-binding T-cell epitope of WT1 |
| RU2286146C1 (ru) * | 2005-04-12 | 2006-10-27 | Ростовский научно-исследовательский онкологический институт МЗ РФ | Способ лечения церебральных метастазов генерализованной меланомы кожи |
| RU2301061C2 (ru) * | 2005-04-28 | 2007-06-20 | Ростовский научно-исследовательский онкологический институт МЗ РФ | Способ лечения генерализованной меланомы кожи |
| ES2352855T3 (es) | 2005-11-30 | 2011-02-23 | International Institute Of Cancer Immunology, Inc. | Nuevos compuestos peptídicos del tumor de wilms. |
| ES2587980T3 (es) | 2006-02-22 | 2016-10-28 | International Institute Of Cancer Immunology, Inc | Péptido WT1 con restricción HLA-A*3303 y composición farmacéutica que lo contiene |
| DK2091965T3 (da) * | 2006-10-17 | 2013-08-05 | Oncotherapy Science Inc | Peptidvacciner mod cancere, der udtrykker MPHOSPH1- eller DEPDC1-polypeptider |
| CA2670658A1 (en) | 2006-12-28 | 2008-07-10 | International Institute Of Cancer Immunology, Inc. | Hla-a*1101-restricted wt1 peptide and pharmaceutical composition comprising the same |
| MX2009009168A (es) | 2007-02-27 | 2009-09-07 | Int Inst Cancer Immunology Inc | Metodo para activacion de celula t auxiliar y composicion para usarse en el metodo. |
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| ES2731343T3 (es) * | 2009-05-19 | 2019-11-15 | Univ Miami | Composiciones, kits y métodos para presentación de antígenos in vitro, evaluación de eficacia de vacunas y evaluación de la inmunotoxicidad de productos biológicos y fármacos |
| SG189287A1 (en) | 2010-10-05 | 2013-05-31 | Int Inst Cancer Immunology Inc | Method for activating helper t cell |
| KR20140033029A (ko) | 2011-04-01 | 2014-03-17 | 메모리얼 슬로안-케터링 캔서 센터 | 에이치엘에이 에이2에 의해 제공된 더블유티1 펩타이드에 특이적인 티 세포 수용체 유사 항체 |
| KR20140039318A (ko) | 2011-06-28 | 2014-04-01 | 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 | 펩티드 암 항원 특이적 t 세포의 리셉터 유전자 |
| EP2868325B1 (en) | 2012-07-02 | 2017-11-01 | Sumitomo Dainippon Pharma Co., Ltd. | Transdermal cancer antigen peptide preparation |
| WO2014098012A1 (ja) | 2012-12-17 | 2014-06-26 | 大塚製薬株式会社 | ヘルパーt細胞の活性化方法 |
| US9663563B2 (en) | 2013-03-12 | 2017-05-30 | Sumitomo Dainippon Pharma Co., Ltd. | Aqueous liquid composition |
| MY171854A (en) | 2013-03-29 | 2019-11-05 | Sumitomo Dainippon Pharma Co Ltd | Wt1 antigen peptide conjugate vaccine |
| EP2980097A4 (en) | 2013-03-29 | 2017-03-08 | Sumitomo Dainippon Pharma Co., Ltd. | Conjugate vaccine using trimming function of erap1 |
| AU2014266396A1 (en) * | 2013-05-13 | 2015-12-03 | International Institute Of Cancer Immunology, Inc. | Method for predicting clinical effect of immunotherapy |
| CN106170297A (zh) * | 2013-09-20 | 2016-11-30 | 纪念斯隆-凯特琳癌症中心 | 用于wt‑1‑阳性疾病的组合/辅助疗法 |
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| MX392470B (es) * | 2014-12-11 | 2025-03-24 | Int Inst Cancer Immunology Inc | Composición farmacéutica que comprende un péptido wt1 para el tratamiento o prevención de una enfermedad angiogénica. |
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| US5705159A (en) * | 1993-08-31 | 1998-01-06 | John Wayne Cancer Institute | Immunoreactive peptide sequence from a 43 KD human cancer antigen |
| US5622835A (en) * | 1994-04-28 | 1997-04-22 | The Wistar Institute Of Anatomy & Biology | WT1 monoclonal antibodies |
| WO1999058135A1 (en) * | 1998-05-11 | 1999-11-18 | The Salk Institute For Biological Studies | Compositions for the treatment of tumors, and uses thereof |
| CN1560078B (zh) * | 1998-07-31 | 2011-06-22 | 株式会社国际癌症免疫研究所 | 基于癌抑制基因wt1的产物的癌抗原 |
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1999
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- 1999-09-30 CZ CZ20011144A patent/CZ20011144A3/cs unknown
- 1999-09-30 PL PL348595A patent/PL201881B1/pl not_active IP Right Cessation
- 1999-09-30 CN CNB998133493A patent/CN100486995C/zh not_active Expired - Fee Related
- 1999-09-30 KR KR1020017004049A patent/KR100752065B1/ko not_active Expired - Fee Related
- 1999-09-30 HU HU0103598A patent/HUP0103598A3/hu unknown
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- 1999-09-30 BR BR9914116-7A patent/BR9914116A/pt not_active Application Discontinuation
- 1999-09-30 WO PCT/US1999/022819 patent/WO2000018795A2/en not_active Ceased
- 1999-09-30 AR ARP990104969A patent/AR021849A1/es active IP Right Grant
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