TR200200076T2 - Oral yoldan aktif androjenler - Google Patents

Oral yoldan aktif androjenler

Info

Publication number
TR200200076T2
TR200200076T2 TR2002/00076T TR200200076T TR200200076T2 TR 200200076 T2 TR200200076 T2 TR 200200076T2 TR 2002/00076 T TR2002/00076 T TR 2002/00076T TR 200200076 T TR200200076 T TR 200200076T TR 200200076 T2 TR200200076 T2 TR 200200076T2
Authority
TR
Turkey
Prior art keywords
alkyl
hydrogen
orally active
active androgens
acyl
Prior art date
Application number
TR2002/00076T
Other languages
English (en)
Inventor
Jan Jozef Loozen Hubert
Leysen Dirk
Van Der Louw Jaap
Original Assignee
Akzo Nobel N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel N.V. filed Critical Akzo Nobel N.V.
Publication of TR200200076T2 publication Critical patent/TR200200076T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Yeni, oral yoldan aktif androjenler, 7 alfa ikameli delta14-nandrolon türevleridir. Bilesikler, fomül (I)'e sahiptirler; buradaki R1, O, (H,H) (H, OR), NOR'dir; R, hidrojen, (C1-6) alkil veya (C1-6) asildir; R2, herbiri seçime bagli olarak halojenle ikame edilen (C2-4) alkil, (C2-4) alkenil veya (C2-4) alkinilden olusan gruptan seçilir; veya R2, herbiri seçime bagli olarak (C1-2) alkil veya halojenle ikame edilen siklopropil veya siklopropenildir; R3, hidrojen, (C^-2) alkil veya etenildir; R4, (C1-2) alkildir; R5, hidrojen veya (C1-15) asildir; ve nokta nokta çizgiler, seçime bagli baglari gösterirler (FORMÜL VAR).
TR2002/00076T 1999-07-16 2000-07-10 Oral yoldan aktif androjenler TR200200076T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99202348 1999-07-16

Publications (1)

Publication Number Publication Date
TR200200076T2 true TR200200076T2 (tr) 2002-04-22

Family

ID=8240463

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/00076T TR200200076T2 (tr) 1999-07-16 2000-07-10 Oral yoldan aktif androjenler

Country Status (28)

Country Link
US (3) US6313108B1 (tr)
EP (1) EP1203011B1 (tr)
JP (1) JP2003505394A (tr)
KR (1) KR20020092890A (tr)
CN (1) CN1360589A (tr)
AR (1) AR024746A1 (tr)
AT (1) ATE257159T1 (tr)
AU (1) AU770412B2 (tr)
BR (1) BR0012489A (tr)
CA (1) CA2379223A1 (tr)
CO (1) CO5200765A1 (tr)
CZ (1) CZ2002192A3 (tr)
DE (1) DE60007530T2 (tr)
ES (1) ES2213596T3 (tr)
HK (1) HK1043797A1 (tr)
HU (1) HUP0201952A3 (tr)
IL (1) IL147332A0 (tr)
MX (1) MXPA02000601A (tr)
NO (1) NO20020222L (tr)
NZ (1) NZ516525A (tr)
PE (1) PE20010330A1 (tr)
PL (1) PL353007A1 (tr)
RU (1) RU2002103883A (tr)
SK (1) SK712002A3 (tr)
TR (1) TR200200076T2 (tr)
TW (1) TW548277B (tr)
WO (1) WO2001005806A1 (tr)
ZA (1) ZA200200106B (tr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2204613T3 (es) * 1999-04-06 2004-05-01 Akzo Nobel N.V. Androgenos 7-alfa alquilo oralmente activos.
US20030069215A1 (en) * 2001-03-30 2003-04-10 The Government Of The United States Of America, Methods of making and using 7a,11b-dimethyl-17b-hydroxy-4-estren-3-one 17b-trans-4-n-butylcyclohexane carboxylate and 7a,11b-dimethyl-17b-hydroxyestr-4-en-3-one 17-undecanoate
ATE334682T1 (de) * 2000-03-31 2006-08-15 Us Gov Health & Human Serv Verfahren zur herstellung von den trans-4-n- butylcyclohexanoicsaüre- und undecanoicsaüreestern von (7-alpha,11-beta)- dimethyl-17 beta -hydroxy-4-estren-3-one und deren medizynische anwendung
BR0112791A (pt) * 2000-07-28 2003-06-24 Akzo Nobel Nv Composto esteroidal 16alfa-substituido, uso do mesmo, métodos de tratamento para ativação seletiva de receptores de estrogênio do subtipo alfa, e para terapia de reposição hormonal ou contracepção, e, composição farmacêutica
ATE321557T1 (de) * 2001-03-30 2006-04-15 Us Gov Health & Human Serv Verfahren zur herstellung von 7alpha,11beta- dimethyl-17beta-hydroxyestra-4, 14-dien-3-one, dessen 17-ester und pharmazeutische zubereitungen die sie enthalten
KR100937179B1 (ko) * 2002-01-21 2010-01-19 엔.브이.오가논 7α-메틸스테로이드의 제조방법
GB0304927D0 (en) * 2003-03-04 2003-04-09 Resolution Chemicals Ltd Process for the production of tibolone
PE20050677A1 (es) 2003-12-22 2005-10-04 Akzo Nobel Nv Esteroides con perfil androgenico y progestagenico mixto
UA89964C2 (ru) 2004-09-08 2010-03-25 Н.В. Органон 15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ
EP2350111A1 (en) * 2008-10-15 2011-08-03 Synthon B.V. Processes and intermediates for the production of fulvestrant
AU2012264602B2 (en) 2011-06-01 2017-03-09 Estetra Srl Process for the production of estetrol intermediates
WO2012164095A1 (en) * 2011-06-01 2012-12-06 Estetra S.A. Process for the production of estetrol intermediates
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
AU2012320423C1 (en) * 2011-10-07 2018-01-25 Estetra Srl Process for the production of estetrol
WO2015181116A1 (en) 2014-05-26 2015-12-03 Crystal Pharma, S.A.U. Process and intermediades for the preparation of 7-alkylated steroids
US20160367567A1 (en) 2015-06-18 2016-12-22 Mithra Pharmaceuticals S.A. Orodispersible dosage unit containing an estetrol component
UA123099C2 (uk) 2015-06-18 2021-02-17 Естетра Спрл Диспергована в порожнині рота одиниця дозування, яка містить естетрольний компонент
HRP20210668T1 (hr) 2015-06-18 2021-05-28 Estetra Sprl Orodisperzibilna tableta koja sadrži estetrol
MD3310346T2 (ro) 2015-06-18 2021-06-30 Estetra Sprl Comprimată orodispersabilă ce conține estetrol
CA3178291A1 (en) 2016-08-05 2018-04-12 Estetra Srl Method for the management of dysmenorrhea and menstrual pain
ES2906117T3 (es) * 2017-02-23 2022-04-13 Siemens Healthcare Diagnostics Inc Conjugados de androstenodiona quimioluminiscente
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
TWI893101B (zh) 2020-04-16 2025-08-11 比利時商埃斯特拉有限責任公司 具有降低之副作用之避孕組成物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA712312B (en) * 1970-04-28 1972-01-26 Ochsner Med Found Alton 4,14-estradiene compounds

Also Published As

Publication number Publication date
DE60007530D1 (de) 2004-02-05
CZ2002192A3 (cs) 2002-06-12
HUP0201952A3 (en) 2003-10-28
RU2002103883A (ru) 2004-02-27
SK712002A3 (en) 2002-06-04
US20020022609A1 (en) 2002-02-21
ZA200200106B (en) 2003-06-25
BR0012489A (pt) 2002-04-02
WO2001005806A1 (en) 2001-01-25
AU770412B2 (en) 2004-02-19
US6780854B2 (en) 2004-08-24
CO5200765A1 (es) 2002-09-27
NO20020222L (no) 2002-01-25
IL147332A0 (en) 2002-08-14
HK1043797A1 (zh) 2002-09-27
EP1203011A1 (en) 2002-05-08
PE20010330A1 (es) 2001-03-22
NO20020222D0 (no) 2002-01-15
TW548277B (en) 2003-08-21
HUP0201952A2 (en) 2002-10-28
DE60007530T2 (de) 2004-12-23
US20030087886A1 (en) 2003-05-08
MXPA02000601A (es) 2002-07-30
ES2213596T3 (es) 2004-09-01
JP2003505394A (ja) 2003-02-12
US6313108B1 (en) 2001-11-06
US6541465B2 (en) 2003-04-01
KR20020092890A (ko) 2002-12-12
CA2379223A1 (en) 2001-01-25
CN1360589A (zh) 2002-07-24
AU6562900A (en) 2001-02-05
NZ516525A (en) 2003-06-30
EP1203011B1 (en) 2004-01-02
AR024746A1 (es) 2002-10-23
ATE257159T1 (de) 2004-01-15
PL353007A1 (en) 2003-09-22

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