TR200200222T2 - Konjügatların üretimi ve moleküllerin taşınması için kullanımları - Google Patents

Konjügatların üretimi ve moleküllerin taşınması için kullanımları

Info

Publication number
TR200200222T2
TR200200222T2 TR2002/00222T TR200200222T TR200200222T2 TR 200200222 T2 TR200200222 T2 TR 200200222T2 TR 2002/00222 T TR2002/00222 T TR 2002/00222T TR 200200222 T TR200200222 T TR 200200222T TR 200200222 T2 TR200200222 T2 TR 200200222T2
Authority
TR
Turkey
Prior art keywords
conjugates
production
transporting molecules
present
subject
Prior art date
Application number
TR2002/00222T
Other languages
English (en)
Inventor
Uhlmann Eugen
Unger Eberhard
Greiner Beate
Gothe Gislinde
Schwerdel Marc
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of TR200200222T2 publication Critical patent/TR200200222T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)

Abstract

Eldeki bulusun konusunu konjügatlar, üretimleri ve bu konjügatlarin düsük moleküllü bilesiklerin ve makromoleküllerin biyolojik zarlarin üzerinden tasinmasi, özellikle de moleküllerin hücrelere tasinmasi amaciyla kullanilmasi olusturuyor. Eldeki bulusun bir diger konusunu da bu konjügatlarin kullanildigi ya da yararlanildigi ilaç ve teshis ürünleri ile test kitleridir.
TR2002/00222T 1999-07-28 2000-07-20 Konjügatların üretimi ve moleküllerin taşınması için kullanımları TR200200222T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19935302A DE19935302A1 (de) 1999-07-28 1999-07-28 Konjugate und Verfahren zu deren Herstellung sowie deren Verwendung zum Transport von Molekülen über biologische Membranen

Publications (1)

Publication Number Publication Date
TR200200222T2 true TR200200222T2 (tr) 2002-07-22

Family

ID=7916258

Family Applications (4)

Application Number Title Priority Date Filing Date
TR2011/09493T TR201109493T2 (tr) 1999-07-28 2000-07-20 Konjügatların üretimi ve moleküllerin taşınması için kullanımları.
TR2007/06709T TR200706709T2 (tr) 1999-07-28 2000-07-20 Konjugatların üretimi ve moleküllerin taşınması için kullanımları
TR2002/00222T TR200200222T2 (tr) 1999-07-28 2000-07-20 Konjügatların üretimi ve moleküllerin taşınması için kullanımları
TR2011/09491T TR201109491T2 (tr) 1999-07-28 2000-07-20 Konjügatların üretimi ve moleküllerin taşınması için kullanımları.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
TR2011/09493T TR201109493T2 (tr) 1999-07-28 2000-07-20 Konjügatların üretimi ve moleküllerin taşınması için kullanımları.
TR2007/06709T TR200706709T2 (tr) 1999-07-28 2000-07-20 Konjugatların üretimi ve moleküllerin taşınması için kullanımları

Family Applications After (1)

Application Number Title Priority Date Filing Date
TR2011/09491T TR201109491T2 (tr) 1999-07-28 2000-07-20 Konjügatların üretimi ve moleküllerin taşınması için kullanımları.

Country Status (32)

Country Link
US (1) US8420396B2 (tr)
EP (1) EP1204430B1 (tr)
JP (1) JP4791665B2 (tr)
KR (1) KR100721696B1 (tr)
CN (1) CN1227035C (tr)
AR (1) AR029385A1 (tr)
AT (1) ATE447413T1 (tr)
AU (1) AU776114B2 (tr)
BR (1) BR0012757A (tr)
CA (1) CA2377977C (tr)
CY (1) CY1109744T1 (tr)
CZ (1) CZ2002300A3 (tr)
DE (2) DE19935302A1 (tr)
DK (1) DK1204430T3 (tr)
EE (1) EE05303B1 (tr)
ES (1) ES2335741T3 (tr)
HR (1) HRP20020074B1 (tr)
HU (1) HUP0201995A3 (tr)
IL (2) IL147527A0 (tr)
ME (1) MEP56408A (tr)
MX (1) MXPA01013114A (tr)
NO (1) NO334155B1 (tr)
NZ (1) NZ516838A (tr)
PL (1) PL202881B1 (tr)
PT (1) PT1204430E (tr)
RS (2) RS20100249A (tr)
RU (1) RU2275936C2 (tr)
SI (1) SI1204430T1 (tr)
SK (1) SK287654B6 (tr)
TR (4) TR201109493T2 (tr)
WO (1) WO2001008707A2 (tr)
ZA (1) ZA200200657B (tr)

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US20030129251A1 (en) * 2000-03-10 2003-07-10 Gary Van Nest Biodegradable immunomodulatory formulations and methods for use thereof
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US20070167388A1 (en) * 2003-09-11 2007-07-19 Universitätsklinikum Schleswig-Holstein Campus Lübeck Nucleotide sequences promoting the trans-membrane transport of nucleic acids
AU2004275876B2 (en) * 2003-09-25 2011-03-31 Coley Pharmaceutical Gmbh Nucleic acid-lipophilic conjugates
EP1886681A3 (en) * 2004-10-07 2008-11-19 Sulfidris S.r.l. 5-(p-hydroxyphenyl)-3H-1,2-dithiol-3-thione valproate ester
KR100690199B1 (ko) * 2006-04-20 2007-03-12 이화여자대학교 산학협력단 구리 이온 선택성을 갖는 플루오레세인 유도체, 이의제조방법 및 이를 이용한 생체 내 구리 이온 검출방법
KR20100068422A (ko) * 2007-10-09 2010-06-23 콜리 파마슈티칼 게엠베하 변경된 당 잔기를 함유하는 면역자극성 올리고뉴클레오티드 유사체
ES2605990T3 (es) * 2010-12-29 2017-03-17 F. Hoffmann-La Roche Ag Conjugados de molécula pequeña para la administración intracelular de ácidos nucleicos
JP6825914B2 (ja) * 2014-05-23 2021-02-03 ジェンザイム・コーポレーション ペプチド担体上の多重オリゴヌクレオチド部分
US20180036312A1 (en) * 2016-08-02 2018-02-08 ISI Life Sciences Inc. Novel Scaffolds for Intracellular Compound Delivery for the Detection of Cancer Cells
EP3493855A4 (en) 2016-08-02 2020-04-01 ISI Life Sciences, Inc. COMPOSITIONS AND METHOD FOR DETECTING CANCER CELLS IN A TISSUE SAMPLE
US10753942B2 (en) 2017-05-15 2020-08-25 Indicator Systems International, Inc. Methods to detect remnant cancer cells
US10539567B2 (en) * 2017-05-15 2020-01-21 Indicator Systems International, Inc. Biopsy methods and devices
KR20230096856A (ko) 2021-12-22 2023-06-30 한국과학기술연구원 신규 펩타이드-올리고뉴클레오티드 접합체 및 이의 용도

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Also Published As

Publication number Publication date
KR100721696B1 (ko) 2007-05-28
MXPA01013114A (es) 2002-06-04
TR200706709T2 (tr) 2008-02-21
WO2001008707A2 (de) 2001-02-08
HUP0201995A2 (en) 2002-10-28
JP2003505517A (ja) 2003-02-12
ES2335741T3 (es) 2010-04-05
IL147527A (en) 2006-08-01
NO334155B1 (no) 2013-12-23
CZ2002300A3 (cs) 2002-05-15
IL147527A0 (en) 2002-08-14
HK1047042A1 (en) 2003-02-07
JP4791665B2 (ja) 2011-10-12
US20080071069A1 (en) 2008-03-20
PL202881B1 (pl) 2009-07-31
ZA200200657B (en) 2003-09-23
DE19935302A1 (de) 2001-02-08
EP1204430A2 (de) 2002-05-15
TR201109493T2 (tr) 2012-03-21
HUP0201995A3 (en) 2005-02-28
CA2377977C (en) 2011-09-20
YU90301A (sh) 2004-05-12
RU2275936C2 (ru) 2006-05-10
CY1109744T1 (el) 2014-09-10
US8420396B2 (en) 2013-04-16
NO20020367L (no) 2002-03-26
NZ516838A (en) 2004-07-30
PT1204430E (pt) 2010-01-26
MEP56408A (en) 2011-05-10
EE05303B1 (et) 2010-06-15
TR201109491T2 (tr) 2012-02-21
DK1204430T3 (da) 2010-03-29
AR029385A1 (es) 2003-06-25
CN1360507A (zh) 2002-07-24
ATE447413T1 (de) 2009-11-15
BR0012757A (pt) 2002-04-02
KR20020031392A (ko) 2002-05-01
AU776114B2 (en) 2004-08-26
AU6825200A (en) 2001-02-19
HRP20020074B1 (en) 2011-01-31
SI1204430T1 (sl) 2010-03-31
CA2377977A1 (en) 2001-02-08
RS20100249A (sr) 2011-02-28
WO2001008707A3 (de) 2001-11-08
HRP20020074A2 (en) 2005-10-31
DE50015781D1 (de) 2009-12-17
NO20020367D0 (no) 2002-01-23
CN1227035C (zh) 2005-11-16
EE200200035A (et) 2003-04-15
PL353069A1 (en) 2003-10-06
SK287654B6 (sk) 2011-05-06
RS51447B (sr) 2011-04-30
EP1204430B1 (de) 2009-11-04
SK1172002A3 (en) 2002-08-06

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