TR200706709T2 - Konjugatların üretimi ve moleküllerin taşınması için kullanımları - Google Patents

Konjugatların üretimi ve moleküllerin taşınması için kullanımları

Info

Publication number
TR200706709T2
TR200706709T2 TR2007/06709T TR200706709T TR200706709T2 TR 200706709 T2 TR200706709 T2 TR 200706709T2 TR 2007/06709 T TR2007/06709 T TR 2007/06709T TR 200706709 T TR200706709 T TR 200706709T TR 200706709 T2 TR200706709 T2 TR 200706709T2
Authority
TR
Turkey
Prior art keywords
conjugates
transport
molecules
production
present
Prior art date
Application number
TR2007/06709T
Other languages
English (en)
Inventor
Uhlmann Eugen
Unger Eberhard
Schwerdel Marc
Gothe Gislinde
Greiner Beate
Original Assignee
Sanofi-Aventis Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis Deutschland Gmbh filed Critical Sanofi-Aventis Deutschland Gmbh
Publication of TR200706709T2 publication Critical patent/TR200706709T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)

Abstract

Eldeki buluşun konusunu konjügatlar, üretimleri ve bu konjügatların düşük moleküllü bileşiklerin ve makromoleküllerin biyolojik zarların üzerinden taşınması, özellikle de moleküllerin hücrelere taşınması amacıyla kullanılması oluşturuyor. Eldeki buluşun bir diğer konusunu da bu konjügatların kullanıldığı ya da yararlanıldığı ilaç ve teşhis ürünleri ile test kitleridir.
TR2007/06709T 1999-07-28 2000-07-20 Konjugatların üretimi ve moleküllerin taşınması için kullanımları TR200706709T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19935302A DE19935302A1 (de) 1999-07-28 1999-07-28 Konjugate und Verfahren zu deren Herstellung sowie deren Verwendung zum Transport von Molekülen über biologische Membranen

Publications (1)

Publication Number Publication Date
TR200706709T2 true TR200706709T2 (tr) 2008-02-21

Family

ID=7916258

Family Applications (4)

Application Number Title Priority Date Filing Date
TR2011/09493T TR201109493T2 (tr) 1999-07-28 2000-07-20 Konjügatların üretimi ve moleküllerin taşınması için kullanımları.
TR2011/09491T TR201109491T2 (tr) 1999-07-28 2000-07-20 Konjügatların üretimi ve moleküllerin taşınması için kullanımları.
TR2007/06709T TR200706709T2 (tr) 1999-07-28 2000-07-20 Konjugatların üretimi ve moleküllerin taşınması için kullanımları
TR2002/00222T TR200200222T2 (tr) 1999-07-28 2000-07-20 Konjügatların üretimi ve moleküllerin taşınması için kullanımları

Family Applications Before (2)

Application Number Title Priority Date Filing Date
TR2011/09493T TR201109493T2 (tr) 1999-07-28 2000-07-20 Konjügatların üretimi ve moleküllerin taşınması için kullanımları.
TR2011/09491T TR201109491T2 (tr) 1999-07-28 2000-07-20 Konjügatların üretimi ve moleküllerin taşınması için kullanımları.

Family Applications After (1)

Application Number Title Priority Date Filing Date
TR2002/00222T TR200200222T2 (tr) 1999-07-28 2000-07-20 Konjügatların üretimi ve moleküllerin taşınması için kullanımları

Country Status (32)

Country Link
US (1) US8420396B2 (tr)
EP (1) EP1204430B1 (tr)
JP (1) JP4791665B2 (tr)
KR (1) KR100721696B1 (tr)
CN (1) CN1227035C (tr)
AR (1) AR029385A1 (tr)
AT (1) ATE447413T1 (tr)
AU (1) AU776114B2 (tr)
BR (1) BR0012757A (tr)
CA (1) CA2377977C (tr)
CY (1) CY1109744T1 (tr)
CZ (1) CZ2002300A3 (tr)
DE (2) DE19935302A1 (tr)
DK (1) DK1204430T3 (tr)
EE (1) EE05303B1 (tr)
ES (1) ES2335741T3 (tr)
HR (1) HRP20020074B1 (tr)
HU (1) HUP0201995A3 (tr)
IL (2) IL147527A0 (tr)
ME (1) MEP56408A (tr)
MX (1) MXPA01013114A (tr)
NO (1) NO334155B1 (tr)
NZ (1) NZ516838A (tr)
PL (1) PL202881B1 (tr)
PT (1) PT1204430E (tr)
RS (2) RS20100249A (tr)
RU (1) RU2275936C2 (tr)
SI (1) SI1204430T1 (tr)
SK (1) SK287654B6 (tr)
TR (4) TR201109493T2 (tr)
WO (1) WO2001008707A2 (tr)
ZA (1) ZA200200657B (tr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030129251A1 (en) * 2000-03-10 2003-07-10 Gary Van Nest Biodegradable immunomodulatory formulations and methods for use thereof
US7026166B2 (en) * 2002-01-22 2006-04-11 Chiron Corporation Fluorogenic dyes
US7704756B2 (en) 2003-01-21 2010-04-27 Novartis Vaccines And Diagnostics, Inc. Fluorogenic dyes
EP1668144B1 (en) * 2003-09-11 2011-08-17 Universitätsklinikum Schleswig-Holstein Campus Lübeck Nucleotide sequences promoting the trans-membrane transport of nucleic acids
AU2004275876B2 (en) * 2003-09-25 2011-03-31 Coley Pharmaceutical Gmbh Nucleic acid-lipophilic conjugates
EP1886681A3 (en) * 2004-10-07 2008-11-19 Sulfidris S.r.l. 5-(p-hydroxyphenyl)-3H-1,2-dithiol-3-thione valproate ester
KR100690199B1 (ko) * 2006-04-20 2007-03-12 이화여자대학교 산학협력단 구리 이온 선택성을 갖는 플루오레세인 유도체, 이의제조방법 및 이를 이용한 생체 내 구리 이온 검출방법
CN101820908A (zh) * 2007-10-09 2010-09-01 科利制药公司 包含改性糖部分的免疫刺激寡核苷酸类似物
CA3131967A1 (en) 2010-12-29 2012-07-05 F. Hoffman-La Roche Ag Small molecule conjugates for intracellular delivery of nucleic acids
CN106459975B (zh) 2014-05-23 2020-03-27 建新公司 肽载体上的多个寡核苷酸部分
WO2018026965A1 (en) 2016-08-02 2018-02-08 Isi Life Sciences, Inc. Compositions and methods for detecting cancer cells in a tissue sample
US20180036312A1 (en) * 2016-08-02 2018-02-08 ISI Life Sciences Inc. Novel Scaffolds for Intracellular Compound Delivery for the Detection of Cancer Cells
US10539567B2 (en) * 2017-05-15 2020-01-21 Indicator Systems International, Inc. Biopsy methods and devices
US10753942B2 (en) 2017-05-15 2020-08-25 Indicator Systems International, Inc. Methods to detect remnant cancer cells
KR20230096856A (ko) 2021-12-22 2023-06-30 한국과학기술연구원 신규 펩타이드-올리고뉴클레오티드 접합체 및 이의 용도

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8801070D0 (sv) * 1988-03-23 1988-03-23 Pharmacia Ab Method for immobilizing a dna sequence on a solid support
US5354844A (en) * 1989-03-16 1994-10-11 Boehringer Ingelheim International Gmbh Protein-polycation conjugates
WO1995006659A1 (en) * 1992-07-01 1995-03-09 Isis Pharmaceuticals, Inc. Amine-derivatized nucleosides and oligonucleosides
US6228982B1 (en) * 1992-05-22 2001-05-08 Benget Norden Double-stranded peptide nucleic acids
US6335434B1 (en) * 1998-06-16 2002-01-01 Isis Pharmaceuticals, Inc., Nucleosidic and non-nucleosidic folate conjugates
US6033909A (en) * 1992-01-22 2000-03-07 Hoechst Aktiengesellschaft Oligonucleotide analogs, their preparation and use
KR930016437A (ko) 1992-01-22 1993-08-26 귀틀라인, 슈미트 올리고뉴클레오티드 유사체, 이의 제조방법 및 용도
US5633360A (en) * 1992-04-14 1997-05-27 Gilead Sciences, Inc. Oligonucleotide analogs capable of passive cell membrane permeation
RU2094059C1 (ru) * 1993-08-30 1997-10-27 Московский государственный университет, химический факультет Способ транспорта нейротропных препаратов в мозг
US5820873A (en) * 1994-09-30 1998-10-13 The University Of British Columbia Polyethylene glycol modified ceramide lipids and liposome uses thereof
RU2127606C1 (ru) * 1994-12-23 1999-03-20 Санкт-Петербургский государственный университет Способ получения растворимых ковалентных конъюгатов
DE19502912A1 (de) * 1995-01-31 1996-08-01 Hoechst Ag G-Cap Stabilisierte Oligonucleotide
US5698411A (en) * 1995-05-18 1997-12-16 Coulter Corporation Method for determining activity of enzymes in metabolically active whole cells
AU7737196A (en) * 1996-11-14 1998-06-03 Brigham And Women's Hospital Polyphosphoinositide binding peptides for intracellular drug delivery
GB9809084D0 (en) 1998-04-28 1998-06-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
DE19824535A1 (de) * 1998-06-03 1999-12-09 Roche Diagnostics Gmbh Neue Rhodamin-Derivate und deren Verwendung
US6335432B1 (en) 1998-08-07 2002-01-01 Bio-Red Laboratories, Inc. Structural analogs of amine bases and nucleosides
US6080580A (en) * 1998-10-05 2000-06-27 Isis Pharmaceuticals Inc. Antisense oligonucleotide modulation of tumor necrosis factor-α (TNF-α) expression
WO2000078791A2 (en) 1999-06-17 2000-12-28 Universiteit Gent FUNCTIONAL POLY-α-AMINOACID DERIVATIVES USEFUL FOR THE MODIFICATION OF BIOLOGICALLY ACTIVE MATERIALS AND THEIR APPLICATION

Also Published As

Publication number Publication date
KR100721696B1 (ko) 2007-05-28
JP2003505517A (ja) 2003-02-12
HUP0201995A3 (en) 2005-02-28
TR200200222T2 (tr) 2002-07-22
WO2001008707A3 (de) 2001-11-08
EE200200035A (et) 2003-04-15
NO20020367D0 (no) 2002-01-23
HUP0201995A2 (en) 2002-10-28
SI1204430T1 (sl) 2010-03-31
JP4791665B2 (ja) 2011-10-12
CA2377977C (en) 2011-09-20
MXPA01013114A (es) 2002-06-04
SK287654B6 (sk) 2011-05-06
YU90301A (sh) 2004-05-12
BR0012757A (pt) 2002-04-02
ATE447413T1 (de) 2009-11-15
IL147527A0 (en) 2002-08-14
MEP56408A (en) 2011-05-10
EE05303B1 (et) 2010-06-15
ES2335741T3 (es) 2010-04-05
KR20020031392A (ko) 2002-05-01
CZ2002300A3 (cs) 2002-05-15
AR029385A1 (es) 2003-06-25
CY1109744T1 (el) 2014-09-10
EP1204430B1 (de) 2009-11-04
CN1227035C (zh) 2005-11-16
HRP20020074B1 (en) 2011-01-31
AU6825200A (en) 2001-02-19
AU776114B2 (en) 2004-08-26
HRP20020074A2 (en) 2005-10-31
SK1172002A3 (en) 2002-08-06
CA2377977A1 (en) 2001-02-08
WO2001008707A2 (de) 2001-02-08
CN1360507A (zh) 2002-07-24
RU2275936C2 (ru) 2006-05-10
TR201109493T2 (tr) 2012-03-21
NO20020367L (no) 2002-03-26
PL202881B1 (pl) 2009-07-31
IL147527A (en) 2006-08-01
US8420396B2 (en) 2013-04-16
RS20100249A (sr) 2011-02-28
US20080071069A1 (en) 2008-03-20
TR201109491T2 (tr) 2012-02-21
DK1204430T3 (da) 2010-03-29
EP1204430A2 (de) 2002-05-15
ZA200200657B (en) 2003-09-23
RS51447B (sr) 2011-04-30
NZ516838A (en) 2004-07-30
PT1204430E (pt) 2010-01-26
NO334155B1 (no) 2013-12-23
DE50015781D1 (de) 2009-12-17
HK1047042A1 (en) 2003-02-07
PL353069A1 (en) 2003-10-06
DE19935302A1 (de) 2001-02-08

Similar Documents

Publication Publication Date Title
TR201109491T2 (tr) Konjügatların üretimi ve moleküllerin taşınması için kullanımları.
DE69714654D1 (de) Verwendung von einem Metalloporphyrinkonjugat für den Nachweis biologischer Verbindungen
CY1122210T1 (el) Ανθρωπινα αντισωματα anti-sod1
CY1116265T1 (el) Kit ραδιοεπισημανσης και προσδιορισμος δεσμευσης
TR201907313T4 (tr) İki PEG zinciri içeren PEG türevleri.
TR200201246T2 (tr) Hidroksieikosatetraenoik asit türevlerini ihtiva eden bileşimler ve göz kuruması bozukluklarının iyileştirilmesinde kullanım yöntemleri
ATE354588T1 (de) Verfahren und zusammestellungen zum nachweis und behandlung von brustkrebs, beruhend auf brustkrebs-assoziierten polypeptiden
NO20043259L (no) Bindingsproteiner som biosensorer
PT1153024E (pt) 2-amino-6-anilino-purinas e sua utilizacao como medicamentos
TR200003461T2 (tr) Adenosin A3 Alıcı Modülatörleri
ATE363074T1 (de) Substrate und screeningverfahren für transportproteine
ATE167680T1 (de) Pteridin-nukleotidderivate als fluoreszierende sonden
ATE515575T1 (de) Verfahren und sonden für den nachweis von krebs
CY1105910T1 (el) ΝΕΥΡΟΠΡΟΣΤΑΤΕΥΤΙΚΕΣ ΙΔΙΟΤΗΤΕΣ ΤΟΥ GDF-15, ΕΝΟΣ ΜΕΛΟΥΣ ΤΗΣ ΥΠEPΟΙΚΟΓΕΝΕΙΑΣ ΤΩΝ TGF-β
CY1114132T1 (el) Γαστροανθεκτικες φαρμακοτεχνικες μορφες που περιεχουν ριφαξιμινη
BR112023016183A2 (pt) Conjugados de peptídeo de penetração celular e métodos de uso dos mesmos
ATE368054T1 (de) Verbindungen und methoden zur modulierung von occludin-abhängiger gewebepermeabilität
BR0313033A (pt) anticorpos, anticorpos monoclonais, linhagens de células de hibridoma, anticorpos receptores de anti-taci isolados, anticorpos anti -taci, métodos de modulação da atividade biológica
EP1687283A4 (en) FOR THE DETERMINATION OF FK506 PROCEDURE AND COMPOSITION
TR200100054T2 (tr) Paroksetin metansülfonat
TR199802344A2 (tr) Ikame edilmis imidazolidin türevleri
ATE333465T1 (de) Methoden und mittel zur hemmung der cdk4- aktivität
BR0112925A (pt) Peptìdeos apresentados por células
ATE455120T1 (de) Derivate von kettenverzweigten lipophilen molekülen und deren verwendung
TR200201119T2 (tr) İnsan alfa1G-C-türü kalsiyum kanalı kodlayan DNA.