TR200706709T2 - Konjugatların üretimi ve moleküllerin taşınması için kullanımları - Google Patents

Konjugatların üretimi ve moleküllerin taşınması için kullanımları

Info

Publication number
TR200706709T2
TR200706709T2 TR2007/06709T TR200706709T TR200706709T2 TR 200706709 T2 TR200706709 T2 TR 200706709T2 TR 2007/06709 T TR2007/06709 T TR 2007/06709T TR 200706709 T TR200706709 T TR 200706709T TR 200706709 T2 TR200706709 T2 TR 200706709T2
Authority
TR
Turkey
Prior art keywords
conjugates
transport
molecules
production
present
Prior art date
Application number
TR2007/06709T
Other languages
English (en)
Inventor
Uhlmann Eugen
Unger Eberhard
Schwerdel Marc
Gothe Gislinde
Greiner Beate
Original Assignee
Sanofi-Aventis Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis Deutschland Gmbh filed Critical Sanofi-Aventis Deutschland Gmbh
Publication of TR200706709T2 publication Critical patent/TR200706709T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)

Abstract

Eldeki buluşun konusunu konjügatlar, üretimleri ve bu konjügatların düşük moleküllü bileşiklerin ve makromoleküllerin biyolojik zarların üzerinden taşınması, özellikle de moleküllerin hücrelere taşınması amacıyla kullanılması oluşturuyor. Eldeki buluşun bir diğer konusunu da bu konjügatların kullanıldığı ya da yararlanıldığı ilaç ve teşhis ürünleri ile test kitleridir.
TR2007/06709T 1999-07-28 2000-07-20 Konjugatların üretimi ve moleküllerin taşınması için kullanımları TR200706709T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19935302A DE19935302A1 (de) 1999-07-28 1999-07-28 Konjugate und Verfahren zu deren Herstellung sowie deren Verwendung zum Transport von Molekülen über biologische Membranen

Publications (1)

Publication Number Publication Date
TR200706709T2 true TR200706709T2 (tr) 2008-02-21

Family

ID=7916258

Family Applications (4)

Application Number Title Priority Date Filing Date
TR2011/09493T TR201109493T2 (tr) 1999-07-28 2000-07-20 Konjügatların üretimi ve moleküllerin taşınması için kullanımları.
TR2007/06709T TR200706709T2 (tr) 1999-07-28 2000-07-20 Konjugatların üretimi ve moleküllerin taşınması için kullanımları
TR2002/00222T TR200200222T2 (tr) 1999-07-28 2000-07-20 Konjügatların üretimi ve moleküllerin taşınması için kullanımları
TR2011/09491T TR201109491T2 (tr) 1999-07-28 2000-07-20 Konjügatların üretimi ve moleküllerin taşınması için kullanımları.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
TR2011/09493T TR201109493T2 (tr) 1999-07-28 2000-07-20 Konjügatların üretimi ve moleküllerin taşınması için kullanımları.

Family Applications After (2)

Application Number Title Priority Date Filing Date
TR2002/00222T TR200200222T2 (tr) 1999-07-28 2000-07-20 Konjügatların üretimi ve moleküllerin taşınması için kullanımları
TR2011/09491T TR201109491T2 (tr) 1999-07-28 2000-07-20 Konjügatların üretimi ve moleküllerin taşınması için kullanımları.

Country Status (32)

Country Link
US (1) US8420396B2 (tr)
EP (1) EP1204430B1 (tr)
JP (1) JP4791665B2 (tr)
KR (1) KR100721696B1 (tr)
CN (1) CN1227035C (tr)
AR (1) AR029385A1 (tr)
AT (1) ATE447413T1 (tr)
AU (1) AU776114B2 (tr)
BR (1) BR0012757A (tr)
CA (1) CA2377977C (tr)
CY (1) CY1109744T1 (tr)
CZ (1) CZ2002300A3 (tr)
DE (2) DE19935302A1 (tr)
DK (1) DK1204430T3 (tr)
EE (1) EE05303B1 (tr)
ES (1) ES2335741T3 (tr)
HR (1) HRP20020074B1 (tr)
HU (1) HUP0201995A3 (tr)
IL (2) IL147527A0 (tr)
ME (1) MEP56408A (tr)
MX (1) MXPA01013114A (tr)
NO (1) NO334155B1 (tr)
NZ (1) NZ516838A (tr)
PL (1) PL202881B1 (tr)
PT (1) PT1204430E (tr)
RS (2) RS20100249A (tr)
RU (1) RU2275936C2 (tr)
SI (1) SI1204430T1 (tr)
SK (1) SK287654B6 (tr)
TR (4) TR201109493T2 (tr)
WO (1) WO2001008707A2 (tr)
ZA (1) ZA200200657B (tr)

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EP1886681A3 (en) * 2004-10-07 2008-11-19 Sulfidris S.r.l. 5-(p-hydroxyphenyl)-3H-1,2-dithiol-3-thione valproate ester
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JP6825914B2 (ja) * 2014-05-23 2021-02-03 ジェンザイム・コーポレーション ペプチド担体上の多重オリゴヌクレオチド部分
US20180036312A1 (en) * 2016-08-02 2018-02-08 ISI Life Sciences Inc. Novel Scaffolds for Intracellular Compound Delivery for the Detection of Cancer Cells
EP3493855A4 (en) 2016-08-02 2020-04-01 ISI Life Sciences, Inc. COMPOSITIONS AND METHOD FOR DETECTING CANCER CELLS IN A TISSUE SAMPLE
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KR20230096856A (ko) 2021-12-22 2023-06-30 한국과학기술연구원 신규 펩타이드-올리고뉴클레오티드 접합체 및 이의 용도

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Also Published As

Publication number Publication date
KR100721696B1 (ko) 2007-05-28
MXPA01013114A (es) 2002-06-04
WO2001008707A2 (de) 2001-02-08
HUP0201995A2 (en) 2002-10-28
JP2003505517A (ja) 2003-02-12
ES2335741T3 (es) 2010-04-05
IL147527A (en) 2006-08-01
NO334155B1 (no) 2013-12-23
CZ2002300A3 (cs) 2002-05-15
IL147527A0 (en) 2002-08-14
HK1047042A1 (en) 2003-02-07
JP4791665B2 (ja) 2011-10-12
US20080071069A1 (en) 2008-03-20
PL202881B1 (pl) 2009-07-31
ZA200200657B (en) 2003-09-23
DE19935302A1 (de) 2001-02-08
EP1204430A2 (de) 2002-05-15
TR201109493T2 (tr) 2012-03-21
HUP0201995A3 (en) 2005-02-28
CA2377977C (en) 2011-09-20
YU90301A (sh) 2004-05-12
RU2275936C2 (ru) 2006-05-10
CY1109744T1 (el) 2014-09-10
US8420396B2 (en) 2013-04-16
NO20020367L (no) 2002-03-26
NZ516838A (en) 2004-07-30
PT1204430E (pt) 2010-01-26
MEP56408A (en) 2011-05-10
EE05303B1 (et) 2010-06-15
TR201109491T2 (tr) 2012-02-21
DK1204430T3 (da) 2010-03-29
AR029385A1 (es) 2003-06-25
CN1360507A (zh) 2002-07-24
ATE447413T1 (de) 2009-11-15
BR0012757A (pt) 2002-04-02
KR20020031392A (ko) 2002-05-01
AU776114B2 (en) 2004-08-26
AU6825200A (en) 2001-02-19
HRP20020074B1 (en) 2011-01-31
SI1204430T1 (sl) 2010-03-31
TR200200222T2 (tr) 2002-07-22
CA2377977A1 (en) 2001-02-08
RS20100249A (sr) 2011-02-28
WO2001008707A3 (de) 2001-11-08
HRP20020074A2 (en) 2005-10-31
DE50015781D1 (de) 2009-12-17
NO20020367D0 (no) 2002-01-23
CN1227035C (zh) 2005-11-16
EE200200035A (et) 2003-04-15
PL353069A1 (en) 2003-10-06
SK287654B6 (sk) 2011-05-06
RS51447B (sr) 2011-04-30
EP1204430B1 (de) 2009-11-04
SK1172002A3 (en) 2002-08-06

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