TR200200614T2 - Vitronektin reseptörü antagonistleri - Google Patents

Vitronektin reseptörü antagonistleri

Info

Publication number
TR200200614T2
TR200200614T2 TR2002/00614T TR200200614T TR200200614T2 TR 200200614 T2 TR200200614 T2 TR 200200614T2 TR 2002/00614 T TR2002/00614 T TR 2002/00614T TR 200200614 T TR200200614 T TR 200200614T TR 200200614 T2 TR200200614 T2 TR 200200614T2
Authority
TR
Turkey
Prior art keywords
receptor antagonists
vitronectin receptor
formula
vitronectin
het
Prior art date
Application number
TR2002/00614T
Other languages
English (en)
Inventor
J. Manley Peter
H. Miller William
N. Uzinskas Irene
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of TR200200614T2 publication Critical patent/TR200200614T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • External Artificial Organs (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Vitronektin reseptörü antagonistleri olan ve osteoporoz tedavisinde faydali olan; R1'in Het veya Ar; R2'nin formül (a) veya (b) oldugu formül (I) bilesimleri veya farmasötik olarak kabul edilebilir bir tuzu.
TR2002/00614T 1999-09-07 2000-09-07 Vitronektin reseptörü antagonistleri TR200200614T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15278099P 1999-09-07 1999-09-07

Publications (1)

Publication Number Publication Date
TR200200614T2 true TR200200614T2 (tr) 2002-07-22

Family

ID=22544416

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/00614T TR200200614T2 (tr) 1999-09-07 2000-09-07 Vitronektin reseptörü antagonistleri

Country Status (29)

Country Link
EP (1) EP1218005B1 (tr)
JP (1) JP4685307B2 (tr)
KR (1) KR100711170B1 (tr)
CN (1) CN1236767C (tr)
AR (1) AR025589A1 (tr)
AT (1) ATE284870T1 (tr)
AU (1) AU768918B2 (tr)
BR (1) BR0013749A (tr)
CA (1) CA2384671A1 (tr)
CO (1) CO5200845A1 (tr)
CZ (1) CZ2002822A3 (tr)
DE (1) DE60016769T2 (tr)
EG (1) EG24179A (tr)
ES (1) ES2234658T3 (tr)
GC (1) GC0000203A (tr)
HK (1) HK1049110B (tr)
HU (1) HUP0202710A3 (tr)
IL (2) IL148325A0 (tr)
MX (1) MXPA02002455A (tr)
NO (1) NO322109B1 (tr)
NZ (1) NZ517296A (tr)
PE (1) PE20010582A1 (tr)
PL (1) PL200404B1 (tr)
PT (1) PT1218005E (tr)
TR (1) TR200200614T2 (tr)
TW (1) TWI255813B (tr)
UY (1) UY26329A1 (tr)
WO (1) WO2001017959A2 (tr)
ZA (1) ZA200201780B (tr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6531494B1 (en) 2001-08-29 2003-03-11 Pharmacia Corporation Gem-substituted αvβ3 antagonists
US6982263B2 (en) 2001-06-08 2006-01-03 Boehringer Ingelheim Pharmaceuticals, Inc. Nitriles useful as reversible inhibitors of cysteine proteases
GB0315509D0 (en) 2003-07-02 2003-08-06 Meridica Ltd Dispensing device
US7678810B2 (en) * 2004-03-05 2010-03-16 Taisho Pharmaceutical Co., Ltd Thiazole derivative
RS55856B1 (sr) 2010-07-14 2017-08-31 Novartis Ag Heterociklična jedinjenja agonisti ip receptora
CN104053659B (zh) 2012-01-13 2016-11-09 诺华股份有限公司 用于治疗肺动脉高压(pah)及相关病症的作为ip 受体激动剂的稠合的吡咯类
EP2956455B1 (en) 2013-02-13 2017-05-17 Novartis AG Ip receptor agonist heterocyclic compounds
CN108675954A (zh) * 2018-04-03 2018-10-19 爱斯特（成都）生物制药股份有限公司 2-氨基-3-羟甲基吡啶的一种制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08325264A (ja) * 1995-05-31 1996-12-10 Sumitomo Metal Ind Ltd 新規２−芳香環置換−３−フェニルプロピオン酸またはアクリル酸誘導体
JPH08325263A (ja) * 1995-05-31 1996-12-10 Sumitomo Metal Ind Ltd 新規２−アミノ−３−フェニルプロピオン酸誘導体
CN1209060A (zh) * 1995-12-29 1999-02-24 史密丝克莱恩比彻姆公司 玻连蛋白受体拮抗剂
WO1999011255A1 (en) * 1997-08-28 1999-03-11 Ono Pharmaceutical Co., Ltd. Peroxisome proliferator-activated receptor controllers
PE122699A1 (es) * 1997-09-19 2000-02-12 Smithkline Beecham Corp Antagonistas de receptores de vitronectina
DZ2741A1 (fr) * 1998-03-10 2003-09-08 Smithkline Beecham Corp Composés nouveaux antagonistes des récepteurs de vitronectine procédé pour leur préparation et compositions.
JP2002522540A (ja) * 1998-08-13 2002-07-23 メルク エンド カムパニー インコーポレーテッド インテグリン受容体拮抗薬

Also Published As

Publication number Publication date
KR100711170B1 (ko) 2007-04-27
HK1049110B (en) 2005-07-22
EP1218005B1 (en) 2004-12-15
EP1218005A2 (en) 2002-07-03
ES2234658T3 (es) 2005-07-01
CA2384671A1 (en) 2001-03-15
HK1049110A1 (en) 2003-05-02
DE60016769T2 (de) 2005-11-24
EP1218005A4 (en) 2002-10-09
GC0000203A (en) 2006-03-29
HUP0202710A3 (en) 2003-06-30
CO5200845A1 (es) 2002-09-27
NO322109B1 (no) 2006-08-14
ATE284870T1 (de) 2005-01-15
AU768918B2 (en) 2004-01-08
DE60016769D1 (de) 2005-01-20
PE20010582A1 (es) 2001-06-23
TWI255813B (en) 2006-06-01
CN1236767C (zh) 2006-01-18
BR0013749A (pt) 2003-06-10
JP2003508516A (ja) 2003-03-04
UY26329A1 (es) 2001-07-31
IL148325A (en) 2007-06-03
EG24179A (en) 2008-09-28
PT1218005E (pt) 2005-05-31
PL200404B1 (pl) 2009-01-30
NZ517296A (en) 2003-11-28
KR20020027624A (ko) 2002-04-13
JP4685307B2 (ja) 2011-05-18
MXPA02002455A (es) 2002-07-02
PL354176A1 (en) 2003-12-29
IL148325A0 (en) 2002-09-12
CN1377269A (zh) 2002-10-30
ZA200201780B (en) 2003-05-28
WO2001017959A2 (en) 2001-03-15
AU7354300A (en) 2001-04-10
HUP0202710A2 (hu) 2002-12-28
NO20021113L (no) 2002-05-03
WO2001017959A3 (en) 2001-05-10
NO20021113D0 (no) 2002-03-06
CZ2002822A3 (cs) 2002-07-17
AR025589A1 (es) 2002-12-04

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