TR200500302T3 - Makrolidlerin kristalizasyonu ve saflaştırılması. - Google Patents
Makrolidlerin kristalizasyonu ve saflaştırılması.Info
- Publication number
- TR200500302T3 TR200500302T3 TR2005/00302T TR200500302T TR200500302T3 TR 200500302 T3 TR200500302 T3 TR 200500302T3 TR 2005/00302 T TR2005/00302 T TR 2005/00302T TR 200500302 T TR200500302 T TR 200500302T TR 200500302 T3 TR200500302 T3 TR 200500302T3
- Authority
- TR
- Turkey
- Prior art keywords
- macrolides
- crystallization
- purification
- solvent
- macloride
- Prior art date
Links
- 239000003120 macrolide antibiotic agent Substances 0.000 title abstract 2
- 238000002425 crystallisation Methods 0.000 title 1
- 230000008025 crystallization Effects 0.000 title 1
- 229940041033 macrolides Drugs 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 abstract 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 229960005167 everolimus Drugs 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- KASDHRXLYQOAKZ-ZPSXYTITSA-N pimecrolimus Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@@H](Cl)[C@H](OC)C1 KASDHRXLYQOAKZ-ZPSXYTITSA-N 0.000 abstract 1
- 229960005330 pimecrolimus Drugs 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 abstract 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 abstract 1
- 229960002930 sirolimus Drugs 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 229960001967 tacrolimus Drugs 0.000 abstract 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Takrolimus, sirolimus, pimekrolimus ya da everolimus gibi bir makloridin kristalize edilmesi ve saflastirilmasi için bir yöntem temin edilmistir, bu yöntem, 7 ya da üzerinde bir pH'ta, bir makrolid ve bir polar çözücü, depolar aprotik çözücü ya da hidrokarbon çözücü kombinasyonunun temin edilmesi asamasini kapsamaktadir.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45959103P | 2003-03-31 | 2003-03-31 | |
| US46170703P | 2003-04-09 | 2003-04-09 | |
| US51288703P | 2003-10-20 | 2003-10-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200500302T3 true TR200500302T3 (tr) | 2005-04-21 |
Family
ID=33162981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2005/00302T TR200500302T3 (tr) | 2003-03-31 | 2004-03-31 | Makrolidlerin kristalizasyonu ve saflaştırılması. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7232486B2 (tr) |
| EP (1) | EP1513847A2 (tr) |
| JP (1) | JP4468943B2 (tr) |
| KR (1) | KR20050114262A (tr) |
| DE (1) | DE04758730T1 (tr) |
| ES (1) | ES2229975T1 (tr) |
| IL (1) | IL170331A (tr) |
| TR (1) | TR200500302T3 (tr) |
| TW (1) | TW200504079A (tr) |
| WO (1) | WO2004089958A2 (tr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6306166B1 (en) * | 1997-08-13 | 2001-10-23 | Scimed Life Systems, Inc. | Loading and release of water-insoluble drugs |
| US7645876B2 (en) * | 2004-12-01 | 2010-01-12 | TEVA Gyógyszergyár Zártkörúen Müködö Részvénytársaság | Processes for producing crystalline macrolides |
| US7468428B2 (en) | 2004-03-17 | 2008-12-23 | App Pharmaceuticals, Llc | Lyophilized azithromycin formulation |
| KR100859670B1 (ko) | 2006-09-13 | 2008-09-23 | 동국제약 주식회사 | 타크로리무스를 고수율 및 고순도로 정제하는 방법 |
| CA2668134A1 (en) * | 2006-11-06 | 2008-05-15 | Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag | Ascomycin and pimecrolimus having reduced levels of des-methylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof |
| AU2006350684B2 (en) * | 2006-11-10 | 2012-07-05 | Biocon Limited | A pure form of rapamycin and a process for recovery and purification thereof |
| CA2673991C (en) | 2007-01-21 | 2012-02-07 | Hemoteq Ag | Methods for coating catheter balloons with a defined quantity of active agent |
| US9192697B2 (en) | 2007-07-03 | 2015-11-24 | Hemoteq Ag | Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis |
| EP2380006A4 (en) * | 2009-01-21 | 2012-05-16 | Biocon Ltd | PROCESS FOR DETERMINING THE SIROLIMUS STABILITY AND METHOD FOR PRODUCING ITS STABLE FORM |
| ES2550634T3 (es) | 2009-07-10 | 2015-11-11 | Boston Scientific Scimed, Inc. | Uso de nanocristales para un balón de suministro de fármaco |
| EP2453938B1 (en) | 2009-07-17 | 2015-08-19 | Boston Scientific Scimed, Inc. | Nucleation of drug delivery balloons to provide improved crystal size and density |
| US20110160645A1 (en) * | 2009-12-31 | 2011-06-30 | Boston Scientific Scimed, Inc. | Cryo Activated Drug Delivery and Cutting Balloons |
| US8889211B2 (en) | 2010-09-02 | 2014-11-18 | Boston Scientific Scimed, Inc. | Coating process for drug delivery balloons using heat-induced rewrap memory |
| WO2013022458A1 (en) | 2011-08-05 | 2013-02-14 | Boston Scientific Scimed, Inc. | Methods of converting amorphous drug substance into crystalline form |
| WO2013028208A1 (en) | 2011-08-25 | 2013-02-28 | Boston Scientific Scimed, Inc. | Medical device with crystalline drug coating |
| CN103159812B (zh) * | 2011-12-08 | 2016-03-23 | 湖南中创化工股份有限公司 | 一种从红霉素水溶液中提取红霉素的方法 |
| WO2014072984A1 (en) | 2012-11-06 | 2014-05-15 | Natco Pharma Limited | Improved process for isolation and purification of rapamycin from fermentation broth |
| CN102942607A (zh) * | 2012-11-28 | 2013-02-27 | 宁夏启元药业有限公司 | 一种复合溶剂结晶红霉素的方法 |
| ES2897473T3 (es) | 2013-03-15 | 2022-03-01 | Biosensors Int Group Ltd | Purificación de derivados de la rapamicina |
| US9439892B2 (en) | 2013-05-16 | 2016-09-13 | Surmodics, Inc. | Macrolide particulates, methods for preparation, and medical devices associated therewith |
| CA2915704C (en) | 2013-06-12 | 2022-06-21 | Surmodics, Inc. | Solvent methods for preparing crystalline macrolide particulates, compositions, and articles containing particulates |
| EP3435988B1 (en) | 2016-03-31 | 2021-10-06 | Surmodics, Inc. | Drug-containing particulate composition with cationic agent, associated medical devices, and methods for treatment |
| US11123459B2 (en) | 2016-12-16 | 2021-09-21 | Surmodics, Inc. | Hydrophobic active agent particle coatings and methods for treatment |
| CN112739392A (zh) | 2018-08-01 | 2021-04-30 | 波士顿科学国际有限公司 | 药物释放涂层组合物 |
| CN119431400A (zh) * | 2020-03-27 | 2025-02-14 | 波士顿科学国际有限公司 | 用于使药物结晶的方法 |
| AU2022362107A1 (en) * | 2021-10-11 | 2024-05-02 | Anebulo Pharmaceuticals, Inc. | Crystalline forms of a cannabinoid receptor type 1 (cb1) modulator and methods of use and preparation thereof |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1666924A (en) | 1924-06-23 | 1928-04-24 | John J Selb | Arch support |
| DE2121517C3 (de) | 1971-04-30 | 1974-06-27 | Leningradskij Nautschno-Issledowatelskij Institut Antibiotikow, Ssr, Leningrad (Sowjetunion) | Verfahren zur Gewinnung von Amphoterizin B |
| US3993749A (en) * | 1974-04-12 | 1976-11-23 | Ayerst Mckenna And Harrison Ltd. | Rapamycin and process of preparation |
| US4160861A (en) * | 1977-10-03 | 1979-07-10 | Merck & Co., Inc. | Method for the separation of antibiotic macrolides |
| US4543334A (en) * | 1983-12-16 | 1985-09-24 | Pfizer Inc. | Streptomyces capable of producing neutral macrolide antibacterial agents |
| US4894366A (en) * | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| JPH0216662A (ja) * | 1988-07-05 | 1990-01-19 | Nec Corp | 代替端末コントロール装置 |
| JP2639737B2 (ja) * | 1990-01-23 | 1997-08-13 | 寳酒造株式会社 | 新規ｒ１０６類化合物 |
| US5116756A (en) * | 1991-01-28 | 1992-05-26 | Merck & Co., Inc. | Process for producing FK-506 |
| JPH06501026A (ja) | 1991-04-11 | 1994-01-27 | ファイザー・インコーポレーテッド | ストレプトミセス・ブレジェンシス由来の新規の免疫抑制剤 |
| US5091389A (en) * | 1991-04-23 | 1992-02-25 | Merck & Co., Inc. | Lipophilic macrolide useful as an immunosuppressant |
| WO1993018042A1 (en) * | 1992-03-02 | 1993-09-16 | Pfizer Inc. | Desosamino derivatives of macrolides as immunosuppressants and antifungal agents |
| UA41884C2 (uk) * | 1993-11-05 | 2001-10-15 | Амерікан Хоум Продактс Корпорейшн | Спосіб відокремлення рапаміцину від кислотних, основних та неполярних нейтральних домішок, присутніх в концентраті екстрактів ферментаційного бульйону або маточних розчинів |
| US5622866A (en) | 1994-06-23 | 1997-04-22 | Merck & Co., Inc. | Expression cassettes useful in construction of integrative and replicative expression vectors for Streptomyces |
| GB9618952D0 (en) | 1996-09-11 | 1996-10-23 | Sandoz Ltd | Process |
| GB9826882D0 (en) * | 1998-12-07 | 1999-01-27 | Novartis Ag | Organic compounds |
| ES2177373B1 (es) * | 1999-11-26 | 2003-11-01 | Astur Pharma Sa | Preparacion de azitromicina en su forma no cristalina |
| HRP20020683A2 (en) * | 2000-02-24 | 2004-12-31 | Biogal Gyogyszergyar | Method of purifying a fermentation broth |
| MXPA04007847A (es) * | 2002-02-13 | 2005-02-24 | Biogal Gyogyszergyar | Metodo para extraer un macrolido de biomateria. |
| US7452692B2 (en) * | 2002-02-13 | 2008-11-18 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Method for extracting a macrolide from biomatter |
-
2004
- 2004-03-31 TR TR2005/00302T patent/TR200500302T3/tr unknown
- 2004-03-31 WO PCT/US2004/010033 patent/WO2004089958A2/en not_active Ceased
- 2004-03-31 DE DE04758730T patent/DE04758730T1/de active Pending
- 2004-03-31 TW TW093108933A patent/TW200504079A/zh unknown
- 2004-03-31 ES ES04758730T patent/ES2229975T1/es active Pending
- 2004-03-31 JP JP2006501251A patent/JP4468943B2/ja not_active Expired - Lifetime
- 2004-03-31 EP EP04758730A patent/EP1513847A2/en not_active Withdrawn
- 2004-03-31 US US10/815,339 patent/US7232486B2/en not_active Expired - Fee Related
- 2004-03-31 KR KR1020057018227A patent/KR20050114262A/ko not_active Ceased
-
2005
- 2005-08-17 IL IL170331A patent/IL170331A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1513847A2 (en) | 2005-03-16 |
| JP4468943B2 (ja) | 2010-05-26 |
| US7232486B2 (en) | 2007-06-19 |
| US20040226501A1 (en) | 2004-11-18 |
| WO2004089958A3 (en) | 2005-01-13 |
| WO2004089958B1 (en) | 2005-03-03 |
| TW200504079A (en) | 2005-02-01 |
| KR20050114262A (ko) | 2005-12-05 |
| IL170331A (en) | 2010-04-15 |
| ES2229975T1 (es) | 2005-05-01 |
| WO2004089958A2 (en) | 2004-10-21 |
| DE04758730T1 (de) | 2005-06-23 |
| JP2006522018A (ja) | 2006-09-28 |
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