WO2004072025A3 - Substituierte n-arylheterozyklen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel - Google Patents

Substituierte n-arylheterozyklen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel Download PDF

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Publication number
WO2004072025A3
WO2004072025A3 PCT/EP2004/001342 EP2004001342W WO2004072025A3 WO 2004072025 A3 WO2004072025 A3 WO 2004072025A3 EP 2004001342 W EP2004001342 W EP 2004001342W WO 2004072025 A3 WO2004072025 A3 WO 2004072025A3
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Prior art keywords
arylheterocycles
production
medicaments
substituted
physiologically
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Ceased
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PCT/EP2004/001342
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English (en)
French (fr)
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WO2004072025A2 (de
Inventor
Lothar Schwink
Siegfried Stengelin
Matthias Gossel
Thomas Boehme
Gerhard Hessler
Petra Stahl
Dirk Gretzke
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Sanofi Aventis Deutschland GmbH
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Aventis Pharma Deutschland GmbH
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Priority to YUP-2005/0666A priority Critical patent/RS20050666A/sr
Priority to AU2004212145A priority patent/AU2004212145B2/en
Priority to CA002516118A priority patent/CA2516118A1/en
Priority to EP04710808A priority patent/EP1597228A2/de
Priority to MXPA05008449A priority patent/MXPA05008449A/es
Priority to BRPI0407504-8A priority patent/BRPI0407504A/pt
Priority to HR20050710A priority patent/HRP20050710A2/xx
Priority to JP2006501827A priority patent/JP2006517563A/ja
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Priority to NZ541823A priority patent/NZ541823A/en
Publication of WO2004072025A2 publication Critical patent/WO2004072025A2/de
Publication of WO2004072025A3 publication Critical patent/WO2004072025A3/de
Priority to TNP2005000194A priority patent/TNSN05194A1/en
Anticipated expiration legal-status Critical
Priority to NO20054220A priority patent/NO20054220L/no
Ceased legal-status Critical Current

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/26—2-Pyrrolidones
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Die Erfindung betrifft substituierte N-Arylheterozyklen sowie deren physiologisch verträgliche Salze und physiologisch funktionelle Derivate. Es werden Verbindungen der Formel (I), worin die Reste die angegebenen Bedeutungen haben, deren N-Oxide sowie deren physiologisch verträglichen Salze und Verfahren zu deren Herstellung beschrieben. Die Verbindungen eignen sich z.B. als Anorektika.
PCT/EP2004/001342 2003-02-14 2004-02-13 Substituierte n-arylheterozyklen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel Ceased WO2004072025A2 (de)

Priority Applications (11)

Application Number Priority Date Filing Date Title
NZ541823A NZ541823A (en) 2003-02-14 2004-02-13 Substituted N-aryl heterocycles, method for production and uses thereof as medicaments
BRPI0407504-8A BRPI0407504A (pt) 2003-02-14 2004-02-13 heterociclos n-arila substituìdo, processo para sua preparação e uso dos mesmos como medicamentos
AU2004212145A AU2004212145B2 (en) 2003-02-14 2004-02-13 Substituted N-arylheterocycles, method for production and use thereof as medicaments
CA002516118A CA2516118A1 (en) 2003-02-14 2004-02-13 Substituted n-arylheterocycles, method for production and use thereof as medicaments
EP04710808A EP1597228A2 (de) 2003-02-14 2004-02-13 Substituierte n-arylheterozyklen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
MXPA05008449A MXPA05008449A (es) 2003-02-14 2004-02-13 N-arilheterociclos sustituidos, procedimientos para su preparacion, y su empleo como medicamentos.
HR20050710A HRP20050710A2 (en) 2003-02-14 2004-02-13 Substituted n-arylheterocycles, method for production and use thereof as medicaments
YUP-2005/0666A RS20050666A (sr) 2003-02-14 2004-02-13 Supstituisani n-aril- heterocikli,postupak njihove proizvodnje i njihova upotreba kao lekova
JP2006501827A JP2006517563A (ja) 2003-02-14 2004-02-13 置換ｎ−アリール複素環化合物、その製造方法およびその医薬としての使用
TNP2005000194A TNSN05194A1 (en) 2003-02-14 2005-08-12 Substituted n-arylheterocycles, method for production and use thereof as medicaments
NO20054220A NO20054220L (no) 2003-02-14 2005-09-12 Substituerte N-arylheterocykler, fremgangsmate for fremstilling derav og deres anvendelse som legemiddel

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10306250A DE10306250A1 (de) 2003-02-14 2003-02-14 Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10306250.5 2003-02-14

Publications (2)

Publication Number Publication Date
WO2004072025A2 WO2004072025A2 (de) 2004-08-26
WO2004072025A3 true WO2004072025A3 (de) 2004-12-23

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PCT/EP2004/001342 Ceased WO2004072025A2 (de) 2003-02-14 2004-02-13 Substituierte n-arylheterozyklen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Country Status (29)

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EP (1) EP1597228A2 (de)
JP (1) JP2006517563A (de)
KR (1) KR20050101215A (de)
CN (1) CN100506792C (de)
AR (1) AR044496A1 (de)
AU (1) AU2004212145B2 (de)
BR (1) BRPI0407504A (de)
CA (1) CA2516118A1 (de)
CO (1) CO5690548A2 (de)
DE (1) DE10306250A1 (de)
EC (1) ECSP055967A (de)
HR (1) HRP20050710A2 (de)
MA (1) MA27735A1 (de)
MX (1) MXPA05008449A (de)
MY (1) MY139102A (de)
NO (1) NO20054220L (de)
NZ (1) NZ541823A (de)
OA (1) OA13027A (de)
PA (1) PA8595901A1 (de)
PE (1) PE20040952A1 (de)
PL (1) PL378065A1 (de)
RS (1) RS20050666A (de)
RU (1) RU2005128551A (de)
TN (1) TNSN05194A1 (de)
TW (1) TW200510297A (de)
UA (1) UA86760C2 (de)
UY (1) UY28186A1 (de)
WO (1) WO2004072025A2 (de)
ZA (1) ZA200506369B (de)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8114873B2 (en) 2004-07-08 2012-02-14 Arqule, Inc. 1,4-disubstituted naphthalenes as inhibitors of p38 map kinase
US8691813B2 (en) 2008-11-28 2014-04-08 Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
US8716480B2 (en) 2009-05-12 2014-05-06 Janssen Pharmaceuticals, Inc. 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
US8722894B2 (en) 2007-09-14 2014-05-13 Janssen Pharmaceuticals, Inc. 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones
US8748621B2 (en) 2007-09-14 2014-06-10 Janssen Pharmaceuticals, Inc. 1,3-disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones
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