TR201900073T4 - Protein Ekspresyonu İçin Rekombinant Bakteriyel Konakçı Hücre - Google Patents
Protein Ekspresyonu İçin Rekombinant Bakteriyel Konakçı Hücre Download PDFInfo
- Publication number
- TR201900073T4 TR201900073T4 TR2019/00073T TR201900073T TR201900073T4 TR 201900073 T4 TR201900073 T4 TR 201900073T4 TR 2019/00073 T TR2019/00073 T TR 2019/00073T TR 201900073 T TR201900073 T TR 201900073T TR 201900073 T4 TR201900073 T4 TR 201900073T4
- Authority
- TR
- Turkey
- Prior art keywords
- host cell
- proteins
- protein expression
- bacterial host
- cell
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Bu buluş aşağıdakileri içeren bir rekombinant gram negatif bakteri hücresine ilişkindir: a.) D133, H145, H157, N31, R62, I70, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 ve G147 arasından seçilen bir veya daha fazla amino asitte bir mutasyona sahip bir spr proteinini kodlayan bir mutant spr geni ve b.) FkpA, Skp, SurA, PPiA ve PPiD gibi, protein katlanmasını kolaylaştırabilen bir veya daha fazla proteini eksprese veya aşırı eksprese edebilen bir gen, burada hücrenin Tsp protein aktivitesi bir yabani tip hücreye göre azalmıştır; hücreleri kullanma usulleri, hücrelerin proteinlerin, özellikle anti-FcRn antikorları gibi antikorların ekspresyonunda kullanımı ve burada açıklanan usullerle yapılan proteinler de açıklanmaktadır.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201208367A GB201208367D0 (en) | 2012-05-14 | 2012-05-14 | Biological product |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201900073T4 true TR201900073T4 (tr) | 2019-01-21 |
Family
ID=46458730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2019/00073T TR201900073T4 (tr) | 2012-05-14 | 2013-05-13 | Protein Ekspresyonu İçin Rekombinant Bakteriyel Konakçı Hücre |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US9951365B2 (tr) |
| EP (1) | EP2850100B1 (tr) |
| JP (2) | JP6420759B2 (tr) |
| KR (1) | KR102036399B1 (tr) |
| CN (2) | CN110591991A (tr) |
| AU (1) | AU2013261915B2 (tr) |
| BR (1) | BR112014027357A2 (tr) |
| CA (1) | CA2872328C (tr) |
| CL (1) | CL2014003112A1 (tr) |
| CO (1) | CO7240426A2 (tr) |
| CY (1) | CY1121192T1 (tr) |
| DK (1) | DK2850100T3 (tr) |
| EA (1) | EA201492100A1 (tr) |
| ES (1) | ES2704425T3 (tr) |
| GB (1) | GB201208367D0 (tr) |
| HR (1) | HRP20190025T1 (tr) |
| HU (1) | HUE040624T2 (tr) |
| IL (1) | IL235041B (tr) |
| LT (1) | LT2850100T (tr) |
| ME (1) | ME03309B (tr) |
| MX (1) | MX353066B (tr) |
| MY (1) | MY166223A (tr) |
| PL (1) | PL2850100T3 (tr) |
| PT (1) | PT2850100T (tr) |
| RS (1) | RS58219B1 (tr) |
| SG (1) | SG11201406474RA (tr) |
| SI (1) | SI2850100T1 (tr) |
| SM (1) | SMT201900011T1 (tr) |
| TR (1) | TR201900073T4 (tr) |
| WO (1) | WO2013171156A1 (tr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9109216B2 (en) | 2009-09-24 | 2015-08-18 | Ucb Pharma, S.A. | Bacterial host strain |
| GB201000591D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
| GB201000590D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial host strain |
| GB201000587D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
| GB201012599D0 (en) | 2010-07-27 | 2010-09-08 | Ucb Pharma Sa | Process for purifying proteins |
| HRP20180226T1 (hr) | 2011-07-13 | 2018-03-09 | Ucb Biopharma Sprl | Bakterijski soj domaćina koji eksprimira rekombinantnu dsbc |
| GB201208367D0 (en) * | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Biological product |
| WO2018119142A1 (en) | 2016-12-21 | 2018-06-28 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| GB201708655D0 (en) | 2017-05-31 | 2017-07-12 | Ucb Biopharma Sprl | Cell culture methods |
| EP3492582A1 (en) | 2017-12-01 | 2019-06-05 | UCB Biopharma SPRL | Cell culture methods |
| EP3774926A1 (en) | 2018-04-05 | 2021-02-17 | Bio-Rad ABD Serotec GmbH | Display systems for proteins of interest |
| US12404512B2 (en) | 2018-05-01 | 2025-09-02 | Ambrx, Inc. | Method for optimizing antibody expression |
| EP3877407B1 (en) * | 2018-11-05 | 2026-03-11 | F. Hoffmann-La Roche AG | Methods of producing two chain proteins in prokaryotic host cells |
| EP3942079A1 (en) * | 2019-03-18 | 2022-01-26 | Bio-Rad ABD Serotec GmbH | Protection of spytag-containing periplasmic fusion proteins from protease tsp and ompt degradation |
| AU2023281650A1 (en) | 2022-05-30 | 2024-10-17 | Hanall Biopharma Co., Ltd. | Anti-fcrn antibody or antigen binding fragment thereof with improved stability |
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| US5508192A (en) | 1990-11-09 | 1996-04-16 | Board Of Regents, The University Of Texas System | Bacterial host strains for producing proteolytically sensitive polypeptides |
| US5264365A (en) | 1990-11-09 | 1993-11-23 | Board Of Regents, The University Of Texas System | Protease-deficient bacterial strains for production of proteolytically sensitive polypeptides |
| GB9215540D0 (en) | 1992-07-22 | 1992-09-02 | Celltech Ltd | Protein expression system |
| US5304472A (en) | 1992-11-20 | 1994-04-19 | Genentech, Inc. | Method of controlling polypeptide production in bacterial cells |
| AU2660397A (en) | 1996-04-05 | 1997-10-29 | Board Of Regents, The University Of Texas System | Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells |
| US6083715A (en) | 1997-06-09 | 2000-07-04 | Board Of Regents, The University Of Texas System | Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells |
| PT1124941E (pt) | 1998-10-28 | 2004-02-27 | Genentech Inc | Processo para recuperar polipeptidos heterologos a partir de celulas bacterianas |
| DE60031533D1 (de) | 1999-06-29 | 2006-12-07 | Siga Technologies Inc | Test für degp-protease inhibitoren |
| GB0006398D0 (en) | 2000-03-16 | 2000-05-03 | Novartis Ag | Organic compounds |
| GB0013810D0 (en) | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
| AU8867501A (en) | 2000-09-01 | 2002-03-13 | Biogen Inc | Co-crystal structure of monoclonal antibody 5c8 and cd154, and use thereof in drug design |
| WO2002018446A2 (en) | 2000-09-01 | 2002-03-07 | Biogen, Inc. | Methods of designing and producing compounds having improved binding affinity for cd154 or other trimeric proteins |
| US7041479B2 (en) | 2000-09-06 | 2006-05-09 | The Board Of Trustess Of The Leland Stanford Junior University | Enhanced in vitro synthesis of active proteins containing disulfide bonds |
| JP4056880B2 (ja) | 2000-12-14 | 2008-03-05 | ジェネンテック・インコーポレーテッド | 細菌性宿主株 |
| WO2002061090A2 (en) * | 2000-12-14 | 2002-08-08 | Genentech, Inc. | Prokaryotically produced antibodies and uses thereof |
| TWI334439B (en) | 2001-08-01 | 2010-12-11 | Centocor Inc | Anti-tnf antibodies, compositions, methods and uses |
| CN100513414C (zh) | 2001-08-27 | 2009-07-15 | 杰南技术公司 | 进行抗体表达和装配的系统 |
| GB0124317D0 (en) | 2001-10-10 | 2001-11-28 | Celltech R&D Ltd | Biological products |
| MXPA04004634A (es) | 2001-11-16 | 2004-08-12 | Idec Pharma Corp | Expresion policistronica de anticuerpos. |
| GB0129105D0 (en) | 2001-12-05 | 2002-01-23 | Celltech R&D Ltd | Expression control using variable intergenic sequences |
| AU2003244817B2 (en) | 2002-06-28 | 2010-08-26 | Domantis Limited | Antigen-binding immunoglobulin single variable domains and dual-specific constructs |
| GB0224082D0 (en) | 2002-10-16 | 2002-11-27 | Celltech R&D Ltd | Biological products |
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| GB0315450D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
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| EP2535349A1 (en) | 2007-09-26 | 2012-12-19 | UCB Pharma S.A. | Dual specificity antibody fusions |
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| US9109216B2 (en) | 2009-09-24 | 2015-08-18 | Ucb Pharma, S.A. | Bacterial host strain |
| US8470552B2 (en) | 2009-10-12 | 2013-06-25 | Keck Graduate Institute | Strategy to reduce lactic acid production and control PH in animal cell culture |
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| GB201000590D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial host strain |
| GB201000591D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
| GB201000587D0 (en) * | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
| GB201000588D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial host strain |
| GB201001791D0 (en) | 2010-02-03 | 2010-03-24 | Ucb Pharma Sa | Process for obtaining antibodies |
| GB201012599D0 (en) | 2010-07-27 | 2010-09-08 | Ucb Pharma Sa | Process for purifying proteins |
| HRP20180226T1 (hr) * | 2011-07-13 | 2018-03-09 | Ucb Biopharma Sprl | Bakterijski soj domaćina koji eksprimira rekombinantnu dsbc |
| EP2546267A1 (en) * | 2011-07-13 | 2013-01-16 | UCB Pharma S.A. | Bacterial host strain expressing recombinant DsbC |
| GB201208367D0 (en) * | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Biological product |
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2012
- 2012-05-14 GB GB201208367A patent/GB201208367D0/en not_active Ceased
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2013
- 2013-05-13 ME MEP-2019-3A patent/ME03309B/me unknown
- 2013-05-13 ES ES13723086T patent/ES2704425T3/es active Active
- 2013-05-13 KR KR1020147032673A patent/KR102036399B1/ko not_active Expired - Fee Related
- 2013-05-13 PT PT13723086T patent/PT2850100T/pt unknown
- 2013-05-13 CA CA2872328A patent/CA2872328C/en active Active
- 2013-05-13 US US14/400,068 patent/US9951365B2/en active Active
- 2013-05-13 DK DK13723086.8T patent/DK2850100T3/en active
- 2013-05-13 PL PL13723086T patent/PL2850100T3/pl unknown
- 2013-05-13 SG SG11201406474RA patent/SG11201406474RA/en unknown
- 2013-05-13 JP JP2015512012A patent/JP6420759B2/ja not_active Expired - Fee Related
- 2013-05-13 AU AU2013261915A patent/AU2013261915B2/en not_active Ceased
- 2013-05-13 LT LTEP13723086.8T patent/LT2850100T/lt unknown
- 2013-05-13 EA EA201492100A patent/EA201492100A1/ru unknown
- 2013-05-13 MX MX2014012623A patent/MX353066B/es active IP Right Grant
- 2013-05-13 HR HRP20190025TT patent/HRP20190025T1/hr unknown
- 2013-05-13 EP EP13723086.8A patent/EP2850100B1/en active Active
- 2013-05-13 SM SM20190011T patent/SMT201900011T1/it unknown
- 2013-05-13 HU HUE13723086A patent/HUE040624T2/hu unknown
- 2013-05-13 TR TR2019/00073T patent/TR201900073T4/tr unknown
- 2013-05-13 BR BR112014027357A patent/BR112014027357A2/pt active Search and Examination
- 2013-05-13 SI SI201331318T patent/SI2850100T1/sl unknown
- 2013-05-13 WO PCT/EP2013/059803 patent/WO2013171156A1/en not_active Ceased
- 2013-05-13 RS RS20190013A patent/RS58219B1/sr unknown
- 2013-05-13 CN CN201910693072.1A patent/CN110591991A/zh active Pending
- 2013-05-13 CN CN201380025191.0A patent/CN104487454A/zh active Pending
- 2013-05-13 MY MYPI2014703261A patent/MY166223A/en unknown
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2014
- 2014-10-07 IL IL23504114A patent/IL235041B/en active IP Right Grant
- 2014-11-14 CL CL2014003112A patent/CL2014003112A1/es unknown
- 2014-12-11 CO CO14272157A patent/CO7240426A2/es unknown
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2018
- 2018-04-23 US US15/959,498 patent/US11261470B2/en not_active Expired - Fee Related
- 2018-07-12 JP JP2018132619A patent/JP2018198597A/ja not_active Abandoned
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2019
- 2019-01-10 CY CY20191100022T patent/CY1121192T1/el unknown
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