TR201910675T4 - Kanserin tedavi edilmesine yönelik PARP inhibitörleri olarak 1-((3-((1-piperazinil)karbonil)fenil)metil)-2,4(1H,3H)-kinazolindion deriveleri. - Google Patents

Kanserin tedavi edilmesine yönelik PARP inhibitörleri olarak 1-((3-((1-piperazinil)karbonil)fenil)metil)-2,4(1H,3H)-kinazolindion deriveleri. Download PDF

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TR201910675T4
TR201910675T4 TR2019/10675T TR201910675T TR201910675T4 TR 201910675 T4 TR201910675 T4 TR 201910675T4 TR 2019/10675 T TR2019/10675 T TR 2019/10675T TR 201910675 T TR201910675 T TR 201910675T TR 201910675 T4 TR201910675 T4 TR 201910675T4
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Prior art keywords
piperazinyl
carbonyl
phenyl
methyl
treating cancer
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TR2019/10675T
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English (en)
Inventor
Xiong Cai Sui
Edward Tian Ye
Dong Haijun
Xu Qingbing
Wu Lizhen
Liu Lijun
Jiang Yangzhen
Bao Qingli
Wang Guoxiang
Yin Feng
Gu Chengyun
Hu Xiuhua
Wang Xiaozhu
Kang Sishun
Chen Shengzhi
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Impact Therapeutics Inc
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Priority claimed from CN2011100824756A external-priority patent/CN102731416A/zh
Application filed by Impact Therapeutics Inc filed Critical Impact Therapeutics Inc
Publication of TR201910675T4 publication Critical patent/TR201910675T4/tr

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Abstract

Ar, R1-R6'nın burada açıklandığı, Formül (I) ile temsil edilen 1-(arilmetil)kinazolin-2,4(1H,3H)-dionlar açıklanır. Formüle (I) sahip bileşikler, PARP inhibitörleridir. Dolayısıyla buluş bileşikleri, PARP aktivitesinin inhibisyonuna yanıt veren klinik durumları tedavi etmek üzere kullanılabilir.
TR2019/10675T 2011-04-01 2012-03-31 Kanserin tedavi edilmesine yönelik PARP inhibitörleri olarak 1-((3-((1-piperazinil)karbonil)fenil)metil)-2,4(1H,3H)-kinazolindion deriveleri. TR201910675T4 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2011100824756A CN102731416A (zh) 2011-04-01 2011-04-01 1-(芳基甲基)-喹唑啉-2，4-二酮作为parp抑制剂及其应用
CN2011077034 2011-07-11

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TR201910675T4 true TR201910675T4 (tr) 2019-08-21

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TR2019/10675T TR201910675T4 (tr) 2011-04-01 2012-03-31 Kanserin tedavi edilmesine yönelik PARP inhibitörleri olarak 1-((3-((1-piperazinil)karbonil)fenil)metil)-2,4(1H,3H)-kinazolindion deriveleri.

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US (4) US9290460B2 (tr)
EP (1) EP2709990B1 (tr)
JP (1) JP6270713B2 (tr)
CN (2) CN103097361B (tr)
AU (1) AU2012237776B2 (tr)
CA (1) CA2831015C (tr)
CY (1) CY1121847T1 (tr)
DK (1) DK2709990T3 (tr)
ES (1) ES2736299T3 (tr)
HR (1) HRP20191273T1 (tr)
HU (1) HUE046121T2 (tr)
PL (1) PL2709990T3 (tr)
PT (1) PT2709990T (tr)
RS (1) RS59091B1 (tr)
SG (1) SG193599A1 (tr)
SI (1) SI2709990T1 (tr)
TR (1) TR201910675T4 (tr)
TW (1) TWI527800B (tr)
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