UA104004C2 - Аналоги бупренорфіну - Google Patents

Аналоги бупренорфіну

Info

Publication number
UA104004C2
UA104004C2 UAA201102272A UAA201102272A UA104004C2 UA 104004 C2 UA104004 C2 UA 104004C2 UA A201102272 A UAA201102272 A UA A201102272A UA A201102272 A UAA201102272 A UA A201102272A UA 104004 C2 UA104004 C2 UA 104004C2
Authority
UA
Ukraine
Prior art keywords
formula
iii
embed isisserver
och3
buprenorphine
Prior art date
Application number
UAA201102272A
Other languages
English (en)
Russian (ru)
Inventor
Дональд Дж. Кайл
Р. Річард Гьорінг
Меріен Е. Фандітус
Original Assignee
Пердью Фарма Л.П.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пердью Фарма Л.П. filed Critical Пердью Фарма Л.П.
Publication of UA104004C2 publication Critical patent/UA104004C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Даний винахід стосується сполук аналогів бупренорфіну Формули І, Формули II або Формули III, наведених нижче, де R1, R2, R8, R3, R3a, R3b, X, Z та Y є такими, як описано у даному документі. EMBED ISISServer , (І) EMBED ISISServer , (II) EMBED ISISServer . (III) Сполуки винаходу є придатними для лікування болю та інших станів, що модулюються активністю опіоїдних та ORL1-рецепторів.
UAA201102272A 2008-07-30 2009-07-30 Аналоги бупренорфіну UA104004C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8476408P 2008-07-30 2008-07-30
US22611909P 2009-07-16 2009-07-16
PCT/US2009/004391 WO2010014229A1 (en) 2008-07-30 2009-07-30 Buprenorphine analogs

Publications (1)

Publication Number Publication Date
UA104004C2 true UA104004C2 (uk) 2013-12-25

Family

ID=41119539

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201102272A UA104004C2 (uk) 2008-07-30 2009-07-30 Аналоги бупренорфіну

Country Status (24)

Country Link
US (1) US8530494B2 (uk)
EP (2) EP2326651B1 (uk)
JP (2) JP5525524B2 (uk)
KR (1) KR101343395B1 (uk)
CN (2) CN103450206A (uk)
AU (1) AU2009277095B2 (uk)
CA (1) CA2731939C (uk)
CO (1) CO6341635A2 (uk)
DK (1) DK2326651T3 (uk)
ES (1) ES2449222T3 (uk)
HR (1) HRP20140182T1 (uk)
IL (1) IL210391A0 (uk)
ME (1) ME01665B (uk)
MX (1) MX2011001268A (uk)
NZ (1) NZ590650A (uk)
PL (1) PL2326651T3 (uk)
PT (1) PT2326651E (uk)
RS (1) RS53154B (uk)
RU (2) RU2520222C2 (uk)
SI (1) SI2326651T1 (uk)
SM (1) SMT201400023B (uk)
UA (1) UA104004C2 (uk)
WO (1) WO2010014229A1 (uk)
ZA (1) ZA201100188B (uk)

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CA2810356C (en) * 2010-09-21 2016-06-14 Purdue Pharma L.P. Buprenorphine analogs
FR2975912B1 (fr) 2011-05-30 2013-06-14 Flamel Tech Sa Composition a liberation controlee de buprenorphine
EP2788358B1 (en) 2011-12-08 2018-08-29 Purdue Pharma LP Quaternized buprenorphine analogs
US10138207B2 (en) 2012-11-09 2018-11-27 Purdue Pharma, L.P. Benzomorphan analogs and the use thereof
EP2931729B1 (en) 2012-12-07 2019-02-06 Purdue Pharma LP Buprenorphine analogs as opiod receptor modulators
ES2631197T3 (es) 2012-12-14 2017-08-29 Purdue Pharma Lp Análogos de piridonamorfinano y actividad biológica sobre los receptores opiodes
WO2014091297A1 (en) 2012-12-14 2014-06-19 Purdue Pharma L.P. Spirocyclic morphinans and their use
CA2896202A1 (en) * 2012-12-28 2014-07-03 Purdue Pharma L.P. Substituted morphinans and the use thereof
CA2900023A1 (en) 2013-01-31 2014-08-07 Purdue Pharma L.P. Benzomorphan analogs and the use thereof
US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
EP3087078B1 (en) * 2013-12-26 2019-05-15 Purdue Pharma LP 7-beta-alkyl analogs of orvinols
EP3087073B1 (en) 2013-12-26 2018-07-04 Purdue Pharma LP 10-substituted morphinan hydantoins
US9340542B2 (en) 2013-12-26 2016-05-17 Purdue Pharma L.P. Propellane-based compounds and the use thereof
US9862726B2 (en) 2013-12-26 2018-01-09 Purdue Pharma L.P. Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
WO2015100092A2 (en) * 2013-12-26 2015-07-02 Purdue Pharma L.P. 7-beta analogs of orvinols
US9656962B2 (en) 2013-12-26 2017-05-23 Purdue Pharma L.P. Ring-contracted morphinans and the use thereof
EP3086790A4 (en) 2013-12-27 2017-07-19 Purdue Pharma LP 6-substituted and 7-substituted morphinan analogs and the use thereof
EP3148535A4 (en) 2014-05-27 2017-11-29 Purdue Pharma LP Spirocyclic morphinans and use thereof
CA2951697A1 (en) 2014-06-13 2015-12-17 Purdue Pharma L.P. Azamophinan derivatives and use thereof
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
MA41125A (fr) 2014-12-05 2017-10-10 Purdue Pharma Lp Dérivés de 6.7-cyclomorphinane et leur utilisation
WO2018125716A1 (en) 2017-01-02 2018-07-05 Purdue Pharma L.P. Morphinan derivatives and use thereof

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Also Published As

Publication number Publication date
RU2520222C2 (ru) 2014-06-20
US8530494B2 (en) 2013-09-10
SI2326651T1 (sl) 2014-03-31
AU2009277095A1 (en) 2010-02-04
HRP20140182T1 (hr) 2014-04-11
CA2731939C (en) 2017-05-23
ZA201100188B (en) 2011-09-28
KR20110036859A (ko) 2011-04-11
RU2011107440A (ru) 2012-09-10
IL210391A0 (en) 2011-03-31
PL2326651T3 (pl) 2014-05-30
HK1158622A1 (en) 2012-07-20
CN102112479B (zh) 2014-10-29
JP2014208640A (ja) 2014-11-06
DK2326651T3 (da) 2014-01-20
ME01665B (me) 2014-09-20
JP5525524B2 (ja) 2014-06-18
NZ590650A (en) 2013-01-25
AU2009277095B2 (en) 2012-09-06
CA2731939A1 (en) 2010-02-04
CN103450206A (zh) 2013-12-18
RS53154B (sr) 2014-06-30
PT2326651E (pt) 2014-02-12
JP2012506839A (ja) 2012-03-22
CN102112479A (zh) 2011-06-29
CO6341635A2 (es) 2011-11-21
MX2011001268A (es) 2011-07-29
EP2326651B1 (en) 2013-11-27
RU2013106944A (ru) 2014-08-27
KR101343395B1 (ko) 2013-12-19
ES2449222T3 (es) 2014-03-18
EP2703404A1 (en) 2014-03-05
SMT201400023B (it) 2014-05-07
US20110136846A1 (en) 2011-06-09
WO2010014229A1 (en) 2010-02-04
EP2326651A1 (en) 2011-06-01

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