UA26860C2 - Спосіб одержаhhя (22r,s)-16 альфа,17 альфа-бутилідеhдіокси-11 бета, 21-дигідроксипрегhа-1,4-дієh-3,20-діоhу - Google Patents

Спосіб одержаhhя (22r,s)-16 альфа,17 альфа-бутилідеhдіокси-11 бета, 21-дигідроксипрегhа-1,4-дієh-3,20-діоhу

Info

Publication number
UA26860C2
UA26860C2 UA94010159A UA94010159A UA26860C2 UA 26860 C2 UA26860 C2 UA 26860C2 UA 94010159 A UA94010159 A UA 94010159A UA 94010159 A UA94010159 A UA 94010159A UA 26860 C2 UA26860 C2 UA 26860C2
Authority
UA
Ukraine
Prior art keywords
alpha
obtaining
dyhydroxypregha
diohu
butylidehdioxy
Prior art date
Application number
UA94010159A
Other languages
English (en)
Russian (ru)
Inventor
Роберт Герріт Хофстрат
Роберт Геррит ХОФСТРАТ
Петрюс Хендрикюс Раймакерс
Пітер Врейхоф
Original Assignee
Астра Актієболаг
Астра АБ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астра Актієболаг, Астра АБ filed Critical Астра Актієболаг
Publication of UA26860C2 publication Critical patent/UA26860C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Paper (AREA)
  • Load-Bearing And Curtain Walls (AREA)

Abstract

Запропонованo спосіб одержання (22 R,S)-16(, 17 (-бутилідендіокси-11 ?, 21 -дигідроксил-регна-1,4-дієн-3,20-діону формули: взаємодією 11 β, 16α, 17α, 21-тетра-гідроксилрегна-1,4-дієн-3,20-діону формули (II): CH2OH с бутаналем CH3CHZCH2CHO у середовищі розчинника в присутності каталізатора. Реакцію проводять в ацетонитрілі з використанням n-толуолсульфокислоти як каталізатора.
UA94010159A 1989-10-02 1990-09-27 Спосіб одержаhhя (22r,s)-16 альфа,17 альфа-бутилідеhдіокси-11 бета, 21-дигідроксипрегhа-1,4-дієh-3,20-діоhу UA26860C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8903219A SE8903219D0 (sv) 1989-10-02 1989-10-02 Process for the manufacture of budesonide
PCT/SE1990/000619 WO1991004984A1 (en) 1989-10-02 1990-09-27 Process for the manufacture of budesonide

Publications (1)

Publication Number Publication Date
UA26860C2 true UA26860C2 (uk) 1999-12-29

Family

ID=20377019

Family Applications (1)

Application Number Title Priority Date Filing Date
UA94010159A UA26860C2 (uk) 1989-10-02 1990-09-27 Спосіб одержаhhя (22r,s)-16 альфа,17 альфа-бутилідеhдіокси-11 бета, 21-дигідроксипрегhа-1,4-дієh-3,20-діоhу

Country Status (25)

Country Link
US (1) US5556964A (uk)
EP (1) EP0494942B1 (uk)
JP (1) JP2965352B2 (uk)
KR (1) KR0160527B1 (uk)
AT (1) ATE130310T1 (uk)
AU (1) AU632864B2 (uk)
BG (1) BG61608B1 (uk)
BR (1) BR9007700A (uk)
CA (1) CA2065861C (uk)
CY (1) CY2084B1 (uk)
DE (1) DE69023664T2 (uk)
DK (1) DK0494942T3 (uk)
ES (1) ES2079491T3 (uk)
FI (1) FI103204B (uk)
HK (1) HK52097A (uk)
HU (1) HU212576B (uk)
LT (1) LT3697B (uk)
LV (1) LV10283B (uk)
NO (1) NO178827C (uk)
RO (1) RO110947B1 (uk)
RU (1) RU2048472C1 (uk)
SE (1) SE8903219D0 (uk)
SG (1) SG43344A1 (uk)
UA (1) UA26860C2 (uk)
WO (1) WO1991004984A1 (uk)

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US6028190A (en) 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
US6166024A (en) 1995-03-30 2000-12-26 Mayo Foundation For Medical Education And Research Use of topical azathioprine and thioguanine to treat colorectal adenomas
IT1291288B1 (it) 1997-04-30 1999-01-07 Farmabios Srl Processo per la preparazione di 16,17 acetali di derivati pregnanici con controllo della distribuzione epimerica al c-22.
SE9704186D0 (sv) * 1997-11-14 1997-11-14 Astra Ab New composition of matter
US6266556B1 (en) 1998-04-27 2001-07-24 Beth Israel Deaconess Medical Center, Inc. Method and apparatus for recording an electroencephalogram during transcranial magnetic stimulation
FR2782823B1 (fr) 1998-09-01 2000-11-17 Neopost Ind Procede d'impression thermique
US6234167B1 (en) 1998-10-14 2001-05-22 Chrysalis Technologies, Incorporated Aerosol generator and methods of making and using an aerosol generator
MY136453A (en) 2000-04-27 2008-10-31 Philip Morris Usa Inc "improved method and apparatus for generating an aerosol"
US6883516B2 (en) 2000-04-27 2005-04-26 Chrysalis Technologies Incorporated Method for generating an aerosol with a predetermined and/or substantially monodispersed particle size distribution
US6681998B2 (en) 2000-12-22 2004-01-27 Chrysalis Technologies Incorporated Aerosol generator having inductive heater and method of use thereof
US7077130B2 (en) 2000-12-22 2006-07-18 Chrysalis Technologies Incorporated Disposable inhaler system
US6799572B2 (en) 2000-12-22 2004-10-05 Chrysalis Technologies Incorporated Disposable aerosol generator system and methods for administering the aerosol
US6491233B2 (en) 2000-12-22 2002-12-10 Chrysalis Technologies Incorporated Vapor driven aerosol generator and method of use thereof
US6701921B2 (en) 2000-12-22 2004-03-09 Chrysalis Technologies Incorporated Aerosol generator having heater in multilayered composite and method of use thereof
US6501052B2 (en) 2000-12-22 2002-12-31 Chrysalis Technologies Incorporated Aerosol generator having multiple heating zones and methods of use thereof
US20030055026A1 (en) * 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
US6640050B2 (en) 2001-09-21 2003-10-28 Chrysalis Technologies Incorporated Fluid vaporizing device having controlled temperature profile heater/capillary tube
US6568390B2 (en) 2001-09-21 2003-05-27 Chrysalis Technologies Incorporated Dual capillary fluid vaporizing device
US6681769B2 (en) 2001-12-06 2004-01-27 Crysalis Technologies Incorporated Aerosol generator having a multiple path heater arrangement and method of use thereof
US6804458B2 (en) 2001-12-06 2004-10-12 Chrysalis Technologies Incorporated Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate
US6701922B2 (en) 2001-12-20 2004-03-09 Chrysalis Technologies Incorporated Mouthpiece entrainment airflow control for aerosol generators
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
US7367334B2 (en) 2003-08-27 2008-05-06 Philip Morris Usa Inc. Fluid vaporizing device having controlled temperature profile heater/capillary tube
US20070020299A1 (en) * 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
US20070020298A1 (en) * 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether gamma-cyclodextrin and corticosteroid
US20070020196A1 (en) * 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid prepared from a unit dose suspension
ATE446581T1 (de) * 2004-03-12 2009-11-15 Trinity College Dublin Magnetoresistives medium
US20070185066A1 (en) * 2005-12-20 2007-08-09 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids
US20070249572A1 (en) * 2005-12-20 2007-10-25 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids
US20070160542A1 (en) * 2005-12-20 2007-07-12 Verus Pharmaceuticals, Inc. Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile
US20070197486A1 (en) * 2005-12-20 2007-08-23 Verus Pharmaceuticals, Inc. Methods and systems for the delivery of corticosteroids
JP2009526858A (ja) * 2006-02-15 2009-07-23 ティカ レーケメデル アーベー コルチコステロイド溶液を製造する方法
US12370352B2 (en) 2007-06-28 2025-07-29 Cydex Pharmaceuticals, Inc. Nasal and ophthalmic delivery of aqueous corticosteroid solutions
CN102060906B (zh) * 2010-12-23 2013-01-16 鲁南贝特制药有限公司 一种r布地奈德的制备方法
WO2016120891A1 (en) 2015-01-30 2016-08-04 Coral Drugs Pvt. Ltd. Novel process for preparation of glucocorticoid steroids

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3197469A (en) * 1958-08-06 1965-07-27 Pharmaceutical Res Products In 16, 17-acetals and ketals of 6-halo-16, 17-dihydroxy steroids of the pregnane seriesand intermediates therefor
US3077471A (en) * 1961-08-04 1963-02-12 Olin Mathieson Steroids of the 19-norpregnane series
SE378109B (uk) * 1972-05-19 1975-08-18 Bofors Ab
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives

Also Published As

Publication number Publication date
AU6530990A (en) 1991-04-28
EP0494942B1 (en) 1995-11-15
FI921426L (fi) 1992-04-01
AU632864B2 (en) 1993-01-14
WO1991004984A1 (en) 1991-04-18
DE69023664T2 (de) 1996-05-02
JPH05500669A (ja) 1993-02-12
HU9201064D0 (en) 1992-06-29
CA2065861C (en) 2001-06-05
LV10283A (lv) 1994-10-20
ES2079491T3 (es) 1996-01-16
DE69023664D1 (de) 1995-12-21
HU212576B (en) 1996-08-29
LT3697B (en) 1996-02-26
SG43344A1 (en) 1997-10-17
RU2048472C1 (ru) 1995-11-20
FI103204B1 (fi) 1999-05-14
BG61608B1 (bg) 1998-01-30
LTIP1729A (en) 1995-07-25
KR0160527B1 (ko) 1998-11-16
HUT60281A (en) 1992-08-28
EP0494942A1 (en) 1992-07-22
SE8903219D0 (sv) 1989-10-02
CA2065861A1 (en) 1991-04-03
LV10283B (en) 1995-04-20
JP2965352B2 (ja) 1999-10-18
ATE130310T1 (de) 1995-12-15
NO921233L (no) 1992-03-30
HK52097A (en) 1997-05-02
FI921426A0 (fi) 1992-04-01
BG96166A (bg) 1993-12-24
NO921233D0 (no) 1992-03-30
US5556964A (en) 1996-09-17
FI103204B (fi) 1999-05-14
NO178827C (no) 1996-06-12
RO110947B1 (ro) 1996-05-30
DK0494942T3 (da) 1996-03-11
NO178827B (no) 1996-03-04
BR9007700A (pt) 1992-08-11
CY2084B1 (en) 1998-10-16

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