CY2084B1 - Process for the manufacture of budesonide - Google Patents

Process for the manufacture of budesonide

Info

Publication number: CY2084B1
Authority: CY; Cyprus
Prior art keywords: alpha; manufacture; budesonide; diene; beta
Prior art date: 1989-10-02

Application number

CY9802084A

Other languages

English (en)

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-02

Filing date

1998-10-16

Publication date

1998-10-16

1998-10-16 Application filed by Astra Ab filed Critical Astra Ab

1998-10-16 Publication of CY2084B1 publication Critical patent/CY2084B1/xx

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 title 1
229960004436 budesonide Drugs 0.000 title 1
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
ZTQSAGDEMFDKMZ-UHFFFAOYSA-N Butyraldehyde Chemical compound CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Paper (AREA)
Load-Bearing And Curtain Walls (AREA)

CY9802084A 1989-10-02 1998-10-16 Process for the manufacture of budesonide CY2084B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE8903219A SE8903219D0 (sv)	1989-10-02	1989-10-02	Process for the manufacture of budesonide
PCT/SE1990/000619 WO1991004984A1 (en)	1989-10-02	1990-09-27	Process for the manufacture of budesonide

Publications (1)

Publication Number	Publication Date
CY2084B1 true CY2084B1 (en)	1998-10-16

Family

ID=20377019

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY9802084A CY2084B1 (en)	1989-10-02	1998-10-16	Process for the manufacture of budesonide

Country Status (25)

Country	Link
US (1)	US5556964A (uk)
EP (1)	EP0494942B1 (uk)
JP (1)	JP2965352B2 (uk)
KR (1)	KR0160527B1 (uk)
AT (1)	ATE130310T1 (uk)
AU (1)	AU632864B2 (uk)
BG (1)	BG61608B1 (uk)
BR (1)	BR9007700A (uk)
CA (1)	CA2065861C (uk)
CY (1)	CY2084B1 (uk)
DE (1)	DE69023664T2 (uk)
DK (1)	DK0494942T3 (uk)
ES (1)	ES2079491T3 (uk)
FI (1)	FI103204B (uk)
HK (1)	HK52097A (uk)
HU (1)	HU212576B (uk)
LT (1)	LT3697B (uk)
LV (1)	LV10283B (uk)
NO (1)	NO178827C (uk)
RO (1)	RO110947B1 (uk)
RU (1)	RU2048472C1 (uk)
SE (1)	SE8903219D0 (uk)
SG (1)	SG43344A1 (uk)
UA (1)	UA26860C2 (uk)
WO (1)	WO1991004984A1 (uk)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6028190A (en)	1994-02-01	2000-02-22	The Regents Of The University Of California	Probes labeled with energy transfer coupled dyes
US6166024A (en)	1995-03-30	2000-12-26	Mayo Foundation For Medical Education And Research	Use of topical azathioprine and thioguanine to treat colorectal adenomas
IT1291288B1 (it)	1997-04-30	1999-01-07	Farmabios Srl	Processo per la preparazione di 16,17 acetali di derivati pregnanici con controllo della distribuzione epimerica al c-22.
SE9704186D0 (sv) *	1997-11-14	1997-11-14	Astra Ab	New composition of matter
US6266556B1 (en)	1998-04-27	2001-07-24	Beth Israel Deaconess Medical Center, Inc.	Method and apparatus for recording an electroencephalogram during transcranial magnetic stimulation
FR2782823B1 (fr)	1998-09-01	2000-11-17	Neopost Ind	Procede d'impression thermique
US6234167B1 (en)	1998-10-14	2001-05-22	Chrysalis Technologies, Incorporated	Aerosol generator and methods of making and using an aerosol generator
MY136453A (en)	2000-04-27	2008-10-31	Philip Morris Usa Inc	"improved method and apparatus for generating an aerosol"
US6883516B2 (en)	2000-04-27	2005-04-26	Chrysalis Technologies Incorporated	Method for generating an aerosol with a predetermined and/or substantially monodispersed particle size distribution
US6681998B2 (en)	2000-12-22	2004-01-27	Chrysalis Technologies Incorporated	Aerosol generator having inductive heater and method of use thereof
US7077130B2 (en)	2000-12-22	2006-07-18	Chrysalis Technologies Incorporated	Disposable inhaler system
US6799572B2 (en)	2000-12-22	2004-10-05	Chrysalis Technologies Incorporated	Disposable aerosol generator system and methods for administering the aerosol
US6491233B2 (en)	2000-12-22	2002-12-10	Chrysalis Technologies Incorporated	Vapor driven aerosol generator and method of use thereof
US6701921B2 (en)	2000-12-22	2004-03-09	Chrysalis Technologies Incorporated	Aerosol generator having heater in multilayered composite and method of use thereof
US6501052B2 (en)	2000-12-22	2002-12-31	Chrysalis Technologies Incorporated	Aerosol generator having multiple heating zones and methods of use thereof
US20030055026A1 (en) *	2001-04-17	2003-03-20	Dey L.P.	Formoterol/steroid bronchodilating compositions and methods of use thereof
US6640050B2 (en)	2001-09-21	2003-10-28	Chrysalis Technologies Incorporated	Fluid vaporizing device having controlled temperature profile heater/capillary tube
US6568390B2 (en)	2001-09-21	2003-05-27	Chrysalis Technologies Incorporated	Dual capillary fluid vaporizing device
US6681769B2 (en)	2001-12-06	2004-01-27	Crysalis Technologies Incorporated	Aerosol generator having a multiple path heater arrangement and method of use thereof
US6804458B2 (en)	2001-12-06	2004-10-12	Chrysalis Technologies Incorporated	Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate
US6701922B2 (en)	2001-12-20	2004-03-09	Chrysalis Technologies Incorporated	Mouthpiece entrainment airflow control for aerosol generators
TWI359675B (en)	2003-07-10	2012-03-11	Dey L P	Bronchodilating β-agonist compositions
US7367334B2 (en)	2003-08-27	2008-05-06	Philip Morris Usa Inc.	Fluid vaporizing device having controlled temperature profile heater/capillary tube
US20070020299A1 (en) *	2003-12-31	2007-01-25	Pipkin James D	Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
US20070020298A1 (en) *	2003-12-31	2007-01-25	Pipkin James D	Inhalant formulation containing sulfoalkyl ether gamma-cyclodextrin and corticosteroid
US20070020196A1 (en) *	2003-12-31	2007-01-25	Pipkin James D	Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid prepared from a unit dose suspension
ATE446581T1 (de) *	2004-03-12	2009-11-15	Trinity College Dublin	Magnetoresistives medium
US20070185066A1 (en) *	2005-12-20	2007-08-09	Verus Pharmaceuticals, Inc.	Systems and methods for the delivery of corticosteroids
US20070249572A1 (en) *	2005-12-20	2007-10-25	Verus Pharmaceuticals, Inc.	Systems and methods for the delivery of corticosteroids
US20070160542A1 (en) *	2005-12-20	2007-07-12	Verus Pharmaceuticals, Inc.	Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile
US20070197486A1 (en) *	2005-12-20	2007-08-23	Verus Pharmaceuticals, Inc.	Methods and systems for the delivery of corticosteroids
JP2009526858A (ja) *	2006-02-15	2009-07-23	ティカレーケメデルアーベー	コルチコステロイド溶液を製造する方法
US12370352B2 (en)	2007-06-28	2025-07-29	Cydex Pharmaceuticals, Inc.	Nasal and ophthalmic delivery of aqueous corticosteroid solutions
CN102060906B (zh) *	2010-12-23	2013-01-16	鲁南贝特制药有限公司	一种r布地奈德的制备方法
WO2016120891A1 (en)	2015-01-30	2016-08-04	Coral Drugs Pvt. Ltd.	Novel process for preparation of glucocorticoid steroids

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3197469A (en) *	1958-08-06	1965-07-27	Pharmaceutical Res Products In	16, 17-acetals and ketals of 6-halo-16, 17-dihydroxy steroids of the pregnane seriesand intermediates therefor
US3077471A (en) *	1961-08-04	1963-02-12	Olin Mathieson	Steroids of the 19-norpregnane series
SE378109B (uk) *	1972-05-19	1975-08-18	Bofors Ab
SE8008524L (sv) *	1980-12-04	1982-06-05	Draco Ab	4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
IT1196142B (it) *	1984-06-11	1988-11-10	Sicor Spa	Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) *	1986-09-25	1986-09-25	Astra Pharma Prod	A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives

1989
- 1989-10-02 SE SE8903219A patent/SE8903219D0/xx unknown
1990
- 1990-09-27 BR BR909007700A patent/BR9007700A/pt not_active IP Right Cessation
- 1990-09-27 ES ES90915222T patent/ES2079491T3/es not_active Expired - Lifetime
- 1990-09-27 EP EP90915222A patent/EP0494942B1/en not_active Expired - Lifetime
- 1990-09-27 CA CA002065861A patent/CA2065861C/en not_active Expired - Lifetime
- 1990-09-27 JP JP2514161A patent/JP2965352B2/ja not_active Expired - Lifetime
- 1990-09-27 RO RO92-200446A patent/RO110947B1/ro unknown
- 1990-09-27 KR KR1019920700728A patent/KR0160527B1/ko not_active Expired - Lifetime
- 1990-09-27 UA UA94010159A patent/UA26860C2/uk unknown
- 1990-09-27 WO PCT/SE1990/000619 patent/WO1991004984A1/en not_active Ceased
- 1990-09-27 DK DK90915222.5T patent/DK0494942T3/da active
- 1990-09-27 AU AU65309/90A patent/AU632864B2/en not_active Expired
- 1990-09-27 RU SU905011922A patent/RU2048472C1/ru active
- 1990-09-27 HU HU9201064A patent/HU212576B/hu unknown
- 1990-09-27 AT AT90915222T patent/ATE130310T1/de not_active IP Right Cessation
- 1990-09-27 DE DE69023664T patent/DE69023664T2/de not_active Expired - Lifetime
- 1990-11-27 SG SG1996008769A patent/SG43344A1/en unknown
1992
- 1992-03-30 NO NO921233A patent/NO178827C/no not_active IP Right Cessation
- 1992-04-01 BG BG96166A patent/BG61608B1/bg unknown
- 1992-04-01 FI FI921426A patent/FI103204B/fi active
1993
- 1993-06-30 LV LVP-93-858A patent/LV10283B/xx unknown
- 1993-12-30 LT LTIP1729A patent/LT3697B/lt not_active IP Right Cessation
1994
- 1994-12-16 US US08/357,773 patent/US5556964A/en not_active Expired - Lifetime
1997
- 1997-04-24 HK HK52097A patent/HK52097A/en not_active IP Right Cessation
1998
- 1998-10-16 CY CY9802084A patent/CY2084B1/xx unknown

Also Published As

Publication number	Publication date
AU6530990A (en)	1991-04-28
EP0494942B1 (en)	1995-11-15
FI921426L (fi)	1992-04-01
AU632864B2 (en)	1993-01-14
WO1991004984A1 (en)	1991-04-18
DE69023664T2 (de)	1996-05-02
JPH05500669A (ja)	1993-02-12
HU9201064D0 (en)	1992-06-29
CA2065861C (en)	2001-06-05
LV10283A (lv)	1994-10-20
ES2079491T3 (es)	1996-01-16
DE69023664D1 (de)	1995-12-21
HU212576B (en)	1996-08-29
LT3697B (en)	1996-02-26
SG43344A1 (en)	1997-10-17
RU2048472C1 (ru)	1995-11-20
FI103204B1 (fi)	1999-05-14
BG61608B1 (bg)	1998-01-30
LTIP1729A (en)	1995-07-25
KR0160527B1 (ko)	1998-11-16
HUT60281A (en)	1992-08-28
EP0494942A1 (en)	1992-07-22
SE8903219D0 (sv)	1989-10-02
CA2065861A1 (en)	1991-04-03
LV10283B (en)	1995-04-20
JP2965352B2 (ja)	1999-10-18
ATE130310T1 (de)	1995-12-15
NO921233L (no)	1992-03-30
HK52097A (en)	1997-05-02
FI921426A0 (fi)	1992-04-01
BG96166A (bg)	1993-12-24
NO921233D0 (no)	1992-03-30
US5556964A (en)	1996-09-17
FI103204B (fi)	1999-05-14
NO178827C (no)	1996-06-12
RO110947B1 (ro)	1996-05-30
DK0494942T3 (da)	1996-03-11
NO178827B (no)	1996-03-04
UA26860C2 (uk)	1999-12-29
BR9007700A (pt)	1992-08-11

Publication	Publication Date	Title
LV10283B (en)	1995-04-20	Process for the manufacture of budesonide
ES8705462A1 (es)	1987-05-01	Un procedimiento para la preparacion de 16,17-acetales de derivados de pregnano
GR1001529B (el)	1994-03-31	Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
JPS57203097A (en)	1982-12-13	Manufacture of high purity ulsodeoxycholic acid
MXPA03004123A (es)	2004-09-10	Proceso para la produccion de 16, 17-[(ciclohexilmetilen) bis(oxy)]-11, 21-dihidroxi-pregna-1, 4-dien-3, 20-dion o su 21-isobutirat por trnasquetalisacion.
Boeckman Jr et al.	1976	Synthesis and reactivity of endocyclic α, β-epoxy-γ-butyrolactones
US2666072A (en)	1954-01-12	Halogenation and oxidation of steroids
EP0335106A3 (en)	1990-08-29	Novel intermediates and an improved process for producing the compound (3 beta, 5 alpha)-3-hydroxycholest-8(14)-en-15-one
GB1292846A (en)	1972-10-11	A process for the synthesis of leupeptins and their analogues
DE1096353B (de)	1961-01-05	Verfahren zur Herstellung von 1, 2-Methylen-3-ketosteroiden
ES8702876A1 (es)	1987-01-16	Procedimiento para la obtencion de acido monocloroacetico a partir de acido glicolico
ES473544A1 (es)	1979-05-16	Nuevo procedimiento de sintesis del valerato de diflucorto- lona.
GB970482A (en)	1964-09-23	New 17-desoxy corticosteroids and processes for their preparation
MD21C2 (ro)	1994-05-31	Metodă de obţinere a 22(R,S)-11, 21-dihidroxi-16, 17-butilidenbisoxipregn-1,4-dien-3, 20-dionului
MX9605428A (es)	1997-12-31	SINTESIS DE 17 beta-CIANO-3-ETOXI-17ALFA-HIDROXI-6-METILANDROSTA-3,5,9(11)-T RIENO.
ES2138753T3 (es)	2000-01-16	Procedimiento para la preparacion de derivados de esteroides 16 alfa, 17 alfa-cetales.
DD274031A1 (de)	1989-12-06	Verfahren zur herstellung von 3-substituierten 5gamma-hydroxy-6beta-fluor-1-en-steroiden