UA37217C2 - Аналоги 15-дезоксиспергуаліну, спосіб їх одержання, фармацевтична композиція та проміжні сполуки - Google Patents

Аналоги 15-дезоксиспергуаліну, спосіб їх одержання, фармацевтична композиція та проміжні сполуки

Info

Publication number
UA37217C2
UA37217C2 UA95028166A UA95028166A UA37217C2 UA 37217 C2 UA37217 C2 UA 37217C2 UA 95028166 A UA95028166 A UA 95028166A UA 95028166 A UA95028166 A UA 95028166A UA 37217 C2 UA37217 C2 UA 37217C2
Authority
UA
Ukraine
Prior art keywords
deoxyspergualine
pharmaceutical composition
analogues
obtaining
intermediate compounds
Prior art date
Application number
UA95028166A
Other languages
English (en)
Russian (ru)
Inventor
Патріція Рено
Патриция Рено
Люк Лебретон
Патрік Дютартре
Патрик Дютартре
Філіпп Деррепас
Филипп Деррепас
Сос Самрес
Original Assignee
Фурнір Індастріє Ет Санте
Фурнир Индастрие Эт Сантэ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9402125A external-priority patent/FR2716451B1/fr
Application filed by Фурнір Індастріє Ет Санте, Фурнир Индастрие Эт Сантэ filed Critical Фурнір Індастріє Ет Санте
Publication of UA37217C2 publication Critical patent/UA37217C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Цей винахід належить до нових сполук структури, аналогічної 15-дезоксиспергуаліну, до способу їх отримання і їх застосування у фармакологічній композиції як імунодепресивних агентів.
UA95028166A 1994-02-24 1995-02-17 Аналоги 15-дезоксиспергуаліну, спосіб їх одержання, фармацевтична композиція та проміжні сполуки UA37217C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9402125A FR2716451B1 (fr) 1994-02-24 1994-02-24 Analogues de la 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.
FR9406706A FR2716452B1 (fr) 1994-02-24 1994-06-01 Analogues de la 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.

Publications (1)

Publication Number Publication Date
UA37217C2 true UA37217C2 (uk) 2001-05-15

Family

ID=26230971

Family Applications (1)

Application Number Title Priority Date Filing Date
UA95028166A UA37217C2 (uk) 1994-02-24 1995-02-17 Аналоги 15-дезоксиспергуаліну, спосіб їх одержання, фармацевтична композиція та проміжні сполуки

Country Status (22)

Country Link
US (1) US5637613A (uk)
EP (1) EP0669316B1 (uk)
JP (1) JP2874839B2 (uk)
KR (1) KR100188991B1 (uk)
CN (1) CN1148378C (uk)
AT (1) ATE156117T1 (uk)
AU (1) AU691847B2 (uk)
CA (1) CA2143216C (uk)
CZ (1) CZ287985B6 (uk)
DE (1) DE69404624T2 (uk)
DK (1) DK0669316T3 (uk)
ES (1) ES2106480T3 (uk)
FI (1) FI950728A7 (uk)
FR (1) FR2716452B1 (uk)
GR (1) GR3025164T3 (uk)
HU (1) HUT70958A (uk)
NO (1) NO302816B1 (uk)
NZ (1) NZ270449A (uk)
RU (1) RU2113431C1 (uk)
SK (1) SK281058B6 (uk)
TW (1) TW317562B (uk)
UA (1) UA37217C2 (uk)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2734263B1 (fr) * 1995-05-17 1997-06-20 Fournier Ind & Sante Analogues de la 15-deoxyspergualine, leur procede de preparation et leur utilisation en therapeutique
US5985824A (en) * 1997-02-27 1999-11-16 Genzyme Corporation Methods and compositions for treating cystic fibrosis
US5834421A (en) * 1997-02-27 1998-11-10 Genzyme Corporation Methods and compositions for treating cystic fibrosis
US20020142000A1 (en) * 1999-01-15 2002-10-03 Digan Mary Ellen Anti-CD3 immunotoxins and therapeutic uses therefor
DE19923961A1 (de) * 1999-05-25 2000-11-30 Euro Nippon Kayaku Gmbh Verwendung von 15-Deoxyspergualin zur Behandlung von hyperreaktiven entzündlichen Erkrankungen und Autoimmunerkrankungen
FR2963238B1 (fr) * 2010-07-29 2012-12-28 Fournier Lab Sa Derives de 15-desoxyspergualine pour le traitement et/ou la prevention des maladies inflammatoires oculaires
EP2598131A1 (fr) * 2010-07-29 2013-06-05 Laboratoires Fournier S.A. Composes pour le traitement/la prevention des maladies inflammatoires oculaires

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5942356A (ja) * 1982-09-02 1984-03-08 Microbial Chem Res Found スパガリン関連化合物およびその製造法
JPS61129119A (ja) * 1984-11-13 1986-06-17 Microbial Chem Res Found 新規免疫抑制剤

Also Published As

Publication number Publication date
KR100188991B1 (ko) 1999-06-01
NO950664L (no) 1995-08-25
RU2113431C1 (ru) 1998-06-20
ATE156117T1 (de) 1997-08-15
FR2716452A1 (fr) 1995-08-25
SK24795A3 (en) 1995-09-13
HK1000489A1 (en) 1998-03-27
AU1028895A (en) 1995-08-31
HUT70958A (en) 1995-11-28
NZ270449A (en) 1996-08-27
DK0669316T3 (da) 1998-03-09
KR950032097A (ko) 1995-12-20
GR3025164T3 (en) 1998-02-27
FI950728A0 (fi) 1995-02-17
HU9500556D0 (en) 1995-04-28
FI950728L (fi) 1995-08-25
CZ287985B6 (cs) 2001-03-14
JPH0841007A (ja) 1996-02-13
DE69404624D1 (de) 1997-09-04
JP2874839B2 (ja) 1999-03-24
TW317562B (uk) 1997-10-11
SK281058B6 (sk) 2000-11-07
DE69404624T2 (de) 1998-02-05
EP0669316B1 (fr) 1997-07-30
CN1119191A (zh) 1996-03-27
ES2106480T3 (es) 1997-11-01
NO950664D0 (no) 1995-02-22
RU95102479A (ru) 1997-05-10
EP0669316A1 (fr) 1995-08-30
CA2143216A1 (en) 1995-08-25
FR2716452B1 (fr) 1996-05-10
AU691847B2 (en) 1998-05-28
FI950728A7 (fi) 1995-08-25
NO302816B1 (no) 1998-04-27
CN1148378C (zh) 2004-05-05
CA2143216C (en) 1999-04-13
US5637613A (en) 1997-06-10
CZ50295A3 (en) 1995-10-18

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