UA41323C2 - Спосіб одержання похідних 3-хінолонкарбонової кислоти - Google Patents

Спосіб одержання похідних 3-хінолонкарбонової кислоти

Info

Publication number
UA41323C2
UA41323C2 UA94129157A UA94129157A UA41323C2 UA 41323 C2 UA41323 C2 UA 41323C2 UA 94129157 A UA94129157 A UA 94129157A UA 94129157 A UA94129157 A UA 94129157A UA 41323 C2 UA41323 C2 UA 41323C2
Authority
UA
Ukraine
Prior art keywords
acid
derivatives
qynolone
carbonic acid
preparing
Prior art date
Application number
UA94129157A
Other languages
English (en)
Russian (ru)
Inventor
Цербес Рудольф
Нааб Пауль
Франковіак Герхард
Франковиак Герхард
Діль Херберт
Диль Херберт
Original Assignee
Байєр Аг
Байер Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байєр Аг, Байер Аг filed Critical Байєр Аг
Publication of UA41323C2 publication Critical patent/UA41323C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Materials For Photolithography (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Винахід належить до технології одержання відомих похідних хінолонкарбонової кислоти, зокрема до способу отримання похідних 3-хінолонкарбонової кислоти. Спосіб одержання похідних 3-хінолонкарбонової кислоти загальної формули (I): Де R1 і R2 разом з атомом азоту, з яким вони пов'язані, утворюють піролідинове кільце, заміщене в положенні 3 аміногрупою, піперазинільне кільце, заміщене в атомі азоту в положенні 4 нижчим алкілом, або 2,8-діазабіцикло[4.3.0]ноніл, А - СН, CF, CCl, що включає стадії взаємодії галогенангідриду кислоти з естером карбонової кислоти в середовищі розчинника у присутності основи, циклізації в присутності основного агента, взаємодії з гетероциклічним аміном, лужного омилення і виділення цільового продукту у вільній формі або у вигляді солі.
UA94129157A 1993-12-10 1994-12-09 Спосіб одержання похідних 3-хінолонкарбонової кислоти UA41323C2 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4342186A DE4342186A1 (de) 1993-12-10 1993-12-10 Eintopfverfahren zur Herstellung von 3-Chinoloncarbonsäurederivaten

Publications (1)

Publication Number Publication Date
UA41323C2 true UA41323C2 (uk) 2001-09-17

Family

ID=6504693

Family Applications (1)

Application Number Title Priority Date Filing Date
UA94129157A UA41323C2 (uk) 1993-12-10 1994-12-09 Спосіб одержання похідних 3-хінолонкарбонової кислоти

Country Status (35)

Country Link
US (1) US5639886A (uk)
EP (1) EP0657448B1 (uk)
JP (1) JP3963490B2 (uk)
KR (1) KR950018008A (uk)
CN (1) CN1109877A (uk)
AT (1) ATE163645T1 (uk)
AU (1) AU693818B2 (uk)
BG (1) BG61947B1 (uk)
CA (1) CA2137523C (uk)
CO (1) CO4180607A1 (uk)
CZ (1) CZ288078B6 (uk)
DE (2) DE4342186A1 (uk)
DK (1) DK0657448T3 (uk)
EE (1) EE03215B1 (uk)
ES (1) ES2113040T3 (uk)
FI (1) FI945776A7 (uk)
GR (1) GR3026383T3 (uk)
HR (1) HRP940950B1 (uk)
HU (1) HU220597B1 (uk)
IL (1) IL111921A (uk)
LV (1) LV11470B (uk)
MY (1) MY113302A (uk)
NO (1) NO307180B1 (uk)
NZ (1) NZ270086A (uk)
PE (1) PE33795A1 (uk)
PL (1) PL180022B1 (uk)
RO (1) RO113345B1 (uk)
RU (1) RU2138483C1 (uk)
SI (1) SI0657448T1 (uk)
SK (1) SK279950B6 (uk)
SV (1) SV1994000071A (uk)
TW (1) TW401412B (uk)
UA (1) UA41323C2 (uk)
YU (1) YU48865B (uk)
ZA (1) ZA949830B (uk)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA024004B1 (ru) * 2013-05-13 2016-08-31 Наталия Николаевна Деркач СПОСОБ ПОЛУЧЕНИЯ (1-ЦИКЛОПРОПИЛ-6-ФТОР-1,4-ДИГИДРО-8-МЕТОКСИ-7-[(4aS,7aS)-ОКТАГИДРО-6H-ПИРРОЛО[3,4-b]ПИРИДИН-6-ИЛ]-4-ОКСО-3-ХИНОЛИНКАРБОНОВОЙ КИСЛОТЫ

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DE19826050A1 (de) * 1998-06-12 1999-12-16 Bayer Ag Verfahren zur Herstellung von Chinolon- und Naphthyridoncarbonsäuren und deren Ester
AU2001234159A1 (en) * 2000-02-25 2001-09-03 Daiichi Pharmaceutical Co., Ltd. Process for producing quinolonecarboxylic acids and intermediates thereof
US6608078B2 (en) 2000-05-08 2003-08-19 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
DE10026903A1 (de) * 2000-06-03 2002-01-10 Cpc Cellular Process Chemistry Verfahren zur Herstellung von Chinolon-3-carbonsäuren
US7098219B2 (en) 2000-08-01 2006-08-29 Wockhart Limited Inhibitors of cellular efflux pumps of microbes
US6878713B2 (en) 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6964966B2 (en) 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
WO2003099815A1 (en) 2002-05-28 2003-12-04 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
KR100519158B1 (ko) * 2002-12-21 2005-10-06 주식회사유한양행 퀴놀론 카르복실레이트 유도체의 제조방법
AU2003304460A1 (en) * 2003-09-04 2005-03-29 Wockhardt Limited Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate
WO2005026145A2 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
CN100412075C (zh) * 2004-06-22 2008-08-20 浙江医药股份有限公司新昌制药厂 左旋氧氟沙星和氧氟沙星的制备方法
JP2010509305A (ja) 2006-11-13 2010-03-25 シプラ・リミテッド モキシフロキサシン塩酸塩の合成方法
EP1992626A1 (en) * 2007-05-10 2008-11-19 Sandoz AG Process for the preparation of moxifloxacin hydrochloride
FR2916446B1 (fr) * 2007-05-24 2009-08-21 Biocodex Sa Nouveau procede de synthese de fluoroquinolones
EP2083010A1 (en) 2008-01-08 2009-07-29 Chemo Ibérica, S.A. Polymorphic Forms of Moxifloxacin hydrochloride and processes for preparation thereof
CN101781299B (zh) * 2010-01-13 2012-06-27 杭州师范大学 一种喹诺酮类药物关键中间体的一锅法合成方法
IT1398952B1 (it) * 2010-03-19 2013-03-28 F S I Fabbrica Italiana Sint Processo di preparazione della moxifloxacina e suoi sali
CN102675306A (zh) * 2011-03-17 2012-09-19 苏州中科天马肽工程中心有限公司 一种莫西沙星或其盐的制备方法
CN102267994B (zh) * 2011-06-17 2013-01-30 江苏正大丰海制药有限公司 一种盐酸莫西沙星已知杂质的制备方法
WO2013157018A1 (en) 2012-04-18 2013-10-24 Indian Institute Of Technology Madras A process for the preparation of the core structure in quinolone and napthyridone class of antibiotics
WO2014087292A1 (en) 2012-12-04 2014-06-12 Mankind Research Centre An improved process for the preparation of moxifloxacin hydrochloride
CN111032622A (zh) * 2017-06-12 2020-04-17 弗吉尼亚联邦大学 流线型合成氟喹诺酮类
CN115385856A (zh) * 2022-09-05 2022-11-25 常州大学 一锅法合成诺氟沙星中间体的方法

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US5468861A (en) * 1984-06-04 1995-11-21 Bayer Aktiengesellschaft 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and alkyl esters thereof
DE3420743A1 (de) 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
JPS63179856A (ja) 1987-01-21 1988-07-23 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体の製造方法並びにその中間体
DE3724466A1 (de) 1987-07-24 1989-02-02 Bayer Ag Verfahren zur herstellung von chinoloncarbonsaeuren
US4780468A (en) * 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
WO1989005643A1 (en) * 1987-12-18 1989-06-29 Pfizer Inc. Heterocyclic-substituted quinoline-carboxylic acids
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
DE4208789A1 (de) 1992-03-19 1993-09-23 Bayer Ag Enantiomerenreine chinolincarbonsaeure-derivate
DE4208792A1 (de) 1992-03-19 1993-09-23 Bayer Ag Enantiomerenreine chinolincarbonsaeure-derivate
TW209865B (uk) * 1992-01-10 1993-07-21 Bayer Ag
WO1994025464A1 (en) * 1993-04-24 1994-11-10 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and process for preparing the same
CN1041202C (zh) * 1993-08-13 1998-12-16 同和药品工业株式会社 一种具有药物活性的喹诺酮羧酸衍生物

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA024004B1 (ru) * 2013-05-13 2016-08-31 Наталия Николаевна Деркач СПОСОБ ПОЛУЧЕНИЯ (1-ЦИКЛОПРОПИЛ-6-ФТОР-1,4-ДИГИДРО-8-МЕТОКСИ-7-[(4aS,7aS)-ОКТАГИДРО-6H-ПИРРОЛО[3,4-b]ПИРИДИН-6-ИЛ]-4-ОКСО-3-ХИНОЛИНКАРБОНОВОЙ КИСЛОТЫ
US9556173B2 (en) 2013-05-13 2017-01-31 Nataliia Mykolaivna Derkach Method for preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid
RU2641699C2 (ru) * 2013-05-13 2018-01-22 Наталия Мыколаивна Деркач Способ получения (1-циклопропил-6-фтор-1,4-дигидро-8-метокси-7-[(4as,7as)-октагидро-6н-пирроло[3,4-в]пиридин-6-ил]-4-оксо-3-хинолинкарбоновой кислоты

Also Published As

Publication number Publication date
LV11470A (lv) 1996-08-20
YU71694A (sh) 1996-10-18
FI945776L (fi) 1995-06-11
HU9403553D0 (en) 1995-02-28
IL111921A0 (en) 1995-03-15
NO944786L (no) 1995-06-12
CN1109877A (zh) 1995-10-11
US5639886A (en) 1997-06-17
NO944786D0 (no) 1994-12-09
TW401412B (en) 2000-08-11
LV11470B (en) 1996-12-20
JP3963490B2 (ja) 2007-08-22
RU2138483C1 (ru) 1999-09-27
BG99248A (en) 1995-09-29
EP0657448A1 (de) 1995-06-14
IL111921A (en) 1999-07-14
BG61947B1 (bg) 1998-10-30
GR3026383T3 (en) 1998-06-30
FI945776A7 (fi) 1995-06-11
CZ288078B6 (cs) 2001-04-11
YU48865B (sh) 2002-08-12
SK279950B6 (sk) 1999-06-11
SI0657448T1 (en) 1998-06-30
PE33795A1 (es) 1995-12-15
CA2137523A1 (en) 1995-06-11
CA2137523C (en) 2007-05-22
JPH07196621A (ja) 1995-08-01
RO113345B1 (ro) 1998-06-30
NZ270086A (en) 1996-02-27
EE03215B1 (et) 1999-08-16
DE59405376D1 (de) 1998-04-09
SV1994000071A (es) 1995-07-29
HRP940950B1 (en) 1998-12-31
FI945776A0 (fi) 1994-12-08
ES2113040T3 (es) 1998-04-16
MY113302A (en) 2002-01-31
PL180022B1 (pl) 2000-12-29
DK0657448T3 (da) 1998-12-21
ZA949830B (en) 1995-08-22
AU693818B2 (en) 1998-07-09
DE4342186A1 (de) 1995-06-14
HRP940950A2 (en) 1997-02-28
SK151494A3 (en) 1995-07-11
ATE163645T1 (de) 1998-03-15
HU220597B1 (hu) 2002-03-28
EP0657448B1 (de) 1998-03-04
CZ310594A3 (en) 1995-09-13
NO307180B1 (no) 2000-02-21
RU94043645A (ru) 1996-10-27
HUT72058A (en) 1996-03-28
PL306198A1 (en) 1995-06-12
AU8024494A (en) 1995-06-15
CO4180607A1 (es) 1995-06-07
KR950018008A (ko) 1995-07-22

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