UA43314C2 - Фрагмент виділеної днк, що кодує дельта-6-десатуразу ціанобактерій (варіанти), вектор, спосіб одержання рослини з підвищеним вмістом гамма-ліноленової кислоти (варіанти), спосіб індукування продукції гамма-ліноленової кислоти (варіанти), спосіб індукування продукції октадекатетраєнової кислоти (варіанти) та ціанобактеріальна дельта-6-десатураза - Google Patents
Фрагмент виділеної днк, що кодує дельта-6-десатуразу ціанобактерій (варіанти), вектор, спосіб одержання рослини з підвищеним вмістом гамма-ліноленової кислоти (варіанти), спосіб індукування продукції гамма-ліноленової кислоти (варіанти), спосіб індукування продукції октадекатетраєнової кислоти (варіанти) та ціанобактеріальна дельта-6-десатуразаInfo
- Publication number
- UA43314C2 UA43314C2 UA94005172A UA94005172A UA43314C2 UA 43314 C2 UA43314 C2 UA 43314C2 UA 94005172 A UA94005172 A UA 94005172A UA 94005172 A UA94005172 A UA 94005172A UA 43314 C2 UA43314 C2 UA 43314C2
- Authority
- UA
- Ukraine
- Prior art keywords
- variants
- desaturase
- delta
- acid
- vector
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000012634 fragment Substances 0.000 title abstract 2
- 102100034544 Acyl-CoA 6-desaturase Human genes 0.000 title 2
- 108010037138 Linoleoyl-CoA Desaturase Proteins 0.000 title 2
- 241000192700 Cyanobacteria Species 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 title 1
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 title 1
- 235000020664 gamma-linolenic acid Nutrition 0.000 title 1
- 229960002733 gamolenic acid Drugs 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 abstract 1
- 229960004488 linolenic acid Drugs 0.000 abstract 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 abstract 1
- 230000008929 regeneration Effects 0.000 abstract 1
- 238000011069 regeneration method Methods 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/19—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
- C12Y114/19003—Linoleoyl-CoA desaturase (1.14.19.3)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Nutrition Science (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
- Fats And Perfumes (AREA)
Abstract
Спосіб отримання рослини з підвищеним вмістом С - ліноленової кислоти (GLA), передбачає трансформацію клітини рослини певним фрагментом ДНК та вектором, а також регенерацію рослини з підвищеним вмістом GLA з клітини рослини.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77447591A | 1991-10-10 | 1991-10-10 | |
| US81791992A | 1992-01-08 | 1992-01-08 | |
| PCT/US1992/008746 WO1993006712A1 (en) | 1991-10-10 | 1992-10-13 | Production of gamma linolenic acid by a δ6-desaturase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA43314C2 true UA43314C2 (uk) | 2001-12-17 |
Family
ID=27118889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA94005172A UA43314C2 (uk) | 1991-10-10 | 1992-10-13 | Фрагмент виділеної днк, що кодує дельта-6-десатуразу ціанобактерій (варіанти), вектор, спосіб одержання рослини з підвищеним вмістом гамма-ліноленової кислоти (варіанти), спосіб індукування продукції гамма-ліноленової кислоти (варіанти), спосіб індукування продукції октадекатетраєнової кислоти (варіанти) та ціанобактеріальна дельта-6-десатураза |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US5552306A (uk) |
| EP (1) | EP0666918B1 (uk) |
| JP (1) | JP3537434B2 (uk) |
| KR (1) | KR100316068B1 (uk) |
| CN (2) | CN1053469C (uk) |
| AT (1) | ATE284961T1 (uk) |
| AU (1) | AU667848B2 (uk) |
| BG (1) | BG61791B1 (uk) |
| BR (1) | BR9206613A (uk) |
| CA (1) | CA2120629C (uk) |
| CZ (1) | CZ285471B6 (uk) |
| DE (1) | DE69233459T2 (uk) |
| DK (1) | DK0666918T3 (uk) |
| ES (1) | ES2231767T3 (uk) |
| HU (1) | HU217328B (uk) |
| IL (1) | IL103407A (uk) |
| MX (1) | MX9205820A (uk) |
| NZ (1) | NZ244685A (uk) |
| PH (1) | PH31293A (uk) |
| RO (1) | RO113256B1 (uk) |
| RU (1) | RU2152996C2 (uk) |
| UA (1) | UA43314C2 (uk) |
| WO (1) | WO1993006712A1 (uk) |
Families Citing this family (121)
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|---|---|---|---|---|
| US5614393A (en) * | 1991-10-10 | 1997-03-25 | Rhone-Poulenc Agrochimie | Production of γ-linolenic acid by a Δ6-desaturase |
| US20070130654A1 (en) * | 1991-10-10 | 2007-06-07 | Thomas Terry L | Production of gamma linolenic acid by a delta6-desaturase |
| US6872872B1 (en) | 1992-11-17 | 2005-03-29 | E. I. Du Pont De Nemours And Company | Genes for microsomal delta-12 fatty acid desaturases and related enzymes from plants |
| US6372965B1 (en) | 1992-11-17 | 2002-04-16 | E.I. Du Pont De Nemours And Company | Genes for microsomal delta-12 fatty acid desaturases and hydroxylases from plants |
| JPH08506490A (ja) | 1993-02-05 | 1996-07-16 | モンサント・カンパニー | 植物中の改変リノレン酸及びリノール酸含量 |
| US5639645A (en) * | 1993-09-22 | 1997-06-17 | Mitsubishi Corporation | Recombinant Δ9 desaturase and a gene encoding the same |
| US6310194B1 (en) * | 1994-09-26 | 2001-10-30 | Carnegie Institution Of Washington | Plant fatty acid hydroxylases |
| US5965793A (en) | 1995-09-20 | 1999-10-12 | Monsanto Company, Inc. | Strong early seed-specific gene regulatory region |
| US5959175A (en) * | 1997-04-09 | 1999-09-28 | Thomas; Terry L. | Sunflower albumin 5' regulatory region for the modification of plant seed lipid composition |
| US5977436A (en) * | 1997-04-09 | 1999-11-02 | Rhone Poulenc Agrochimie | Oleosin 5' regulatory region for the modification of plant seed lipid composition |
| US7745694B1 (en) | 1997-04-11 | 2010-06-29 | Monsanto Technology Llc | Methods and compositions for synthesis of long chain polyunsaturated fatty acids in plants |
| US6051754A (en) * | 1997-04-11 | 2000-04-18 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
| US5968809A (en) * | 1997-04-11 | 1999-10-19 | Abbot Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| US5972664A (en) * | 1997-04-11 | 1999-10-26 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| US6428990B1 (en) | 1997-04-11 | 2002-08-06 | Abbott Laboratories | Human desaturase gene and uses thereof |
| US6075183A (en) * | 1997-04-11 | 2000-06-13 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
| NZ337459A (en) * | 1997-04-11 | 2000-07-28 | Abbott Lab | Nucleic acid construct in plants and dietary supplement |
| US6432684B1 (en) | 1997-04-11 | 2002-08-13 | Abbott Laboratories | Human desaturase gene and uses thereof |
| US6080911A (en) * | 1997-04-15 | 2000-06-27 | Ohio University | Mice models of growth hormone insensitivity |
| IL132393A0 (en) * | 1997-04-15 | 2001-03-19 | Commw Scient Ind Res Org | Plant fatty acid epoxygenase genes and uses therefor |
| US6100450A (en) * | 1997-10-22 | 2000-08-08 | Rhone-Poulenc Agrochimie | Seed specific promoters based on arabidopsis genes |
| GB9724783D0 (en) * | 1997-11-24 | 1998-01-21 | Inst Arable Crops Research | Novel polypeptides |
| EP1080189A4 (en) * | 1998-05-29 | 2003-01-08 | Univ Ohio | COMPOSITIONS AND METHODS FOR THE PRODUCTION OF FATTY ACIDS, THEIR DERIVATIVES AND SUBSEQUENT PRODUCTS |
| CA2330024C (en) * | 1998-06-12 | 2012-01-24 | Calgene Llc | Polyunsaturated fatty acids in plants |
| US20030163845A1 (en) * | 1998-09-02 | 2003-08-28 | Pradip Mukerji | Elongase genes and uses thereof |
| US6403349B1 (en) | 1998-09-02 | 2002-06-11 | Abbott Laboratories | Elongase gene and uses thereof |
| US6677145B2 (en) | 1998-09-02 | 2004-01-13 | Abbott Laboratories | Elongase genes and uses thereof |
| US6913916B1 (en) | 1998-09-02 | 2005-07-05 | Abbott Laboratories | Elongase genes and uses thereof |
| IL146782A0 (en) | 1999-06-07 | 2002-07-25 | Basf Plant Science Gmbh | 6-acetylenase and 6-desaturase from ceratodon purpureus |
| RU2268939C2 (ru) * | 1999-06-07 | 2006-01-27 | Басф Плант Сайенс Гмбх | ДЕЛЬТА 6-АЦЕТИЛЕНАЗА/ДЕЛЬТА-6-ДЕСАТУРАЗА И ДЕЛЬТА-6-ДЕСАТУРАЗА ИЗ Ceratodon purpureus |
| DE10030976A1 (de) | 2000-06-30 | 2002-01-10 | Basf Ag | DELTA6-Desaturasegene exprimierende Pflanzen und PUFAS enthaltende Öle aus diesen Pflanzen und ein Verfahren zur Herstellung ungesättigter Fettsäuren |
| US7070970B2 (en) | 1999-08-23 | 2006-07-04 | Abbott Laboratories | Elongase genes and uses thereof |
| GB9929897D0 (en) * | 1999-12-18 | 2000-02-09 | Slabas Antoni R | Improvements in or relating to conjugated fatty acids and related compounds |
| FR2803592A1 (fr) | 2000-01-06 | 2001-07-13 | Aventis Cropscience Sa | Nouveaux derives de l'acide 3-hydroxypicolinique, leur procede de preparation et compositions fongicides les contenant. |
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| FR2810994B1 (fr) * | 2000-06-30 | 2004-03-12 | Biogemma Fr | Acides nucleiques codant pour une phosphatase vegetale de type mipp a activite phytasique et applications |
| EP1197550A3 (en) * | 2000-08-25 | 2002-11-20 | Pfizer Products Inc. | Methods and compositions for diagnosing and treating disorders involving angiogenesis |
| CN101845446B (zh) | 2000-09-28 | 2016-01-20 | 生物源食物及科学公司 | 脂肪酸去饱和酶家族成员fad4、fad5、fad5-2和fad6及它们的应用 |
| FR2815969B1 (fr) | 2000-10-30 | 2004-12-10 | Aventis Cropscience Sa | Plantes tolerantes aux herbicides par contournement de voie metabolique |
| DE10102337A1 (de) | 2001-01-19 | 2002-07-25 | Basf Plant Science Gmbh | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren, neue Biosynthesegene sowie neue pflanzliche Expressionskonstrukte |
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| CA2446059C (en) * | 2001-05-14 | 2010-03-23 | Dsm Ip Assets B.V. | Production and use of a polar lipid-rich fraction containing stearidonic acid and gamma linolenic acid from plant seeds and microbes |
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| EP1472357B1 (de) | 2002-01-30 | 2009-12-16 | BASF Plant Science GmbH | Verfahren zur herstellung mehrfach ungesättigter fettsäuren mittels eines neuen elongase-gens |
| GB2385852A (en) | 2002-02-27 | 2003-09-03 | Rothamsted Ex Station | Delta 6-desaturases from Primulaceae |
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| FR2848064B1 (fr) * | 2002-12-06 | 2006-01-13 | Bayer Cropscience Sa | Plantes legumineuses transplastomiques fertiles |
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| US7078234B2 (en) | 2002-12-18 | 2006-07-18 | Monsanto Technology Llc | Maize embryo-specific promoter compositions and methods for use thereof |
| CA2510462A1 (en) | 2002-12-19 | 2004-07-08 | University Of Bristol | Method for producing polyunsaturated fatty acids in a transgenic plant or microorganism comprising an introduced delta-9-elongase and a delta-8-desaturase |
| CA2517253C (en) | 2003-02-27 | 2018-07-03 | Basf Plant Science Gmbh | Method for the production of polyunsaturated fatty acids |
| WO2004087878A2 (en) | 2003-03-28 | 2004-10-14 | Monsanto Technology, Llc | Novel plant promoters for use in early seed development |
| EP1613746B1 (de) | 2003-03-31 | 2013-03-06 | University Of Bristol | Neue pflanzliche acyltransferasen spezifisch für langkettige, mehrfach ungesättigte fettsäuren |
| MXPA05010571A (es) | 2003-04-08 | 2005-11-23 | Basf Plant Science Gmbh | Delta-4-desaturasas a partir de euglena gracilis, que expresan plantas y aceites que comprenden pufa |
| ES2713548T3 (es) | 2003-08-01 | 2019-05-22 | Basf Plant Science Gmbh | Procedimiento para la producción de ácidos grasos poliinsaturados en organismos transgénicos |
| ATE430802T1 (de) | 2003-08-21 | 2009-05-15 | Monsanto Technology Llc | Fettsäuredesaturasen aus primula |
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| WO2005083053A2 (de) | 2004-02-27 | 2005-09-09 | Basf Plant Science Gmbh | Verfahren zur herstellung von ungesättigten omega-3-fettsäuren in transgenen organismen |
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| CA3056110C (en) | 2004-04-22 | 2020-07-14 | Surinder Pal Singh | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
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-
1992
- 1992-10-07 PH PH45060A patent/PH31293A/en unknown
- 1992-10-09 IL IL10340792A patent/IL103407A/en not_active IP Right Cessation
- 1992-10-09 MX MX9205820A patent/MX9205820A/es not_active IP Right Cessation
- 1992-10-09 NZ NZ244685A patent/NZ244685A/en not_active IP Right Cessation
- 1992-10-10 CN CN92113085A patent/CN1053469C/zh not_active Expired - Lifetime
- 1992-10-13 JP JP50724393A patent/JP3537434B2/ja not_active Expired - Fee Related
- 1992-10-13 BR BR9206613A patent/BR9206613A/pt not_active Application Discontinuation
- 1992-10-13 DE DE69233459T patent/DE69233459T2/de not_active Expired - Lifetime
- 1992-10-13 ES ES92922205T patent/ES2231767T3/es not_active Expired - Lifetime
- 1992-10-13 RU RU94030816/13A patent/RU2152996C2/ru active
- 1992-10-13 HU HU9401007A patent/HU217328B/hu not_active IP Right Cessation
- 1992-10-13 CA CA002120629A patent/CA2120629C/en not_active Expired - Lifetime
- 1992-10-13 UA UA94005172A patent/UA43314C2/uk unknown
- 1992-10-13 AU AU28812/92A patent/AU667848B2/en not_active Expired
- 1992-10-13 KR KR1019940701152A patent/KR100316068B1/ko not_active Expired - Fee Related
- 1992-10-13 CZ CZ94817A patent/CZ285471B6/cs not_active IP Right Cessation
- 1992-10-13 AT AT92922205T patent/ATE284961T1/de not_active IP Right Cessation
- 1992-10-13 RO RO94-00585A patent/RO113256B1/ro unknown
- 1992-10-13 DK DK92922205T patent/DK0666918T3/da active
- 1992-10-13 WO PCT/US1992/008746 patent/WO1993006712A1/en not_active Ceased
- 1992-10-13 EP EP92922205A patent/EP0666918B1/en not_active Expired - Lifetime
-
1994
- 1994-04-05 BG BG98695A patent/BG61791B1/bg unknown
- 1994-09-14 US US08/307,382 patent/US5552306A/en not_active Expired - Lifetime
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1995
- 1995-06-07 US US08/478,727 patent/US5663068A/en not_active Expired - Lifetime
- 1995-06-07 US US08/473,508 patent/US5689050A/en not_active Expired - Lifetime
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1997
- 1997-03-21 CN CN97104566A patent/CN1121499C/zh not_active Expired - Lifetime
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