UA61955C2 - Novel salts of bpc-peptides with organoprojective activity, a process for preparing and use thereof in therapy - Google Patents

Novel salts of bpc-peptides with organoprojective activity, a process for preparing and use thereof in therapy Download PDF

Info

Publication number: UA61955C2
Authority: UA; Ukraine
Prior art keywords: mavrs157; disorders; rgo; rko; salt
Prior art date: 1997-05-23

Application number

UA99127002A

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English (en)

Ukrainian (uk)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-23

Filing date

1998-05-20

Publication date

2003-12-15

1998-05-20 Application filed filed Critical

2003-12-15 Publication of UA61955C2 publication Critical patent/UA61955C2/uk

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OWMZNFCDEHGFEP-NFBCVYDUSA-N secretin human Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)C1=CC=CC=C1 OWMZNFCDEHGFEP-NFBCVYDUSA-N 0.000 description 1
230000028327 secretion Effects 0.000 description 1
239000013049 sediment Substances 0.000 description 1
239000012896 selective serotonin reuptake inhibitor Substances 0.000 description 1
229940124834 selective serotonin reuptake inhibitor Drugs 0.000 description 1
230000009528 severe injury Effects 0.000 description 1
231100000161 signs of toxicity Toxicity 0.000 description 1
206010040882 skin lesion Diseases 0.000 description 1
231100000444 skin lesion Toxicity 0.000 description 1
210000000813 small intestine Anatomy 0.000 description 1
239000011734 sodium Substances 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
229910001948 sodium oxide Inorganic materials 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
210000000278 spinal cord Anatomy 0.000 description 1
238000013112 stability test Methods 0.000 description 1
238000011272 standard treatment Methods 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
238000005728 strengthening Methods 0.000 description 1
ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
229960001052 streptozocin Drugs 0.000 description 1
229960005453 strychnine Drugs 0.000 description 1
229940120904 succinylcholine chloride Drugs 0.000 description 1
YOEWQQVKRJEPAE-UHFFFAOYSA-L succinylcholine chloride (anhydrous) Chemical compound [Cl-].[Cl-].C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C YOEWQQVKRJEPAE-UHFFFAOYSA-L 0.000 description 1
230000001629 suppression Effects 0.000 description 1
230000008961 swelling Effects 0.000 description 1
230000009182 swimming Effects 0.000 description 1
230000009044 synergistic interaction Effects 0.000 description 1
229940037128 systemic glucocorticoids Drugs 0.000 description 1
210000001550 testis Anatomy 0.000 description 1
210000002303 tibia Anatomy 0.000 description 1
230000036962 time dependent Effects 0.000 description 1
231100000816 toxic dose Toxicity 0.000 description 1
230000008733 trauma Effects 0.000 description 1
230000000472 traumatic effect Effects 0.000 description 1
229940036248 turpentine Drugs 0.000 description 1
210000000689 upper leg Anatomy 0.000 description 1
230000002792 vascular Effects 0.000 description 1
230000003966 vascular damage Effects 0.000 description 1
230000002227 vasoactive effect Effects 0.000 description 1
208000001319 vasomotor rhinitis Diseases 0.000 description 1
238000009423 ventilation Methods 0.000 description 1
230000001018 virulence Effects 0.000 description 1
235000015041 whisky Nutrition 0.000 description 1
208000016153 withdrawal disease Diseases 0.000 description 1
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Genetics & Genomics (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Zoology (AREA)
Heart & Thoracic Surgery (AREA)
Reproductive Health (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Psychology (AREA)
Hematology (AREA)
Gynecology & Obstetrics (AREA)
Dermatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

UA99127002A 1997-05-23 1998-05-20 Novel salts of bpc-peptides with organoprojective activity, a process for preparing and use thereof in therapy UA61955C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97108384		1997-05-23
PCT/EP1998/002953 WO1998052973A1 (en)	1997-05-23	1998-05-20	New bpc peptide salts with organo-protective activity, the process for their preparation and their use in therapy

Publications (1)

Publication Number	Publication Date
UA61955C2 true UA61955C2 (en)	2003-12-15

Family

ID=8226822

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA99127002A UA61955C2 (en)	1997-05-23	1998-05-20	Novel salts of bpc-peptides with organoprojective activity, a process for preparing and use thereof in therapy

Country Status (28)

Country	Link
US (1)	US6288028B1 (pl)
EP (1)	EP0983300B1 (pl)
JP (1)	JP3492381B2 (pl)
KR (1)	KR100488038B1 (pl)
CN (1)	CN1166683C (pl)
AR (1)	AR011478A1 (pl)
AT (1)	ATE277948T1 (pl)
AU (1)	AU731317B2 (pl)
BG (1)	BG64023B1 (pl)
BR (1)	BR9809457B1 (pl)
CA (1)	CA2290739C (pl)
CZ (1)	CZ299423B6 (pl)
DE (1)	DE69826653T2 (pl)
DK (1)	DK0983300T3 (pl)
EA (1)	EA002058B1 (pl)
ES (1)	ES2229507T3 (pl)
HU (1)	HU227800B1 (pl)
ID (1)	ID23184A (pl)
IL (2)	IL132884A0 (pl)
NO (1)	NO321126B1 (pl)
NZ (1)	NZ501323A (pl)
PL (1)	PL193790B1 (pl)
PT (1)	PT983300E (pl)
RS (1)	RS49733B (pl)
SK (1)	SK159599A3 (pl)
TR (1)	TR199902866T2 (pl)
UA (1)	UA61955C2 (pl)
WO (1)	WO1998052973A1 (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4912875B2 (ja) *	2004-02-27	2012-04-11	不二製油株式会社	癌転移抑制組成物
US8022216B2 (en) *	2007-10-17	2011-09-20	Wyeth Llc	Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
SI24318A (sl)	2013-03-13	2014-09-30	Diagen D.O.O.	Nove stabilne soli pentadekapeptida, postopek za njihovo pripravo, njihova uporaba za izdelavo farmacevtskih pripravkov in njihova uporaba v terapiji
US10350293B2 (en)	2016-08-23	2019-07-16	Pharmacotherapia d.o.o.	Compositions and methods for treating symptoms associated with multiple sclerosis
HRP20240485T1 (hr)	2017-08-24	2024-07-05	Novo Nordisk A/S	Pripravci glp-1 i njihova upotreba
PE20230819A1 (es)	2020-02-18	2023-05-19	Novo Nordisk As	Composiciones y usos de glp-1
US11065298B1 (en) *	2020-04-24	2021-07-20	Chanda Zaveri	Compositions and methods for treating or preventing viral infections
US12605427B2 (en) *	2023-05-15	2026-04-21	Red Mountain Med Spa, LLC	Sublingual semaglutide-BPC 157 combination for weight loss

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1992004368A1 (en) *	1990-09-11	1992-03-19	Sikiric Predrag	Pharmacologically active substance bpc, the process for its preparation and its use in the therapy
ATE152734T1 (de) *	1992-05-30	1997-05-15	Sikiric Predrag	Bpc-peptide, deren herstellung und verwendung
EP0624164B1 (en) *	1992-11-16	1998-02-11	Marijan Mr.Sc. Petek	Peptides with organo-protective activity, process for their preparation and their use in the therapy

1998
- 1998-05-20 DE DE69826653T patent/DE69826653T2/de not_active Expired - Lifetime
- 1998-05-20 AT AT98929345T patent/ATE277948T1/de active
- 1998-05-20 EP EP98929345A patent/EP0983300B1/en not_active Expired - Lifetime
- 1998-05-20 CZ CZ0414299A patent/CZ299423B6/cs not_active IP Right Cessation
- 1998-05-20 HU HU0002329A patent/HU227800B1/hu not_active IP Right Cessation
- 1998-05-20 CN CNB988053934A patent/CN1166683C/zh not_active Expired - Fee Related
- 1998-05-20 CA CA002290739A patent/CA2290739C/en not_active Expired - Fee Related
- 1998-05-20 SK SK1595-99A patent/SK159599A3/sk unknown
- 1998-05-20 US US09/424,414 patent/US6288028B1/en not_active Expired - Lifetime
- 1998-05-20 KR KR10-1999-7010862A patent/KR100488038B1/ko not_active Expired - Fee Related
- 1998-05-20 PT PT98929345T patent/PT983300E/pt unknown
- 1998-05-20 JP JP54994898A patent/JP3492381B2/ja not_active Expired - Fee Related
- 1998-05-20 ID IDW991444A patent/ID23184A/id unknown
- 1998-05-20 RS YUP-601/99A patent/RS49733B/sr unknown
- 1998-05-20 ES ES98929345T patent/ES2229507T3/es not_active Expired - Lifetime
- 1998-05-20 PL PL98336897A patent/PL193790B1/pl unknown
- 1998-05-20 NZ NZ501323A patent/NZ501323A/en not_active IP Right Cessation
- 1998-05-20 TR TR1999/02866T patent/TR199902866T2/xx unknown
- 1998-05-20 UA UA99127002A patent/UA61955C2/uk unknown
- 1998-05-20 WO PCT/EP1998/002953 patent/WO1998052973A1/en not_active Ceased
- 1998-05-20 AU AU79141/98A patent/AU731317B2/en not_active Ceased
- 1998-05-20 IL IL13288498A patent/IL132884A0/xx active IP Right Grant
- 1998-05-20 EA EA199901061A patent/EA002058B1/ru not_active IP Right Cessation
- 1998-05-20 DK DK98929345T patent/DK0983300T3/da active
- 1998-05-20 BR BRPI9809457-2A patent/BR9809457B1/pt not_active IP Right Cessation
- 1998-05-26 AR ARP980102425A patent/AR011478A1/es active IP Right Grant
1999
- 1999-11-11 IL IL132884A patent/IL132884A/en not_active IP Right Cessation
- 1999-11-19 BG BG103905A patent/BG64023B1/bg unknown
- 1999-11-19 NO NO19995692A patent/NO321126B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
NZ501323A (en)	2001-04-27
CZ299423B6 (cs)	2008-07-23
TR199902866T2 (xx)	2000-02-21
YU60199A (sh)	2002-09-19
EA199901061A1 (ru)	2000-06-26
NO995692L (no)	2000-01-24
BG103905A (en)	2000-07-31
RS49733B (sr)	2008-04-04
DK0983300T3 (da)	2005-01-31
AR011478A1 (es)	2000-08-16
JP2000515558A (ja)	2000-11-21
BR9809457A (pt)	2000-06-20
HUP0002329A3 (en)	2001-03-28
NO321126B1 (no)	2006-03-20
CN1257510A (zh)	2000-06-21
PT983300E (pt)	2005-02-28
NO995692D0 (no)	1999-11-19
CN1166683C (zh)	2004-09-15
DE69826653T2 (de)	2006-03-09
WO1998052973A1 (en)	1998-11-26
HUP0002329A1 (hu)	2000-12-28
IL132884A (en)	2007-08-19
EP0983300B1 (en)	2004-09-29
IL132884A0 (en)	2001-03-19
SK159599A3 (en)	2000-11-07
AU7914198A (en)	1998-12-11
KR100488038B1 (ko)	2005-05-09
ES2229507T3 (es)	2005-04-16
EP0983300A1 (en)	2000-03-08
ID23184A (id)	2000-03-23
US6288028B1 (en)	2001-09-11
DE69826653D1 (de)	2004-11-04
EA002058B1 (ru)	2001-12-24
CA2290739A1 (en)	1998-11-26
HU227800B1 (en)	2012-03-28
ATE277948T1 (de)	2004-10-15
BR9809457B1 (pt)	2010-11-30
JP3492381B2 (ja)	2004-02-03
CA2290739C (en)	2007-06-26
KR20010012895A (ko)	2001-02-26
AU731317B2 (en)	2001-03-29
PL193790B1 (pl)	2007-03-30
BG64023B1 (bg)	2003-10-31
PL336897A1 (en)	2000-07-17
CZ9904142A3 (cs)	2002-03-13

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