UA70319C2 - Combination of levodopa and riluzole for treating combination of levodopa and riluzole for treating parkinson disease parkinson disease - Google Patents

Combination of levodopa and riluzole for treating combination of levodopa and riluzole for treating parkinson disease parkinson disease Download PDF

Info

Publication number: UA70319C2
Authority: UA; Ukraine
Prior art keywords: riluzole; dof; combination; combination according; levodopa
Prior art date: 1998-04-24

Application number

UA2000105983A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Aventis Pharma S A Aventis Pha

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-24

Filing date

1999-04-22

Publication date

2004-10-15

1999-04-22 Application filed by Aventis Pharma S A Aventis Pha filed Critical Aventis Pharma S A Aventis Pha

2004-10-15 Publication of UA70319C2 publication Critical patent/UA70319C2/uk

Links

FTALBRSUTCGOEG-UHFFFAOYSA-N Riluzole Chemical compound C1=C(OC(F)(F)F)C=C2SC(N)=NC2=C1 FTALBRSUTCGOEG-UHFFFAOYSA-N 0.000 title claims abstract description 29
229960004181 riluzole Drugs 0.000 title claims abstract description 28
208000018737 Parkinson disease Diseases 0.000 title claims abstract description 8
229960004502 levodopa Drugs 0.000 title abstract description 10
WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 title abstract description 4
WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 title abstract description 4
150000003839 salts Chemical class 0.000 claims abstract description 8
239000003954 decarboxylase inhibitor Substances 0.000 claims description 14
229940123736 Decarboxylase inhibitor Drugs 0.000 claims description 13
208000012661 Dyskinesia Diseases 0.000 claims description 12
239000000203 mixture Substances 0.000 claims description 11
238000011282 treatment Methods 0.000 claims description 10
229940079593 drug Drugs 0.000 claims description 2
239000003814 drug Substances 0.000 claims description 2
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238000012876 topography Methods 0.000 claims 1
150000001875 compounds Chemical class 0.000 abstract description 2
230000037023 motor activity Effects 0.000 description 13
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208000027089 Parkinsonian disease Diseases 0.000 description 11
206010034010 Parkinsonism Diseases 0.000 description 11
238000002347 injection Methods 0.000 description 11
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238000012360 testing method Methods 0.000 description 9
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 8
230000002354 daily effect Effects 0.000 description 7
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239000000243 solution Substances 0.000 description 6
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229960003638 dopamine Drugs 0.000 description 4
208000024891 symptom Diseases 0.000 description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
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HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
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PLRACCBDVIHHLZ-UHFFFAOYSA-N 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Chemical compound C1N(C)CCC(C=2C=CC=CC=2)=C1 PLRACCBDVIHHLZ-UHFFFAOYSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
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241000282693 Cercopithecidae Species 0.000 description 1
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
208000006083 Hypokinesia Diseases 0.000 description 1
241000764773 Inna Species 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
229910002651 NO3 Inorganic materials 0.000 description 1
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
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239000005662 Paraffin oil Substances 0.000 description 1
229920005372 Plexiglas® Polymers 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 description 1
241000159610 Roya <green alga> Species 0.000 description 1
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QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
206010044565 Tremor Diseases 0.000 description 1
108010035075 Tyrosine decarboxylase Proteins 0.000 description 1
VYEYJCBEXFTGBN-UHFFFAOYSA-N acetic acid;1,3-dimethyl-7h-purine-2,6-dione Chemical compound CC(O)=O.O=C1N(C)C(=O)N(C)C2=C1NC=N2 VYEYJCBEXFTGBN-UHFFFAOYSA-N 0.000 description 1
239000002253 acid Substances 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000000654 additive Substances 0.000 description 1
206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 1
229910052786 argon Inorganic materials 0.000 description 1
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
230000008499 blood brain barrier function Effects 0.000 description 1
210000001218 blood-brain barrier Anatomy 0.000 description 1
239000002775 capsule Substances 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
229940110456 cocoa butter Drugs 0.000 description 1
235000019868 cocoa butter Nutrition 0.000 description 1
230000006378 damage Effects 0.000 description 1
238000011161 development Methods 0.000 description 1
SPCNPOWOBZQWJK-UHFFFAOYSA-N dimethoxy-(2-propan-2-ylsulfanylethylsulfanyl)-sulfanylidene-$l^{5}-phosphane Chemical compound COP(=S)(OC)SCCSC(C)C SPCNPOWOBZQWJK-UHFFFAOYSA-N 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000002270 dispersing agent Substances 0.000 description 1
238000001647 drug administration Methods 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
230000001804 emulsifying effect Effects 0.000 description 1
230000003203 everyday effect Effects 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
238000001914 filtration Methods 0.000 description 1
235000021022 fresh fruits Nutrition 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
125000005456 glyceride group Chemical group 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
239000008187 granular material Substances 0.000 description 1
244000144993 groups of animals Species 0.000 description 1
238000003306 harvesting Methods 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000007788 liquid Substances 0.000 description 1
238000011866 long-term treatment Methods 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
235000013336 milk Nutrition 0.000 description 1
239000008267 milk Substances 0.000 description 1
210000004080 milk Anatomy 0.000 description 1
239000011707 mineral Substances 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
230000000324 neuroprotective effect Effects 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
150000002895 organic esters Chemical class 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000006187 pill Substances 0.000 description 1
239000004926 polymethyl methacrylate Substances 0.000 description 1
239000000843 powder Substances 0.000 description 1
235000018102 proteins Nutrition 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
229960001860 salicylate Drugs 0.000 description 1
230000009291 secondary effect Effects 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000003826 tablet Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
230000008719 thickening Effects 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
239000002966 varnish Substances 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
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238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Emergency Medicine (AREA)
Psychiatry (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
External Artificial Organs (AREA)

UA2000105983A 1998-04-24 1999-04-22 Combination of levodopa and riluzole for treating combination of levodopa and riluzole for treating parkinson disease parkinson disease UA70319C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9805153A FR2777781B1 (fr)	1998-04-24	1998-04-24	Associations riluzole et l-dopa pour le traitement de la maladie de parkinson
PCT/FR1999/000953 WO1999055336A1 (fr)	1998-04-24	1999-04-22	Associations de riluzole et de levodopa pour le traitement de la maladie de parkinson

Publications (1)

Publication Number	Publication Date
UA70319C2 true UA70319C2 (en)	2004-10-15

Family

ID=9525640

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA2000105983A UA70319C2 (en)	1998-04-24	1999-04-22	Combination of levodopa and riluzole for treating combination of levodopa and riluzole for treating parkinson disease parkinson disease

Country Status (22)

Country	Link
US (1)	US6387936B1 (de)
EP (1)	EP1071422B1 (de)
JP (1)	JP2002512963A (de)
KR (1)	KR100597170B1 (de)
AT (1)	ATE386520T1 (de)
AU (1)	AU768069B2 (de)
CA (1)	CA2329636C (de)
CY (1)	CY1110448T1 (de)
CZ (1)	CZ300825B6 (de)
DE (1)	DE69938179T2 (de)
DK (1)	DK1071422T3 (de)
ES (1)	ES2300141T3 (de)
FR (1)	FR2777781B1 (de)
HU (1)	HU228902B1 (de)
IL (1)	IL139164A (de)
NO (1)	NO329032B1 (de)
PT (1)	PT1071422E (de)
RU (1)	RU2225204C2 (de)
SK (1)	SK285531B6 (de)
UA (1)	UA70319C2 (de)
WO (1)	WO1999055336A1 (de)
ZA (1)	ZA200005758B (de)

Families Citing this family (22)

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Publication number	Priority date	Publication date	Assignee	Title
FR2786101B1 (fr) *	1998-11-24	2002-07-05	Aventis Laboratoire	Utilisation de la nicergoline dans le traitement de la spasticite
US6872739B1 (en) *	1999-06-04	2005-03-29	Vereniging Voor Christelijk Wetenshappelikjk Onderwijs	Use of riluzole for the treatment of multiple sclerosis
GB0007193D0 (en) *	2000-03-25	2000-05-17	Univ Manchester	Treatment of movrmrnt disorders
US8158149B2 (en) *	2004-05-12	2012-04-17	Chelsea Therapeutics, Inc.	Threo-DOPS controlled release formulation
WO2004100929A1 (en)	2003-05-12	2004-11-25	Synergia Pharma, Inc.	Threo-dops controlled release formulation
WO2005025561A1 (en) *	2003-09-04	2005-03-24	Synergia Pharma, Inc.	Compositions and methods for orthostatic intolerance
EP1746985A4 (de) *	2004-05-21	2010-08-11	Univ Duke	Verfahren zur erhöhung der wirkung von serotonin-wiederaufnahmehemmern
SE0401842D0 (sv)	2004-07-12	2004-07-12	Dizlin Medical Design Ab	Infusion and injection solution of levodopa
JP5112876B2 (ja) *	2004-11-07	2013-01-09	エフ．ギルフォードティモシー	還元型グルタチオン経口投与のためのリポソーム処方物
GB0504103D0 (en) *	2005-02-28	2005-04-06	Syngenta Ltd	Novel method
AU2006261893A1 (en) *	2005-06-23	2007-01-04	Combinatorx, Incorporated	Improved dosage forms for movement disorder treatment
US20080131492A1 (en) *	2006-06-23	2008-06-05	Spherics, Inc.	Dosage forms for movement disorder treatment
ES2383768T3 (es) *	2006-06-28	2012-06-26	Chelsea Therapeutics Inc.	Composiciones farmacéuticas que comprenden droxidopa
AU2007338631A1 (en) *	2006-12-22	2008-07-03	Combinatorx, Incorporated	Pharmaceutical compositions for treatment of parkinson's disease and related disorders
CN101657193A (zh) *	2007-03-09	2010-02-24	切尔西治疗公司	用于治疗纤维肌痛的屈昔多巴及其药物组合物
EP2514417A3 (de) *	2007-05-07	2013-01-30	Chelsea Therapeutics, Inc.	Droxidopa und pharmazeutische Zusammensetzung davon, zur Behandlung von Stimmungsstörungen, Schlafstörungen oder Aufmerksamkeitsdefizit-Störungen
EP2320892A2 (de) *	2008-06-30	2011-05-18	Novartis AG	Kombinationsprodukte
MX2011004769A (es) *	2008-11-06	2011-11-29	Biotie Therapies Inc	Tratamiento de sindrome de pierna sin reposo y alteraciones del sueño.
EP2228054A1 (de) *	2009-03-13	2010-09-15	ITALFARMACO S.p.A.	Wässrige Riluzol-Suspensionen
EP2629615B1 (de)	2010-10-22	2018-10-10	Duke University	Retardformulierungen aus 5-hydroxytryptophan als zusatz für pro-serotonergische therapien
JP5880913B2 (ja)	2011-05-17	2016-03-09	三郎佐古田	パーキンソン病の体幹症状（姿勢反射異常）の治療剤
WO2014172372A1 (en)	2013-04-15	2014-10-23	Northwestern University	Treatment for dopaminergic disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2700117B1 (fr) *	1993-01-07	1995-02-03	Rhone Poulenc Rorer Sa	Application d'anticonvulsivants dans le traitement de la maladie de Parkinson et des syndromes parkinsoniens.
RU2057529C1 (ru) *	1994-05-30	1996-04-10	Алексей Михайлович Коршунов	Способ лечения синдрома паркинсонизма

1998
- 1998-04-24 FR FR9805153A patent/FR2777781B1/fr not_active Expired - Fee Related
1999
- 1999-04-22 EP EP99915809A patent/EP1071422B1/de not_active Expired - Lifetime
- 1999-04-22 DE DE69938179T patent/DE69938179T2/de not_active Expired - Lifetime
- 1999-04-22 CA CA002329636A patent/CA2329636C/fr not_active Expired - Fee Related
- 1999-04-22 PT PT99915809T patent/PT1071422E/pt unknown
- 1999-04-22 SK SK1588-2000A patent/SK285531B6/sk not_active IP Right Cessation
- 1999-04-22 IL IL13916499A patent/IL139164A/xx not_active IP Right Cessation
- 1999-04-22 RU RU2000129121/15A patent/RU2225204C2/ru not_active IP Right Cessation
- 1999-04-22 UA UA2000105983A patent/UA70319C2/uk unknown
- 1999-04-22 AT AT99915809T patent/ATE386520T1/de active
- 1999-04-22 CZ CZ20003908A patent/CZ300825B6/cs not_active IP Right Cessation
- 1999-04-22 DK DK99915809T patent/DK1071422T3/da active
- 1999-04-22 ES ES99915809T patent/ES2300141T3/es not_active Expired - Lifetime
- 1999-04-22 AU AU34255/99A patent/AU768069B2/en not_active Ceased
- 1999-04-22 HU HU0101645A patent/HU228902B1/hu not_active IP Right Cessation
- 1999-04-22 KR KR1020007011786A patent/KR100597170B1/ko not_active Expired - Fee Related
- 1999-04-22 JP JP2000545534A patent/JP2002512963A/ja not_active Withdrawn
- 1999-04-22 WO PCT/FR1999/000953 patent/WO1999055336A1/fr not_active Ceased
2000
- 2000-10-17 ZA ZA200005758A patent/ZA200005758B/en unknown
- 2000-10-20 NO NO20005290A patent/NO329032B1/no not_active IP Right Cessation
- 2000-10-24 US US09/694,860 patent/US6387936B1/en not_active Expired - Lifetime
2008
- 2008-04-24 CY CY20081100457T patent/CY1110448T1/el unknown

Also Published As

Publication number	Publication date
CA2329636C (fr)	2009-09-08
FR2777781A1 (fr)	1999-10-29
AU768069B2 (en)	2003-12-04
KR100597170B1 (ko)	2006-07-05
ATE386520T1 (de)	2008-03-15
WO1999055336A1 (fr)	1999-11-04
CY1110448T1 (el)	2015-04-29
HUP0101645A3 (en)	2002-10-28
EP1071422B1 (de)	2008-02-20
NO329032B1 (no)	2010-08-02
ZA200005758B (en)	2002-01-17
RU2225204C2 (ru)	2004-03-10
IL139164A0 (en)	2001-11-25
NO20005290L (no)	2000-10-20
DK1071422T3 (da)	2008-06-16
DE69938179T2 (de)	2009-02-12
JP2002512963A (ja)	2002-05-08
AU3425599A (en)	1999-11-16
IL139164A (en)	2005-12-18
CZ20003908A3 (cs)	2001-02-14
DE69938179D1 (de)	2008-04-03
CA2329636A1 (fr)	1999-11-04
SK15882000A3 (sk)	2001-04-09
FR2777781B1 (fr)	2004-04-09
KR20010042960A (ko)	2001-05-25
SK285531B6 (sk)	2007-03-01
HU228902B1 (en)	2013-06-28
CZ300825B6 (cs)	2009-08-19
ES2300141T3 (es)	2008-06-01
EP1071422A1 (de)	2001-01-31
US6387936B1 (en)	2002-05-14
NO20005290D0 (no)	2000-10-20
PT1071422E (pt)	2008-05-05
HUP0101645A2 (hu)	2001-09-28

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