UA71004C2 - Похідні 1-трифторометил-4-гідрокси-7-піперидиніламінометилхроману - Google Patents

Похідні 1-трифторометил-4-гідрокси-7-піперидиніламінометилхроману

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Publication number
UA71004C2
UA71004C2 UA2001117936A UA2001117936A UA71004C2 UA 71004 C2 UA71004 C2 UA 71004C2 UA 2001117936 A UA2001117936 A UA 2001117936A UA 2001117936 A UA2001117936 A UA 2001117936A UA 71004 C2 UA71004 C2 UA 71004C2
Authority
UA
Ukraine
Prior art keywords
alkyl
hydroxy
halo
trifluoromethyl
hydrogen
Prior art date
Application number
UA2001117936A
Other languages
English (en)
Russian (ru)
Inventor
Рональд Скотт ОБАЧ
Дуглас Ален Скаллі
Original Assignee
Пфайзер Продактс Інк.
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Продактс Інк., Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Інк.
Publication of UA71004C2 publication Critical patent/UA71004C2/uk

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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
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  • Diabetes (AREA)
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  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
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Abstract

Винахід стосується похідних 1-трифторометил-4-гідрокси-7-піперідиніламінометилхроману формули (І), в яких R1 - C1-C6алкіл; R2 - кисень, С1-С6алкіл, галоС1-С6алкіл або феніл; R3 - кисень або галоген; та R4 і R5 -, незалежно, кисень, С1-С6алкіл або галоС1-С6алкіл, їх фармацевтично прийнятних солей, фармацевтичних композицій, що містять такі сполуки, а також використання таких сполук для лікування розладів ЦНС, шлунковокишкових та інших розладів. (І)
UA2001117936A 1999-05-21 2000-04-20 Похідні 1-трифторометил-4-гідрокси-7-піперидиніламінометилхроману UA71004C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13539999P 1999-05-21 1999-05-21
PCT/IB2000/000493 WO2000071538A2 (en) 1999-05-21 2000-04-20 1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchroman derivatives

Publications (1)

Publication Number Publication Date
UA71004C2 true UA71004C2 (uk) 2004-11-15

Family

ID=22467939

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2001117936A UA71004C2 (uk) 1999-05-21 2000-04-20 Похідні 1-трифторометил-4-гідрокси-7-піперидиніламінометилхроману

Country Status (49)

Country Link
US (1) US6239147B1 (uk)
EP (1) EP1178984B1 (uk)
JP (1) JP3802762B2 (uk)
KR (1) KR100453301B1 (uk)
CN (1) CN1140525C (uk)
AP (1) AP1396A (uk)
AR (1) AR020294A1 (uk)
AT (1) ATE234832T1 (uk)
AU (1) AU775861B2 (uk)
BG (1) BG106152A (uk)
BR (1) BR0011284A (uk)
CA (1) CA2374643C (uk)
CO (1) CO5170464A1 (uk)
CR (1) CR6503A (uk)
CZ (1) CZ20014164A3 (uk)
DE (1) DE60001736T2 (uk)
DK (1) DK1178984T3 (uk)
DZ (1) DZ3044A1 (uk)
EA (1) EA004233B1 (uk)
EE (1) EE04719B1 (uk)
ES (1) ES2190781T3 (uk)
GC (1) GC0000254A (uk)
GE (1) GEP20043225B (uk)
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HK (1) HK1046280B (uk)
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HR (1) HRP20010861A2 (uk)
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IL (1) IL145949A0 (uk)
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MA (1) MA26734A1 (uk)
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PA (1) PA8495201A1 (uk)
PE (1) PE20010165A1 (uk)
PL (1) PL198658B1 (uk)
PT (1) PT1178984E (uk)
SK (1) SK285819B6 (uk)
SV (1) SV2002000077A (uk)
TN (1) TNSN00105A1 (uk)
TR (1) TR200103332T2 (uk)
TW (1) TWI275588B (uk)
UA (1) UA71004C2 (uk)
UY (1) UY26147A1 (uk)
WO (1) WO2000071538A2 (uk)
ZA (1) ZA200109554B (uk)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW426667B (en) * 1997-11-19 2001-03-21 Pfizer Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance P antagonists
ATE257477T1 (de) * 1999-10-18 2004-01-15 Pfizer Prod Inc Verfahren zur herstellung von zyklischen piperidinylaminomethyl-trifluoromethyl- etherderivaten
DE10311984A1 (de) * 2003-03-12 2004-09-23 Freie Universität Berlin Verwendung von NEP-assoziierten Molekülen zur Behandlung von nichtimmunogenen-nichthypertensiven Zivilisationskrankheiten
US7122700B2 (en) * 2004-07-30 2006-10-17 Xerox Corporation Arylamine processes
US7868016B2 (en) * 2005-07-13 2011-01-11 Baxter International Inc. Pharmaceutical formulations of endo-N-(9-methyl-9-azabicyclo[3,3.1]non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride
WO2009109001A1 (en) * 2008-03-04 2009-09-11 Adelaide Research & Innovation Pty Ltd Method for preventing and/or treating a disease, condition or state associated with reduced dopaminergic neuron function
EP2307397B1 (en) 2008-06-25 2014-08-20 Array Biopharma, Inc. 6-substituted phenoxychroman carboxylic acid derivatives
CN117343036A (zh) * 2023-03-20 2024-01-05 江苏联环药业股份有限公司 异苯并二氢吡喃类化合物及其药物组合物和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
GB9317987D0 (en) * 1993-08-26 1993-10-13 Glaxo Group Ltd Chemical compounds
ATE209204T1 (de) * 1995-03-27 2001-12-15 Hisamitsu Pharmaceutical Co Piperidinderivate.
RU2156250C2 (ru) * 1995-04-24 2000-09-20 Новартис Аг Производные хромона, способ их получения и фармацевтическая композиция
US6180647B1 (en) * 1995-07-07 2001-01-30 Pfizer Inc. Substituted benzolactam compounds as substance P antagonists
TW340842B (en) * 1995-08-24 1998-09-21 Pfizer Substituted benzylaminopiperidine compounds
TW426667B (en) * 1997-11-19 2001-03-21 Pfizer Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance P antagonists

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SK285819B6 (sk) 2007-09-06
AU775861B2 (en) 2004-08-19
HN2000000057A (es) 2001-03-02
DK1178984T3 (da) 2003-06-10
CR6503A (es) 2004-02-03
KR100453301B1 (ko) 2004-10-20
AU3667300A (en) 2000-12-12
AP1396A (en) 2005-04-19
NO20015652D0 (no) 2001-11-20
PE20010165A1 (es) 2001-02-20
JP3802762B2 (ja) 2006-07-26
HUP0201443A2 (en) 2002-08-28
BR0011284A (pt) 2002-03-05
OA11944A (en) 2006-04-12
HRP20010861A2 (en) 2003-04-30
DE60001736D1 (de) 2003-04-24
DZ3044A1 (fr) 2004-03-27
WO2000071538A2 (en) 2000-11-30
ES2190781T3 (es) 2003-08-16
AR020294A1 (es) 2002-05-02
BG106152A (en) 2002-06-28
CO5170464A1 (es) 2002-06-27
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ZA200109554B (en) 2002-11-20
TNSN00105A1 (fr) 2005-11-10
PT1178984E (pt) 2003-06-30
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JP2003500405A (ja) 2003-01-07
TWI275588B (en) 2007-03-11
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AP2001002327A0 (en) 2001-12-31
CN1355799A (zh) 2002-06-26
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HUP0201443A3 (en) 2005-09-28
MXPA01011977A (es) 2002-05-06
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PL198658B1 (pl) 2008-07-31
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MA26734A1 (fr) 2004-12-20
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