UA72448C2 - Azabenzimidazole-based compounds, methods for their synthesis and pharmaceutical composition, method for modulating function of serine/threonine protein kinases with azabenzimidazole-based compounds, method for identifying compounds modulating functioning of serine/threonine protein kinase, method for preventing and treating serine/threonine protein kinase-related abnormal conditions with azabenzimidazole-based compounds - Google Patents

Azabenzimidazole-based compounds, methods for their synthesis and pharmaceutical composition, method for modulating function of serine/threonine protein kinases with azabenzimidazole-based compounds, method for identifying compounds modulating functioning of serine/threonine protein kinase, method for preventing and treating serine/threonine protein kinase-related abnormal conditions with azabenzimidazole-based compounds Download PDF

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Publication number
UA72448C2
UA72448C2 UA2000042349A UA2000042349A UA72448C2 UA 72448 C2 UA72448 C2 UA 72448C2 UA 2000042349 A UA2000042349 A UA 2000042349A UA 2000042349 A UA2000042349 A UA 2000042349A UA 72448 C2 UA72448 C2 UA 72448C2
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Ukraine
Prior art keywords
meml
trifluoromethyl
eml
protein kinase
phenyl
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UA2000042349A
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English (en)
Ukrainian (uk)
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Zentaris Gmbh
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Publication of UA72448C2 publication Critical patent/UA72448C2/uk

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
UA2000042349A 1997-09-26 1998-09-23 Azabenzimidazole-based compounds, methods for their synthesis and pharmaceutical composition, method for modulating function of serine/threonine protein kinases with azabenzimidazole-based compounds, method for identifying compounds modulating functioning of serine/threonine protein kinase, method for preventing and treating serine/threonine protein kinase-related abnormal conditions with azabenzimidazole-based compounds UA72448C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6014597P 1997-09-26 1997-09-26
PCT/US1998/019973 WO1999016438A1 (fr) 1997-09-26 1998-09-23 Composes a base d'azabenzimidazole destines a la modulation d'une fonction de proteine kinase de serine/threonine

Publications (1)

Publication Number Publication Date
UA72448C2 true UA72448C2 (en) 2005-03-15

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Family Applications (1)

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UA2000042349A UA72448C2 (en) 1997-09-26 1998-09-23 Azabenzimidazole-based compounds, methods for their synthesis and pharmaceutical composition, method for modulating function of serine/threonine protein kinases with azabenzimidazole-based compounds, method for identifying compounds modulating functioning of serine/threonine protein kinase, method for preventing and treating serine/threonine protein kinase-related abnormal conditions with azabenzimidazole-based compounds

Country Status (27)

Country Link
US (2) US6093728A (fr)
EP (1) EP1017384B1 (fr)
JP (1) JP2001517699A (fr)
KR (1) KR100547929B1 (fr)
CN (1) CN1167420C (fr)
AR (1) AR017266A1 (fr)
AT (1) ATE281834T1 (fr)
AU (1) AU748849B2 (fr)
BG (1) BG64784B1 (fr)
BR (1) BR9812682A (fr)
CA (1) CA2305370C (fr)
DE (1) DE69827516T2 (fr)
DK (1) DK1017384T3 (fr)
ES (1) ES2230719T3 (fr)
HU (1) HUP0004024A3 (fr)
IL (4) IL158649A0 (fr)
NO (1) NO325663B1 (fr)
NZ (2) NZ503432A (fr)
PL (1) PL191618B1 (fr)
PT (1) PT1017384E (fr)
RU (1) RU2230553C2 (fr)
SK (1) SK285357B6 (fr)
TR (1) TR200001546T2 (fr)
TW (1) TW581815B (fr)
UA (1) UA72448C2 (fr)
WO (1) WO1999016438A1 (fr)
ZA (1) ZA988797B (fr)

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Also Published As

Publication number Publication date
US20030181480A1 (en) 2003-09-25
US6855723B2 (en) 2005-02-15
BR9812682A (pt) 2000-08-22
AU9578198A (en) 1999-04-23
ZA988797B (en) 1999-12-02
DE69827516D1 (de) 2004-12-16
IL158649A0 (en) 2004-05-12
CN1167420C (zh) 2004-09-22
WO1999016438A1 (fr) 1999-04-08
TW581815B (en) 2004-04-01
HUP0004024A3 (en) 2001-10-29
ATE281834T1 (de) 2004-11-15
AU748849B2 (en) 2002-06-13
NO20001555D0 (no) 2000-03-24
AR017266A1 (es) 2001-09-05
HK1032206A1 (en) 2001-07-13
CA2305370A1 (fr) 1999-04-08
HUP0004024A2 (hu) 2001-04-28
TR200001546T2 (tr) 2000-10-23
NZ517808A (en) 2003-07-25
CA2305370C (fr) 2006-11-28
IL158649A (en) 2006-12-10
NO20001555L (no) 2000-03-24
SK4152000A3 (en) 2002-02-05
EP1017384B1 (fr) 2004-11-10
BG64784B1 (bg) 2006-04-28
RU2230553C2 (ru) 2004-06-20
US6093728A (en) 2000-07-25
NO325663B1 (no) 2008-07-07
BG104356A (en) 2000-12-29
DK1017384T3 (da) 2005-01-31
CN1278172A (zh) 2000-12-27
PL191618B1 (pl) 2006-06-30
ES2230719T3 (es) 2005-05-01
KR100547929B1 (ko) 2006-02-02
JP2001517699A (ja) 2001-10-09
SK285357B6 (sk) 2006-11-03
IL135109A (en) 2007-07-04
NZ503432A (en) 2002-11-26
EP1017384A1 (fr) 2000-07-12
PT1017384E (pt) 2005-03-31
KR20010015623A (ko) 2001-02-26
IL135109A0 (en) 2001-05-20
DE69827516T2 (de) 2005-12-01
PL339744A1 (en) 2001-01-02

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