UA72632C2 - Карбамати, похідні від арилалкіламінів - Google Patents

Карбамати, похідні від арилалкіламінів Download PDF

Info

Publication number: UA72632C2
Authority: UA; Ukraine
Prior art keywords: compound according; alkyl; group; drugs; substituted
Prior art date: 2000-06-27

Application number

UA2003010718A

Other languages

English (en)

Russian (ru)

Ukrainian (uk)

Inventor

Галлемі Карлес Фарреронс

Руіс Хуан Лоренцо Катена

Серрат Анна Фернандес

Боно Ігнасіо Хосе Мікель

Лопез Долорс Балса

Наварро Хосе Ігнасіо Бонілла

Арнал Кармен Лагунас

Рока Кароліна Салседо

Гарсіа Андрес Фернандес

Original Assignee

Лабораторіос С.А.Л.В.А.Т., С.А.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-27

Filing date

2001-06-25

Publication date

2005-03-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8494130&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA72632(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-06-25 Application filed by Лабораторіос С.А.Л.В.А.Т., С.А. filed Critical Лабораторіос С.А.Л.В.А.Т., С.А.

2005-03-15 Publication of UA72632C2 publication Critical patent/UA72632C2/uk

Links

150000004657 carbamic acid derivatives Chemical class 0.000 title abstract description 9
150000003975 aryl alkyl amines Chemical class 0.000 title description 7
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical group NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract description 13
125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract description 8
206010046543 Urinary incontinence Diseases 0.000 claims abstract description 5
SBYHFKPVCBCYGV-UHFFFAOYSA-N quinuclidine Chemical group C1CC2CCN1CC2 SBYHFKPVCBCYGV-UHFFFAOYSA-N 0.000 claims abstract description 5
206010006458 Bronchitis chronic Diseases 0.000 claims abstract description 4
208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims abstract description 4
206010014561 Emphysema Diseases 0.000 claims abstract description 4
208000006673 asthma Diseases 0.000 claims abstract description 4
206010006451 bronchitis Diseases 0.000 claims abstract description 4
208000007451 chronic bronchitis Diseases 0.000 claims abstract description 4
201000010099 disease Diseases 0.000 claims abstract description 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 4
208000002551 irritable bowel syndrome Diseases 0.000 claims abstract description 4
206010039083 rhinitis Diseases 0.000 claims abstract description 4
150000001875 compounds Chemical class 0.000 claims description 31
-1 2-benzodioxolanyl Chemical group 0.000 claims description 14
239000003814 drug Substances 0.000 claims description 13
229940079593 drug Drugs 0.000 claims description 12
239000000203 mixture Substances 0.000 claims description 8
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
150000003839 salts Chemical class 0.000 claims description 6
229910052757 nitrogen Inorganic materials 0.000 claims description 5
210000003932 urinary bladder Anatomy 0.000 claims description 5
125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims description 4
125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims description 4
125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 4
125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 4
125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims description 4
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 4
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 4
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 4
ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims description 4
125000003518 norbornenyl group Chemical group C12(C=CC(CC1)C2)* 0.000 claims description 4
125000001424 substituent group Chemical group 0.000 claims description 4
125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims description 3
208000023504 respiratory system disease Diseases 0.000 claims description 3
239000012453 solvate Substances 0.000 claims description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
238000004519 manufacturing process Methods 0.000 claims 6
208000020564 Eye injury Diseases 0.000 claims 1
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 1
208000035474 group of disease Diseases 0.000 claims 1
102000014415 Muscarinic acetylcholine receptor Human genes 0.000 abstract description 9
108050003473 Muscarinic acetylcholine receptor Proteins 0.000 abstract description 9
210000002345 respiratory system Anatomy 0.000 abstract description 2
102000017926 CHRM2 Human genes 0.000 abstract 1
101150012960 Chrm2 gene Proteins 0.000 abstract 1
206010020853 Hypertonic bladder Diseases 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
150000003254 radicals Chemical group 0.000 abstract 1
125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
102000005962 receptors Human genes 0.000 description 26
108020003175 receptors Proteins 0.000 description 26
238000000034 method Methods 0.000 description 13
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 12
239000002904 solvent Substances 0.000 description 12
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 9
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 9
230000000694 effects Effects 0.000 description 7
230000002829 reductive effect Effects 0.000 description 7
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
238000006243 chemical reaction Methods 0.000 description 6
239000000126 substance Substances 0.000 description 6
WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 5
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 4
FZFAMSAMCHXGEF-UHFFFAOYSA-N chloro formate Chemical compound ClOC=O FZFAMSAMCHXGEF-UHFFFAOYSA-N 0.000 description 4
239000002244 precipitate Substances 0.000 description 4
239000000047 product Substances 0.000 description 4
239000007787 solid Substances 0.000 description 4
102000017925 CHRM3 Human genes 0.000 description 3
101150060249 CHRM3 gene Proteins 0.000 description 3
229910052799 carbon Inorganic materials 0.000 description 3
238000004440 column chromatography Methods 0.000 description 3
239000003480 eluent Substances 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 3
229910000041 hydrogen chloride Inorganic materials 0.000 description 3
239000012442 inert solvent Substances 0.000 description 3
239000003208 petroleum Substances 0.000 description 3
238000010992 reflux Methods 0.000 description 3
229910000104 sodium hydride Inorganic materials 0.000 description 3
239000012312 sodium hydride Substances 0.000 description 3
239000012265 solid product Substances 0.000 description 3
IVLICPVPXWEGCA-UHFFFAOYSA-N 3-quinuclidinol Chemical compound C1C[C@@H]2C(O)C[N@]1CC2 IVLICPVPXWEGCA-UHFFFAOYSA-N 0.000 description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 2
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
239000002253 acid Substances 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
239000000654 additive Substances 0.000 description 2
125000000217 alkyl group Chemical group 0.000 description 2
230000027455 binding Effects 0.000 description 2
HCUYBXPSSCRKRF-UHFFFAOYSA-N diphosgene Chemical compound ClC(=O)OC(Cl)(Cl)Cl HCUYBXPSSCRKRF-UHFFFAOYSA-N 0.000 description 2
206010013781 dry mouth Diseases 0.000 description 2
231100000040 eye damage Toxicity 0.000 description 2
210000001035 gastrointestinal tract Anatomy 0.000 description 2
238000011534 incubation Methods 0.000 description 2
230000005764 inhibitory process Effects 0.000 description 2
238000002844 melting Methods 0.000 description 2
230000008018 melting Effects 0.000 description 2
239000012528 membrane Substances 0.000 description 2
230000003472 neutralizing effect Effects 0.000 description 2
230000002093 peripheral effect Effects 0.000 description 2
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
229920006395 saturated elastomer Polymers 0.000 description 2
230000028327 secretion Effects 0.000 description 2
239000013049 sediment Substances 0.000 description 2
238000003756 stirring Methods 0.000 description 2
239000000725 suspension Substances 0.000 description 2
210000001519 tissue Anatomy 0.000 description 2
WKHABRRJMGVELW-UHFFFAOYSA-N (3-phenylphenyl)methanamine Chemical compound NCC1=CC=CC(C=2C=CC=CC=2)=C1 WKHABRRJMGVELW-UHFFFAOYSA-N 0.000 description 1
NXLNNXIXOYSCMB-UHFFFAOYSA-N (4-nitrophenyl) carbonochloridate Chemical compound [O-][N+](=O)C1=CC=C(OC(Cl)=O)C=C1 NXLNNXIXOYSCMB-UHFFFAOYSA-N 0.000 description 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
229930003347 Atropine Natural products 0.000 description 1
102000017923 CHRM5 Human genes 0.000 description 1
101150064612 CHRM5 gene Proteins 0.000 description 1
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
XIQVNETUBQGFHX-UHFFFAOYSA-N Ditropan Chemical compound C=1C=CC=CC=1C(O)(C(=O)OCC#CCN(CC)CC)C1CCCCC1 XIQVNETUBQGFHX-UHFFFAOYSA-N 0.000 description 1
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 1
230000005526 G1 to G0 transition Effects 0.000 description 1
RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 1
206010062717 Increased upper airway secretion Diseases 0.000 description 1
208000006550 Mydriasis Diseases 0.000 description 1
239000004793 Polystyrene Substances 0.000 description 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
235000009337 Spinacia oleracea Nutrition 0.000 description 1
244000300264 Spinacia oleracea Species 0.000 description 1
208000001871 Tachycardia Diseases 0.000 description 1
208000005946 Xerostomia Diseases 0.000 description 1
230000010933 acylation Effects 0.000 description 1
238000005917 acylation reaction Methods 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
230000002411 adverse Effects 0.000 description 1
125000005210 alkyl ammonium group Chemical group 0.000 description 1
230000029936 alkylation Effects 0.000 description 1
238000005804 alkylation reaction Methods 0.000 description 1
229940051881 anilide analgesics and antipyretics Drugs 0.000 description 1
150000003931 anilides Chemical class 0.000 description 1
125000002490 anilino group Chemical class [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
150000001450 anions Chemical class 0.000 description 1
RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 1
229960000396 atropine Drugs 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
210000000621 bronchi Anatomy 0.000 description 1
229940124630 bronchodilator Drugs 0.000 description 1
230000001813 broncholytic effect Effects 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
210000004027 cell Anatomy 0.000 description 1
210000003710 cerebral cortex Anatomy 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 description 1
238000013375 chromatographic separation Methods 0.000 description 1
230000008602 contraction Effects 0.000 description 1
230000001595 contractor effect Effects 0.000 description 1
HXGBXQDTNZMWGS-RUZDIDTESA-N darifenacin Chemical compound C=1C=CC=CC=1C([C@H]1CN(CCC=2C=C3CCOC3=CC=2)CC1)(C(=O)N)C1=CC=CC=C1 HXGBXQDTNZMWGS-RUZDIDTESA-N 0.000 description 1
229960002677 darifenacin Drugs 0.000 description 1
238000010586 diagram Methods 0.000 description 1
230000010339 dilation Effects 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
238000006073 displacement reaction Methods 0.000 description 1
238000010494 dissociation reaction Methods 0.000 description 1
230000005593 dissociations Effects 0.000 description 1
RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
239000004744 fabric Substances 0.000 description 1
239000006260 foam Substances 0.000 description 1
238000001640 fractional crystallisation Methods 0.000 description 1
230000006870 function Effects 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
210000004051 gastric juice Anatomy 0.000 description 1
210000004907 gland Anatomy 0.000 description 1
230000000762 glandular Effects 0.000 description 1
239000011521 glass Substances 0.000 description 1
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
230000002757 inflammatory effect Effects 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
239000013067 intermediate product Substances 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
239000007791 liquid phase Substances 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
XMJHPCRAQCTCFT-UHFFFAOYSA-N methyl chloroformate Chemical compound COC(Cl)=O XMJHPCRAQCTCFT-UHFFFAOYSA-N 0.000 description 1
239000011707 mineral Substances 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
230000004899 motility Effects 0.000 description 1
210000004165 myocardium Anatomy 0.000 description 1
210000001577 neostriatum Anatomy 0.000 description 1
210000002569 neuron Anatomy 0.000 description 1
239000002858 neurotransmitter agent Substances 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
239000012044 organic layer Substances 0.000 description 1
229960005434 oxybutynin Drugs 0.000 description 1
230000001734 parasympathetic effect Effects 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
208000026435 phlegm Diseases 0.000 description 1
235000011007 phosphoric acid Nutrition 0.000 description 1
150000003016 phosphoric acids Chemical class 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
230000001242 postsynaptic effect Effects 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
239000002243 precursor Substances 0.000 description 1
230000002265 prevention Effects 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
210000001747 pupil Anatomy 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
238000006722 reduction reaction Methods 0.000 description 1
238000006268 reductive amination reaction Methods 0.000 description 1
210000003079 salivary gland Anatomy 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
210000002460 smooth muscle Anatomy 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
235000019345 sodium thiosulphate Nutrition 0.000 description 1
241000894007 species Species 0.000 description 1
230000009870 specific binding Effects 0.000 description 1
230000001629 suppression Effects 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
230000006794 tachycardia Effects 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
OOGJQPCLVADCPB-HXUWFJFHSA-N tolterodine Chemical compound C1([C@@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(C)C=2)O)=CC=CC=C1 OOGJQPCLVADCPB-HXUWFJFHSA-N 0.000 description 1
229960004045 tolterodine Drugs 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
238000005809 transesterification reaction Methods 0.000 description 1
230000002485 urinary effect Effects 0.000 description 1
BDIAUFOIMFAIPU-UHFFFAOYSA-N valepotriate Natural products CC(C)CC(=O)OC1C=C(C(=COC2OC(=O)CC(C)C)COC(C)=O)C2C11CO1 BDIAUFOIMFAIPU-UHFFFAOYSA-N 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03B—APPARATUS OR ARRANGEMENTS FOR TAKING PHOTOGRAPHS OR FOR PROJECTING OR VIEWING THEM; APPARATUS OR ARRANGEMENTS EMPLOYING ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ACCESSORIES THEREFOR
- G03B27/00—Photographic printing apparatus
- G03B27/02—Exposure apparatus for contact printing
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03B—APPARATUS OR ARRANGEMENTS FOR TAKING PHOTOGRAPHS OR FOR PROJECTING OR VIEWING THEM; APPARATUS OR ARRANGEMENTS EMPLOYING ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ACCESSORIES THEREFOR
- G03B27/00—Photographic printing apparatus
- G03B27/02—Exposure apparatus for contact printing
- G03B27/14—Details
- G03B27/16—Illumination arrangements, e.g. positioning of lamps, positioning of reflectors
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03B—APPARATUS OR ARRANGEMENTS FOR TAKING PHOTOGRAPHS OR FOR PROJECTING OR VIEWING THEM; APPARATUS OR ARRANGEMENTS EMPLOYING ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ACCESSORIES THEREFOR
- G03B27/00—Photographic printing apparatus
- G03B27/02—Exposure apparatus for contact printing
- G03B27/14—Details
- G03B27/30—Details adapted to be combined with processing apparatus
- G03B27/303—Gas processing
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03D—APPARATUS FOR PROCESSING EXPOSED PHOTOGRAPHIC MATERIALS; ACCESSORIES THEREFOR
- G03D13/00—Processing apparatus or accessories therefor, not covered by groups G11B3/00 - G11B11/00
- G03D13/002—Heat development apparatus, e.g. Kalvar

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Physics & Mathematics (AREA)
General Physics & Mathematics (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Ophthalmology & Optometry (AREA)
Otolaryngology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

UA2003010718A 2000-06-27 2001-06-25 Карбамати, похідні від арилалкіламінів UA72632C2 (uk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES200001661		2000-06-27
PCT/ES2001/000252 WO2002000652A1 (fr)	2000-06-27	2001-06-25	Carbamates derives d'arylalkylamines

Publications (1)

Publication Number	Publication Date
UA72632C2 true UA72632C2 (uk)	2005-03-15

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ID=8494130

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UA2003010718A UA72632C2 (uk)	2000-06-27	2001-06-25	Карбамати, похідні від арилалкіламінів

Country Status (29)

Country	Link
US (2)	US6916828B2 (fr)
EP (1)	EP1300407B2 (fr)
JP (1)	JP5046465B2 (fr)
KR (1)	KR100751981B1 (fr)
CN (1)	CN1227251C (fr)
AP (1)	AP1420A (fr)
AT (1)	ATE260277T1 (fr)
AU (2)	AU2001266100B9 (fr)
BG (1)	BG66102B1 (fr)
BR (1)	BR0112297A (fr)
CA (1)	CA2414514C (fr)
CR (1)	CR6889A (fr)
CZ (1)	CZ294251B6 (fr)
DE (2)	DE20122417U1 (fr)
DK (1)	DK1300407T4 (fr)
EA (1)	EA005520B1 (fr)
ES (1)	ES2213703T5 (fr)
HU (1)	HU229306B1 (fr)
IL (1)	IL153707A0 (fr)
MX (1)	MXPA03000141A (fr)
NO (1)	NO328499B1 (fr)
OA (1)	OA12300A (fr)
PL (1)	PL201530B1 (fr)
PT (1)	PT1300407E (fr)
SI (1)	SI1300407T2 (fr)
TR (1)	TR200400420T4 (fr)
UA (1)	UA72632C2 (fr)
WO (1)	WO2002000652A1 (fr)
ZA (1)	ZA200300644B (fr)

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2001
- 2001-06-25 AU AU2001266100A patent/AU2001266100B9/en not_active Ceased
- 2001-06-25 IL IL15370701A patent/IL153707A0/xx not_active IP Right Cessation
- 2001-06-25 OA OA1200200393A patent/OA12300A/en unknown
- 2001-06-25 ES ES01943553T patent/ES2213703T5/es not_active Expired - Lifetime
- 2001-06-25 DE DE20122417U patent/DE20122417U1/de not_active Expired - Lifetime
- 2001-06-25 MX MXPA03000141A patent/MXPA03000141A/es active IP Right Grant
- 2001-06-25 HU HU0301414A patent/HU229306B1/hu not_active IP Right Cessation
- 2001-06-25 BR BR0112297-5A patent/BR0112297A/pt active Search and Examination
- 2001-06-25 AU AU6610001A patent/AU6610001A/xx not_active Withdrawn
- 2001-06-25 PL PL359333A patent/PL201530B1/pl unknown
- 2001-06-25 DK DK01943553.6T patent/DK1300407T4/da active
- 2001-06-25 PT PT01943553T patent/PT1300407E/pt unknown
- 2001-06-25 AP APAP/P/2003/002722A patent/AP1420A/en active
- 2001-06-25 TR TR2004/00420T patent/TR200400420T4/xx unknown
- 2001-06-25 EP EP01943553A patent/EP1300407B2/fr not_active Expired - Lifetime
- 2001-06-25 EA EA200300072A patent/EA005520B1/ru not_active IP Right Cessation
- 2001-06-25 CZ CZ2003261A patent/CZ294251B6/cs not_active IP Right Cessation
- 2001-06-25 KR KR1020027017706A patent/KR100751981B1/ko not_active Expired - Fee Related
- 2001-06-25 CA CA002414514A patent/CA2414514C/fr not_active Expired - Fee Related
- 2001-06-25 US US10/312,227 patent/US6916828B2/en not_active Expired - Fee Related
- 2001-06-25 UA UA2003010718A patent/UA72632C2/uk unknown
- 2001-06-25 WO PCT/ES2001/000252 patent/WO2002000652A1/fr not_active Ceased
- 2001-06-25 DE DE60102160T patent/DE60102160T3/de not_active Expired - Lifetime
- 2001-06-25 AT AT01943553T patent/ATE260277T1/de active
- 2001-06-25 CN CNB018148042A patent/CN1227251C/zh not_active Expired - Fee Related
- 2001-06-25 JP JP2002505776A patent/JP5046465B2/ja not_active Expired - Fee Related
- 2001-06-25 SI SI200130075T patent/SI1300407T2/sl unknown
2002
- 2002-12-23 NO NO20026211A patent/NO328499B1/no not_active IP Right Cessation
2003
- 2003-01-17 BG BG107474A patent/BG66102B1/bg unknown
- 2003-01-20 CR CR6889A patent/CR6889A/es not_active Application Discontinuation
- 2003-01-23 ZA ZA200300644A patent/ZA200300644B/en unknown
2004
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RU2441868C2 (ru) *	2007-02-09	2012-02-10	Астеллас Фарма Инк.	Аза-кольцевое соединение с внутренним мостиком
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Publication number	Publication date
MXPA03000141A (es)	2003-05-27
DE60102160T2 (de)	2004-09-09
CZ2003261A3 (cs)	2003-06-18
AU6610001A (en)	2002-01-08
IL153707A0 (en)	2003-07-06
SI1300407T1 (en)	2004-06-30
CR6889A (es)	2008-08-21
EP1300407A1 (fr)	2003-04-09
US20040063950A1 (en)	2004-04-01
CZ294251B6 (cs)	2004-11-10
NO328499B1 (no)	2010-03-01
JP5046465B2 (ja)	2012-10-10
EA200300072A1 (ru)	2003-06-26
AU2001266100B2 (en)	2005-06-30
HUP0301414A3 (en)	2008-03-28
KR20030022159A (ko)	2003-03-15
AP2003002722A0 (en)	2003-06-30
HK1054934A1 (en)	2003-12-19
US7115629B2 (en)	2006-10-03
ES2213703T3 (es)	2004-09-01
CA2414514A1 (fr)	2002-01-03
KR100751981B1 (ko)	2007-08-28
US20040235887A1 (en)	2004-11-25
PT1300407E (pt)	2004-05-31
US6916828B2 (en)	2005-07-12
EP1300407B1 (fr)	2004-02-25
HU229306B1 (en)	2013-10-28
ES2213703T5 (es)	2011-11-02
BG107474A (en)	2003-09-30
DE60102160D1 (de)	2004-04-01
EA005520B1 (ru)	2005-04-28
AP1420A (en)	2005-05-30
PL201530B1 (pl)	2009-04-30
NO20026211D0 (no)	2002-12-23
TR200400420T4 (tr)	2004-03-22
JP2004501916A (ja)	2004-01-22
ATE260277T1 (de)	2004-03-15
EP1300407B2 (fr)	2011-06-08
NO20026211L (no)	2003-02-26
DE20122417U1 (de)	2005-08-04
ZA200300644B (en)	2004-02-10
BG66102B1 (bg)	2011-04-29
SI1300407T2 (sl)	2011-09-30
PL359333A1 (en)	2004-08-23
DK1300407T3 (da)	2004-03-22
WO2002000652A1 (fr)	2002-01-03
AU2001266100B9 (en)	2005-10-06
OA12300A (en)	2006-05-12
DE60102160T3 (de)	2012-05-03
CN1449396A (zh)	2003-10-15
BR0112297A (pt)	2003-05-06
DK1300407T4 (da)	2011-09-05
HUP0301414A2 (hu)	2003-09-29
CA2414514C (fr)	2009-12-22
CN1227251C (zh)	2005-11-16

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