UA75625C2 - Condensed purine derivatives as a1 adenosine receptor antagonists - Google Patents

Condensed purine derivatives as a1 adenosine receptor antagonists Download PDF

Info

Publication number: UA75625C2
Authority: UA; Ukraine
Prior art keywords: group; alkyl; compound; substituted; amino
Prior art date: 2000-12-01

Application number

UA2003066041A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Biogen Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-01

Filing date

2001-11-30

Publication date

2006-05-15

2001-11-30 Application filed by Biogen Inc filed Critical Biogen Inc

2006-05-15 Publication of UA75625C2 publication Critical patent/UA75625C2/uk

Links

101150007969 ADORA1 gene Proteins 0.000 title abstract 2
239000000296 purinergic P1 receptor antagonist Substances 0.000 title description 5
229940121359 adenosine receptor antagonist Drugs 0.000 title 1
229940083251 peripheral vasodilators purine derivative Drugs 0.000 title 1
150000003212 purines Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 97
238000011282 treatment Methods 0.000 claims abstract description 11
206010007559 Cardiac failure congestive Diseases 0.000 claims abstract description 6
206010019280 Heart failures Diseases 0.000 claims abstract description 6
208000006673 asthma Diseases 0.000 claims abstract description 4
230000008085 renal dysfunction Effects 0.000 claims abstract description 4
208000001647 Renal Insufficiency Diseases 0.000 claims abstract description 3
206010012601 diabetes mellitus Diseases 0.000 claims abstract description 3
230000002497 edematous effect Effects 0.000 claims abstract description 3
201000006370 kidney failure Diseases 0.000 claims abstract description 3
208000037905 systemic hypertension Diseases 0.000 claims abstract description 3
OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims description 48
125000000217 alkyl group Chemical group 0.000 claims description 46
-1 thiocarbamoyl Chemical group 0.000 claims description 45
238000000034 method Methods 0.000 claims description 40
125000003342 alkenyl group Chemical group 0.000 claims description 27
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 27
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 27
125000000304 alkynyl group Chemical group 0.000 claims description 26
238000006243 chemical reaction Methods 0.000 claims description 26
102000005962 receptors Human genes 0.000 claims description 26
108020003175 receptors Proteins 0.000 claims description 26
125000000623 heterocyclic group Chemical group 0.000 claims description 25
239000002126 C01EB10 - Adenosine Substances 0.000 claims description 24
229960005305 adenosine Drugs 0.000 claims description 24
239000002253 acid Substances 0.000 claims description 23
125000001424 substituent group Chemical group 0.000 claims description 23
239000000203 mixture Substances 0.000 claims description 22
125000003118 aryl group Chemical group 0.000 claims description 21
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239000000047 product Substances 0.000 claims description 19
201000010099 disease Diseases 0.000 claims description 17
125000004663 dialkyl amino group Chemical group 0.000 claims description 16
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125000003282 alkyl amino group Chemical group 0.000 claims description 12
SKOLWUPSYHWYAM-UHFFFAOYSA-N carbonodithioic O,S-acid Chemical compound SC(S)=O SKOLWUPSYHWYAM-UHFFFAOYSA-N 0.000 claims description 11
125000004432 carbon atom Chemical group C* 0.000 claims description 10
208000035475 disorder Diseases 0.000 claims description 10
238000007363 ring formation reaction Methods 0.000 claims description 10
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125000004442 acylamino group Chemical group 0.000 claims description 9
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BBTNLADSUVOPPN-UHFFFAOYSA-N 5,6-diaminouracil Chemical compound NC=1NC(=O)NC(=O)C=1N BBTNLADSUVOPPN-UHFFFAOYSA-N 0.000 claims description 8
125000003710 aryl alkyl group Chemical group 0.000 claims description 8
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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 7
125000002252 acyl group Chemical group 0.000 claims description 7
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125000005115 alkyl carbamoyl group Chemical group 0.000 claims description 6
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125000006170 pentacyclic group Chemical group 0.000 claims description 6
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Landscapes

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UA2003066041A 2000-12-01 2001-11-30 Condensed purine derivatives as a1 adenosine receptor antagonists UA75625C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US25065800P	2000-12-01	2000-12-01
PCT/US2001/044991 WO2002044182A1 (en)	2000-12-01	2001-11-30	Condensed purine derivatives as a1 adenosine receptor antagonists

Publications (1)

Publication Number	Publication Date
UA75625C2 true UA75625C2 (en)	2006-05-15

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Application Number	Title	Priority Date	Filing Date
UA2003066041A UA75625C2 (en)	2000-12-01	2001-11-30	Condensed purine derivatives as a1 adenosine receptor antagonists

Country Status (32)

Country	Link
US (2)	US6605601B2 (de)
EP (1)	EP1347981B1 (de)
JP (2)	JP2004514723A (de)
KR (1)	KR20040011439A (de)
CN (1)	CN100497340C (de)
AR (1)	AR035400A1 (de)
AT (1)	ATE394402T1 (de)
AU (2)	AU1997702A (de)
BG (1)	BG107849A (de)
BR (1)	BR0115833A (de)
CA (1)	CA2430508C (de)
CZ (1)	CZ20031513A3 (de)
DE (1)	DE60133931D1 (de)
EA (1)	EA009814B1 (de)
EE (1)	EE200300260A (de)
ES (1)	ES2305139T3 (de)
GE (1)	GEP20094697B (de)
HU (1)	HUP0400530A3 (de)
IL (1)	IL156046A0 (de)
IS (1)	IS6821A (de)
MX (1)	MXPA03004857A (de)
MY (1)	MY127120A (de)
NO (1)	NO20032483L (de)
NZ (1)	NZ526511A (de)
PL (1)	PL362642A1 (de)
SK (1)	SK6552003A3 (de)
TR (1)	TR200300766T2 (de)
TW (1)	TWI293301B (de)
UA (1)	UA75625C2 (de)
WO (1)	WO2002044182A1 (de)
YU (1)	YU42903A (de)
ZA (2)	ZA200304067B (de)

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UA75625C2 (en) *	2000-12-01	2006-05-15	Biogen Inc	Condensed purine derivatives as a1 adenosine receptor antagonists
JP2006518390A (ja) *	2003-02-19	2006-08-10	エンダシア，インコーポレイテッド	Ａ１アデノシンレセプターアンタゴニスト
US20040229901A1 (en) *	2003-02-24	2004-11-18	Lauren Otsuki	Method of treatment of disease using an adenosine A1 receptor antagonist
EP1637532A1 (de) *	2003-04-25	2006-03-22	Kyowa Hakko Kogyo Co., Ltd.	Kondensiertes pyrimidinderivat
AU2004233852A1 (en)	2003-04-25	2004-11-11	Novacardia, Inc.	Method of improved diuresis in individuals with impaired renal function
US7247639B2 (en) *	2003-06-06	2007-07-24	Endacea, Inc.	A1 adenosine receptor antagonists
JP2008534445A (ja) *	2005-03-11	2008-08-28	アデリスファーマシューティカルズ，インコーポレイテッド	置換９−アルキルアデニンおよびその使用
WO2007095161A2 (en) *	2006-02-14	2007-08-23	New York University	Methods and compositions for treating disorders associated with increased bone turnover and osteopenia
CA2648281A1 (en) *	2006-04-06	2007-10-18	Novacardia, Inc.	Co-administration of adenosine a1 receptor antagonists and anticonvulsants
RS52062B (sr)	2006-05-19	2012-06-30	Abbott Laboratories	Cns aktivni azabiciklični alkanski derivati koji su supstituisani spojenim bicikloheterociklom
EP2035009A1 (de) *	2006-06-16	2009-03-18	Novacardia, Inc.	Dauerhafte verbesserung der nierenfunktion mit seltener verabreichung eines aa1ra
ATE486874T1 (de)	2006-06-23	2010-11-15	Incyte Corp	Purinonderivate als hm74a-agonisten
AR061625A1 (es)	2006-06-23	2008-09-10	Incyte Corp	Derivados de purinona como agonistas de hm74a
WO2008121882A1 (en) *	2007-03-29	2008-10-09	Novacardia, Inc.	Improved methods of administration of adenosine a1 receptor antagonists
WO2008121893A1 (en) *	2007-03-29	2008-10-09	Novacardia, Inc.	Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist
WO2011063268A2 (en) *	2009-11-19	2011-05-26	Biogen Idec Ma Inc	Novel synthetic methods
US20130109645A1 (en)	2010-03-31	2013-05-02	The united States of America,as represented by Secretary,Dept.,of Health and Human Services	Adenosine receptor agonists for the treatment and prevention of vascular or joint capsule calcification disorders
IL275817B2 (en)	2018-01-04	2024-04-01	Impetis Biosciences Ltd	Tricyclic compounds, compositions and medicinal applications thereof

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JPH06102662B2 (ja)	1989-09-01	1994-12-14	協和醗酵工業株式会社	キサンチン誘導体
JP2988711B2 (ja) *	1989-10-20	1999-12-13	協和醗酵工業株式会社	縮合プリン誘導体
CA2254273C (en)	1991-09-23	2003-03-25	Florida State University	Preparation of substituted isoserine esters using metal alkoxides and .beta.-lactams
EP0884318A4 (de) *	1996-10-07	2002-10-23	Kyowa Hakko Kogyo Kk	Kondensierte purinderivate
AU740770B2 (en)	1997-06-18	2001-11-15	Aderis Pharmaceuticals, Inc.	Compositions and methods for preventing restenosis following revascularization procedures
WO2000001388A1 (en) *	1998-07-02	2000-01-13	Kyowa Hakko Kogyo Co., Ltd.	Remedies for diabetes
ES2238335T3 (es) *	1999-12-24	2005-09-01	Kyowa Hakko Kogyo Co., Ltd.	Derivados de purina condensados.
UA75625C2 (en) *	2000-12-01	2006-05-15	Biogen Inc	Condensed purine derivatives as a1 adenosine receptor antagonists

2001
- 2001-11-30 UA UA2003066041A patent/UA75625C2/uk unknown
- 2001-11-30 EA EA200300629A patent/EA009814B1/ru not_active IP Right Cessation
- 2001-11-30 TR TR2003/00766T patent/TR200300766T2/xx unknown
- 2001-11-30 TW TW090129678A patent/TWI293301B/zh active
- 2001-11-30 GE GEAP20017016A patent/GEP20094697B/en unknown
- 2001-11-30 BR BR0115833-3A patent/BR0115833A/pt not_active Application Discontinuation
- 2001-11-30 ES ES01998550T patent/ES2305139T3/es not_active Expired - Lifetime
- 2001-11-30 MY MYPI20015481A patent/MY127120A/en unknown
- 2001-11-30 AU AU1997702A patent/AU1997702A/xx active Pending
- 2001-11-30 WO PCT/US2001/044991 patent/WO2002044182A1/en not_active Ceased
- 2001-11-30 CZ CZ20031513A patent/CZ20031513A3/cs unknown
- 2001-11-30 CN CNB018208711A patent/CN100497340C/zh not_active Expired - Fee Related
- 2001-11-30 PL PL01362642A patent/PL362642A1/xx not_active Application Discontinuation
- 2001-11-30 CA CA2430508A patent/CA2430508C/en not_active Expired - Fee Related
- 2001-11-30 AU AU2002219977A patent/AU2002219977B2/en not_active Ceased
- 2001-11-30 YU YU42903A patent/YU42903A/sh unknown
- 2001-11-30 SK SK655-2003A patent/SK6552003A3/sk not_active Application Discontinuation
- 2001-11-30 HU HU0400530A patent/HUP0400530A3/hu unknown
- 2001-11-30 NZ NZ526511A patent/NZ526511A/en unknown
- 2001-11-30 US US09/997,740 patent/US6605601B2/en not_active Expired - Fee Related
- 2001-11-30 DE DE60133931T patent/DE60133931D1/de not_active Expired - Lifetime
- 2001-11-30 IL IL15604601A patent/IL156046A0/xx unknown
- 2001-11-30 JP JP2002546552A patent/JP2004514723A/ja active Pending
- 2001-11-30 AT AT01998550T patent/ATE394402T1/de not_active IP Right Cessation
- 2001-11-30 MX MXPA03004857A patent/MXPA03004857A/es active IP Right Grant
- 2001-11-30 AR ARP010105594A patent/AR035400A1/es unknown
- 2001-11-30 EP EP01998550A patent/EP1347981B1/de not_active Expired - Lifetime
- 2001-11-30 KR KR10-2003-7007322A patent/KR20040011439A/ko not_active Abandoned
- 2001-11-30 EE EEP200300260A patent/EE200300260A/xx unknown
2003
- 2003-05-20 IS IS6821A patent/IS6821A/is unknown
- 2003-05-26 ZA ZA200304067A patent/ZA200304067B/en unknown
- 2003-05-27 BG BG107849A patent/BG107849A/bg unknown
- 2003-05-27 US US10/446,573 patent/US7022686B2/en not_active Expired - Fee Related
- 2003-06-02 NO NO20032483A patent/NO20032483L/no not_active Application Discontinuation
2004
- 2004-10-28 ZA ZA200408755A patent/ZA200408755B/xx unknown
2009
- 2009-12-07 JP JP2009278047A patent/JP2010053148A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
SK6552003A3 (en)	2003-12-02
US7022686B2 (en)	2006-04-04
MXPA03004857A (es)	2003-08-19
AU1997702A (en)	2002-06-11
ES2305139T3 (es)	2008-11-01
HK1059927A1 (en)	2004-07-23
AU2002219977B2 (en)	2008-01-24
CZ20031513A3 (cs)	2003-09-17
JP2004514723A (ja)	2004-05-20
EE200300260A (et)	2003-08-15
CA2430508A1 (en)	2002-06-06
NZ526511A (en)	2005-04-29
MY127120A (en)	2006-11-30
DE60133931D1 (de)	2008-06-19
IL156046A0 (en)	2003-12-23
TWI293301B (en)	2008-02-11
KR20040011439A (ko)	2004-02-05
US20030220358A1 (en)	2003-11-27
US20020111333A1 (en)	2002-08-15
ZA200304067B (en)	2005-05-30
PL362642A1 (en)	2004-11-02
HUP0400530A3 (en)	2007-05-29
US6605601B2 (en)	2003-08-12
GEP20094697B (en)	2009-06-10
AR035400A1 (es)	2004-05-26
BG107849A (bg)	2004-01-30
ATE394402T1 (de)	2008-05-15
NO20032483L (no)	2003-07-30
BR0115833A (pt)	2003-10-28
IS6821A (is)	2003-05-20
EP1347981A1 (de)	2003-10-01
EA009814B1 (ru)	2008-04-28
HUP0400530A2 (hu)	2004-06-28
NO20032483D0 (no)	2003-06-02
ZA200408755B (en)	2005-07-27
EA200300629A1 (ru)	2003-12-25
JP2010053148A (ja)	2010-03-11
WO2002044182A1 (en)	2002-06-06
CA2430508C (en)	2010-05-18
CN1481387A (zh)	2004-03-10
YU42903A (sh)	2006-05-25
TR200300766T2 (tr)	2004-09-21
EP1347981B1 (de)	2008-05-07
CN100497340C (zh)	2009-06-10

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