UA77984C2 - Derivatives of 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indol-1-carboxamide, method for synthesis, pharmaceutical compositions, intermediates (variants) - Google Patents

Derivatives of 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indol-1-carboxamide, method for synthesis, pharmaceutical compositions, intermediates (variants) Download PDF

Info

Publication number
UA77984C2
UA77984C2 UA20040503612A UA20040503612A UA77984C2 UA 77984 C2 UA77984 C2 UA 77984C2 UA 20040503612 A UA20040503612 A UA 20040503612A UA 20040503612 A UA20040503612 A UA 20040503612A UA 77984 C2 UA77984 C2 UA 77984C2
Authority
UA
Ukraine
Prior art keywords
general formula
alkyl
oxo
dihydro
carboxamide
Prior art date
Application number
UA20040503612A
Other languages
English (en)
Ukrainian (uk)
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of UA77984C2 publication Critical patent/UA77984C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
UA20040503612A 2001-12-21 2002-11-20 Derivatives of 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indol-1-carboxamide, method for synthesis, pharmaceutical compositions, intermediates (variants) UA77984C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0116701A FR2833953B1 (fr) 2001-12-21 2001-12-21 DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
PCT/FR2002/003979 WO2003055884A1 (fr) 2001-12-21 2002-11-20 Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indole-1-carboxamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
UA77984C2 true UA77984C2 (en) 2007-02-15

Family

ID=8870861

Family Applications (1)

Application Number Title Priority Date Filing Date
UA20040503612A UA77984C2 (en) 2001-12-21 2002-11-20 Derivatives of 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indol-1-carboxamide, method for synthesis, pharmaceutical compositions, intermediates (variants)

Country Status (32)

Country Link
US (4) US7109194B2 (de)
EP (1) EP1458721B1 (de)
JP (1) JP5087204B2 (de)
KR (1) KR100936565B1 (de)
CN (1) CN100376579C (de)
AR (1) AR038024A1 (de)
AT (1) ATE346069T1 (de)
AU (1) AU2002361325B2 (de)
BR (1) BR0215174A (de)
CA (1) CA2465750C (de)
CY (1) CY1106029T1 (de)
DE (1) DE60216321T2 (de)
DK (1) DK1458721T3 (de)
EA (1) EA006251B1 (de)
ES (1) ES2276978T3 (de)
FR (1) FR2833953B1 (de)
HR (1) HRP20040549B1 (de)
HU (1) HU229419B1 (de)
IL (2) IL161859A0 (de)
IS (1) IS2380B (de)
ME (2) MEP22408A (de)
MX (1) MXPA04006144A (de)
NO (1) NO328587B1 (de)
NZ (1) NZ532996A (de)
PL (1) PL371201A1 (de)
PT (1) PT1458721E (de)
RS (1) RS51103B (de)
SI (1) SI1458721T1 (de)
TW (1) TWI275391B (de)
UA (1) UA77984C2 (de)
WO (1) WO2003055884A1 (de)
ZA (1) ZA200404245B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
FR2838124B1 (fr) * 2002-04-03 2004-05-28 Sanofi Synthelabo Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique
US7732447B2 (en) * 2006-06-22 2010-06-08 Cephalon, Inc. Fused [d]pyridazin-7-ones
CN1995041B (zh) * 2006-12-18 2012-06-27 沈阳药科大学 哒嗪并吲哚类衍生物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2754262B1 (fr) * 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
FR2766823B1 (fr) * 1997-07-30 1999-10-08 Synthelabo Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
FR2788776B1 (fr) * 1999-01-26 2001-02-23 Synthelabo Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
FR2811990A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Also Published As

Publication number Publication date
DE60216321T2 (de) 2007-06-21
US7402682B2 (en) 2008-07-22
US20090275576A1 (en) 2009-11-05
WO2003055884A1 (fr) 2003-07-10
US20060241116A1 (en) 2006-10-26
TWI275391B (en) 2007-03-11
IL161859A0 (en) 2005-11-20
HK1065792A1 (en) 2005-03-04
CN100376579C (zh) 2008-03-26
NZ532996A (en) 2006-11-30
AU2002361325B2 (en) 2008-10-02
IL161859A (en) 2009-11-18
ATE346069T1 (de) 2006-12-15
HRP20040549A2 (en) 2004-10-31
MXPA04006144A (es) 2004-11-01
US20080249098A1 (en) 2008-10-09
AU2002361325A1 (en) 2003-07-15
SI1458721T1 (sl) 2007-04-30
FR2833953A1 (fr) 2003-06-27
JP5087204B2 (ja) 2012-12-05
ZA200404245B (en) 2005-08-31
ES2276978T3 (es) 2007-07-01
RS51103B (sr) 2010-10-31
ME00117B (me) 2010-06-10
HU229419B1 (en) 2013-12-30
DK1458721T3 (da) 2007-03-26
CN1604898A (zh) 2005-04-06
CA2465750C (en) 2011-05-31
KR100936565B1 (ko) 2010-01-13
EA006251B1 (ru) 2005-10-27
HUP0402578A2 (hu) 2005-03-29
EP1458721B1 (de) 2006-11-22
PT1458721E (pt) 2007-02-28
MEP22408A (en) 2010-06-10
RS50304A (sr) 2006-12-15
NO20042536L (no) 2004-09-21
CA2465750A1 (en) 2003-07-10
IS7259A (is) 2004-05-10
US7569567B2 (en) 2009-08-04
FR2833953B1 (fr) 2004-12-03
NO328587B1 (no) 2010-03-22
CY1106029T1 (el) 2011-04-06
EA200400560A1 (ru) 2004-12-30
KR20040068958A (ko) 2004-08-02
PL371201A1 (en) 2005-06-13
HRP20040549B1 (hr) 2012-10-31
HUP0402578A3 (en) 2009-01-28
US20050096321A1 (en) 2005-05-05
DE60216321D1 (de) 2007-01-04
JP2005513158A (ja) 2005-05-12
AR038024A1 (es) 2004-12-22
BR0215174A (pt) 2004-11-30
US7109194B2 (en) 2006-09-19
IS2380B (is) 2008-07-15
EP1458721A1 (de) 2004-09-22
TW200301120A (en) 2003-07-01

Similar Documents

Publication Publication Date Title
WO2021073439A1 (zh) 用于抑制shp2活性的吡嗪衍生物
WO2022166974A1 (zh) 吡啶并嘧啶酮类衍生物及其制备方法和用途
US7323467B2 (en) 3-heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics
US20080249098A1 (en) 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-B]indole-1-carboxamide Derivatives, Their Preparation and Therapeutic Use
HK1065792B (en) 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-carboxamide derivatives, their preparation and therapeutic use