ATE346069T1 - 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino(4, - b)indol-1-karboxamid-derivate, ihre herstellung und therapeutische verwendung - Google Patents

3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino(4, - b)indol-1-karboxamid-derivate, ihre herstellung und therapeutische verwendung

Info

Publication number: ATE346069T1
Authority: AT; Austria
Prior art keywords: pyridazino; indole; dihydro; heteroaryl; oxo
Prior art date: 2001-12-21

Application number

AT02796852T

Other languages

English (en)

Inventor

Philippe Burnier

Jacques Froissant

Benoit Marabout

Frank Marguet

Frederic Puech

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-21

Filing date

2002-11-20

Publication date

2006-12-15

2002-11-20 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2006-12-15 Application granted granted Critical

2006-12-15 Publication of ATE346069T1 publication Critical patent/ATE346069T1/de

Links

CQILOHWHIWNQOE-UHFFFAOYSA-N indole-1-carboxamide Chemical class C1=CC=C2N(C(=O)N)C=CC2=C1 CQILOHWHIWNQOE-UHFFFAOYSA-N 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Endocrinology (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Pulmonology (AREA)
Psychology (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

AT02796852T 2001-12-21 2002-11-20 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino(4, - b)indol-1-karboxamid-derivate, ihre herstellung und therapeutische verwendung ATE346069T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0116701A FR2833953B1 (fr)	2001-12-21	2001-12-21	DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Publications (1)

Publication Number	Publication Date
ATE346069T1 true ATE346069T1 (de)	2006-12-15

Family

ID=8870861

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02796852T ATE346069T1 (de)	2001-12-21	2002-11-20	3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino(4, - b)indol-1-karboxamid-derivate, ihre herstellung und therapeutische verwendung

Country Status (32)

Country	Link
US (4)	US7109194B2 (de)
EP (1)	EP1458721B1 (de)
JP (1)	JP5087204B2 (de)
KR (1)	KR100936565B1 (de)
CN (1)	CN100376579C (de)
AR (1)	AR038024A1 (de)
AT (1)	ATE346069T1 (de)
AU (1)	AU2002361325B2 (de)
BR (1)	BR0215174A (de)
CA (1)	CA2465750C (de)
CY (1)	CY1106029T1 (de)
DE (1)	DE60216321T2 (de)
DK (1)	DK1458721T3 (de)
EA (1)	EA006251B1 (de)
ES (1)	ES2276978T3 (de)
FR (1)	FR2833953B1 (de)
HR (1)	HRP20040549B1 (de)
HU (1)	HU229419B1 (de)
IL (2)	IL161859A0 (de)
IS (1)	IS2380B (de)
ME (2)	MEP22408A (de)
MX (1)	MXPA04006144A (de)
NO (1)	NO328587B1 (de)
NZ (1)	NZ532996A (de)
PL (1)	PL371201A1 (de)
PT (1)	PT1458721E (de)
RS (1)	RS51103B (de)
SI (1)	SI1458721T1 (de)
TW (1)	TWI275391B (de)
UA (1)	UA77984C2 (de)
WO (1)	WO2003055884A1 (de)
ZA (1)	ZA200404245B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6278893B1 (en)	1998-01-05	2001-08-21	Nycomed Imaging As	Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
FR2838124B1 (fr) *	2002-04-03	2004-05-28	Sanofi Synthelabo	Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique
US7732447B2 (en) *	2006-06-22	2010-06-08	Cephalon, Inc.	Fused [d]pyridazin-7-ones
CN1995041B (zh) *	2006-12-18	2012-06-27	沈阳药科大学	哒嗪并吲哚类衍生物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2754262B1 (fr) *	1996-10-08	1998-10-30	Synthelabo	Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
FR2766823B1 (fr) *	1997-07-30	1999-10-08	Synthelabo	Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
FR2788776B1 (fr) *	1999-01-26	2001-02-23	Synthelabo	Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
FR2811990A1 (fr) *	2000-07-24	2002-01-25	Sanofi Synthelabo	DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

2001
- 2001-12-21 FR FR0116701A patent/FR2833953B1/fr not_active Expired - Fee Related
2002
- 2002-11-20 AU AU2002361325A patent/AU2002361325B2/en not_active Ceased
- 2002-11-20 HU HU0402578A patent/HU229419B1/hu not_active IP Right Cessation
- 2002-11-20 CN CNB028253353A patent/CN100376579C/zh not_active Expired - Fee Related
- 2002-11-20 RS YUP-503/04A patent/RS51103B/sr unknown
- 2002-11-20 UA UA20040503612A patent/UA77984C2/uk unknown
- 2002-11-20 SI SI200230482T patent/SI1458721T1/sl unknown
- 2002-11-20 EP EP02796852A patent/EP1458721B1/de not_active Expired - Lifetime
- 2002-11-20 MX MXPA04006144A patent/MXPA04006144A/es active IP Right Grant
- 2002-11-20 HR HRP20040549AA patent/HRP20040549B1/hr not_active IP Right Cessation
- 2002-11-20 JP JP2003556414A patent/JP5087204B2/ja not_active Expired - Fee Related
- 2002-11-20 EA EA200400560A patent/EA006251B1/ru not_active IP Right Cessation
- 2002-11-20 ME MEP-224/08A patent/MEP22408A/xx unknown
- 2002-11-20 CA CA2465750A patent/CA2465750C/en not_active Expired - Fee Related
- 2002-11-20 IL IL16185902A patent/IL161859A0/xx unknown
- 2002-11-20 DK DK02796852T patent/DK1458721T3/da active
- 2002-11-20 WO PCT/FR2002/003979 patent/WO2003055884A1/fr not_active Ceased
- 2002-11-20 PT PT02796852T patent/PT1458721E/pt unknown
- 2002-11-20 BR BR0215174-0A patent/BR0215174A/pt not_active IP Right Cessation
- 2002-11-20 ES ES02796852T patent/ES2276978T3/es not_active Expired - Lifetime
- 2002-11-20 NZ NZ532996A patent/NZ532996A/en not_active IP Right Cessation
- 2002-11-20 AT AT02796852T patent/ATE346069T1/de active
- 2002-11-20 ME MEP-2008-224A patent/ME00117B/me unknown
- 2002-11-20 KR KR1020047009601A patent/KR100936565B1/ko not_active Expired - Fee Related
- 2002-11-20 DE DE60216321T patent/DE60216321T2/de not_active Expired - Lifetime
- 2002-11-20 PL PL02371201A patent/PL371201A1/xx unknown
- 2002-11-20 US US10/499,725 patent/US7109194B2/en not_active Expired - Lifetime
- 2002-12-18 TW TW091136504A patent/TWI275391B/zh not_active IP Right Cessation
- 2002-12-18 AR ARP020104928A patent/AR038024A1/es active IP Right Grant
2004
- 2004-05-06 IL IL161859A patent/IL161859A/en not_active IP Right Cessation
- 2004-05-10 IS IS7259A patent/IS2380B/is unknown
- 2004-05-31 ZA ZA2004/04245A patent/ZA200404245B/en unknown
- 2004-06-17 NO NO20042536A patent/NO328587B1/no not_active IP Right Cessation
2006
- 2006-06-29 US US11/427,508 patent/US7402682B2/en not_active Expired - Fee Related
2007
- 2007-02-20 CY CY20071100220T patent/CY1106029T1/el unknown
2008
- 2008-06-17 US US12/140,608 patent/US7569567B2/en not_active Expired - Fee Related
2009
- 2009-06-19 US US12/487,902 patent/US20090275576A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE60216321T2 (de)	2007-06-21
US7402682B2 (en)	2008-07-22
US20090275576A1 (en)	2009-11-05
WO2003055884A1 (fr)	2003-07-10
US20060241116A1 (en)	2006-10-26
TWI275391B (en)	2007-03-11
IL161859A0 (en)	2005-11-20
HK1065792A1 (en)	2005-03-04
CN100376579C (zh)	2008-03-26
NZ532996A (en)	2006-11-30
AU2002361325B2 (en)	2008-10-02
IL161859A (en)	2009-11-18
HRP20040549A2 (en)	2004-10-31
MXPA04006144A (es)	2004-11-01
US20080249098A1 (en)	2008-10-09
AU2002361325A1 (en)	2003-07-15
SI1458721T1 (sl)	2007-04-30
FR2833953A1 (fr)	2003-06-27
JP5087204B2 (ja)	2012-12-05
ZA200404245B (en)	2005-08-31
ES2276978T3 (es)	2007-07-01
RS51103B (sr)	2010-10-31
ME00117B (me)	2010-06-10
HU229419B1 (en)	2013-12-30
DK1458721T3 (da)	2007-03-26
CN1604898A (zh)	2005-04-06
CA2465750C (en)	2011-05-31
KR100936565B1 (ko)	2010-01-13
EA006251B1 (ru)	2005-10-27
HUP0402578A2 (hu)	2005-03-29
EP1458721B1 (de)	2006-11-22
PT1458721E (pt)	2007-02-28
MEP22408A (en)	2010-06-10
RS50304A (sr)	2006-12-15
NO20042536L (no)	2004-09-21
CA2465750A1 (en)	2003-07-10
IS7259A (is)	2004-05-10
US7569567B2 (en)	2009-08-04
FR2833953B1 (fr)	2004-12-03
NO328587B1 (no)	2010-03-22
CY1106029T1 (el)	2011-04-06
EA200400560A1 (ru)	2004-12-30
UA77984C2 (en)	2007-02-15
KR20040068958A (ko)	2004-08-02
PL371201A1 (en)	2005-06-13
HRP20040549B1 (hr)	2012-10-31
HUP0402578A3 (en)	2009-01-28
US20050096321A1 (en)	2005-05-05
DE60216321D1 (de)	2007-01-04
JP2005513158A (ja)	2005-05-12
AR038024A1 (es)	2004-12-22
BR0215174A (pt)	2004-11-30
US7109194B2 (en)	2006-09-19
IS2380B (is)	2008-07-15
EP1458721A1 (de)	2004-09-22
TW200301120A (en)	2003-07-01

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