UA78577C2 - Diphenylazetidinons with substituted acid groups, method for production thereof, drugs containing and use thereof - Google Patents

Diphenylazetidinons with substituted acid groups, method for production thereof, drugs containing and use thereof Download PDF

Info

Publication number: UA78577C2
Authority: UA; Ukraine
Prior art keywords: alkyl; phenyl; mean; agonists; compounds
Prior art date: 2002-06-19

Application number

UAA200500488A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-06-19

Filing date

2003-04-06

Publication date

2007-04-10

2003-04-06 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

2007-04-10 Publication of UA78577C2 publication Critical patent/UA78577C2/uk

Links

239000002253 acid Substances 0.000 title claims description 12
229940079593 drug Drugs 0.000 title description 2
239000003814 drug Substances 0.000 title description 2
238000004519 manufacturing process Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 104
150000003839 salts Chemical class 0.000 claims abstract description 18
239000000556 agonist Substances 0.000 claims description 38
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 23
239000003112 inhibitor Substances 0.000 claims description 17
239000013543 active substance Substances 0.000 claims description 15
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 14
229940088623 biologically active substance Drugs 0.000 claims description 13
125000002947 alkylene group Chemical group 0.000 claims description 11
229940126601 medicinal product Drugs 0.000 claims description 11
125000004432 carbon atom Chemical group C* 0.000 claims description 10
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 10
102000004877 Insulin Human genes 0.000 claims description 8
108090001061 Insulin Proteins 0.000 claims description 8
239000005557 antagonist Substances 0.000 claims description 8
125000000217 alkyl group Chemical group 0.000 claims description 7
235000012000 cholesterol Nutrition 0.000 claims description 7
125000000896 monocarboxylic acid group Chemical group 0.000 claims description 7
229940100389 Sulfonylurea Drugs 0.000 claims description 6
125000001153 fluoro group Chemical group F* 0.000 claims description 6
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 6
HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims description 4
239000003613 bile acid Substances 0.000 claims description 4
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230000037356 lipid metabolism Effects 0.000 claims description 4
SWLAMJPTOQZTAE-UHFFFAOYSA-N 4-[2-[(5-chloro-2-methoxybenzoyl)amino]ethyl]benzoic acid Chemical class COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(C(O)=O)C=C1 SWLAMJPTOQZTAE-UHFFFAOYSA-N 0.000 claims description 3
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NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims description 3
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DNDCVAGJPBKION-DOPDSADYSA-N bombesin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1NC2=CC=CC=C2C=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1NC(=O)CC1)C(C)C)C1=CN=CN1 DNDCVAGJPBKION-DOPDSADYSA-N 0.000 claims description 2
238000010504 bond cleavage reaction Methods 0.000 claims description 2
OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 claims description 2
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SLZIZIJTGAYEKK-CIJSCKBQSA-N molport-023-220-247 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CN)[C@@H](C)O)C1=CNC=N1 SLZIZIJTGAYEKK-CIJSCKBQSA-N 0.000 claims description 2
230000002474 noradrenergic effect Effects 0.000 claims description 2
108060005714 orexin Proteins 0.000 claims description 2
229910052698 phosphorus Inorganic materials 0.000 claims description 2
102000004169 proteins and genes Human genes 0.000 claims description 2
239000000952 serotonin receptor agonist Substances 0.000 claims description 2
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210000002966 serum Anatomy 0.000 claims description 2
239000004059 squalene synthase inhibitor Substances 0.000 claims description 2
125000000542 sulfonic acid group Chemical group 0.000 claims description 2
150000001467 thiazolidinediones Chemical class 0.000 claims description 2
239000000777 urocortin Substances 0.000 claims description 2
125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 3
229940127470 Lipase Inhibitors Drugs 0.000 claims 2
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims 2
101100167667 Arabidopsis thaliana CML24 gene Proteins 0.000 claims 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
206010022489 Insulin Resistance Diseases 0.000 claims 1
102000004895 Lipoproteins Human genes 0.000 claims 1
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239000000637 Melanocyte-Stimulating Hormone Substances 0.000 claims 1
108010007013 Melanocyte-Stimulating Hormones Proteins 0.000 claims 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
125000004429 atom Chemical group 0.000 claims 1
150000004283 biguanides Chemical class 0.000 claims 1
229910052799 carbon Inorganic materials 0.000 claims 1
150000001735 carboxylic acids Chemical group 0.000 claims 1
239000004026 insulin derivative Substances 0.000 claims 1
229920000642 polymer Polymers 0.000 claims 1
229910052700 potassium Inorganic materials 0.000 claims 1
239000011591 potassium Substances 0.000 claims 1
229940076279 serotonin Drugs 0.000 claims 1
208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
230000000055 hyoplipidemic effect Effects 0.000 abstract description 2
JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 description 42
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 33
239000000243 solution Substances 0.000 description 33
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 27
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 24
DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 23
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XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 18
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NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 15
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MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical compound O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 description 7
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LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
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AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 6
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210000004185 liver Anatomy 0.000 description 6
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FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 description 6
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QDHFHIQKOVNCNC-UHFFFAOYSA-N butane-1-sulfonic acid Chemical compound CCCCS(O)(=O)=O QDHFHIQKOVNCNC-UHFFFAOYSA-N 0.000 description 5
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125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 description 4
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VDOXIAUNJCHYRC-UHFFFAOYSA-N 1,3-diphenylazetidin-2-one Chemical class O=C1C(C=2C=CC=CC=2)CN1C1=CC=CC=C1 VDOXIAUNJCHYRC-UHFFFAOYSA-N 0.000 description 3
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ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 3
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TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 description 1
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UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical compound C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 description 1
229960002855 simvastatin Drugs 0.000 description 1
RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
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JVBXVOWTABLYPX-UHFFFAOYSA-L sodium dithionite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])=O JVBXVOWTABLYPX-UHFFFAOYSA-L 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
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239000012453 solvate Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000004544 sputter deposition Methods 0.000 description 1
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WBWWGRHZICKQGZ-GIHLXUJPSA-N taurocholic acid Chemical compound C([C@@H]1C[C@H]2O)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@H](O)C1 WBWWGRHZICKQGZ-GIHLXUJPSA-N 0.000 description 1
BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
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FTVLMFQEYACZNP-UHFFFAOYSA-N trimethylsilyl trifluoromethanesulfonate Chemical compound C[Si](C)(C)OS(=O)(=O)C(F)(F)F FTVLMFQEYACZNP-UHFFFAOYSA-N 0.000 description 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

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Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Obesity (AREA)
Biochemistry (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

UAA200500488A 2002-06-19 2003-04-06 Diphenylazetidinons with substituted acid groups, method for production thereof, drugs containing and use thereof UA78577C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10227508A DE10227508A1 (de)	2002-06-19	2002-06-19	Säuregruppen-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
PCT/EP2003/005816 WO2004000805A1 (de)	2002-06-19	2003-06-04	Säuregruppen-substituierte diphenylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung

Publications (1)

Publication Number	Publication Date
UA78577C2 true UA78577C2 (en)	2007-04-10

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UAA200500488A UA78577C2 (en)	2002-06-19	2003-04-06	Diphenylazetidinons with substituted acid groups, method for production thereof, drugs containing and use thereof

Country Status (28)

Country	Link
EP (1)	EP1517891B1 (sr)
JP (1)	JP2005533073A (sr)
KR (1)	KR20050008835A (sr)
CN (1)	CN100467448C (sr)
AR (1)	AR039690A1 (sr)
AU (1)	AU2003238210B2 (sr)
BR (1)	BR0311896A (sr)
CA (1)	CA2490112A1 (sr)
DE (1)	DE10227508A1 (sr)
EC (1)	ECSP045497A (sr)
HN (1)	HN2003000185A (sr)
HR (1)	HRPK20041201B3 (sr)
IL (1)	IL165789A0 (sr)
MA (1)	MA27206A1 (sr)
MX (1)	MXPA04012093A (sr)
NO (1)	NO20050134L (sr)
OA (1)	OA12869A (sr)
PA (1)	PA8576101A1 (sr)
PE (1)	PE20040564A1 (sr)
PL (1)	PL372700A1 (sr)
RS (1)	RS108404A (sr)
RU (1)	RU2287522C2 (sr)
SV (1)	SV2004001548A (sr)
TN (1)	TNSN04250A1 (sr)
TW (1)	TW200413311A (sr)
UA (1)	UA78577C2 (sr)
UY (1)	UY27853A1 (sr)
WO (1)	WO2004000805A1 (sr)

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GB0215579D0 (en)	2002-07-05	2002-08-14	Astrazeneca Ab	Chemical compounds
CA2550215A1 (en)	2003-12-23	2005-07-07	Astrazeneca Ab	Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity
MX2007006695A (es)	2004-12-03	2007-08-14	Schering Corp	Piperazinas sustituidas como antagonistas de cb1.
MX2007012253A (es)	2005-04-04	2007-12-07	Univ Pontificia Catolica Chile	Uso de ezetimibe para la prevencion y tratamiento de calculos de colesterol en la via biliar.
EP1902046B1 (en)	2005-06-20	2009-12-02	Schering Corporation	Piperidine derivatives useful as histamine h3 antagonists
SA06270191B1 (ar)	2005-06-22	2010-03-29	استرازينيكا ايه بي	مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
TW200811098A (en)	2006-04-27	2008-03-01	Astrazeneca Ab	Chemical compounds
MX2008016343A (es) *	2006-06-23	2009-01-19	Abbott Lab	Derivados ciclopropil amina como moduladores del receptro de histamina h3.
AU2007283113A1 (en)	2006-08-08	2008-02-14	Sanofi-Aventis	Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use
DE102007002260A1 (de)	2007-01-16	2008-07-31	Sanofi-Aventis	Verwendung von substituierten Pyranonsäurederivaten zur Herstellung von Medikamenten zur Behandlung des Metabolischen Syndroms
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CN101200443B (zh) *	2007-10-17	2011-06-29	中国药科大学	氮杂环丁酮衍生物、其制备方法及含有它们的药物组合
DE102007054497B3 (de)	2007-11-13	2009-07-23	Sanofi-Aventis Deutschland Gmbh	Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung
UY31968A (es)	2008-07-09	2010-01-29	Sanofi Aventis	Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
WO2010068601A1 (en)	2008-12-08	2010-06-17	Sanofi-Aventis	A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
US9212175B2 (en)	2009-03-06	2015-12-15	Lipideon Biotechnology Ag	Pharmaceutical hypocholesterolemic compositions
CN101993403B (zh)	2009-08-11	2012-07-11	浙江海正药业股份有限公司	氮杂环丁酮类化合物及医药应用
KR20120060207A (ko)	2009-08-26	2012-06-11	사노피	신규한 결정성 헤테로방향족 플루오로글리코시드 수화물, 이들 화합물을 포함하는 약제 및 이들의 용도
EP2582709B1 (de)	2010-06-18	2018-01-24	Sanofi	Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
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2002
- 2002-06-19 DE DE10227508A patent/DE10227508A1/de not_active Withdrawn
2003
- 2003-04-06 UA UAA200500488A patent/UA78577C2/uk unknown
- 2003-06-02 SV SV2003001548A patent/SV2004001548A/es not_active Application Discontinuation
- 2003-06-04 WO PCT/EP2003/005816 patent/WO2004000805A1/de not_active Ceased
- 2003-06-04 HR HR20041201A patent/HRPK20041201B3/xx not_active IP Right Cessation
- 2003-06-04 RS YUP-1084/04A patent/RS108404A/sr unknown
- 2003-06-04 KR KR10-2004-7020643A patent/KR20050008835A/ko not_active Ceased
- 2003-06-04 EP EP03735535A patent/EP1517891B1/de not_active Expired - Lifetime
- 2003-06-04 JP JP2004514661A patent/JP2005533073A/ja not_active Abandoned
- 2003-06-04 BR BR0311896-7A patent/BR0311896A/pt not_active IP Right Cessation
- 2003-06-04 CA CA002490112A patent/CA2490112A1/en not_active Abandoned
- 2003-06-04 MX MXPA04012093A patent/MXPA04012093A/es active IP Right Grant
- 2003-06-04 OA OA1200400331A patent/OA12869A/en unknown
- 2003-06-04 RU RU2005101093/04A patent/RU2287522C2/ru not_active IP Right Cessation
- 2003-06-04 CN CNB038143321A patent/CN100467448C/zh not_active Expired - Fee Related
- 2003-06-04 AU AU2003238210A patent/AU2003238210B2/en not_active Ceased
- 2003-06-04 PL PL03372700A patent/PL372700A1/xx not_active Application Discontinuation
- 2003-06-16 PE PE2003000596A patent/PE20040564A1/es not_active Application Discontinuation
- 2003-06-16 UY UY27853A patent/UY27853A1/es unknown
- 2003-06-17 AR ARP030102144A patent/AR039690A1/es unknown
- 2003-06-17 TW TW092116321A patent/TW200413311A/zh unknown
- 2003-06-17 HN HN2003000185A patent/HN2003000185A/es unknown
- 2003-06-18 PA PA20038576101A patent/PA8576101A1/es unknown
2004
- 2004-11-16 MA MA27954A patent/MA27206A1/fr unknown
- 2004-12-15 IL IL16578904A patent/IL165789A0/xx unknown
- 2004-12-16 TN TNP2004000250A patent/TNSN04250A1/en unknown
- 2004-12-16 EC EC2004005497A patent/ECSP045497A/es unknown
2005
- 2005-01-11 NO NO20050134A patent/NO20050134L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
IL165789A0 (en)	2006-01-15
DE10227508A1 (de)	2004-01-08
JP2005533073A (ja)	2005-11-04
HN2003000185A (es)	2005-10-20
RU2005101093A (ru)	2005-07-20
HRP20041201A2 (en)	2005-08-31
PE20040564A1 (es)	2004-10-25
BR0311896A (pt)	2005-04-05
WO2004000805A1 (de)	2003-12-31
CN100467448C (zh)	2009-03-11
AU2003238210A1 (en)	2004-01-06
RS108404A (sr)	2007-02-05
UY27853A1 (es)	2003-12-31
SV2004001548A (es)	2004-03-19
PL372700A1 (en)	2005-07-25
TW200413311A (en)	2004-08-01
AU2003238210B2 (en)	2008-10-23
CN1662495A (zh)	2005-08-31
PA8576101A1 (es)	2004-02-07
NO20050134D0 (no)	2005-01-11
CA2490112A1 (en)	2003-12-31
MXPA04012093A (es)	2005-04-19
EP1517891B1 (de)	2013-04-03
EP1517891A1 (de)	2005-03-30
HRPK20041201B3 (en)	2006-12-31
TNSN04250A1 (en)	2007-03-12
AR039690A1 (es)	2005-03-09
HK1079511A1 (zh)	2006-04-07
RU2287522C2 (ru)	2006-11-20
MA27206A1 (fr)	2005-01-03
NO20050134L (no)	2005-03-18
KR20050008835A (ko)	2005-01-21
ECSP045497A (es)	2005-03-10
OA12869A (en)	2006-09-15

Publication	Publication Date	Title
UA78577C2 (en)	2007-04-10	Diphenylazetidinons with substituted acid groups, method for production thereof, drugs containing and use thereof
ES2277890T3 (es)	2007-08-01	Nuevas difenilazetidinonas, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su uso para el tratamiento de trastornos del metabolismo de lipidos.
US6498156B2 (en)	2002-12-24	Diphenylazetidinone derivatives, process for their preparation, medicaments comprising these compounds and their use
RU2315754C2 (ru)	2008-01-27	Циклическизамещенные дифенилазетидиноны, применение их для получения лекарственного средства
RU2315753C2 (ru)	2008-01-27	Катионозамещенные дифенилазетидиноны, способ их получения, лекарственные средства, содержащие эти соединения, и их применение
KR20030063462A (ko)	2003-07-28	디페닐 아제티디논 유도체, 이의 제조 방법, 이들화합물을 함유하는 약제 및 이의 용도
US7388004B2 (en)	2008-06-17	Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
US20040077623A1 (en)	2004-04-22	Cationically substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
RU2286985C2 (ru)	2006-11-10	Новые 1,2-дифенилазетидиноны, их применение для лечения нарушений липидного обмена, лекарственное средство и способ его получения
RU2282628C2 (ru)	2006-08-27	Производные дифенилазетидинона, фармацевтическая композиция на их основе и способ ее получения
NZ537302A (en)	2006-06-30	Diphenyl azetidinones substituted by acidic groups, method for their production, medicaments containing said compounds and use thereof
HK1079511B (en)	2009-07-03	Diphenyl azetidinones substituted by acidic groups, method for their production, medicaments containing said compounds and use thereof
NZ537303A (en)	2006-06-30	Cationically substituted diphenyl azetidinones, method for their production, medicaments containing said compounds and use thereof
KR20050016583A (ko)	2005-02-21	환 치환된 디페닐 아제티디논, 이의 제조방법, 이를함유하는 약제 및 이의 용도