UA79294C2 - Use of metal complexes containing perfluoroalkyl as contrast agents in magnetic resonance imaging for representing intravascular thrombi - Google Patents

Use of metal complexes containing perfluoroalkyl as contrast agents in magnetic resonance imaging for representing intravascular thrombi Download PDF

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Publication number
UA79294C2
UA79294C2 UAA200500956A UA2005000956A UA79294C2 UA 79294 C2 UA79294 C2 UA 79294C2 UA A200500956 A UAA200500956 A UA A200500956A UA 2005000956 A UA2005000956 A UA 2005000956A UA 79294 C2 UA79294 C2 UA 79294C2
Authority
UA
Ukraine
Prior art keywords
сно
groups
residue
group
general formula
Prior art date
Application number
UAA200500956A
Other languages
English (en)
Ukrainian (uk)
Inventor
Bernd Misselwitz
Johannes Platzek
Yoko Kawata
Hanns-Joachim Weinmann
Takishi Yokawa
Ulrich Niedballa
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of UA79294C2 publication Critical patent/UA79294C2/uk

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
UAA200500956A 2002-07-10 2003-05-07 Use of metal complexes containing perfluoroalkyl as contrast agents in magnetic resonance imaging for representing intravascular thrombi UA79294C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10231799A DE10231799B4 (de) 2002-07-10 2002-07-10 Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben
PCT/EP2003/007274 WO2004006965A2 (de) 2002-07-10 2003-07-05 Verwendung von perfluoralkylhaltigen metallkomplexen als kontrastmittel im mr-imaging zur darstellung von intravasalen thromben

Publications (1)

Publication Number Publication Date
UA79294C2 true UA79294C2 (en) 2007-06-11

Family

ID=30009959

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200500956A UA79294C2 (en) 2002-07-10 2003-05-07 Use of metal complexes containing perfluoroalkyl as contrast agents in magnetic resonance imaging for representing intravascular thrombi

Country Status (23)

Country Link
EP (1) EP1519756B1 (no)
JP (1) JP2005532404A (no)
CN (1) CN1668338A (no)
AR (1) AR041187A1 (no)
AT (1) ATE361103T1 (no)
AU (2) AU2003281146A1 (no)
BR (1) BR0312552A (no)
CA (1) CA2491933A1 (no)
DE (2) DE10231799B4 (no)
DK (1) DK1519756T3 (no)
ES (1) ES2285143T3 (no)
IL (1) IL165889A0 (no)
MX (1) MXPA04012950A (no)
NO (1) NO20050679L (no)
PE (1) PE20040656A1 (no)
PL (1) PL374027A1 (no)
PT (1) PT1519756E (no)
RS (1) RS20050020A (no)
RU (1) RU2328310C2 (no)
TW (1) TW200413008A (no)
UA (1) UA79294C2 (no)
WO (2) WO2004006979A2 (no)
ZA (1) ZA200501172B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006021495A1 (de) * 2006-05-09 2007-11-15 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel zur Diagnose der Alzheimer Krankheit
TW201034691A (en) * 2008-12-05 2010-10-01 Molecular Insight Pharm Inc Technetium-and rhenium-bis(heteroaryl) complexes and methods of use thereof
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
RU2755181C2 (ru) 2016-11-28 2021-09-14 Байер Фарма Акциенгезельшафт Новые хелатные соединения гадолиния с высокой релаксивностью для применения в магнитно-резонансной визуализации
CN107445911B (zh) * 2017-06-19 2019-07-05 南京科技职业学院 一种二核含钆磁共振对比剂及其制备与应用
CN113164628A (zh) 2018-11-23 2021-07-23 拜耳股份有限公司 造影介质制剂及其制备方法
CN109867635A (zh) * 2019-02-14 2019-06-11 华东师范大学 一种t1型胶束磁共振成像造影剂及其制备方法
EP4059925A1 (en) 2021-03-15 2022-09-21 Bayer Aktiengesellschaft New contrast agent for use in magnetic resonance imaging
EP4335840A1 (en) 2022-09-09 2024-03-13 Bayer Aktiengesellschaft New contrast agents for use in diagnostic imaging
EP4335462A1 (en) 2022-09-09 2024-03-13 Bayer AG Contrast agents for use in diagnostic computed tomography imaging

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571498A (en) * 1994-06-02 1996-11-05 Hemagen/Pfc Emulsions of paramagnetic contrast agents for magnetic resonance imaging (MRI).
DE19603033A1 (de) * 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
WO1998016256A1 (en) * 1996-10-16 1998-04-23 The Burnham Institute Magnetic resonance imaging of thrombi
DE19729013A1 (de) * 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis
DE19914101C1 (de) * 1999-03-22 2000-10-12 Schering Ag Perfluoralkylamide, ihre Herstellung und ihre Verwendung in der Diagnostik
BR0013171A (pt) * 1999-07-29 2002-05-28 Epix Medical Inc Agentes multimericos para formação de imagem de objetivação através de ligação multi-local
DE19948651B4 (de) * 1999-09-29 2006-10-05 Schering Ag Para- und diamagnetische perfluorhaltige Verbindungen enthaltende galenische Formulierungen, deren Herstellung und Verwendung
US6565828B2 (en) * 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
DE10040380B4 (de) * 2000-08-11 2006-03-09 Schering Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques
DE10040381C1 (de) * 2000-08-11 2002-06-06 Schering Ag Perfluoralkylhaltige Komplexe mit Zuckerresten, Verfahren zu deren Herstellung und ihre Verwendung
DE10040858C2 (de) * 2000-08-11 2003-12-18 Schering Ag Perfluoralkylhaltige Komplexe mit polaren Resten, Verfahren zu deren Herstellung und ihre Verwendung
DE10066210B4 (de) * 2000-08-11 2008-02-28 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques

Also Published As

Publication number Publication date
DE10231799A1 (de) 2004-02-12
EP1519756B1 (de) 2007-05-02
RU2005103598A (ru) 2005-11-20
EP1519756A2 (de) 2005-04-06
PL374027A1 (pl) 2005-09-19
ZA200501172B (en) 2006-04-26
PE20040656A1 (es) 2004-12-01
PT1519756E (pt) 2007-07-12
NO20050679L (no) 2005-04-08
AU2003281146A1 (en) 2004-02-02
CN1668338A (zh) 2005-09-14
JP2005532404A (ja) 2005-10-27
CA2491933A1 (en) 2004-01-22
DE50307180D1 (de) 2007-06-14
IL165889A0 (en) 2006-01-15
AU2003281150A1 (en) 2004-02-02
WO2004006979A2 (de) 2004-01-22
AR041187A1 (es) 2005-05-04
DE10231799B4 (de) 2006-10-05
MXPA04012950A (es) 2005-05-16
DK1519756T3 (da) 2007-08-13
WO2004006965A2 (de) 2004-01-22
ES2285143T3 (es) 2007-11-16
ATE361103T1 (de) 2007-05-15
WO2004006965A3 (de) 2004-07-15
RU2328310C2 (ru) 2008-07-10
BR0312552A (pt) 2005-04-26
RS20050020A (sr) 2007-08-03
TW200413008A (en) 2004-08-01

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