UA79300C2 - N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion - Google Patents

N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion Download PDF

Info

Publication number: UA79300C2
Authority: UA; Ukraine
Prior art keywords: compounds; acid; formula; osm; compound
Prior art date: 2002-08-12

Application number

UAA200501990A

Other languages

English (en)

Ukrainian (uk)

Inventor

Lieven Meerpoel

Leo Jacobus Jozef Backx

Peter Walter Maria Roevens

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-12

Filing date

2003-05-08

Publication date

2007-06-11

2003-05-08 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2007-06-11 Publication of UA79300C2 publication Critical patent/UA79300C2/uk

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4

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UAA200501990A 2002-08-12 2003-05-08 N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion UA79300C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02078309		2002-08-12
PCT/EP2003/008694 WO2004017969A1 (en)	2002-08-12	2003-08-05	N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion

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UA79300C2 true UA79300C2 (en)	2007-06-11

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UAA200501990A UA79300C2 (en)	2002-08-12	2003-05-08	N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion

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US (2)	US20060040989A1 (de)
EP (1)	EP1536796B1 (de)
JP (1)	JP4559856B2 (de)
KR (1)	KR101052204B1 (de)
CN (3)	CN100366252C (de)
AR (1)	AR040968A1 (de)
AT (1)	ATE385796T1 (de)
AU (1)	AU2003250215B2 (de)
BR (1)	BR0313377A (de)
CA (1)	CA2494208C (de)
CY (1)	CY1107945T1 (de)
DE (1)	DE60319097T2 (de)
DK (1)	DK1536796T3 (de)
EA (1)	EA008061B1 (de)
EG (1)	EG25699A (de)
ES (1)	ES2301873T3 (de)
HR (1)	HRP20050103B1 (de)
IL (1)	IL166795A (de)
IS (1)	IS2726B (de)
MX (1)	MXPA05001712A (de)
MY (1)	MY136632A (de)
NO (1)	NO329308B1 (de)
NZ (1)	NZ538680A (de)
PA (1)	PA8579901A1 (de)
PL (1)	PL212405B1 (de)
PT (1)	PT1536796E (de)
SI (1)	SI1536796T1 (de)
TW (1)	TWI342775B (de)
UA (1)	UA79300C2 (de)
WO (1)	WO2004017969A1 (de)
ZA (1)	ZA200501225B (de)

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EP2623599B1 (de) *	2007-10-04	2019-01-02	Roche Innovation Center Copenhagen A/S	Mikromir-Moleküle
EP2268811A1 (de) *	2008-03-07	2011-01-05	Santaris Pharma A/S	Pharmazeutische zusammensetzungen zur behandlung von krankheiten in verbindung mit microrna
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2003
- 2003-05-08 UA UAA200501990A patent/UA79300C2/uk unknown
- 2003-08-02 EG EG2003080749A patent/EG25699A/xx active
- 2003-08-05 BR BR0313377-0A patent/BR0313377A/pt not_active Application Discontinuation
- 2003-08-05 EP EP03792260A patent/EP1536796B1/de not_active Expired - Lifetime
- 2003-08-05 MX MXPA05001712A patent/MXPA05001712A/es active IP Right Grant
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- 2003-08-05 CA CA2494208A patent/CA2494208C/en not_active Expired - Fee Related
- 2003-08-05 EA EA200500348A patent/EA008061B1/ru not_active IP Right Cessation
- 2003-08-05 SI SI200331203T patent/SI1536796T1/sl unknown
- 2003-08-05 DK DK03792260T patent/DK1536796T3/da active
- 2003-08-05 NZ NZ538680A patent/NZ538680A/en not_active IP Right Cessation
- 2003-08-05 CN CNB03818592XA patent/CN100366252C/zh not_active Expired - Fee Related
- 2003-08-05 WO PCT/EP2003/008694 patent/WO2004017969A1/en not_active Ceased
- 2003-08-05 AT AT03792260T patent/ATE385796T1/de active
- 2003-08-05 US US10/524,051 patent/US20060040989A1/en not_active Abandoned
- 2003-08-05 JP JP2004530089A patent/JP4559856B2/ja not_active Expired - Fee Related
- 2003-08-05 HR HRP20050103AA patent/HRP20050103B1/hr not_active IP Right Cessation
- 2003-08-05 ES ES03792260T patent/ES2301873T3/es not_active Expired - Lifetime
- 2003-08-05 DE DE60319097T patent/DE60319097T2/de not_active Expired - Lifetime
- 2003-08-05 CN CN2007101866730A patent/CN101165052B/zh not_active Expired - Fee Related
- 2003-08-05 KR KR1020057000829A patent/KR101052204B1/ko not_active Expired - Fee Related
- 2003-08-05 AU AU2003250215A patent/AU2003250215B2/en not_active Ceased
- 2003-08-05 PL PL373379A patent/PL212405B1/pl unknown
- 2003-08-05 CN CNA2007101866745A patent/CN101165053A/zh active Pending
- 2003-08-07 PA PA20038579901A patent/PA8579901A1/es unknown
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- 2003-08-11 TW TW092121938A patent/TWI342775B/zh not_active IP Right Cessation
- 2003-08-11 AR ARP030102901A patent/AR040968A1/es not_active Application Discontinuation
2004
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2005
- 2005-01-31 NO NO20050563A patent/NO329308B1/no not_active IP Right Cessation
- 2005-02-10 IL IL166795A patent/IL166795A/en unknown
- 2005-02-10 ZA ZA200501225A patent/ZA200501225B/en unknown
2008
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Publication number	Publication date
CY1107945T1 (el)	2013-09-04
IS7622A (is)	2004-12-29
SI1536796T1 (sl)	2008-08-31
CN1674900A (zh)	2005-09-28
US20060040989A1 (en)	2006-02-23
NZ538680A (en)	2006-01-27
PL373379A1 (en)	2005-08-22
MXPA05001712A (es)	2005-04-19
DK1536796T3 (da)	2008-06-09
IL166795A0 (en)	2006-01-15
KR20050026483A (ko)	2005-03-15
PL212405B1 (pl)	2012-09-28
IS2726B (is)	2011-03-15
ATE385796T1 (de)	2008-03-15
PA8579901A1 (es)	2005-03-03
HRP20050103B1 (hr)	2013-09-30
CN100366252C (zh)	2008-02-06
US8258304B2 (en)	2012-09-04
WO2004017969A1 (en)	2004-03-04
EA008061B1 (ru)	2007-02-27
MY136632A (en)	2008-11-28
AU2003250215B2 (en)	2009-01-22
ES2301873T3 (es)	2008-07-01
DE60319097D1 (de)	2008-03-27
DE60319097T2 (de)	2009-06-04
NO329308B1 (no)	2010-09-27
TWI342775B (en)	2011-06-01
AR040968A1 (es)	2005-04-27
CA2494208C (en)	2011-05-10
HK1083451A1 (en)	2006-07-07
EP1536796B1 (de)	2008-02-13
HRP20050103A2 (en)	2006-09-30
EA200500348A1 (ru)	2005-08-25
JP4559856B2 (ja)	2010-10-13
ZA200501225B (en)	2006-07-26
CN101165053A (zh)	2008-04-23
IL166795A (en)	2010-11-30
NO20050563L (no)	2005-01-31
CN101165052B (zh)	2012-04-18
TW200412954A (en)	2004-08-01
BR0313377A (pt)	2005-07-12
KR101052204B1 (ko)	2011-07-29
CN101165052A (zh)	2008-04-23
EP1536796A1 (de)	2005-06-08
JP2006500371A (ja)	2006-01-05
PT1536796E (pt)	2008-05-13
CA2494208A1 (en)	2004-03-04
EG25699A (en)	2012-05-22
US20090156623A1 (en)	2009-06-18
AU2003250215A1 (en)	2004-03-11

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