UA79463C2 - Perindopril salt and pharmaceutical composition containing thereof - Google Patents

Perindopril salt and pharmaceutical composition containing thereof Download PDF

Info

Publication number: UA79463C2
Authority: UA; Ukraine
Prior art keywords: perindopril; salt; pharmaceutical composition; arginine salt; composition according
Prior art date: 2002-04-18

Application number

UA20041109440A

Other languages

English (en)

Ukrainian (uk)

Inventor

Gerard Damien

Francois Lefoulon

Bernard Marchand

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-18

Filing date

2003-02-17

Publication date

2007-06-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8871521&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA79463(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-02-17 Application filed by Servier Lab filed Critical Servier Lab

2007-06-25 Publication of UA79463C2 publication Critical patent/UA79463C2/uk

Links

IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical class C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title claims abstract description 22
239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 15
239000003814 drug Substances 0.000 claims abstract 2
229960002582 perindopril Drugs 0.000 claims description 20
206010019280 Heart failures Diseases 0.000 claims description 3
150000004677 hydrates Chemical class 0.000 claims description 3
239000012729 immediate-release (IR) formulation Substances 0.000 claims description 3
206010020772 Hypertension Diseases 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims description 2
239000000546 pharmaceutical excipient Substances 0.000 claims description 2
125000000637 arginyl group Chemical class N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 3
239000004480 active ingredient Substances 0.000 claims 1
229940079593 drug Drugs 0.000 claims 1
238000012876 topography Methods 0.000 claims 1
150000003839 salts Chemical class 0.000 description 15
YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical class CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 11
150000001483 arginine derivatives Chemical class 0.000 description 8
239000003826 tablet Substances 0.000 description 8
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
239000004475 Arginine Substances 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 3
159000000000 sodium salts Chemical class 0.000 description 3
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 3
239000002253 acid Substances 0.000 description 2
230000015556 catabolic process Effects 0.000 description 2
238000006731 degradation reaction Methods 0.000 description 2
238000004806 packaging method and process Methods 0.000 description 2
RYCSJJXKEWBUTI-YDYAIEMNSA-N perindopril arginine Chemical class OC(=O)[C@@H](N)CCCNC(N)=N.C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 RYCSJJXKEWBUTI-YDYAIEMNSA-N 0.000 description 2
102000015427 Angiotensins Human genes 0.000 description 1
108010064733 Angiotensins Proteins 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
239000008346 aqueous phase Substances 0.000 description 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
208000037849 arterial hypertension Diseases 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000037396 body weight Effects 0.000 description 1
239000006071 cream Substances 0.000 description 1
238000001514 detection method Methods 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000008298 dragée Substances 0.000 description 1
239000003480 eluent Substances 0.000 description 1
239000000499 gel Substances 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
230000007774 longterm Effects 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
238000000034 method Methods 0.000 description 1
239000000203 mixture Substances 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
239000002674 ointment Substances 0.000 description 1
230000008520 organization Effects 0.000 description 1
IYNMDWMQHSMDDE-MHXJNQAMSA-N perindopril erbumine Chemical class CC(C)(C)N.C1CCC[C@@H]2N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H](C(O)=O)C[C@@H]21 IYNMDWMQHSMDDE-MHXJNQAMSA-N 0.000 description 1
238000004007 reversed phase HPLC Methods 0.000 description 1
REFMEZARFCPESH-UHFFFAOYSA-M sodium;heptane-1-sulfonate Chemical compound [Na+].CCCCCCCS([O-])(=O)=O REFMEZARFCPESH-UHFFFAOYSA-M 0.000 description 1
239000006190 sub-lingual tablet Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Heart & Thoracic Surgery (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Indole Compounds (AREA)
Peptides Or Proteins (AREA)

UA20041109440A 2002-04-18 2003-02-17 Perindopril salt and pharmaceutical composition containing thereof UA79463C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0204847A FR2838648B1 (fr)	2002-04-18	2002-04-18	Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent
PCT/FR2003/000507 WO2003087050A2 (fr)	2002-04-18	2003-02-17	Sel de perindopril et les compositions pharmaceutiques qui le contiennent

Publications (1)

Publication Number	Publication Date
UA79463C2 true UA79463C2 (en)	2007-06-25

Family

ID=8871521

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA20041109440A UA79463C2 (en)	2002-04-18	2003-02-17	Perindopril salt and pharmaceutical composition containing thereof

Country Status (37)

Country	Link
US (1)	US6696481B2 (de)
EP (1)	EP1354873B1 (de)
JP (1)	JP3737488B2 (de)
KR (1)	KR100542468B1 (de)
CN (1)	CN1211365C (de)
AP (1)	AP1787A (de)
AR (1)	AR039428A1 (de)
AT (1)	ATE271036T1 (de)
AU (2)	AU2003222921A1 (de)
BR (1)	BR0300709A (de)
CA (1)	CA2423825C (de)
CR (1)	CR7576A (de)
DE (1)	DE60300011T2 (de)
DK (1)	DK1354873T3 (de)
EA (1)	EA005676B1 (de)
EC (1)	ECSP045441A (de)
ES (1)	ES2224092T3 (de)
FR (1)	FR2838648B1 (de)
GE (1)	GEP20074211B (de)
HR (1)	HRP20041079B1 (de)
IL (1)	IL164424A (de)
IS (1)	IS2842B (de)
MA (1)	MA27115A1 (de)
ME (1)	ME00454B (de)
MX (1)	MXPA03002346A (de)
NO (1)	NO324323B1 (de)
NZ (1)	NZ524478A (de)
OA (1)	OA12806A (de)
PL (1)	PL359321A1 (de)
PT (1)	PT1354873E (de)
RS (1)	RS51694B (de)
SI (1)	SI1354873T1 (de)
TN (1)	TNSN04206A1 (de)
TR (1)	TR200401793T4 (de)
UA (1)	UA79463C2 (de)
WO (1)	WO2003087050A2 (de)
ZA (1)	ZA200301395B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2395195A (en) *	2002-11-18	2004-05-19	Cipla Ltd	Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
JP4948392B2 (ja) *	2004-03-29	2012-06-06	レラボラトアセルビエ	固形薬学的組成物を調製するためのプロセス
SI21800A (sl)	2004-05-14	2005-12-31	Krka, Tovarna Zdravil, D.D., Novo Mesto	Nov postopek sinteze perindoprila
SI1679072T1 (sl) *	2005-01-06	2009-02-28	Ipca Lab Ltd	Postopek za sintezo derivatov (2S,3aS,7aS)-1-(S)-alanil-oktahidro-1H-indol-2-karboksilne kisline inuporaba v sintezi perindoprila
EP1861367B1 (de) *	2005-03-14	2009-07-15	Les Laboratoires Servier	Verbessertes verfahren zur aufreinigung von perindopril
FR2894825B1 (fr) *	2005-12-21	2010-12-03	Servier Lab	Nouvelle association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion et les compositions pharmaceutiques qui la contiennent
FR2897866B1 (fr) *	2006-02-28	2008-04-18	Servier Lab	Forme cristalline alpha du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2897865B1 (fr) *	2006-02-28	2008-04-18	Servier Lab	Forme cristalline beta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
GB0624084D0 (en) *	2006-12-01	2007-01-10	Selamine Ltd	Ramipril amino acid salts
GB0624087D0 (en) *	2006-12-01	2007-01-10	Selamine Ltd	Ramipril combination salt
GB0624090D0 (en) *	2006-12-01	2007-01-10	Selamine Ltd	Ramipril amine salts
SI22542A (sl) *	2007-06-04	2008-12-31	Diagen D.O.O.	Stabilna formulacija amorfnih soli perindoprila, postopek za njeno pripravo v industrijskem merilu in njena uporaba za zdravljenje hipertenzije
HUE025982T2 (en)	2008-06-24	2016-05-30	Mylan Laboratories Ltd	New polymorphic forms of perindopril (L) -arginine and a process for their preparation
AU2009212902A1 (en) *	2008-09-03	2010-03-18	Apotex Pharmachem Inc.	Amorphous form of an L-arginine salt of perindopril and processes of preparation thereof
CN101766598A (zh) *	2008-12-31	2010-07-07	东英（江苏）药业有限公司	含有培哚普利的药物组合物
GB0910692D0 (en)	2009-06-20	2009-08-05	Teva Pharma	Compound
SI23149A (sl)	2009-09-21	2011-03-31	Silverstone Pharma	Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni
FR2961105B1 (fr) *	2010-06-15	2013-02-08	Servier Lab	Utilisation de l'association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion de l'angiotensine pour le traitement de l'insuffisance cardiaque
FR2985512B1 (fr)	2012-01-05	2014-06-20	Servier Lab	Procede de preparation du sel de l-arginine du perindopril
FR2985511B1 (fr) *	2012-01-05	2014-01-03	Servier Lab	Forme cristalline delta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
CN103172696B (zh) *	2012-12-19	2014-12-17	宁波美诺华药业股份有限公司	一种γ晶型的培哚普利精氨酸盐的制备方法
FR3040303B1 (fr) *	2015-08-27	2019-04-05	Les Laboratoires Servier Suivi Par Sabine Goudeau-Wenger	Composition pharmaceutique comprenant un inhibiteur de la hmg-coa reductase et un inhibiteur eca
PH12018502155B1 (en)	2016-04-20	2024-03-27	Servier Lab	Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
EP3842035A1 (de)	2019-12-23	2021-06-30	KRKA, d.d., Novo mesto	Zusammensetzung zur herstellung von perindopril-arginin-granulaten, verfahren zu ihrer herstellung und pharmazeutische zusammensetzung damit
SI26268A (sl)	2021-11-18	2023-05-31	Zupet Rok	Postopek za pripravo hidratirane oblike perindopril l-arginina

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2503155A2 (fr) *	1980-10-02	1982-10-08	Science Union & Cie	Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2811320B1 (fr) *	2000-07-06	2002-08-23	Adir	Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent

2002
- 2002-04-18 FR FR0204847A patent/FR2838648B1/fr not_active Expired - Lifetime
2003
- 2003-02-17 ME MEP-2008-688A patent/ME00454B/me unknown
- 2003-02-17 HR HRP20041079AA patent/HRP20041079B1/hr not_active IP Right Cessation
- 2003-02-17 AP APAP/P/2004/003154A patent/AP1787A/en active
- 2003-02-17 DK DK03290383T patent/DK1354873T3/da active
- 2003-02-17 TR TR2004/01793T patent/TR200401793T4/xx unknown
- 2003-02-17 AT AT03290383T patent/ATE271036T1/de active
- 2003-02-17 GE GEAP8501A patent/GEP20074211B/en unknown
- 2003-02-17 PT PT03290383T patent/PT1354873E/pt unknown
- 2003-02-17 WO PCT/FR2003/000507 patent/WO2003087050A2/fr not_active Ceased
- 2003-02-17 AU AU2003222921A patent/AU2003222921A1/en not_active Abandoned
- 2003-02-17 RS YU90904A patent/RS51694B/sr unknown
- 2003-02-17 OA OA1200400279A patent/OA12806A/en unknown
- 2003-02-17 ES ES03290383T patent/ES2224092T3/es not_active Expired - Lifetime
- 2003-02-17 UA UA20041109440A patent/UA79463C2/uk unknown
- 2003-02-17 SI SI200330002T patent/SI1354873T1/xx unknown
- 2003-02-17 EP EP03290383A patent/EP1354873B1/de not_active Expired - Lifetime
- 2003-02-17 DE DE60300011T patent/DE60300011T2/de not_active Expired - Lifetime
- 2003-02-20 ZA ZA200301395A patent/ZA200301395B/xx unknown
- 2003-02-21 US US10/371,865 patent/US6696481B2/en not_active Expired - Lifetime
- 2003-02-24 NO NO20030849A patent/NO324323B1/no not_active IP Right Cessation
- 2003-02-27 AU AU2003200700A patent/AU2003200700C1/en not_active Revoked
- 2003-02-28 NZ NZ524478A patent/NZ524478A/en not_active IP Right Cessation
- 2003-03-07 CN CNB031071481A patent/CN1211365C/zh not_active Expired - Lifetime
- 2003-03-18 MX MXPA03002346A patent/MXPA03002346A/es active IP Right Grant
- 2003-03-20 KR KR1020030017434A patent/KR100542468B1/ko not_active Expired - Lifetime
- 2003-03-21 BR BR0300709-0A patent/BR0300709A/pt not_active Application Discontinuation
- 2003-03-24 PL PL03359321A patent/PL359321A1/xx not_active Application Discontinuation
- 2003-03-25 JP JP2003083250A patent/JP3737488B2/ja not_active Expired - Lifetime
- 2003-04-03 EA EA200300334A patent/EA005676B1/ru unknown
- 2003-04-03 CA CA002423825A patent/CA2423825C/fr not_active Expired - Fee Related
- 2003-04-16 AR ARP030101332A patent/AR039428A1/es not_active Application Discontinuation
2004
- 2004-10-05 IL IL164424A patent/IL164424A/en active IP Right Grant
- 2004-10-15 TN TNP2004000206A patent/TNSN04206A1/en unknown
- 2004-10-27 IS IS7516A patent/IS2842B/is unknown
- 2004-11-03 MA MA27926A patent/MA27115A1/fr unknown
- 2004-11-18 CR CR7576A patent/CR7576A/es unknown
- 2004-11-18 EC EC2004005441A patent/ECSP045441A/es unknown

Also Published As

Publication number	Publication date
SI1354873T1 (en)	2004-12-31
ECSP045441A (es)	2005-03-10
AR039428A1 (es)	2005-02-16
EP1354873A1 (de)	2003-10-22
ZA200301395B (en)	2003-09-02
DE60300011D1 (de)	2004-08-19
IL164424A0 (en)	2005-12-18
WO2003087050A3 (fr)	2004-03-25
AU2003222921A1 (en)	2003-10-27
DK1354873T3 (da)	2004-11-01
AU2003200700C1 (en)	2015-04-23
CN1451656A (zh)	2003-10-29
AU2003200700A1 (en)	2003-11-06
CA2423825A1 (fr)	2003-10-18
JP3737488B2 (ja)	2006-01-18
PL359321A1 (en)	2003-10-20
AU2003200700B2 (en)	2005-01-20
HK1057367A1 (en)	2004-04-02
FR2838648A1 (fr)	2003-10-24
AP1787A (en)	2007-10-04
MXPA03002346A (es)	2005-08-26
ES2224092T3 (es)	2005-03-01
EA200300334A1 (ru)	2003-12-25
WO2003087050A2 (fr)	2003-10-23
FR2838648B1 (fr)	2004-05-21
KR100542468B1 (ko)	2006-01-11
US6696481B2 (en)	2004-02-24
MA27115A1 (fr)	2004-12-20
NO20030849D0 (no)	2003-02-24
US20030199568A1 (en)	2003-10-23
DE60300011T2 (de)	2005-03-17
HRP20041079B1 (hr)	2013-04-30
NO20030849L (no)	2003-10-20
EA005676B1 (ru)	2005-04-28
TNSN04206A1 (en)	2007-03-12
ME00454B (me)	2011-10-10
ATE271036T1 (de)	2004-07-15
BR0300709A (pt)	2004-09-08
IL164424A (en)	2010-12-30
RS51694B (sr)	2011-10-31
AP2004003154A0 (en)	2004-12-31
EP1354873B1 (de)	2004-07-14
CR7576A (es)	2008-08-21
HRP20041079A2 (en)	2004-12-31
IS2842B (is)	2013-08-15
PT1354873E (pt)	2004-10-29
TR200401793T4 (tr)	2004-08-23
CN1211365C (zh)	2005-07-20
NZ524478A (en)	2004-05-28
CA2423825C (fr)	2006-02-21
OA12806A (en)	2006-07-11
KR20030082902A (ko)	2003-10-23
RS90904A (sr)	2007-02-05
NO324323B1 (no)	2007-09-24
GEP20074211B (en)	2007-10-10
IS7516A (is)	2004-10-27
AU2003222921A8 (en)	2003-10-27
JP2003321493A (ja)	2003-11-11

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