UA80965C2 - Kit comprising steroids, tetrahydrofolate components and vitamin b12 kit for use in a hormonal contraceptive method or hormone replacement therapy - Google Patents

Kit comprising steroids, tetrahydrofolate components and vitamin b12 kit for use in a hormonal contraceptive method or hormone replacement therapy Download PDF

Info

Publication number: UA80965C2
Authority: UA; Ukraine
Prior art keywords: vitamin; acid; kit according; tetrahydrofolic; standard doses
Prior art date: 2002-02-21

Application number

UA20040907578A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-21

Filing date

2002-11-15

Publication date

2007-11-26

2002-11-15 Application filed by Schering Ag filed Critical Schering Ag

2007-11-26 Publication of UA80965C2 publication Critical patent/UA80965C2/uk

Links

238000000034 method Methods 0.000 title claims abstract description 66
MSTNYGQPCMXVAQ-RYUDHWBXSA-N (6S)-5,6,7,8-tetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1)N)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-RYUDHWBXSA-N 0.000 title claims abstract description 54
239000005460 tetrahydrofolate Substances 0.000 title claims abstract description 54
150000003431 steroids Chemical class 0.000 title claims abstract description 34
238000002657 hormone replacement therapy Methods 0.000 title claims abstract description 19
239000003433 contraceptive agent Substances 0.000 title abstract description 16
RMRCNWBMXRMIRW-WYVZQNDMSA-L vitamin b12 Chemical compound N([C@@H]([C@@]1(C)[C@@](C)(CC(N)=O)[C@H](CCC(N)=O)\C(N1[Co+]C#N)=C(/C)\C1=N\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NCC(C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO RMRCNWBMXRMIRW-WYVZQNDMSA-L 0.000 title 1
229940011871 estrogen Drugs 0.000 claims abstract description 32
239000000262 estrogen Substances 0.000 claims abstract description 32
239000000583 progesterone congener Substances 0.000 claims abstract description 31
150000003839 salts Chemical class 0.000 claims abstract description 15
125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims abstract description 14
MSTNYGQPCMXVAQ-KIYNQFGBSA-N 5,6,7,8-tetrahydrofolic acid Chemical class N1C=2C(=O)NC(N)=NC=2NCC1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-KIYNQFGBSA-N 0.000 claims abstract description 12
229940095055 progestogen systemic hormonal contraceptives Drugs 0.000 claims abstract description 10
229930003270 Vitamin B Natural products 0.000 claims description 68
235000019156 vitamin B Nutrition 0.000 claims description 68
239000011720 vitamin B Substances 0.000 claims description 68
OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 52
235000019152 folic acid Nutrition 0.000 claims description 48
239000011724 folic acid Substances 0.000 claims description 45
229940014144 folate Drugs 0.000 claims description 38
229940088594 vitamin Drugs 0.000 claims description 27
229930003231 vitamin Natural products 0.000 claims description 27
235000013343 vitamin Nutrition 0.000 claims description 27
239000011782 vitamin Substances 0.000 claims description 27
150000003722 vitamin derivatives Chemical class 0.000 claims description 24
230000007812 deficiency Effects 0.000 claims description 21
VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 claims description 17
MPJKWIXIYCLVCU-UHFFFAOYSA-N Folinic acid Natural products NC1=NC2=C(N(C=O)C(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)CC(=O)O)CN2)C(=O)N1 MPJKWIXIYCLVCU-UHFFFAOYSA-N 0.000 claims description 17
VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 claims description 17
235000008191 folinic acid Nutrition 0.000 claims description 17
239000011672 folinic acid Substances 0.000 claims description 17
229960001691 leucovorin Drugs 0.000 claims description 17
BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims description 13
BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims description 13
229960002568 ethinylestradiol Drugs 0.000 claims description 13
206010016880 Folate deficiency Diseases 0.000 claims description 12
230000003054 hormonal effect Effects 0.000 claims description 12
239000002253 acid Substances 0.000 claims description 11
241000124008 Mammalia Species 0.000 claims description 10
239000002243 precursor Substances 0.000 claims description 10
229960004400 levonorgestrel Drugs 0.000 claims description 9
239000000126 substance Substances 0.000 claims description 9
208000024891 symptom Diseases 0.000 claims description 9
WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 claims description 7
150000007513 acids Chemical class 0.000 claims description 7
229940126601 medicinal product Drugs 0.000 claims description 7
229940105150 5-methyltetrahydrofolic acid Drugs 0.000 claims description 5
GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims description 5
229930003571 Vitamin B5 Natural products 0.000 claims description 5
FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 5
229960002079 calcium pantothenate Drugs 0.000 claims description 5
229940079593 drug Drugs 0.000 claims description 5
239000003814 drug Substances 0.000 claims description 5
ZNOVTXRBGFNYRX-ABLWVSNPSA-N levomefolic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 ZNOVTXRBGFNYRX-ABLWVSNPSA-N 0.000 claims description 5
235000009492 vitamin B5 Nutrition 0.000 claims description 5
239000011675 vitamin B5 Substances 0.000 claims description 5
206010058359 Hypogonadism Diseases 0.000 claims description 3
230000016087 ovulation Effects 0.000 claims description 3
238000012876 topography Methods 0.000 claims 1
QYNUQALWYRSVHF-OLZOCXBDSA-N (6R)-5,10-methylenetetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1C1)N)N1C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QYNUQALWYRSVHF-OLZOCXBDSA-N 0.000 abstract description 2
VVIAGPKUTFNRDU-STQMWFEESA-N (6S)-5-formyltetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1C=O)N)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-STQMWFEESA-N 0.000 abstract description 2
FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 abstract 2
229940045999 vitamin b 12 Drugs 0.000 abstract 2
ZNOVTXRBGFNYRX-STQMWFEESA-N (6S)-5-methyltetrahydrofolic acid Chemical compound C([C@@H]1N(C=2C(=O)N=C(N)NC=2NC1)C)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 ZNOVTXRBGFNYRX-STQMWFEESA-N 0.000 abstract 1
AUFGTPPARQZWDO-YPMHNXCESA-N 10-formyltetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1)N)N(C=O)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 AUFGTPPARQZWDO-YPMHNXCESA-N 0.000 abstract 1
210000002966 serum Anatomy 0.000 description 23
229940127234 oral contraceptive Drugs 0.000 description 16
239000003539 oral contraceptive agent Substances 0.000 description 16
208000007642 Vitamin B Deficiency Diseases 0.000 description 15
239000000203 mixture Substances 0.000 description 13
229940124558 contraceptive agent Drugs 0.000 description 9
238000002474 experimental method Methods 0.000 description 9
230000015572 biosynthetic process Effects 0.000 description 8
239000006187 pill Substances 0.000 description 8
NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 description 8
OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 7
229960000304 folic acid Drugs 0.000 description 7
-1 kinestranol Chemical compound 0.000 description 7
229930003451 Vitamin B1 Natural products 0.000 description 6
230000008901 benefit Effects 0.000 description 6
RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 6
229960003495 thiamine Drugs 0.000 description 6
DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 6
238000011282 treatment Methods 0.000 description 6
235000010374 vitamin B1 Nutrition 0.000 description 6
239000011691 vitamin B1 Substances 0.000 description 6
FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 description 5
230000005856 abnormality Effects 0.000 description 5
VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 5
235000007682 pyridoxal 5'-phosphate Nutrition 0.000 description 5
239000011589 pyridoxal 5'-phosphate Substances 0.000 description 5
RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 5
YNOXCRMFGMSKIJ-UHFFFAOYSA-N 2-methylcitric acid Chemical compound OC(=O)C(C)C(O)(C(O)=O)CC(O)=O YNOXCRMFGMSKIJ-UHFFFAOYSA-N 0.000 description 4
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 4
150000001875 compounds Chemical class 0.000 description 4
230000002254 contraceptive effect Effects 0.000 description 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
229940088597 hormone Drugs 0.000 description 4
230000004060 metabolic process Effects 0.000 description 4
239000002207 metabolite Substances 0.000 description 4
229960001327 pyridoxal phosphate Drugs 0.000 description 4
LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 4
238000003786 synthesis reaction Methods 0.000 description 4
208000000412 Avitaminosis Diseases 0.000 description 3
102000004190 Enzymes Human genes 0.000 description 3
108090000790 Enzymes Proteins 0.000 description 3
229920002472 Starch Polymers 0.000 description 3
206010047627 Vitamin deficiencies Diseases 0.000 description 3
239000001913 cellulose Chemical class 0.000 description 3
229920002678 cellulose Chemical class 0.000 description 3
235000000639 cyanocobalamin Nutrition 0.000 description 3
239000011666 cyanocobalamin Substances 0.000 description 3
229960002104 cyanocobalamin Drugs 0.000 description 3
METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 description 3
229960004845 drospirenone Drugs 0.000 description 3
METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 description 3
150000002224 folic acids Chemical class 0.000 description 3
230000002489 hematologic effect Effects 0.000 description 3
239000005556 hormone Substances 0.000 description 3
230000007774 longterm Effects 0.000 description 3
230000002503 metabolic effect Effects 0.000 description 3
ZIYVHBGGAOATLY-UHFFFAOYSA-N methylmalonic acid Chemical compound OC(=O)C(C)C(O)=O ZIYVHBGGAOATLY-UHFFFAOYSA-N 0.000 description 3
229940053934 norethindrone Drugs 0.000 description 3
229960000417 norgestimate Drugs 0.000 description 3
KIQQMECNKUGGKA-NMYWJIRASA-N norgestimate Chemical compound O/N=C/1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(OC(C)=O)C#C)[C@@H]4[C@@H]3CCC2=C\1 KIQQMECNKUGGKA-NMYWJIRASA-N 0.000 description 3
239000000902 placebo Substances 0.000 description 3
239000008107 starch Substances 0.000 description 3
235000019698 starch Nutrition 0.000 description 3
DBPWSSGDRRHUNT-CEGNMAFCSA-N 17α-hydroxyprogesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 DBPWSSGDRRHUNT-CEGNMAFCSA-N 0.000 description 2
VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 2
GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 2
206010002065 Anaemia megaloblastic Diseases 0.000 description 2
206010003591 Ataxia Diseases 0.000 description 2
GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 2
206010025476 Malabsorption Diseases 0.000 description 2
208000004155 Malabsorption Syndromes Diseases 0.000 description 2
208000000682 Megaloblastic Anemia Diseases 0.000 description 2
206010028980 Neoplasm Diseases 0.000 description 2
206010060860 Neurological symptom Diseases 0.000 description 2
AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
229930003776 Vitamin B4 Natural products 0.000 description 2
238000010521 absorption reaction Methods 0.000 description 2
239000013543 active substance Substances 0.000 description 2
229960000643 adenine Drugs 0.000 description 2
208000007502 anemia Diseases 0.000 description 2
210000004369 blood Anatomy 0.000 description 2
239000008280 blood Substances 0.000 description 2
201000011510 cancer Diseases 0.000 description 2
230000008859 change Effects 0.000 description 2
125000003346 cobalamin group Chemical group 0.000 description 2
229910017052 cobalt Inorganic materials 0.000 description 2
239000010941 cobalt Substances 0.000 description 2
GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 2
230000002860 competitive effect Effects 0.000 description 2
238000000354 decomposition reaction Methods 0.000 description 2
238000011161 development Methods 0.000 description 2
230000018109 developmental process Effects 0.000 description 2
201000010099 disease Diseases 0.000 description 2
208000035475 disorder Diseases 0.000 description 2
AJIPIJNNOJSSQC-NYLIRDPKSA-N estetrol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)[C@@H]4O)O)[C@@H]4[C@@H]3CCC2=C1 AJIPIJNNOJSSQC-NYLIRDPKSA-N 0.000 description 2
229950009589 estetrol Drugs 0.000 description 2
CHNXZKVNWQUJIB-CEGNMAFCSA-N ethisterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 CHNXZKVNWQUJIB-CEGNMAFCSA-N 0.000 description 2
210000003754 fetus Anatomy 0.000 description 2
229960002949 fluorouracil Drugs 0.000 description 2
230000003834 intracellular effect Effects 0.000 description 2
FRQMUZJSZHZSGN-HBNHAYAOSA-N medroxyprogesterone Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](O)(C(C)=O)CC[C@H]21 FRQMUZJSZHZSGN-HBNHAYAOSA-N 0.000 description 2
231100001016 megaloblastic anemia Toxicity 0.000 description 2
229960000485 methotrexate Drugs 0.000 description 2
229940068196 placebo Drugs 0.000 description 2
210000002381 plasma Anatomy 0.000 description 2
229960003387 progesterone Drugs 0.000 description 2
239000000186 progesterone Substances 0.000 description 2
235000008164 pyridoxal Nutrition 0.000 description 2
239000011674 pyridoxal Substances 0.000 description 2
229960003581 pyridoxal Drugs 0.000 description 2
150000003223 pyridoxals Chemical class 0.000 description 2
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
229950008546 trimegestone Drugs 0.000 description 2
JUNDJWOLDSCTFK-MTZCLOFQSA-N trimegestone Chemical compound C1CC2=CC(=O)CCC2=C2[C@@H]1[C@@H]1CC[C@@](C(=O)[C@@H](O)C)(C)[C@@]1(C)CC2 JUNDJWOLDSCTFK-MTZCLOFQSA-N 0.000 description 2
DZGWFCGJZKJUFP-UHFFFAOYSA-N tyramine Chemical compound NCCC1=CC=C(O)C=C1 DZGWFCGJZKJUFP-UHFFFAOYSA-N 0.000 description 2
235000008979 vitamin B4 Nutrition 0.000 description 2
239000011579 vitamin B4 Substances 0.000 description 2
229940011671 vitamin b6 Drugs 0.000 description 2
DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 description 1
PROQIPRRNZUXQM-UHFFFAOYSA-N (16alpha,17betaOH)-Estra-1,3,5(10)-triene-3,16,17-triol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 PROQIPRRNZUXQM-UHFFFAOYSA-N 0.000 description 1
GAIHSQSRHYQICG-DACBVQKSSA-N 1-[(6s,8r,9s,10r,13s,14s,17r)-17-hydroxy-6,10,13-trimethyl-1,2,3,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl]ethanone Chemical compound C([C@@]12C)CCC=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](O)(C(C)=O)CC[C@H]21 GAIHSQSRHYQICG-DACBVQKSSA-N 0.000 description 1
DBPWSSGDRRHUNT-UHFFFAOYSA-N 17alpha-hydroxy progesterone Natural products C1CC2=CC(=O)CCC2(C)C2C1C1CCC(C(=O)C)(O)C1(C)CC2 DBPWSSGDRRHUNT-UHFFFAOYSA-N 0.000 description 1
NVUUMOOKVFONOM-GPBSYSOESA-N 19-Norprogesterone Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 NVUUMOOKVFONOM-GPBSYSOESA-N 0.000 description 1
108010075604 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase Proteins 0.000 description 1
102000011848 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase Human genes 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
206010000598 Acrodynia Diseases 0.000 description 1
231100000455 Acrodynia Toxicity 0.000 description 1
206010001497 Agitation Diseases 0.000 description 1
208000007848 Alcoholism Diseases 0.000 description 1
ATXHVCQZZJYMCF-XUDSTZEESA-N Allylestrenol Chemical compound C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)CC=C)[C@@H]4[C@@H]3CCC2=C1 ATXHVCQZZJYMCF-XUDSTZEESA-N 0.000 description 1
206010002064 Anaemia macrocytic Diseases 0.000 description 1
206010010356 Congenital anomaly Diseases 0.000 description 1
206010010904 Convulsion Diseases 0.000 description 1
AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
208000020401 Depressive disease Diseases 0.000 description 1
201000004624 Dermatitis Diseases 0.000 description 1
LVHOURKCKUYIGK-RGUJTQARSA-N Dimethisterone Chemical compound C1([C@@H](C)C2)=CC(=O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@](C#CC)(O)[C@@]2(C)CC1 LVHOURKCKUYIGK-RGUJTQARSA-N 0.000 description 1
241000283073 Equus caballus Species 0.000 description 1
DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 description 1
JKQQZJHNUVDHKP-FQJIPJFPSA-N Flurogestone acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)C[C@@H]2O JKQQZJHNUVDHKP-FQJIPJFPSA-N 0.000 description 1
BJJXHLWLUDYTGC-ANULTFPQSA-N Gestrinone Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](CC)([C@](CC3)(O)C#C)C=C3)C3=C21 BJJXHLWLUDYTGC-ANULTFPQSA-N 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
102000001554 Hemoglobins Human genes 0.000 description 1
108010054147 Hemoglobins Proteins 0.000 description 1
UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
YNVGQYHLRCDXFQ-XGXHKTLJSA-N Lynestrenol Chemical compound C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 YNVGQYHLRCDXFQ-XGXHKTLJSA-N 0.000 description 1
208000002720 Malnutrition Diseases 0.000 description 1
UDKABVSQKJNZBH-DWNQPYOZSA-N Melengestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC(=C)[C@](OC(=O)C)(C(C)=O)[C@@]1(C)CC2 UDKABVSQKJNZBH-DWNQPYOZSA-N 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
206010027540 Microcytosis Diseases 0.000 description 1
208000010428 Muscle Weakness Diseases 0.000 description 1
206010028372 Muscular weakness Diseases 0.000 description 1
GFKCZHFKMGKIAQ-ABLWVSNPSA-N N1C=2C(=O)NC(N)=NC=2NCC1CNC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 Chemical compound N1C=2C(=O)NC(N)=NC=2NCC1CNC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 GFKCZHFKMGKIAQ-ABLWVSNPSA-N 0.000 description 1
208000012902 Nervous system disease Diseases 0.000 description 1
NIPLIJLVGZCKMP-UHFFFAOYSA-M Neurine Chemical compound [OH-].C[N+](C)(C)C=C NIPLIJLVGZCKMP-UHFFFAOYSA-M 0.000 description 1
208000025966 Neurological disease Diseases 0.000 description 1
PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
ICTXHFFSOAJUMG-SLHNCBLASA-N Norethynodrel Chemical compound C1CC(=O)CC2=C1[C@H]1CC[C@](C)([C@](CC3)(O)C#C)[C@@H]3[C@@H]1CC2 ICTXHFFSOAJUMG-SLHNCBLASA-N 0.000 description 1
ZXSWTMLNIIZPET-ZOFHRBRSSA-N Normethandrolone Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C)(O)[C@@]1(C)CC2 ZXSWTMLNIIZPET-ZOFHRBRSSA-N 0.000 description 1
CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 description 1
241000700159 Rattus Species 0.000 description 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
108010022394 Threonine synthase Proteins 0.000 description 1
IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical group O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 1
206010047601 Vitamin B1 deficiency Diseases 0.000 description 1
229930003471 Vitamin B2 Natural products 0.000 description 1
208000022440 X-linked sideroblastic anemia 1 Diseases 0.000 description 1
XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 1
230000009471 action Effects 0.000 description 1
201000007930 alcohol dependence Diseases 0.000 description 1
AHBKIEXBQNRDNL-FVCOMRFXSA-N algestone acetophenide Chemical compound C1([C@@]2(C)O[C@@]3([C@H](O2)C[C@@H]2[C@@]3(CC[C@@H]3[C@@]4(C)CCC(=O)C=C4CC[C@H]32)C)C(=O)C)=CC=CC=C1 AHBKIEXBQNRDNL-FVCOMRFXSA-N 0.000 description 1
229950006673 algestone acetophenide Drugs 0.000 description 1
229960002692 allylestrenol Drugs 0.000 description 1
150000001412 amines Chemical class 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
229950008564 anagestone Drugs 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
210000004102 animal cell Anatomy 0.000 description 1
208000002894 beriberi Diseases 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
230000000740 bleeding effect Effects 0.000 description 1
YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical class [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
239000002775 capsule Substances 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
238000002512 chemotherapy Methods 0.000 description 1
229960003996 chlormadinone Drugs 0.000 description 1
VUHJZBBCZGVNDZ-TTYLFXKOSA-N chlormadinone Chemical compound C1=C(Cl)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 VUHJZBBCZGVNDZ-TTYLFXKOSA-N 0.000 description 1
UUWYBLVKLIHDAU-UHFFFAOYSA-K cobalt(3+);[5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] 1-[3-[2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1h-corrin-21-id-3-yl]propanoylamino]propan-2 Chemical compound [Co+3].[O-]N=O.OCC1OC(N2C3=CC(C)=C(C)C=C3N=C2)C(O)C1OP([O-])(=O)OC(C)CNC(=O)CCC1(C)C(CC(N)=O)C2[N-]\C1=C(C)/C(C(C\1(C)C)CCC(N)=O)=N/C/1=C\C(C(C/1(CC(N)=O)C)CCC(N)=O)=N\C\1=C(C)/C1=NC2(C)C(C)(CC(N)=O)C1CCC(N)=O UUWYBLVKLIHDAU-UHFFFAOYSA-K 0.000 description 1
239000005515 coenzyme Substances 0.000 description 1
230000036461 convulsion Effects 0.000 description 1
229960003843 cyproterone Drugs 0.000 description 1
DUSHUSLJJMDGTE-ZJPMUUANSA-N cyproterone Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 DUSHUSLJJMDGTE-ZJPMUUANSA-N 0.000 description 1
238000006114 decarboxylation reaction Methods 0.000 description 1
230000002950 deficient Effects 0.000 description 1
229960001853 demegestone Drugs 0.000 description 1
JWAHBTQSSMYISL-MHTWAQMVSA-N demegestone Chemical compound C1CC2=CC(=O)CCC2=C2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(C)[C@@]1(C)CC2 JWAHBTQSSMYISL-MHTWAQMVSA-N 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
229960004976 desogestrel Drugs 0.000 description 1
RPLCPCMSCLEKRS-BPIQYHPVSA-N desogestrel Chemical compound C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 RPLCPCMSCLEKRS-BPIQYHPVSA-N 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
229960003309 dienogest Drugs 0.000 description 1
AZFLJNIPTRTECV-FUMNGEBKSA-N dienogest Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)([C@](CC3)(O)CC#N)CC3)C3=C21 AZFLJNIPTRTECV-FUMNGEBKSA-N 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000037213 diet Effects 0.000 description 1
102000004419 dihydrofolate reductase Human genes 0.000 description 1
OZRNSSUDZOLUSN-LBPRGKRZSA-N dihydrofolic acid Chemical compound N=1C=2C(=O)NC(N)=NC=2NCC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OZRNSSUDZOLUSN-LBPRGKRZSA-N 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
229950006690 dimethisterone Drugs 0.000 description 1
229960004913 dydrogesterone Drugs 0.000 description 1
JGMOKGBVKVMRFX-HQZYFCCVSA-N dydrogesterone Chemical compound C1=CC2=CC(=O)CC[C@@]2(C)[C@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 JGMOKGBVKVMRFX-HQZYFCCVSA-N 0.000 description 1
238000006911 enzymatic reaction Methods 0.000 description 1
206010015037 epilepsy Diseases 0.000 description 1
210000003743 erythrocyte Anatomy 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
229930182833 estradiol Natural products 0.000 description 1
229960005309 estradiol Drugs 0.000 description 1
GRXPVLPQNMUNNX-MHJRRCNVSA-N estrane Chemical compound C1CC2CCCC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 GRXPVLPQNMUNNX-MHJRRCNVSA-N 0.000 description 1
PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 description 1
229960001348 estriol Drugs 0.000 description 1
229960003399 estrone Drugs 0.000 description 1
229960000445 ethisterone Drugs 0.000 description 1
229960002941 etonogestrel Drugs 0.000 description 1
GCKFUYQCUCGESZ-BPIQYHPVSA-N etonogestrel Chemical compound O=C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 GCKFUYQCUCGESZ-BPIQYHPVSA-N 0.000 description 1
230000005714 functional activity Effects 0.000 description 1
BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
229960004761 gestrinone Drugs 0.000 description 1
150000003278 haem Chemical class 0.000 description 1
230000036541 health Effects 0.000 description 1
238000005534 hematocrit Methods 0.000 description 1
229960001340 histamine Drugs 0.000 description 1
210000005260 human cell Anatomy 0.000 description 1
DQOCFCZRZOAIBN-WZHZPDAFSA-L hydroxycobalamin Chemical compound O.[Co+2].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O DQOCFCZRZOAIBN-WZHZPDAFSA-L 0.000 description 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
229960002899 hydroxyprogesterone Drugs 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical class OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
208000006278 hypochromic anemia Diseases 0.000 description 1
230000031891 intestinal absorption Effects 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
238000010255 intramuscular injection Methods 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
229960001910 lynestrenol Drugs 0.000 description 1
201000006437 macrocytic anemia Diseases 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
230000036244 malformation Effects 0.000 description 1
239000003550 marker Substances 0.000 description 1
230000008774 maternal effect Effects 0.000 description 1
229960004616 medroxyprogesterone Drugs 0.000 description 1
229960001786 megestrol Drugs 0.000 description 1
RQZAXGRLVPAYTJ-GQFGMJRRSA-N megestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RQZAXGRLVPAYTJ-GQFGMJRRSA-N 0.000 description 1
229960004805 melengestrol Drugs 0.000 description 1
230000005906 menstruation Effects 0.000 description 1
IMSSROKUHAOUJS-MJCUULBUSA-N mestranol Chemical compound C1C[C@]2(C)[C@@](C#C)(O)CC[C@H]2[C@@H]2CCC3=CC(OC)=CC=C3[C@H]21 IMSSROKUHAOUJS-MJCUULBUSA-N 0.000 description 1
229960001390 mestranol Drugs 0.000 description 1
JEWJRMKHSMTXPP-BYFNXCQMSA-M methylcobalamin Chemical compound C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O JEWJRMKHSMTXPP-BYFNXCQMSA-M 0.000 description 1
235000007672 methylcobalamin Nutrition 0.000 description 1
239000011585 methylcobalamin Substances 0.000 description 1
229960000270 methylestrenolone Drugs 0.000 description 1
235000019691 monocalcium phosphate Nutrition 0.000 description 1
229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
229960003512 nicotinic acid Drugs 0.000 description 1
235000001968 nicotinic acid Nutrition 0.000 description 1
239000011664 nicotinic acid Substances 0.000 description 1
229960004911 nomegestrol Drugs 0.000 description 1
KZUIYQJTUIACIG-YBZCJVABSA-N nomegestrol Chemical compound C1=C(C)C2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 KZUIYQJTUIACIG-YBZCJVABSA-N 0.000 description 1
229960002831 norgestrienone Drugs 0.000 description 1
GVDMJXQHPUYPHP-FYQPLNBISA-N norgestrienone Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)([C@](CC3)(O)C#C)C=C3)C3=C21 GVDMJXQHPUYPHP-FYQPLNBISA-N 0.000 description 1
235000021590 normal diet Nutrition 0.000 description 1
235000016709 nutrition Nutrition 0.000 description 1
208000035824 paresthesia Diseases 0.000 description 1
230000000737 periodic effect Effects 0.000 description 1
208000033808 peripheral neuropathy Diseases 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
229960002036 phenytoin Drugs 0.000 description 1
230000001766 physiological effect Effects 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Chemical class 0.000 description 1
229920000036 polyvinylpyrrolidone Chemical class 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
230000035935 pregnancy Effects 0.000 description 1
238000009597 pregnancy test Methods 0.000 description 1
230000002265 prevention Effects 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
230000000757 progestagenic effect Effects 0.000 description 1
229960001584 promegestone Drugs 0.000 description 1
QFFCYTLOTYIJMR-XMGTWHOFSA-N promegestone Chemical compound C1CC2=CC(=O)CCC2=C2[C@@H]1[C@@H]1CC[C@@](C(=O)CC)(C)[C@@]1(C)CC2 QFFCYTLOTYIJMR-XMGTWHOFSA-N 0.000 description 1
ZMJGSOSNSPKHNH-UHFFFAOYSA-N pyridoxamine 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(CN)=C1O ZMJGSOSNSPKHNH-UHFFFAOYSA-N 0.000 description 1
235000008160 pyridoxine Nutrition 0.000 description 1
239000011677 pyridoxine Substances 0.000 description 1
WKSAUQYGYAYLPV-UHFFFAOYSA-N pyrimethamine Chemical compound CCC1=NC(N)=NC(N)=C1C1=CC=C(Cl)C=C1 WKSAUQYGYAYLPV-UHFFFAOYSA-N 0.000 description 1
229960000611 pyrimethamine Drugs 0.000 description 1
238000003127 radioimmunoassay Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
229960002477 riboflavin Drugs 0.000 description 1
229940076279 serotonin Drugs 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 1
229960001940 sulfasalazine Drugs 0.000 description 1
NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 description 1
229940124530 sulfonamide Drugs 0.000 description 1
150000003456 sulfonamides Chemical class 0.000 description 1
230000001629 suppression Effects 0.000 description 1
230000002195 synergetic effect Effects 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
238000011287 therapeutic dose Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
WZDGZWOAQTVYBX-XOINTXKNSA-N tibolone Chemical compound C([C@@H]12)C[C@]3(C)[C@@](C#C)(O)CC[C@H]3[C@@H]1[C@H](C)CC1=C2CCC(=O)C1 WZDGZWOAQTVYBX-XOINTXKNSA-N 0.000 description 1
229960001023 tibolone Drugs 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
238000005891 transamination reaction Methods 0.000 description 1
238000012546 transfer Methods 0.000 description 1
IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
229960001082 trimethoprim Drugs 0.000 description 1
229960003732 tyramine Drugs 0.000 description 1
210000003606 umbilical vein Anatomy 0.000 description 1
235000019164 vitamin B2 Nutrition 0.000 description 1
239000011716 vitamin B2 Substances 0.000 description 1
235000019158 vitamin B6 Nutrition 0.000 description 1
239000011726 vitamin B6 Substances 0.000 description 1
238000005303 weighing Methods 0.000 description 1
XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical class [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Gynecology & Obstetrics (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)

UA20040907578A 2002-02-21 2002-11-15 Kit comprising steroids, tetrahydrofolate components and vitamin b12 kit for use in a hormonal contraceptive method or hormone replacement therapy UA80965C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02075695		2002-02-21
PCT/NL2002/000741 WO2003070255A1 (en)	2002-02-21	2002-11-15	Pharmaceutical compositions comprising one or more steroids one or more tetrahydrofolate components and vitamin b12

Publications (1)

Publication Number	Publication Date
UA80965C2 true UA80965C2 (en)	2007-11-26

Family

ID=27741182

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA20040907578A UA80965C2 (en)	2002-02-21	2002-11-15	Kit comprising steroids, tetrahydrofolate components and vitamin b12 kit for use in a hormonal contraceptive method or hormone replacement therapy

Country Status (28)

Country	Link
US (1)	US20050164977A1 (sr)
EP (1)	EP1478373B1 (sr)
JP (1)	JP5037779B2 (sr)
KR (1)	KR100936827B1 (sr)
CN (1)	CN1620302B (sr)
AT (1)	ATE341333T1 (sr)
AU (1)	AU2002343249B2 (sr)
BR (1)	BR0215613A (sr)
CA (1)	CA2476940C (sr)
CR (1)	CR7420A (sr)
CY (1)	CY1106273T1 (sr)
DE (1)	DE60215224T2 (sr)
DK (1)	DK1478373T3 (sr)
EA (1)	EA007599B1 (sr)
EC (1)	ECSP045305A (sr)
ES (1)	ES2274107T3 (sr)
HU (1)	HUP0402674A3 (sr)
IL (2)	IL163579A0 (sr)
ME (1)	MEP37208A (sr)
MX (1)	MXPA04008185A (sr)
NO (1)	NO20043932L (sr)
NZ (1)	NZ534806A (sr)
PL (1)	PL209558B1 (sr)
PT (1)	PT1478373E (sr)
RS (1)	RS50909B (sr)
UA (1)	UA80965C2 (sr)
WO (1)	WO2003070255A1 (sr)
ZA (1)	ZA200407545B (sr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UY29527A1 (es) *	2005-05-13	2006-12-29	Schering Ag	Composicinn farmaccutica que contienen gestrgenos y/o estrngenos y 5-metil - (6s) - tetrhidrofolato.
US20060293295A1 (en) *	2005-05-13	2006-12-28	Kai Strothmann	Pharmaceutical composition comprising progestogens and/or estrogens and 5-methyl- (6S)-tetrahydrofolate
AU2012227235B2 (en) *	2005-05-13	2015-06-11	Bayer Intellectual Property Gmbh	Pharmaceutical composition comprising progestogens and/or estrogens and 5-methyl-(6S)-tetrahydrofolate
DE102005023301B4 (de) *	2005-05-13	2012-05-31	Bayer Schering Pharma Aktiengesellschaft	Pharmazeutische Zusammensetzung enthaltend Gestagene und/oder Estrogene und 5-Methyl-(6S)-tetrahydrofolat
AU2013202756B2 (en) *	2006-07-06	2015-06-04	Bayer Intellectual Property Gmbh	Pharmaceutical composition containing a tetrahydrofolic acid
MX2009000256A (es) *	2006-07-06	2009-02-18	Bayer Schering Pharma Ag	Preparaciones farmaceuticas para la anticoncepcion y para prevenir el riesgo de malformaciones congenitas.
EP1891959A1 (de) *	2006-08-14	2008-02-27	Bayer Schering Pharma Aktiengesellschaft	Pharmazeutische Zusammensetzung zur Kontrazeption und zur Verminderung des Risikos angeborener Fehlbildungen
US8617597B2 (en) *	2006-07-06	2013-12-31	Bayer Intellectual Property Gmbh	Pharmaceutical composition containing a tetrahydrofolic acid
CN101489563A (zh)	2006-07-06	2009-07-22	拜耳先灵医药股份有限公司	用于避孕和预防先天性畸形风险的药物制剂
GB0715502D0 (en) *	2007-08-08	2007-09-19	Univ Manchester	Methods
BRPI0908477A2 (pt) *	2008-02-13	2018-03-27	Bayer Schering Pharma Ag	sistema de distribuição de medicamento contendo estradiol
UY32836A (es)	2009-08-12	2011-03-31	Bayer Schering Pharma Ag	Partículas estabilizadas que comprenden 5-metil-(6s)-tetrahidrofolato
EP2324832B2 (de) *	2009-11-09	2016-11-30	Biogena Naturprodukte GmbH & Co KG	Nahrungsergänzungsmittel bei Einnahme von hormonellen Kontrazeptiva
AU2012264602B2 (en)	2011-06-01	2017-03-09	Estetra Srl	Process for the production of estetrol intermediates
WO2012164095A1 (en)	2011-06-01	2012-12-06	Estetra S.A.	Process for the production of estetrol intermediates
EP2383279A1 (en)	2011-07-19	2011-11-02	Pantarhei Bioscience B.V.	Process for the preparation of estetrol
ES2925534T3 (es) *	2011-11-05	2022-10-18	South Alabama Medical Science Found	Métodos, formulaciones y kits para reponer rápidamente los niveles de folato en mujeres
US9301920B2 (en)	2012-06-18	2016-04-05	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
ES2885523T3 (es)	2011-11-23	2021-12-14	Therapeuticsmd Inc	Formulaciones y terapias de reposición hormonal de combinación naturales
US20130338122A1 (en)	2012-06-18	2013-12-19	Therapeuticsmd, Inc.	Transdermal hormone replacement therapies
US20150196640A1 (en)	2012-06-18	2015-07-16	Therapeuticsmd, Inc.	Progesterone formulations having a desirable pk profile
US10806740B2 (en)	2012-06-18	2020-10-20	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
US10806697B2 (en)	2012-12-21	2020-10-20	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en)	2012-12-21	2015-11-10	Therapeuticsmd, Inc.	Soluble estradiol capsule for vaginal insertion
US10471072B2 (en)	2012-12-21	2019-11-12	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en)	2012-12-21	2022-02-15	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en)	2012-12-21	2020-02-25	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en)	2012-12-21	2020-01-21	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en)	2012-12-21	2022-03-08	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
WO2015086643A1 (en) *	2013-12-12	2015-06-18	Donesta Bioscience B.V.	Orally disintegrating solid dosage unit containing an estetrol component
MX2016014281A (es)	2014-05-22	2017-02-22	Therapeuticsmd Inc	Formulaciones y terapias de reemplazo de combinación de hormonas naturales.
US20160367567A1 (en)	2015-06-18	2016-12-22	Mithra Pharmaceuticals S.A.	Orodispersible dosage unit containing an estetrol component
HRP20210668T1 (hr)	2015-06-18	2021-05-28	Estetra Sprl	Orodisperzibilna tableta koja sadrži estetrol
UA123099C2 (uk)	2015-06-18	2021-02-17	Естетра Спрл	Диспергована в порожнині рота одиниця дозування, яка містить естетрольний компонент
MD3310346T2 (ro)	2015-06-18	2021-06-30	Estetra Sprl	Comprimată orodispersabilă ce conține estetrol
US10328087B2 (en)	2015-07-23	2019-06-25	Therapeuticsmd, Inc.	Formulations for solubilizing hormones
US10286077B2 (en)	2016-04-01	2019-05-14	Therapeuticsmd, Inc.	Steroid hormone compositions in medium chain oils
AU2017239645A1 (en)	2016-04-01	2018-10-18	Therapeuticsmd, Inc.	Steroid hormone pharmaceutical composition
CA3178291A1 (en)	2016-08-05	2018-04-12	Estetra Srl	Method for the management of dysmenorrhea and menstrual pain
TWI801561B (zh)	2018-04-19	2023-05-11	比利時商依思特拉私人有限責任公司	化合物及其用於緩解絕經相關症狀的用途
JOP20200260A1 (ar)	2018-04-19	2019-10-19	Estetra Sprl	مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
US11633405B2 (en)	2020-02-07	2023-04-25	Therapeuticsmd, Inc.	Steroid hormone pharmaceutical formulations
TWI893101B (zh)	2020-04-16	2025-08-11	比利時商埃斯特拉有限責任公司	具有降低之副作用之避孕組成物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0877563T3 (da) *	1996-01-31	2004-07-26	Univ South Alabama	Levnedsmiddel- og vitaminpræparater, der indeholder den naturlige isomer af reducerede folater
EP0934060A4 (en) *	1996-07-30	2001-01-03	Energetics	FOOD SUPPLEMENTS
US6274564B1 (en) *	1996-09-18	2001-08-14	William J. Sarill	Compositions of cobalamin and related corrinoids, and uses thereof
US6220453B1 (en) *	1998-04-07	2001-04-24	Fuji Photo Film Co., Ltd.	Blood filter unit
EP2002839A1 (en) *	1998-04-17	2008-12-17	Ortho McNeil Pharmaceutical, Inc.	Folic acid-containing pharmaceutical compositions, and related methods and delivery systems
AU4573899A (en) *	1998-06-19	2000-01-05	Beth Israel Deaconess Medical Center	Dietary supplement for post-menopausal women
US6479545B1 (en) *	1999-09-30	2002-11-12	Drugtech Corporation	Formulation for menopausal women
DE10022510A1 (de) *	2000-05-10	2001-11-15	Basf Ag	Zusammensetzungen enthaltend Folsäure und reduziertes Folat
BG104880A (en) *	2000-10-24	2002-04-30	Иван ХРИСТОВ	Medicamentous preparation for multiple sclerosis treatment

2002
- 2002-11-15 AU AU2002343249A patent/AU2002343249B2/en not_active Ceased
- 2002-11-15 DE DE60215224T patent/DE60215224T2/de not_active Expired - Lifetime
- 2002-11-15 PT PT02780174T patent/PT1478373E/pt unknown
- 2002-11-15 IL IL16357902A patent/IL163579A0/xx active IP Right Grant
- 2002-11-15 HU HU0402674A patent/HUP0402674A3/hu unknown
- 2002-11-15 DK DK02780174T patent/DK1478373T3/da active
- 2002-11-15 RS YUP-733/04A patent/RS50909B/sr unknown
- 2002-11-15 NZ NZ534806A patent/NZ534806A/en not_active IP Right Cessation
- 2002-11-15 WO PCT/NL2002/000741 patent/WO2003070255A1/en not_active Ceased
- 2002-11-15 KR KR1020047012983A patent/KR100936827B1/ko not_active Expired - Fee Related
- 2002-11-15 EA EA200401014A patent/EA007599B1/ru not_active IP Right Cessation
- 2002-11-15 ES ES02780174T patent/ES2274107T3/es not_active Expired - Lifetime
- 2002-11-15 US US10/505,555 patent/US20050164977A1/en not_active Abandoned
- 2002-11-15 BR BR0215613-0A patent/BR0215613A/pt not_active IP Right Cessation
- 2002-11-15 CN CN028282809A patent/CN1620302B/zh not_active Expired - Fee Related
- 2002-11-15 PL PL371441A patent/PL209558B1/pl not_active IP Right Cessation
- 2002-11-15 MX MXPA04008185A patent/MXPA04008185A/es active IP Right Grant
- 2002-11-15 JP JP2003569211A patent/JP5037779B2/ja not_active Expired - Fee Related
- 2002-11-15 EP EP02780174A patent/EP1478373B1/en not_active Expired - Lifetime
- 2002-11-15 ME MEP-372/08A patent/MEP37208A/xx unknown
- 2002-11-15 UA UA20040907578A patent/UA80965C2/uk unknown
- 2002-11-15 AT AT02780174T patent/ATE341333T1/de active
- 2002-11-15 CA CA2476940A patent/CA2476940C/en not_active Expired - Fee Related
2004
- 2004-08-17 IL IL163579A patent/IL163579A/en not_active IP Right Cessation
- 2004-08-20 CR CR7420A patent/CR7420A/es not_active Application Discontinuation
- 2004-09-20 NO NO20043932A patent/NO20043932L/no not_active Application Discontinuation
- 2004-09-20 ZA ZA200407545A patent/ZA200407545B/en unknown
- 2004-09-21 EC EC2004005305A patent/ECSP045305A/es unknown
2006
- 2006-11-30 CY CY20061101724T patent/CY1106273T1/el unknown

Also Published As

Publication number	Publication date
NO20043932L (no)	2004-11-19
RS50909B (sr)	2010-08-31
CA2476940C (en)	2011-11-01
CR7420A (es)	2006-02-06
AU2002343249A1 (en)	2003-09-09
PL371441A1 (en)	2005-06-13
MEP37208A (en)	2011-02-10
EP1478373B1 (en)	2006-10-04
US20050164977A1 (en)	2005-07-28
JP2005523283A (ja)	2005-08-04
JP5037779B2 (ja)	2012-10-03
PL209558B1 (pl)	2011-09-30
DK1478373T3 (da)	2007-01-15
PT1478373E (pt)	2007-01-31
EA200401014A1 (ru)	2006-10-27
HK1078780A1 (en)	2006-03-24
ECSP045305A (es)	2004-10-26
KR20040094711A (ko)	2004-11-10
CY1106273T1 (el)	2011-10-12
CN1620302A (zh)	2005-05-25
WO2003070255A1 (en)	2003-08-28
BR0215613A (pt)	2004-12-07
IL163579A0 (en)	2005-12-18
CA2476940A1 (en)	2003-08-28
IL163579A (en)	2011-03-31
ES2274107T3 (es)	2007-05-16
NZ534806A (en)	2006-05-26
MXPA04008185A (es)	2004-11-26
EP1478373A1 (en)	2004-11-24
CN1620302B (zh)	2011-04-27
ATE341333T1 (de)	2006-10-15
DE60215224T2 (de)	2007-08-23
HUP0402674A3 (en)	2012-12-28
DE60215224D1 (de)	2006-11-16
ZA200407545B (en)	2006-06-28
AU2002343249B2 (en)	2009-02-05
KR100936827B1 (ko)	2010-01-14
RS73304A (sr)	2007-02-05
EA007599B1 (ru)	2006-12-29
HUP0402674A2 (hu)	2005-04-28

Publication	Publication Date	Title
UA80965C2 (en)	2007-11-26	Kit comprising steroids, tetrahydrofolate components and vitamin b12 kit for use in a hormonal contraceptive method or hormone replacement therapy
US10463666B2 (en)	2019-11-05	Pharmaceutical composition comprising progestogens and/or estrogens and 5-methyl-(6S)-tetrahydrofolate
EP1071428A2 (en)	2001-01-31	Folic acid-containing pharmaceutical compositions, and related methods and delivery systems
US20060293295A1 (en)	2006-12-28	Pharmaceutical composition comprising progestogens and/or estrogens and 5-methyl- (6S)-tetrahydrofolate
HK1078780B (en)	2011-12-16	Pharmaceutical compositions comprising one or more steroids, one or more tetrahydrofolate components and vitamin b12
EP1148882B1 (en)	2007-08-01	Use of a plasma homocysteine content reducing agent for the reduction of the thromboembolic side effect risk induced by gestagen type hormones
AU2012227235B2 (en)	2015-06-11	Pharmaceutical composition comprising progestogens and/or estrogens and 5-methyl-(6S)-tetrahydrofolate
HK1153408A (en)	2012-03-30	Pharmazeutische zusammensetzung enthaltend gestagene und/oder estrogene und 5-methyl-(6s)-tetrahydrofolat
HK1118729B (en)	2013-05-10	Pharmazeutische zusammensetzung enthaltend gestagene und/oder estrogene und 5-methyl-(6s)-tetrahydrofolat