UA80965C2 - Kit comprising steroids, tetrahydrofolate components and vitamin b12 kit for use in a hormonal contraceptive method or hormone replacement therapy - Google Patents

Kit comprising steroids, tetrahydrofolate components and vitamin b12 kit for use in a hormonal contraceptive method or hormone replacement therapy Download PDF

Info

Publication number: UA80965C2
Authority: UA; Ukraine
Prior art keywords: vitamin; acid; kit according; tetrahydrofolic; standard doses
Prior art date: 2002-02-21

Application number

UA20040907578A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-21

Filing date

2002-11-15

Publication date

2007-11-26

2002-11-15 Application filed by Schering Ag filed Critical Schering Ag

2007-11-26 Publication of UA80965C2 publication Critical patent/UA80965C2/uk

Links

238000000034 method Methods 0.000 title claims abstract description 66
MSTNYGQPCMXVAQ-RYUDHWBXSA-N (6S)-5,6,7,8-tetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1)N)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-RYUDHWBXSA-N 0.000 title claims abstract description 54
239000005460 tetrahydrofolate Substances 0.000 title claims abstract description 54
150000003431 steroids Chemical class 0.000 title claims abstract description 34
238000002657 hormone replacement therapy Methods 0.000 title claims abstract description 19
239000003433 contraceptive agent Substances 0.000 title abstract description 16
RMRCNWBMXRMIRW-WYVZQNDMSA-L vitamin b12 Chemical compound N([C@@H]([C@@]1(C)[C@@](C)(CC(N)=O)[C@H](CCC(N)=O)\C(N1[Co+]C#N)=C(/C)\C1=N\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NCC(C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO RMRCNWBMXRMIRW-WYVZQNDMSA-L 0.000 title 1
229940011871 estrogen Drugs 0.000 claims abstract description 32
239000000262 estrogen Substances 0.000 claims abstract description 32
239000000583 progesterone congener Substances 0.000 claims abstract description 31
150000003839 salts Chemical class 0.000 claims abstract description 15
125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims abstract description 14
MSTNYGQPCMXVAQ-KIYNQFGBSA-N 5,6,7,8-tetrahydrofolic acid Chemical class N1C=2C(=O)NC(N)=NC=2NCC1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-KIYNQFGBSA-N 0.000 claims abstract description 12
229940095055 progestogen systemic hormonal contraceptives Drugs 0.000 claims abstract description 10
229930003270 Vitamin B Natural products 0.000 claims description 68
235000019156 vitamin B Nutrition 0.000 claims description 68
239000011720 vitamin B Substances 0.000 claims description 68
OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 52
235000019152 folic acid Nutrition 0.000 claims description 48
239000011724 folic acid Substances 0.000 claims description 45
229940014144 folate Drugs 0.000 claims description 38
229940088594 vitamin Drugs 0.000 claims description 27
229930003231 vitamin Natural products 0.000 claims description 27
235000013343 vitamin Nutrition 0.000 claims description 27
239000011782 vitamin Substances 0.000 claims description 27
150000003722 vitamin derivatives Chemical class 0.000 claims description 24
230000007812 deficiency Effects 0.000 claims description 21
VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 claims description 17
MPJKWIXIYCLVCU-UHFFFAOYSA-N Folinic acid Natural products NC1=NC2=C(N(C=O)C(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)CC(=O)O)CN2)C(=O)N1 MPJKWIXIYCLVCU-UHFFFAOYSA-N 0.000 claims description 17
VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 claims description 17
235000008191 folinic acid Nutrition 0.000 claims description 17
239000011672 folinic acid Substances 0.000 claims description 17
229960001691 leucovorin Drugs 0.000 claims description 17
BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims description 13
BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims description 13
229960002568 ethinylestradiol Drugs 0.000 claims description 13
206010016880 Folate deficiency Diseases 0.000 claims description 12
230000003054 hormonal effect Effects 0.000 claims description 12
239000002253 acid Substances 0.000 claims description 11
241000124008 Mammalia Species 0.000 claims description 10
239000002243 precursor Substances 0.000 claims description 10
229960004400 levonorgestrel Drugs 0.000 claims description 9
239000000126 substance Substances 0.000 claims description 9
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WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 claims description 7
150000007513 acids Chemical class 0.000 claims description 7
229940126601 medicinal product Drugs 0.000 claims description 7
229940105150 5-methyltetrahydrofolic acid Drugs 0.000 claims description 5
GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims description 5
229930003571 Vitamin B5 Natural products 0.000 claims description 5
FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 5
229960002079 calcium pantothenate Drugs 0.000 claims description 5
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239000003814 drug Substances 0.000 claims description 5
ZNOVTXRBGFNYRX-ABLWVSNPSA-N levomefolic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 ZNOVTXRBGFNYRX-ABLWVSNPSA-N 0.000 claims description 5
235000009492 vitamin B5 Nutrition 0.000 claims description 5
239000011675 vitamin B5 Substances 0.000 claims description 5
206010058359 Hypogonadism Diseases 0.000 claims description 3
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238000012876 topography Methods 0.000 claims 1
QYNUQALWYRSVHF-OLZOCXBDSA-N (6R)-5,10-methylenetetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1C1)N)N1C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QYNUQALWYRSVHF-OLZOCXBDSA-N 0.000 abstract description 2
VVIAGPKUTFNRDU-STQMWFEESA-N (6S)-5-formyltetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1C=O)N)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-STQMWFEESA-N 0.000 abstract description 2
FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 abstract 2
229940045999 vitamin b 12 Drugs 0.000 abstract 2
ZNOVTXRBGFNYRX-STQMWFEESA-N (6S)-5-methyltetrahydrofolic acid Chemical compound C([C@@H]1N(C=2C(=O)N=C(N)NC=2NC1)C)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 ZNOVTXRBGFNYRX-STQMWFEESA-N 0.000 abstract 1
AUFGTPPARQZWDO-YPMHNXCESA-N 10-formyltetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1)N)N(C=O)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 AUFGTPPARQZWDO-YPMHNXCESA-N 0.000 abstract 1
210000002966 serum Anatomy 0.000 description 23
229940127234 oral contraceptive Drugs 0.000 description 16
239000003539 oral contraceptive agent Substances 0.000 description 16
208000007642 Vitamin B Deficiency Diseases 0.000 description 15
239000000203 mixture Substances 0.000 description 13
229940124558 contraceptive agent Drugs 0.000 description 9
238000002474 experimental method Methods 0.000 description 9
230000015572 biosynthetic process Effects 0.000 description 8
239000006187 pill Substances 0.000 description 8
NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 description 8
OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 7
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-1 kinestranol Chemical compound 0.000 description 7
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230000008901 benefit Effects 0.000 description 6
RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 6
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DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 6
238000011282 treatment Methods 0.000 description 6
235000010374 vitamin B1 Nutrition 0.000 description 6
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FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 description 5
230000005856 abnormality Effects 0.000 description 5
VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 5
235000007682 pyridoxal 5'-phosphate Nutrition 0.000 description 5
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RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 5
YNOXCRMFGMSKIJ-UHFFFAOYSA-N 2-methylcitric acid Chemical compound OC(=O)C(C)C(O)(C(O)=O)CC(O)=O YNOXCRMFGMSKIJ-UHFFFAOYSA-N 0.000 description 4
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Reproductive Health (AREA)
Molecular Biology (AREA)
Gynecology & Obstetrics (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)

UA20040907578A 2002-02-21 2002-11-15 Kit comprising steroids, tetrahydrofolate components and vitamin b12 kit for use in a hormonal contraceptive method or hormone replacement therapy UA80965C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02075695		2002-02-21
PCT/NL2002/000741 WO2003070255A1 (en)	2002-02-21	2002-11-15	Pharmaceutical compositions comprising one or more steroids one or more tetrahydrofolate components and vitamin b12

Publications (1)

Publication Number	Publication Date
UA80965C2 true UA80965C2 (en)	2007-11-26

Family

ID=27741182

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA20040907578A UA80965C2 (en)	2002-02-21	2002-11-15	Kit comprising steroids, tetrahydrofolate components and vitamin b12 kit for use in a hormonal contraceptive method or hormone replacement therapy

Country Status (28)

Country	Link
US (1)	US20050164977A1 (sr)
EP (1)	EP1478373B1 (sr)
JP (1)	JP5037779B2 (sr)
KR (1)	KR100936827B1 (sr)
CN (1)	CN1620302B (sr)
AT (1)	ATE341333T1 (sr)
AU (1)	AU2002343249B2 (sr)
BR (1)	BR0215613A (sr)
CA (1)	CA2476940C (sr)
CR (1)	CR7420A (sr)
CY (1)	CY1106273T1 (sr)
DE (1)	DE60215224T2 (sr)
DK (1)	DK1478373T3 (sr)
EA (1)	EA007599B1 (sr)
EC (1)	ECSP045305A (sr)
ES (1)	ES2274107T3 (sr)
HU (1)	HUP0402674A3 (sr)
IL (2)	IL163579A0 (sr)
ME (1)	MEP37208A (sr)
MX (1)	MXPA04008185A (sr)
NO (1)	NO20043932L (sr)
NZ (1)	NZ534806A (sr)
PL (1)	PL209558B1 (sr)
PT (1)	PT1478373E (sr)
RS (1)	RS50909B (sr)
UA (1)	UA80965C2 (sr)
WO (1)	WO2003070255A1 (sr)
ZA (1)	ZA200407545B (sr)

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EP2324832B2 (de) *	2009-11-09	2016-11-30	Biogena Naturprodukte GmbH & Co KG	Nahrungsergänzungsmittel bei Einnahme von hormonellen Kontrazeptiva
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US10357496B2 (en) *	2011-11-05	2019-07-23	South Alabama Medical Science Foundation	Methods, formulations, and kits for rapidly repleting folate levels in women
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RS62297B1 (sr)	2011-11-23	2021-09-30	Therapeuticsmd Inc	Prirodne kombinovane hormonske supstitucione formulacije i terapije
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US10806697B2 (en)	2012-12-21	2020-10-20	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en)	2012-06-18	2015-07-16	Therapeuticsmd, Inc.	Progesterone formulations having a desirable pk profile
US10806740B2 (en)	2012-06-18	2020-10-20	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
US11266661B2 (en)	2012-12-21	2022-03-08	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en)	2012-12-21	2022-02-15	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en)	2012-12-21	2019-11-12	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en)	2012-12-21	2015-11-10	Therapeuticsmd, Inc.	Soluble estradiol capsule for vaginal insertion
US10568891B2 (en)	2012-12-21	2020-02-25	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en)	2012-12-21	2020-01-21	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
HUE035848T2 (en) *	2013-12-12	2018-05-28	Donesta Bioscience B V	Solid dispensing unit containing an estetrol compound in the mouth
RU2016143081A (ru)	2014-05-22	2018-06-26	Терапьютиксмд, Инк.	Натуральные комбинированные гормонозаместительные составы и терапии
RS57328B1 (sr)	2015-06-18	2018-08-31	Mithra Pharmaceuticals S A	Orodisperzibilna dozna jedinica koja sadrži estetrolsku komponentu
WO2016203044A1 (en)	2015-06-18	2016-12-22	Mithra Pharmaceuticals S.A.	Orodispersible tablet containing estetrol
NZ737945A (en) *	2015-06-18	2023-06-30	Estetra Sprl	Orodispersible dosage unit containing an estetrol component
LT3310345T (lt)	2015-06-18	2021-06-25	Estetra Sprl	Burnoje disperguojama tabletė, turinti estetrolio
US10328087B2 (en)	2015-07-23	2019-06-25	Therapeuticsmd, Inc.	Formulations for solubilizing hormones
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2002
- 2002-11-15 CA CA2476940A patent/CA2476940C/en not_active Expired - Fee Related
- 2002-11-15 CN CN028282809A patent/CN1620302B/zh not_active Expired - Fee Related
- 2002-11-15 ES ES02780174T patent/ES2274107T3/es not_active Expired - Lifetime
- 2002-11-15 RS YUP-733/04A patent/RS50909B/sr unknown
- 2002-11-15 WO PCT/NL2002/000741 patent/WO2003070255A1/en not_active Ceased
- 2002-11-15 DK DK02780174T patent/DK1478373T3/da active
- 2002-11-15 BR BR0215613-0A patent/BR0215613A/pt not_active IP Right Cessation
- 2002-11-15 AU AU2002343249A patent/AU2002343249B2/en not_active Ceased
- 2002-11-15 PT PT02780174T patent/PT1478373E/pt unknown
- 2002-11-15 MX MXPA04008185A patent/MXPA04008185A/es active IP Right Grant
- 2002-11-15 AT AT02780174T patent/ATE341333T1/de active
- 2002-11-15 PL PL371441A patent/PL209558B1/pl not_active IP Right Cessation
- 2002-11-15 NZ NZ534806A patent/NZ534806A/en not_active IP Right Cessation
- 2002-11-15 EP EP02780174A patent/EP1478373B1/en not_active Expired - Lifetime
- 2002-11-15 HU HU0402674A patent/HUP0402674A3/hu unknown
- 2002-11-15 EA EA200401014A patent/EA007599B1/ru not_active IP Right Cessation
- 2002-11-15 ME MEP-372/08A patent/MEP37208A/xx unknown
- 2002-11-15 US US10/505,555 patent/US20050164977A1/en not_active Abandoned
- 2002-11-15 IL IL16357902A patent/IL163579A0/xx active IP Right Grant
- 2002-11-15 JP JP2003569211A patent/JP5037779B2/ja not_active Expired - Fee Related
- 2002-11-15 UA UA20040907578A patent/UA80965C2/uk unknown
- 2002-11-15 DE DE60215224T patent/DE60215224T2/de not_active Expired - Lifetime
- 2002-11-15 KR KR1020047012983A patent/KR100936827B1/ko not_active Expired - Fee Related
2004
- 2004-08-17 IL IL163579A patent/IL163579A/en not_active IP Right Cessation
- 2004-08-20 CR CR7420A patent/CR7420A/es not_active Application Discontinuation
- 2004-09-20 NO NO20043932A patent/NO20043932L/no not_active Application Discontinuation
- 2004-09-20 ZA ZA200407545A patent/ZA200407545B/en unknown
- 2004-09-21 EC EC2004005305A patent/ECSP045305A/es unknown
2006
- 2006-11-30 CY CY20061101724T patent/CY1106273T1/el unknown

Also Published As

Publication number	Publication date
PL209558B1 (pl)	2011-09-30
US20050164977A1 (en)	2005-07-28
HUP0402674A3 (en)	2012-12-28
EP1478373B1 (en)	2006-10-04
MXPA04008185A (es)	2004-11-26
EA007599B1 (ru)	2006-12-29
KR20040094711A (ko)	2004-11-10
ZA200407545B (en)	2006-06-28
CN1620302B (zh)	2011-04-27
HK1078780A1 (en)	2006-03-24
JP5037779B2 (ja)	2012-10-03
DE60215224T2 (de)	2007-08-23
CR7420A (es)	2006-02-06
NZ534806A (en)	2006-05-26
RS73304A (sr)	2007-02-05
JP2005523283A (ja)	2005-08-04
EP1478373A1 (en)	2004-11-24
NO20043932L (no)	2004-11-19
CY1106273T1 (el)	2011-10-12
RS50909B (sr)	2010-08-31
AU2002343249B2 (en)	2009-02-05
KR100936827B1 (ko)	2010-01-14
CA2476940A1 (en)	2003-08-28
PT1478373E (pt)	2007-01-31
MEP37208A (en)	2011-02-10
PL371441A1 (en)	2005-06-13
HUP0402674A2 (hu)	2005-04-28
BR0215613A (pt)	2004-12-07
DE60215224D1 (de)	2006-11-16
AU2002343249A1 (en)	2003-09-09
IL163579A (en)	2011-03-31
ECSP045305A (es)	2004-10-26
WO2003070255A1 (en)	2003-08-28
CA2476940C (en)	2011-11-01
DK1478373T3 (da)	2007-01-15
ES2274107T3 (es)	2007-05-16
EA200401014A1 (ru)	2006-10-27
IL163579A0 (en)	2005-12-18
CN1620302A (zh)	2005-05-25
ATE341333T1 (de)	2006-10-15

Publication	Publication Date	Title
CA2476940C (en)	2011-11-01	Pharmaceutical compositions comprising one or more steroids, one or more tetrahydrofolate components and vitamin b12
US10463666B2 (en)	2019-11-05	Pharmaceutical composition comprising progestogens and/or estrogens and 5-methyl-(6S)-tetrahydrofolate
EP1071428A2 (en)	2001-01-31	Folic acid-containing pharmaceutical compositions, and related methods and delivery systems
EP2037935A1 (de)	2009-03-25	Pharmazeutische zubereitung zur kontrazeption und zur verminderung des risikos angeborener fehlbildungen
US20060293295A1 (en)	2006-12-28	Pharmaceutical composition comprising progestogens and/or estrogens and 5-methyl- (6S)-tetrahydrofolate
HK1078780B (en)	2011-12-16	Pharmaceutical compositions comprising one or more steroids, one or more tetrahydrofolate components and vitamin b12
EP1148882B1 (en)	2007-08-01	Use of a plasma homocysteine content reducing agent for the reduction of the thromboembolic side effect risk induced by gestagen type hormones
AU2012227235B2 (en)	2015-06-11	Pharmaceutical composition comprising progestogens and/or estrogens and 5-methyl-(6S)-tetrahydrofolate
WO2021102053A1 (en)	2021-05-27	Vitamin b12 compound supplementation methods and compositions
HK1153408A (en)	2012-03-30	Pharmazeutische zusammensetzung enthaltend gestagene und/oder estrogene und 5-methyl-(6s)-tetrahydrofolat
HK1118729B (en)	2013-05-10	Pharmazeutische zusammensetzung enthaltend gestagene und/oder estrogene und 5-methyl-(6s)-tetrahydrofolat