UA87278C2 - Пептиды, которые биологически не разлагаются; ингибитор ангиотензинпревращающего фермента, лекарственное средство и функциональный пищевой продукт - Google Patents

Пептиды, которые биологически не разлагаются; ингибитор ангиотензинпревращающего фермента, лекарственное средство и функциональный пищевой продукт

Info

Publication number: UA87278C2
Authority: UA; Ukraine
Prior art keywords: pro; drug; functional food; biologically non; ace inhibitor
Prior art date: 2003-08-01

Application number

UAA200602217A

Other languages

English (en)

Ukrainian (uk)

Inventor

Наоюки Ямамото

Сейити Мизуно

Синго Нисимура (умер)

Таканобу Готоу

Кейити Мацуура

Original Assignee

Калпис Ко., Лтд.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-08-01

Filing date

2004-07-30

Publication date

2009-07-10

2004-07-30 Application filed by Калпис Ко., Лтд. filed Critical Калпис Ко., Лтд.

2009-07-10 Publication of UA87278C2 publication Critical patent/UA87278C2/ru

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
239000005541 ACE inhibitor Substances 0.000 title abstract 2
229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 title abstract 2
229940079593 drug Drugs 0.000 title abstract 2
239000003814 drug Substances 0.000 title abstract 2
235000013376 functional food Nutrition 0.000 title abstract 2
102000004196 processed proteins & peptides Human genes 0.000 title 1
238000001727 in vivo Methods 0.000 abstract 3
230000001077 hypotensive effect Effects 0.000 abstract 2
LQJAALCCPOTJGB-YUMQZZPRSA-N Arg-Pro Chemical compound NC(N)=NCCC[C@H](N)C(=O)N1CCC[C@H]1C(O)=O LQJAALCCPOTJGB-YUMQZZPRSA-N 0.000 abstract 1
108010016626 Dipeptides Proteins 0.000 abstract 1
-1 Gin-Pro Chemical compound 0.000 abstract 1
YBTCBQBIJKGSJP-BQBZGAKWSA-N Glu-Pro Chemical compound OC(=O)CC[C@H](N)C(=O)N1CCC[C@H]1C(O)=O YBTCBQBIJKGSJP-BQBZGAKWSA-N 0.000 abstract 1
BBIXOODYWPFNDT-CIUDSAMLSA-N Ile-Pro Chemical compound CC[C@H](C)[C@H](N)C(=O)N1CCC[C@H]1C(O)=O BBIXOODYWPFNDT-CIUDSAMLSA-N 0.000 abstract 1
DZMGFGQBRYWJOR-YUMQZZPRSA-N Met-Pro Chemical compound CSCC[C@H](N)C(=O)N1CCC[C@H]1C(O)=O DZMGFGQBRYWJOR-YUMQZZPRSA-N 0.000 abstract 1
DINQYZRMXGWWTG-GUBZILKMSA-N Ser-Pro-Pro Chemical compound OC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(O)=O)CCC1 DINQYZRMXGWWTG-GUBZILKMSA-N 0.000 abstract 1
108010060035 arginylproline Proteins 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C07K5/06095—Arg-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Food Science & Technology (AREA)
Polymers & Plastics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Mycology (AREA)
Nutrition Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

UAA200602217A 2003-08-01 2004-07-30 Пептиды, которые биологически не разлагаются; ингибитор ангиотензинпревращающего фермента, лекарственное средство и функциональный пищевой продукт UA87278C2 (ru)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2003285007		2003-08-01

Publications (1)

Publication Number	Publication Date
UA87278C2 true UA87278C2 (ru)	2009-07-10

Family

ID=34113859

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
UAA200602217A UA87278C2 (ru)	2003-08-01	2004-07-30	Пептиды, которые биологически не разлагаются; ингибитор ангиотензинпревращающего фермента, лекарственное средство и функциональный пищевой продукт
UAA200602131A UA89616C2 (ru)	2003-08-01	2004-07-30	Гидролизат казеина, способ его получения и применения

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
UAA200602131A UA89616C2 (ru)	2003-08-01	2004-07-30	Гидролизат казеина, способ его получения и применения

Country Status (22)

Country	Link
US (3)	US20070122451A1 (ru)
EP (2)	EP1661909B1 (ru)
JP (3)	JP5341300B2 (ru)
KR (3)	KR101115560B1 (ru)
CN (3)	CN101381401A (ru)
AT (2)	ATE411035T1 (ru)
AU (2)	AU2004261855B2 (ru)
BR (2)	BRPI0413238A (ru)
CA (2)	CA2532537A1 (ru)
DE (2)	DE602004017202D1 (ru)
DK (2)	DK1661909T3 (ru)
EA (2)	EA010098B1 (ru)
ES (2)	ES2331312T3 (ru)
MX (2)	MXPA06000879A (ru)
NO (2)	NO20060994L (ru)
NZ (2)	NZ545340A (ru)
PL (1)	PL1669463T3 (ru)
PT (2)	PT1661909E (ru)
TW (2)	TWI349676B (ru)
UA (2)	UA87278C2 (ru)
WO (2)	WO2005012334A1 (ru)
ZA (2)	ZA200601746B (ru)

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AU2006239559B2 (en) *	2005-04-28	2010-09-02	Dsm Ip Assets B.V.	Peptides having an ace inhibiting effect
AU2006239560B2 (en) *	2005-04-28	2010-03-25	Unilever Plc	Peptides having an ace inhibiting effect
CA2616789A1 (en)	2005-07-26	2007-02-01	Calpis Co., Ltd.	Process for production of fermented milk and fermented milk beverage/food
CA2627566A1 (en) *	2005-10-28	2007-05-10	Nestec S.A.	Methods for the use of branched chain amino acids
US20100167979A1 (en) *	2006-02-09	2010-07-01	Calpis Co. Ltd	Rheumatoid arthritis-preventive agent for oral intake
JP4956164B2 (ja) *	2006-12-06	2012-06-20	味の素株式会社	メラニン輸送及び／又は放出抑制剤
CA2681746C (en) *	2007-03-27	2014-04-29	Calpis Co., Ltd.	Prophylactic agent for heart failure
CN101095457B (zh) *	2007-06-23	2010-04-07	临夏州华安生物制品有限责任公司	酸水解酪蛋白的生产方法
AU2009228250B2 (en) *	2008-03-26	2015-03-19	Glanbia Nutritionals (Ireland) Ltd.	Leucine-rich peptide compositions and methods for isolation
CN101768209B (zh) *	2009-01-05	2011-08-31	北京林业大学	具有高体内活性的降血压肽及其制备和纯化方法
CN101570568B (zh) *	2009-06-15	2012-05-30	东北农业大学	一种发酵乳中的ace抑制肽及其制备方法
CN102187935B (zh) *	2010-03-19	2012-12-19	江南大学	一种制备酪蛋白磷酸肽与ace抑制肽的方法
CN102399261B (zh) *	2010-09-07	2014-06-25	任发政	具有血管紧张素转化酶c-端选择性抑制活性的三肽及其应用和组合物
US20120115786A1 (en) *	2010-11-09	2012-05-10	Calpis Co., Ltd.	Agent for reducing risk in onset of disease ascribable to non-dipper circadian rhythm of blood pressure
US9523109B2 (en)	2011-06-24	2016-12-20	Calpis Co., Ltd.	Method for enzymatically preparing peptides for use in improvement of brain function
JP5718741B2 (ja) *	2011-06-24	2015-05-13	カルピス株式会社	脳機能改善用ペプチドの酵素的製造方法
HK1200058A1 (en) *	2011-10-14	2015-07-31	Abbott Laboratories	Sterilized liquid protein supplement
CN103215332A (zh) *	2013-04-16	2013-07-24	陕西科技大学	一种分步酶解羊乳酪蛋白制备ace抑制肽的方法
KR101850064B1 (ko)	2013-10-04	2018-04-19	주식회사 이노웨이	동물성 단백질 가수분해물, 이의 제조방법 및 이의 용도
FR3017536B1 (fr) *	2014-02-18	2017-05-26	Univ La Rochelle	Compositions pour la prevention et/ou le traitement de pathologies liees a l'alpha-glucosidase
ES2544153B1 (es) *	2014-02-24	2016-06-06	Ntd Labs, S.L.	Uso de un hidrolizado de caseína como agente antiviral
JP6251667B2 (ja)	2014-06-03	2017-12-20	アサヒカルピスウェルネス株式会社	錠剤型即放性製剤及びその製造方法
CN105693817B (zh)	2014-11-27	2020-06-05	西北大学	一类三肽化合物及其制备方法与应用
JP6005202B2 (ja) *	2015-03-19	2016-10-12	アサヒグループホールディングス株式会社	脳機能改善用ペプチドの酵素的製造方法
JP6625366B2 (ja) *	2015-08-05	2019-12-25	学校法人北里研究所	豚肉の熟成中に生成する生理活性ペプチドを含む血圧降下剤及び食品、並びにペプチドを指標とする豚肉の熟成評価法
CN106119325A (zh) *	2016-06-23	2016-11-16	哈尔滨商业大学	一种具有增加肌肉含量和力量作用的酪蛋白水解物的制备方法
CN107375897A (zh) *	2017-08-15	2017-11-24	普维食品发展（上海）有限公司	一种辅助降血压的组合物及其用途
CN107348511B (zh) *	2017-08-21	2018-04-06	东方红（通化）生物医药股份有限公司	一种具有辅助降血压作用的西洋参/人参提取物的发酵提取方法
CN108003231A (zh) *	2017-11-13	2018-05-08	江苏大学	一种降低小分子肽中游离氨基酸含量的方法
CN108588156A (zh) *	2018-04-24	2018-09-28	浙江大学	一种水牛乳酪蛋白抗氧化活性肽的制备方法
CN112041328B (zh) *	2018-04-26	2024-06-21	志瑞亚新药工业株式会社	二肽和含有该二肽的药物组合物
CN110467649A (zh) *	2019-09-12	2019-11-19	浙江省农业科学院	一种抑制血管紧张素转换酶活性的多肽qeip及其应用
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2004
- 2004-07-30 JP JP2005512524A patent/JP5341300B2/ja not_active Expired - Lifetime
- 2004-07-30 DE DE602004017202T patent/DE602004017202D1/de not_active Expired - Lifetime
- 2004-07-30 CN CNA2008101459809A patent/CN101381401A/zh active Pending
- 2004-07-30 MX MXPA06000879A patent/MXPA06000879A/es active IP Right Grant
- 2004-07-30 DK DK04771089.2T patent/DK1661909T3/da active
- 2004-07-30 EP EP04771089A patent/EP1661909B1/en not_active Expired - Lifetime
- 2004-07-30 ES ES04771089T patent/ES2331312T3/es not_active Expired - Lifetime
- 2004-07-30 AT AT04771088T patent/ATE411035T1/de active
- 2004-07-30 EA EA200600349A patent/EA010098B1/ru not_active IP Right Cessation
- 2004-07-30 CA CA002532537A patent/CA2532537A1/en not_active Abandoned
- 2004-07-30 NZ NZ545340A patent/NZ545340A/en not_active IP Right Cessation
- 2004-07-30 TW TW093123001A patent/TWI349676B/zh not_active IP Right Cessation
- 2004-07-30 EA EA200600352A patent/EA011570B1/ru not_active IP Right Cessation
- 2004-07-30 CN CNB2004800223447A patent/CN100439393C/zh not_active Expired - Fee Related
- 2004-07-30 ES ES04771088T patent/ES2313067T3/es not_active Expired - Lifetime
- 2004-07-30 PT PT04771089T patent/PT1661909E/pt unknown
- 2004-07-30 DE DE602004023210T patent/DE602004023210D1/de not_active Expired - Lifetime
- 2004-07-30 DK DK04771088T patent/DK1669463T3/da active
- 2004-07-30 BR BRPI0413238-6A patent/BRPI0413238A/pt not_active IP Right Cessation
- 2004-07-30 AU AU2004261855A patent/AU2004261855B2/en not_active Ceased
- 2004-07-30 US US10/566,057 patent/US20070122451A1/en not_active Abandoned
- 2004-07-30 TW TW093123003A patent/TWI341866B/zh not_active IP Right Cessation
- 2004-07-30 UA UAA200602217A patent/UA87278C2/ru unknown
- 2004-07-30 US US10/565,497 patent/US20070299014A1/en not_active Abandoned
- 2004-07-30 MX MXPA06000878A patent/MXPA06000878A/es active IP Right Grant
- 2004-07-30 AT AT04771089T patent/ATE442855T1/de not_active IP Right Cessation
- 2004-07-30 PT PT04771088T patent/PT1669463E/pt unknown
- 2004-07-30 CA CA002546497A patent/CA2546497A1/en not_active Abandoned
- 2004-07-30 EP EP04771088A patent/EP1669463B1/en not_active Expired - Lifetime
- 2004-07-30 KR KR1020117005091A patent/KR101115560B1/ko not_active Expired - Fee Related
- 2004-07-30 WO PCT/JP2004/010929 patent/WO2005012334A1/ja not_active Ceased
- 2004-07-30 CN CNB2004800222139A patent/CN100398661C/zh not_active Expired - Lifetime
- 2004-07-30 NZ NZ545341A patent/NZ545341A/en not_active IP Right Cessation
- 2004-07-30 AU AU2004261522A patent/AU2004261522B2/en not_active Ceased
- 2004-07-30 BR BRPI0413242-4A patent/BRPI0413242A/pt not_active IP Right Cessation
- 2004-07-30 KR KR1020067000144A patent/KR101115557B1/ko not_active Expired - Fee Related
- 2004-07-30 PL PL04771088T patent/PL1669463T3/pl unknown
- 2004-07-30 JP JP2005512525A patent/JP4669396B2/ja not_active Expired - Fee Related
- 2004-07-30 UA UAA200602131A patent/UA89616C2/ru unknown
- 2004-07-30 WO PCT/JP2004/010928 patent/WO2005012542A1/ja not_active Ceased
- 2004-07-30 KR KR1020067000142A patent/KR101174299B1/ko not_active Expired - Lifetime
2006
- 2006-02-28 ZA ZA200601746A patent/ZA200601746B/en unknown
- 2006-02-28 ZA ZA200601739A patent/ZA200601739B/en unknown
- 2006-02-28 NO NO20060994A patent/NO20060994L/no not_active Application Discontinuation
- 2006-02-28 NO NO20060995A patent/NO20060995L/no not_active Application Discontinuation
2010
- 2010-09-01 US US12/873,500 patent/US8580557B2/en not_active Expired - Fee Related
2011
- 2011-02-16 JP JP2011031140A patent/JP2011102327A/ja active Pending

Also Published As

Publication number	Publication date
EA200600352A1 (ru)	2006-08-25
KR20060118395A (ko)	2006-11-23
KR20110039379A (ko)	2011-04-15
CN100398661C (zh)	2008-07-02
AU2004261522A1 (en)	2005-02-10
CN1833031A (zh)	2006-09-13
JPWO2005012334A1 (ja)	2008-01-17
DK1669463T3 (da)	2009-01-26
EP1661909A1 (en)	2006-05-31
NO20060995L (no)	2006-02-28
AU2004261855B2 (en)	2010-09-16
TW200507869A (en)	2005-03-01
EP1669463A4 (en)	2006-08-23
JP2011102327A (ja)	2011-05-26
NZ545341A (en)	2009-06-26
ES2313067T3 (es)	2009-03-01
CN101381401A (zh)	2009-03-11
AU2004261522B2 (en)	2010-09-16
KR20060120567A (ko)	2006-11-27
UA89616C2 (ru)	2010-02-25
MXPA06000879A (es)	2006-03-30
PT1661909E (pt)	2009-12-17
CA2546497A1 (en)	2005-02-10
BRPI0413242A (pt)	2006-10-03
CN1832958A (zh)	2006-09-13
EA200600349A1 (ru)	2006-08-25
HK1094008A1 (zh)	2007-03-16
EA010098B1 (ru)	2008-06-30
TWI349676B (en)	2011-10-01
WO2005012334A8 (ja)	2005-06-30
NZ545340A (en)	2010-04-30
AU2004261855A1 (en)	2005-02-10
KR101115560B1 (ko)	2012-03-13
PT1669463E (pt)	2009-01-23
US8580557B2 (en)	2013-11-12
DE602004023210D1 (de)	2009-10-29
EP1669463B1 (en)	2008-10-15
ES2331312T3 (es)	2009-12-29
CN100439393C (zh)	2008-12-03
ZA200601746B (en)	2007-05-30
US20110082281A1 (en)	2011-04-07
JP4669396B2 (ja)	2011-04-13
ATE442855T1 (de)	2009-10-15
US20070122451A1 (en)	2007-05-31
WO2005012542A1 (ja)	2005-02-10
WO2005012334A1 (ja)	2005-02-10
EP1669463A1 (en)	2006-06-14
HK1093991A1 (zh)	2007-03-16
ZA200601739B (en)	2007-05-30
TWI341866B (en)	2011-05-11
KR101115557B1 (ko)	2012-03-13
BRPI0413238A (pt)	2006-10-03
EA011570B1 (ru)	2009-04-28
MXPA06000878A (es)	2006-03-30
TW200505471A (en)	2005-02-16
US20070299014A1 (en)	2007-12-27
CA2532537A1 (en)	2005-02-10
DK1661909T3 (da)	2010-01-18
JPWO2005012542A1 (ja)	2007-09-27
KR101174299B1 (ko)	2012-08-16
PL1669463T3 (pl)	2009-02-27
DE602004017202D1 (de)	2008-11-27
ATE411035T1 (de)	2008-10-15
JP5341300B2 (ja)	2013-11-13
NO20060994L (no)	2006-02-28
EP1661909B1 (en)	2009-09-16
EP1661909A4 (en)	2006-08-30

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