BRPI0413238A - hidrolisato de caseìna, processo para a produção do mesmo e uso do mesmo - Google Patents

hidrolisato de caseìna, processo para a produção do mesmo e uso do mesmo

Info

Publication number
BRPI0413238A
BRPI0413238A BRPI0413238-6A BRPI0413238A BRPI0413238A BR PI0413238 A BRPI0413238 A BR PI0413238A BR PI0413238 A BRPI0413238 A BR PI0413238A BR PI0413238 A BRPI0413238 A BR PI0413238A
Authority
BR
Brazil
Prior art keywords
pro
vivo
peptides
casein
amino acids
Prior art date
Application number
BRPI0413238-6A
Other languages
English (en)
Inventor
Naoyuki Yamamoto
Seiichi Mizuno
Shingo Nishimura
Takanobu Gotou
Keiichi Matsuura
Tadashi Shinoda
Original Assignee
Calpis Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calpis Co Ltd filed Critical Calpis Co Ltd
Publication of BRPI0413238A publication Critical patent/BRPI0413238A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"HIDROLISATO DE CASEìNA, PROCESSO PARA A PRODUçãO DO MESMO E USO DO MESMO". A presente invenção refere-se a um hidrolisato de caseína contendo aminoácidos livres e peptídeos indigeríveis in vivo tendo capacidade de digestão enzimática in vivo minimamente suprimida e expressando funções, tal como efeito hipotensivo, no organismo vivo e a um método para o preparo de tal hidrolisato e ao uso do mesmo. O hidrolisato de caseína da presente invenção contém aminoácidos livres e peptídeos, tais como peptídeos indigeríveis in vivo, incluindo Xaa-Pro e Xaa-Pro-Pro, obtidos através de hidrólise de caseína de leite animal tendo um comprimento meio de cadeia de não mais do que 2,1 em termos do número de resíduos de aminoácido e tendo atividade inibitória da ACE ou efeito hipotensivo.
BRPI0413238-6A 2003-08-01 2004-07-30 hidrolisato de caseìna, processo para a produção do mesmo e uso do mesmo BRPI0413238A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003285007 2003-08-01
PCT/JP2004/010928 WO2005012542A1 (ja) 2003-08-01 2004-07-30 カゼイン加水分解物、その製造法及びその用途

Publications (1)

Publication Number Publication Date
BRPI0413238A true BRPI0413238A (pt) 2006-10-03

Family

ID=34113859

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0413242-4A BRPI0413242A (pt) 2003-08-01 2004-07-30 peptìdeos não-degradáveis biologicamente, inibidor de enzima de conversão em angiotensina, alimentos medicinais e funcionais
BRPI0413238-6A BRPI0413238A (pt) 2003-08-01 2004-07-30 hidrolisato de caseìna, processo para a produção do mesmo e uso do mesmo

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0413242-4A BRPI0413242A (pt) 2003-08-01 2004-07-30 peptìdeos não-degradáveis biologicamente, inibidor de enzima de conversão em angiotensina, alimentos medicinais e funcionais

Country Status (22)

Country Link
US (3) US20070122451A1 (pt)
EP (2) EP1669463B1 (pt)
JP (3) JP5341300B2 (pt)
KR (3) KR101115560B1 (pt)
CN (3) CN100398661C (pt)
AT (2) ATE442855T1 (pt)
AU (2) AU2004261855B2 (pt)
BR (2) BRPI0413242A (pt)
CA (2) CA2546497A1 (pt)
DE (2) DE602004017202D1 (pt)
DK (2) DK1661909T3 (pt)
EA (2) EA011570B1 (pt)
ES (2) ES2313067T3 (pt)
MX (2) MXPA06000878A (pt)
NO (2) NO20060995L (pt)
NZ (2) NZ545341A (pt)
PL (1) PL1669463T3 (pt)
PT (2) PT1661909E (pt)
TW (2) TWI341866B (pt)
UA (2) UA89616C2 (pt)
WO (2) WO2005012542A1 (pt)
ZA (2) ZA200601739B (pt)

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BRPI0611469A2 (pt) * 2005-04-28 2010-09-08 Unilever Nv usos do tripeptìdeo itp e produto alimentìcio
ATE497704T1 (de) * 2005-04-28 2011-02-15 Unilever Nv Gesundheitsfördernde peptide und sie enthaltende zusammensetzungen
CN101272693B (zh) 2005-07-26 2012-08-01 卡尔皮斯株式会社 发酵乳的制造方法和发酵乳饮料食品
BRPI0617824A2 (pt) * 2005-10-28 2011-08-09 Nestec Sa métodos para o uso de aminoácidos de cadeia ramificada
JP5096173B2 (ja) * 2006-02-09 2012-12-12 カルピス株式会社 経口摂取用関節リウマチ抑制剤
JP4956164B2 (ja) * 2006-12-06 2012-06-20 味の素株式会社 メラニン輸送及び／又は放出抑制剤
BRPI0809319A2 (pt) * 2007-03-27 2014-09-23 Calpis Co Ltd Agente para suprimir espessamento de parede de coração, agente profilático para hipertrofia cardíaca, agente profilático para insuficiência cardíaca, e, alimento funcional
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CN101768209B (zh) * 2009-01-05 2011-08-31 北京林业大学 具有高体内活性的降血压肽及其制备和纯化方法
CN101570568B (zh) * 2009-06-15 2012-05-30 东北农业大学 一种发酵乳中的ace抑制肽及其制备方法
CN102187935B (zh) * 2010-03-19 2012-12-19 江南大学 一种制备酪蛋白磷酸肽与ace抑制肽的方法
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CN103215332A (zh) * 2013-04-16 2013-07-24 陕西科技大学 一种分步酶解羊乳酪蛋白制备ace抑制肽的方法
AU2014330269B2 (en) * 2013-10-04 2017-06-01 Innoway Co., Ltd Hydrolysate of animal protein, manufacturing method thereof and use thereof
FR3017536B1 (fr) * 2014-02-18 2017-05-26 Univ La Rochelle Compositions pour la prevention et/ou le traitement de pathologies liees a l'alpha-glucosidase
ES2544153B1 (es) * 2014-02-24 2016-06-06 Ntd Labs, S.L. Uso de un hidrolizado de caseína como agente antiviral
JP6251667B2 (ja) 2014-06-03 2017-12-20 アサヒカルピスウェルネス株式会社 錠剤型即放性製剤及びその製造方法
CN105693817B (zh) 2014-11-27 2020-06-05 西北大学 一类三肽化合物及其制备方法与应用
JP6005202B2 (ja) * 2015-03-19 2016-10-12 アサヒグループホールディングス株式会社 脳機能改善用ペプチドの酵素的製造方法
JP6625366B2 (ja) * 2015-08-05 2019-12-25 学校法人北里研究所 豚肉の熟成中に生成する生理活性ペプチドを含む血圧降下剤及び食品、並びにペプチドを指標とする豚肉の熟成評価法
CN106119325A (zh) * 2016-06-23 2016-11-16 哈尔滨商业大学 一种具有增加肌肉含量和力量作用的酪蛋白水解物的制备方法
CN107375897A (zh) * 2017-08-15 2017-11-24 普维食品发展（上海）有限公司 一种辅助降血压的组合物及其用途
CN107348511B (zh) * 2017-08-21 2018-04-06 东方红（通化）生物医药股份有限公司 一种具有辅助降血压作用的西洋参/人参提取物的发酵提取方法
CN108003231A (zh) * 2017-11-13 2018-05-08 江苏大学 一种降低小分子肽中游离氨基酸含量的方法
CN108588156A (zh) * 2018-04-24 2018-09-28 浙江大学 一种水牛乳酪蛋白抗氧化活性肽的制备方法
KR102836091B1 (ko) * 2018-04-26 2025-07-18 제리아 신야쿠 고교 가부시키 가이샤 디펩티드 및 이것을 함유하는 의약 조성물
CN110467649A (zh) * 2019-09-12 2019-11-19 浙江省农业科学院 一种抑制血管紧张素转换酶活性的多肽qeip及其应用
JP2022135015A (ja) * 2021-03-04 2022-09-15 国立大学法人東京工業大学 オピオイド受容体作動剤
CN113321719B (zh) * 2021-05-20 2022-03-18 澳优乳业（中国）有限公司 一种寡肽及其制备方法与应用
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Also Published As

Publication number Publication date
UA87278C2 (ru) 2009-07-10
EP1669463A4 (en) 2006-08-23
CN100439393C (zh) 2008-12-03
WO2005012334A1 (ja) 2005-02-10
DE602004017202D1 (de) 2008-11-27
EP1661909B1 (en) 2009-09-16
KR20060118395A (ko) 2006-11-23
EA200600349A1 (ru) 2006-08-25
EA010098B1 (ru) 2008-06-30
NZ545341A (en) 2009-06-26
WO2005012334A8 (ja) 2005-06-30
KR101174299B1 (ko) 2012-08-16
MXPA06000878A (es) 2006-03-30
JP4669396B2 (ja) 2011-04-13
ES2313067T3 (es) 2009-03-01
KR101115557B1 (ko) 2012-03-13
EA011570B1 (ru) 2009-04-28
EP1661909A4 (en) 2006-08-30
TW200505471A (en) 2005-02-16
KR101115560B1 (ko) 2012-03-13
EA200600352A1 (ru) 2006-08-25
KR20110039379A (ko) 2011-04-15
NO20060994L (no) 2006-02-28
NZ545340A (en) 2010-04-30
WO2005012542A1 (ja) 2005-02-10
UA89616C2 (ru) 2010-02-25
BRPI0413242A (pt) 2006-10-03
ZA200601739B (en) 2007-05-30
US20110082281A1 (en) 2011-04-07
US20070122451A1 (en) 2007-05-31
CN1833031A (zh) 2006-09-13
PT1669463E (pt) 2009-01-23
US8580557B2 (en) 2013-11-12
DK1661909T3 (da) 2010-01-18
NO20060995L (no) 2006-02-28
HK1094008A1 (zh) 2007-03-16
CN1832958A (zh) 2006-09-13
JP2011102327A (ja) 2011-05-26
HK1093991A1 (zh) 2007-03-16
AU2004261522B2 (en) 2010-09-16
ATE411035T1 (de) 2008-10-15
ZA200601746B (en) 2007-05-30
PL1669463T3 (pl) 2009-02-27
DK1669463T3 (da) 2009-01-26
AU2004261522A1 (en) 2005-02-10
DE602004023210D1 (de) 2009-10-29
TW200507869A (en) 2005-03-01
EP1669463A1 (en) 2006-06-14
EP1669463B1 (en) 2008-10-15
US20070299014A1 (en) 2007-12-27
AU2004261855B2 (en) 2010-09-16
JPWO2005012542A1 (ja) 2007-09-27
ATE442855T1 (de) 2009-10-15
JPWO2005012334A1 (ja) 2008-01-17
PT1661909E (pt) 2009-12-17
AU2004261855A1 (en) 2005-02-10
EP1661909A1 (en) 2006-05-31
CN101381401A (zh) 2009-03-11
CA2532537A1 (en) 2005-02-10
CN100398661C (zh) 2008-07-02
ES2331312T3 (es) 2009-12-29
KR20060120567A (ko) 2006-11-27
CA2546497A1 (en) 2005-02-10
MXPA06000879A (es) 2006-03-30
TWI349676B (en) 2011-10-01
JP5341300B2 (ja) 2013-11-13
TWI341866B (en) 2011-05-11

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