UA98098C2 - ПРОИЗВОДНЫЕ ПИРИДИНОНА И ИХ ПРИМЕНЕНИЕ КАК ПОЛОЖИТЕЛЬНЫХ АЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 - Google Patents

ПРОИЗВОДНЫЕ ПИРИДИНОНА И ИХ ПРИМЕНЕНИЕ КАК ПОЛОЖИТЕЛЬНЫХ АЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2

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Publication number
UA98098C2
UA98098C2 UAA200703393A UAA200703393A UA98098C2 UA 98098 C2 UA98098 C2 UA 98098C2 UA A200703393 A UAA200703393 A UA A200703393A UA A200703393 A UAA200703393 A UA A200703393A UA 98098 C2 UA98098 C2 UA 98098C2
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UA
Ukraine
Prior art keywords
mglur2
compounds
diseases
receptors
positive allosteric
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UAA200703393A
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English (en)
Ukrainian (uk)
Inventor
Ассан Жюльен Эмоге
Хозе Мария Суд-Нуньес
Гийом Альбер Жак Дюве
Кристель Мартин Болеа
Вантеа Нем
Терри Патрик Финн
Пуль Эманюэль Кристиан Ле
Жан-Филлипп Франсуа Кристиан Роше
Роберт Йоганнес Лютьенс
Original Assignee
Орто-МакНилл-Янссен Фармасутикала, Инк.
Аддекс Фарма Са
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Application filed by Орто-МакНилл-Янссен Фармасутикала, Инк., Аддекс Фарма Са filed Critical Орто-МакНилл-Янссен Фармасутикала, Инк.
Publication of UA98098C2 publication Critical patent/UA98098C2/ru

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Abstract

Изобретение касается новых соединений, в частности новых производных пиридинона формулы (I) X R1 N Y Y (I) R2 R3, где все радикалы определены в заявке.Соединения согласно изобретению являются положительными аллостерическими модуляторами метаботропных рецепторов субтипа 2 (mGluR2), которые могут быть использованы для лечения или профилактики неврологических и психиатрических расстройств, связанных с глютаматной дисфункцией, и болезней, связанных с метаботропными рецепторами субтипа mGluR2. В частности, такими болезнями являются болезни центральной нервной системы, как тревожность, шизофрения, мигрень, депрессия и эпилепсия.Изобретение также касается фармацевтических композиций, способов приготовления таких соединений и композиций, а также использование таких соединений для профилактики и лечения болезней, связанных с mGluR2.
UAA200703393A 2004-09-17 2005-09-16 ПРОИЗВОДНЫЕ ПИРИДИНОНА И ИХ ПРИМЕНЕНИЕ КАК ПОЛОЖИТЕЛЬНЫХ АЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 UA98098C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0420722A GB0420722D0 (en) 2004-09-17 2004-09-17 Novel allosteric modulators
PCT/EP2005/054636 WO2006030032A1 (en) 2004-09-17 2005-09-16 Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors

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AU2005284098A1 (en) 2006-03-23
JP5179873B2 (ja) 2013-04-10
EP1799646B1 (en) 2014-12-10
NO20071660L (no) 2007-06-15
KR20070085262A (ko) 2007-08-27
US20070213323A1 (en) 2007-09-13

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