Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
  • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C247/00—Compounds containing azido groups
  • C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
  • C07C247/12—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D331/00—Heterocyclic compounds containing rings of less than five members, having one sulfur atom as the only ring hetero atom
  • C07D331/04—Four-membered rings

Definitions

• the present invention relates to a novel synthesis of optically active amino-amides which are useful in the preparation of sweetners and for other purposes. Certain compounds derived and utilized in the synthesis are believed novel.
• W. R. Huber, J.A.C.S. 77, 112-116 (1955) discloses a method (p. 112) for making racemic mixtures of aminoacyl glycerides by treating an alpha-halogen ester with sodium azide to form an alpha-azido ester, which was then saponified to give the alpha-azido acid.
• This acid was then converted to the acid chloride with thionyl chloride, which was, in turn, reacted with glycerol, or a monoglyceride, or a diglyceride, to form a tri-, di-, or mono-alpha-azidoacyl glyceride.
• the formation of the glyceride was accomplished via a ketene intermediate and yielded a racemic mixture.
• the formal glyceride was hydrogenated to convert the azido group to an amino group.
• Col. 1 the paper states that an alpha-aminoacyl glyceride was treated with an alpha-azidoacryl chloride "to yield an alpha-azido-acylaminoacyl glyceride which, on hydrogenation, yielded the ⁇ dipeptide-glyceride ⁇ .”
• the relevant reactions are considered to be: ##STR1##
• R is identified as a long chain fatty residue, such as laurin, palmitin, stearin, etc. Note that the ester moiety (glyceryl) is retained intact and is not converted to amide. My ester group, on the other hand, reacts with and is replaced by amine to form an amide group.
• the ester moiety (glyceryl) is retained in tact and is not converted to an amide, as presently achieved. Further, Huber's synthesis provides a product which is a racemic mixture and is not capable of achieving an optically active product nor one which is substantially free of one enantiomer as is possible by the present invention.
• the present invention provides a synthesis for forming optically active amino-amides in four sequential steps.
• the present synthesis utilizes readily available hydroxy carboxylic acid esters and provides substantially one enantiomer of the resultant amino-amide product.
• a hydroxy-carboxylate ester is converted to an amino-amide in four sequential steps:
• Step I the hydroxyl group is replaced by a group capable of reacting with an azide salt.
• This group is called herein an azido-coupler, and it will be defined and described in detail later in this specification.
• the reaction in this first Step I is (using methane sulfonyl chloride as the azido-coupler exemplar with triethylamine as the base to neutralize by-product HCl):
• reaction (II) is treated with an amine to yield the corresponding amide according to the following reaction:
• R is H or alkyl of 1-18 carbons
• R' is --CH 2 --
• n 0-8;
• R" is alkyl of 1-18 carbons
• R"' is a monovalent organic radical.
• the present invention is particularly useful in the preparation of the D-alanine-amides.
• the only practical way to prepare the D-alanine-amides required starting with D-alanine, blocking the amino group, esterifying, reacting with an amine to convert the ester group to an amide group, and finally deblocking to form the desired D-alanine-amide.
• This blocking-deblocking process is described in U.S. Pat. No.
• D-alanine is relatively expensive.
• the present process has unexpectedly been found to achieve the same end product (D-alanine-amide) starting from lactic acid ester, which is relatively cheap.
• the D-enantiomer is formed in reaction II and no other transformation occurs during subsequent reactions which change the integrety of the optical center.
• Alpha-hydroxy acids e.g., glycolic, lactic, alpha-hydroxy butyric, alpha-hydroxy-n- and -iso-valeric acids; etc.;
• Beta-hydroxy acids e.g., beta-hydroxy propionic acid, beta-hydroxybutyric, beta-hydroxy valeric acid; etc.;
• Gamma-hydroxy acids e.g., gamma-hydroxy butyric acid, gamma-hydroxy valeric acid, etc.;
• hydroxy carboxylic acids which are useful include delta-hydroxy valeric acid, epsilon-hydroxy caproic acid, and the like.
• Step I of the 4-step invention process the hydroxyl group is replaced by a group capable of reacting with an azide salt (i.e., an azide-reactable group).
• an azide salt i.e., an azide-reactable group
• an azido-coupler There are at least two basic types of azido-coupler. One type (preferred) reacts with and replaces the H atom of the --OH group. Another type replaces the whole --OH group.
• the first type includes, by way of example, methane sulfonylchloride, toluene sulfonylchloride, benzyl sulfonylchloride, and the like.
• the class reaction (with methane sulfonylchloride as exemplar) is given above.
• the resulting methane sulfonyl derivative reacts readily with the azide salt in Step II, as indicated above.
• the second type of azido-coupler includes, by way of example, PX 3 or PX 5 where X represents a halogen atom, preferably chlorine or bromine; and SOCl 2 .
• X represents a halogen atom, preferably chlorine or bromine; and SOCl 2 .
• the class reaction (with thionyl chloride as exemplar) is
• the cheapest and easiest to use is sodium azide, NaN 3 although KN 3 , TlN 3 , and other azide salts may be used.
• the azides are heat-sensitive, and care should be taken in their use.
• Alkyl amines linear or branched:
• this group includes H 2 NR'", where R'" is a branched member, as for example, a member selected from diiopropylcarbinyl, d-methyl-t-butylcarbinyl, d-ethyl-t-butylcarbinyl, di-t-butylcarbinyl, 2-methylthio-2,4-dimethylpentan-3-yl as well as the carbocyclic and heterocyclic groups described hereinbelow.
• Aromatic amines (aralkyl, alkaryl, and the like): ##STR3##
• Carbo- and heterocyclic amines This group includes H 2 NR'" where R'" is a carbocyclic group such as fenchyl or ##STR4## or a heterocyclic group, such as ##STR5## where at least one of R 1 , R 2 , R 3 , R 4 is alkyl having from 1 to 4 carbon atoms and the remainder are hydrogen or alkyl having from 1 to 4 carbon atoms;
• X is O, S, SO, SO 2 , C ⁇ O or CHOH;
• m is zero, 1, 2, 3, or 4;
• n and p are each zero, 1, 2, or 3, and the sum of n+p is not greater than 3; the sum of the carbon atoms in R 1 , R 2 , R 3 , and R 4 is not greater than 6; and when both or R 1 and R 2 or R 3 and R 4 are alkyl they are methyl or ethyl.
• a preferred amine of this group is 3-amino-2,2,4,4-tetramethylthietane. ##STR6##
• the amine can be an amino group attached to substantially any organic radical.
• the hydrogenation reaction of step (IV) can be carried out using conventional hydrogenation conditions and catalysts.
• the reaction can be carried out using hydrogen (low to moderate pressure) in the presence of a supported catalyst of Pd, Pt, Rh and the like or a Raney catalyst of Co, Ni, Fe and the like. It has been observed that the hydrogenation can be accomplished under mild conditions and even with the use of a Raney catalyst without the need of additional hydrogen being present, as illustrated by Example 3 hereinbelow. This was possible because Raney catalysts conventionally carry a substantial amount of adsorbed hydrogen, resulting from the activation process and because the hydrogen requirement in the Example was comparatively modest.

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• Chemical & Material Sciences (AREA)
• Organic Chemistry (AREA)
• Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
• Heterocyclic Compounds Containing Sulfur Atoms (AREA)
• Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

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• 1988
  • 1988-01-22 US US07/146,861 patent/US4855455A/en not_active Expired - Lifetime
• 1989
  • 1989-01-20 EP EP89300565A patent/EP0325485B1/de not_active Expired - Lifetime
  • 1989-01-20 DE DE68917160T patent/DE68917160T2/de not_active Expired - Fee Related
  • 1989-01-20 ES ES89300565T patent/ES2057100T3/es not_active Expired - Lifetime
  • 1989-01-20 AT AT89300565T patent/ATE109457T1/de not_active IP Right Cessation
  • 1989-01-20 JP JP1010043A patent/JP2912375B2/ja not_active Expired - Lifetime
• 1997
  • 1997-12-19 JP JP09364362A patent/JP3140993B2/ja not_active Expired - Fee Related

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