WO2009080910A3 - Procédé de criblage de composés utilisables pour le traitement de troubles respiratoires - Google Patents

Procédé de criblage de composés utilisables pour le traitement de troubles respiratoires Download PDF

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Publication number
WO2009080910A3
WO2009080910A3 PCT/FR2008/001391 FR2008001391W WO2009080910A3 WO 2009080910 A3 WO2009080910 A3 WO 2009080910A3 FR 2008001391 W FR2008001391 W FR 2008001391W WO 2009080910 A3 WO2009080910 A3 WO 2009080910A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
screening
respiratory conditions
compounds
functional activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2008/001391
Other languages
English (en)
Other versions
WO2009080910A8 (fr
WO2009080910A2 (fr
Inventor
Paul Cezanne Marseille Universite Iii
Jacques Barhanin
Christian Gestreau
Richard Warth
Dirk Heitzmann
Jörg Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aix Marseille Universite
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite Paul Cezanne Aix Marseille III
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Universite Paul Cezanne Aix Marseille III filed Critical Centre National de la Recherche Scientifique CNRS
Priority to US12/681,452 priority Critical patent/US8119362B2/en
Priority to EP08865189A priority patent/EP2193377A2/fr
Priority to CA2700875A priority patent/CA2700875A1/fr
Priority to JP2010527497A priority patent/JP2011501657A/ja
Publication of WO2009080910A2 publication Critical patent/WO2009080910A2/fr
Publication of WO2009080910A3 publication Critical patent/WO2009080910A3/fr
Anticipated expiration legal-status Critical
Publication of WO2009080910A8 publication Critical patent/WO2009080910A8/fr
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/12—Pulmonary diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention se rapporte à l'utilisation d'un procédé de criblage pour l'identification de molécules candidates utilisables pour le traitement de troubles respiratoires chez un mammifère, ledit procédé de criblage comprenant une étape consistant à déterminer si l'activité fonctionnelle d'un polypeptide TASK-2 en présence d'une molécule test est diminuée ou supprimée par rapport à l'activité fonctionnelle dudit polypeptide TASK-2 en l'absence de ladite molécule test, la molécule test étant considérée comme étant une molécule candidate lorsqu'elle diminue ou supprime ladite activité fonctionnelle.
PCT/FR2008/001391 2007-10-05 2008-10-03 Procédé de criblage de composés utilisables pour le traitement de troubles respiratoires Ceased WO2009080910A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US12/681,452 US8119362B2 (en) 2007-10-05 2008-10-03 Method of screening for compounds that can be used for the treatment of respiratory conditions
EP08865189A EP2193377A2 (fr) 2007-10-05 2008-10-03 Procédé de criblage de composés utilisables pour le traitement de troubles respiratoires
CA2700875A CA2700875A1 (fr) 2007-10-05 2008-10-03 Procede de criblage de composes utilisables pour le traitement de troubles respiratoires
JP2010527497A JP2011501657A (ja) 2007-10-05 2008-10-03 呼吸器系疾患の治療に使用することができる化合物をスクリーニングする方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0706999A FR2921935B1 (fr) 2007-10-05 2007-10-05 Procede de criblage de composes utilisables pour le traitement de troubles respiratoires
FR07/06999 2007-10-05

Publications (3)

Publication Number Publication Date
WO2009080910A2 WO2009080910A2 (fr) 2009-07-02
WO2009080910A3 true WO2009080910A3 (fr) 2009-09-03
WO2009080910A8 WO2009080910A8 (fr) 2010-04-29

Family

ID=39401127

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2008/001391 Ceased WO2009080910A2 (fr) 2007-10-05 2008-10-03 Procédé de criblage de composés utilisables pour le traitement de troubles respiratoires

Country Status (6)

Country Link
US (1) US8119362B2 (fr)
EP (1) EP2193377A2 (fr)
JP (1) JP2011501657A (fr)
CA (1) CA2700875A1 (fr)
FR (1) FR2921935B1 (fr)
WO (1) WO2009080910A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4209783A1 (fr) 2016-12-02 2023-07-12 Sophion Bioscience A/S Dispositif d'amélioration de joint

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005054867A2 (fr) * 2003-11-25 2005-06-16 Bayer Healthcare Ag Diagnostics et therapeutique pour maladies associees au canal potassique de la sous-famille k, membre 5 (kcnk5)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005044981A2 (fr) * 2003-10-23 2005-05-19 Sirna Therapeutics, Inc. Inhibition a mediation d'interference d'arn de l'expression genetique a l'aide d'acide nucleique d'interference court (sina)
JP2007513968A (ja) * 2003-12-12 2007-05-31 ウイスコンシン アラムニ リサーチ ファンデーション 哺乳動物神経細胞へのｓｉＲＮＡのデリバリー
DE102005044817A1 (de) * 2005-09-20 2007-03-22 Sanofi-Aventis Deutschland Gmbh Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005054867A2 (fr) * 2003-11-25 2005-06-16 Bayer Healthcare Ag Diagnostics et therapeutique pour maladies associees au canal potassique de la sous-famille k, membre 5 (kcnk5)

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GABRIEL ANJA ET AL: "Localization of the tandem pore domain K+ channel KCNK5 (TASK-2) in the rat central nervous system.", BRAIN RESEARCH. MOLECULAR BRAIN RESEARCH, vol. 98, no. 1-2, 31 January 2002 (2002-01-31), Netherlands (09-12-2001: on-line), pages 153 - 163, XP002329398, ISSN: 0169-328X, DOI: 10.1016/S0169-328X(01)00330-8 *
NIEMEYER M I ET AL: "Modulation of the two-pore domain acid-sensitive K+ channel TASK-2 (KCNK5) by changes in cell volume.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 46, 16 November 2001 (2001-11-16), pages 43166 - 43174, XP009100818, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
EP2193377A2 (fr) 2010-06-09
CA2700875A1 (fr) 2009-07-02
FR2921935A1 (fr) 2009-04-10
US8119362B2 (en) 2012-02-21
JP2011501657A (ja) 2011-01-13
FR2921935B1 (fr) 2011-10-28
WO2009080910A8 (fr) 2010-04-29
US20110014642A1 (en) 2011-01-20
WO2009080910A2 (fr) 2009-07-02

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