WO2009151728A3 - Microorganismes pour la production d'acide adipique et autres composés - Google Patents

Microorganismes pour la production d'acide adipique et autres composés Download PDF

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Publication number
WO2009151728A3
WO2009151728A3 PCT/US2009/038663 US2009038663W WO2009151728A3 WO 2009151728 A3 WO2009151728 A3 WO 2009151728A3 US 2009038663 W US2009038663 W US 2009038663W WO 2009151728 A3 WO2009151728 A3 WO 2009151728A3
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WO
WIPO (PCT)
Prior art keywords
adipate
caprolactam
aminocaproic acid
microbial organism
microorganisms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/038663
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English (en)
Other versions
WO2009151728A2 (fr
Inventor
Anthony P. Burgard
Priti Pharkya
Robin E. Osterhout
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genomatica Inc
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Genomatica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genomatica Inc filed Critical Genomatica Inc
Priority to EP09763021.4A priority Critical patent/EP2265709B1/fr
Priority to DK09763021.4T priority patent/DK2265709T3/en
Priority to NO09763021A priority patent/NO2265709T3/no
Priority to JP2011502115A priority patent/JP5951990B2/ja
Priority to SI200931794T priority patent/SI2265709T1/en
Priority to BRPI0910928A priority patent/BRPI0910928A2/pt
Priority to EP17195557.8A priority patent/EP3351619A1/fr
Priority to ES09763021.4T priority patent/ES2656790T3/es
Priority to CA2719679A priority patent/CA2719679C/fr
Priority to CN200980119404XA priority patent/CN102066551B/zh
Priority to LTEP09763021.4T priority patent/LT2265709T/lt
Priority to PL09763021T priority patent/PL2265709T3/pl
Publication of WO2009151728A2 publication Critical patent/WO2009151728A2/fr
Publication of WO2009151728A3 publication Critical patent/WO2009151728A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
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    • C12N9/0004—Oxidoreductases (1.)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
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    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
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    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
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    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
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    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
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    • C12P7/00—Preparation of oxygen-containing organic compounds
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
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    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01035—3-Hydroxyacyl-CoA dehydrogenase (1.1.1.35)
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    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/0101—Acetaldehyde dehydrogenase (acetylating) (1.2.1.10)
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    • C12Y206/01—Transaminases (2.6.1)
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    • C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
    • C12Y103/01031—2-Enoate reductase (1.3.1.31)

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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention porte sur un organisme microbien non présent dans la nature qui présente une voie d’ester adipique, d’acide 6-aminocaproïque ou de caprolactame. L'organisme microbien contient au moins un acide nucléique exogène codant pour une enzyme dans la voie respective d’ester adipique, d’acide 6-aminocaproïque ou de caprolactame. L'invention porte de plus sur un procédé de production d'ester adipique, d'acide 6-aminocaproïque ou de caprolactame. Le procédé peut comprendre la culture d'un organisme microbien producteur d'ester adipique, d'acide 6-aminocaproïque ou de caprolactame, l'organisme microbien exprimant au moins un acide nucléique exogène codant pour une enzyme de la voie d'ester adipique, d’acide 6-aminocaproïque ou de caprolactame en une quantité suffisante pour donner le produit respectif, dans des conditions et pendant une période de temps suffisante pour produire de l'ester adipique, de l'acide 6-aminocaproïque ou du caprolactame.
PCT/US2009/038663 2008-03-27 2009-03-27 Microorganismes pour la production d'acide adipique et autres composés Ceased WO2009151728A2 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
EP09763021.4A EP2265709B1 (fr) 2008-03-27 2009-03-27 Microorganismes pour la production d'acide adipique et autres composés
DK09763021.4T DK2265709T3 (en) 2008-03-27 2009-03-27 MICROORGANISMS FOR PRODUCING ADIPINIC ACID AND OTHER COMPOUNDS
NO09763021A NO2265709T3 (fr) 2008-03-27 2009-03-27
JP2011502115A JP5951990B2 (ja) 2008-03-27 2009-03-27 アジピン酸および他の化合物を生成するための微生物
SI200931794T SI2265709T1 (en) 2008-03-27 2009-03-27 MICROORGANISMS FOR PREPARATION OF ADYPIC ACID AND OTHER COMPOUNDS
BRPI0910928A BRPI0910928A2 (pt) 2008-03-27 2009-03-27 micro-organismos para a produção de ácido adípico e outros compostos
EP17195557.8A EP3351619A1 (fr) 2008-03-27 2009-03-27 Micro-organismes pour la production d'acide adipique et d'autres composés
ES09763021.4T ES2656790T3 (es) 2008-03-27 2009-03-27 Microorganismos para la producción de ácido adípico y otros compuestos
CA2719679A CA2719679C (fr) 2008-03-27 2009-03-27 Microorganismes pour la production d'acide adipique et autres composes
CN200980119404XA CN102066551B (zh) 2008-03-27 2009-03-27 用于产生己二酸和其他化合物的微生物
LTEP09763021.4T LT2265709T (lt) 2008-03-27 2009-03-27 Mikroorganizmai, skirti adipo rūgšties ir kitų junginių gamybai
PL09763021T PL2265709T3 (pl) 2008-03-27 2009-03-27 Mikroorganizmy do produkcji kwasu adypinowego i innych związków

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4005908P 2008-03-27 2008-03-27
US61/040,059 2008-03-27

Publications (2)

Publication Number Publication Date
WO2009151728A2 WO2009151728A2 (fr) 2009-12-17
WO2009151728A3 true WO2009151728A3 (fr) 2010-05-27

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ID=41400667

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Application Number Title Priority Date Filing Date
PCT/US2009/038663 Ceased WO2009151728A2 (fr) 2008-03-27 2009-03-27 Microorganismes pour la production d'acide adipique et autres composés

Country Status (14)

Country Link
US (11) US7799545B2 (fr)
EP (2) EP2265709B1 (fr)
JP (6) JP5951990B2 (fr)
CN (4) CN103555643B (fr)
BR (1) BRPI0910928A2 (fr)
CA (3) CA2719679C (fr)
DK (1) DK2265709T3 (fr)
ES (1) ES2656790T3 (fr)
HU (1) HUE035611T2 (fr)
LT (1) LT2265709T (fr)
NO (1) NO2265709T3 (fr)
PL (1) PL2265709T3 (fr)
SI (1) SI2265709T1 (fr)
WO (1) WO2009151728A2 (fr)

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US7799545B2 (en) 2010-09-21
CN103555643B (zh) 2016-08-10
JP2014147399A (ja) 2014-08-21
US20200248189A1 (en) 2020-08-06
CA2995870A1 (fr) 2009-12-17
CN103555643A (zh) 2014-02-05
EP2265709A2 (fr) 2010-12-29
US20090305364A1 (en) 2009-12-10
CA2995870C (fr) 2022-11-01
US8592189B2 (en) 2013-11-26
HUE035611T2 (en) 2018-05-28
EP2265709A4 (fr) 2012-08-29
US20120115194A1 (en) 2012-05-10
CN113430119A (zh) 2021-09-24
JP2016195612A (ja) 2016-11-24
EP2265709B1 (fr) 2017-11-08

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