YU6592A - Novi steroidi - Google Patents

Novi steroidi

Info

Publication number
YU6592A
YU6592A YU6592A YU6592A YU6592A YU 6592 A YU6592 A YU 6592A YU 6592 A YU6592 A YU 6592A YU 6592 A YU6592 A YU 6592A YU 6592 A YU6592 A YU 6592A
Authority
YU
Yugoslavia
Prior art keywords
new steroids
compounds
hydrogen atom
steroids
new
Prior art date
Application number
YU6592A
Other languages
English (en)
Other versions
YU48892B (sh
Inventor
P.H. Andersson
B.I. Axelsson
R.L. Brattsand
A.B. Thalen
Original Assignee
Aktiebolaget Astra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aktiebolaget Astra filed Critical Aktiebolaget Astra
Priority to SI9210065A priority Critical patent/SI9210065B/sl
Publication of YU6592A publication Critical patent/YU6592A/sh
Publication of YU48892B publication Critical patent/YU48892B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NOVI STEROIDI, jedinjenja opšte formule: u obliku 22R i 22S epimera, gde su X1 i X2 iste ili različiti i svaki pretstavlja atom vodonika ili atom fluora, pod uslovom da X1 i X2 nisu istovremeno atom vodonika, postupci za njihovo pravljenje, farmaceutski preparati koji ih sadrže i korišćenje jedinjenja u lečenju inflamatornih i alergijskih stanja.
YU6592A 1991-02-04 1992-01-22 Novi steroidi YU48892B (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SI9210065A SI9210065B (en) 1991-02-04 1992-01-22 Novel antiinflamatory and antialergic active compounds, glucocorticosteroids and processes for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9100341A SE9100341D0 (sv) 1991-02-04 1991-02-04 Novel steroids

Publications (2)

Publication Number Publication Date
YU6592A true YU6592A (sh) 1995-01-31
YU48892B YU48892B (sh) 2002-10-18

Family

ID=20381806

Family Applications (1)

Application Number Title Priority Date Filing Date
YU6592A YU48892B (sh) 1991-02-04 1992-01-22 Novi steroidi

Country Status (39)

Country Link
US (2) US5674861A (sh)
EP (1) EP0570454B1 (sh)
JP (1) JPH06505232A (sh)
KR (1) KR100216720B1 (sh)
CN (3) CN1034868C (sh)
AP (1) AP366A (sh)
AT (1) ATE178611T1 (sh)
BG (1) BG62211B1 (sh)
CA (1) CA2103924A1 (sh)
CZ (1) CZ281685B6 (sh)
DE (1) DE69228870T2 (sh)
DK (1) DK0570454T3 (sh)
DZ (1) DZ1553A1 (sh)
EE (1) EE03111B1 (sh)
ES (1) ES2133315T3 (sh)
FI (1) FI933450L (sh)
GR (1) GR3030657T3 (sh)
HU (1) HU218275B (sh)
IE (1) IE920166A1 (sh)
IL (1) IL100532A (sh)
IS (1) IS1601B (sh)
MA (1) MA22406A1 (sh)
MX (1) MX9200324A (sh)
NO (1) NO304073B1 (sh)
NZ (1) NZ241210A (sh)
PH (1) PH31284A (sh)
PL (1) PL170000B1 (sh)
PT (1) PT100086B (sh)
RO (1) RO111195B1 (sh)
RU (1) RU2111212C1 (sh)
SE (1) SE9100341D0 (sh)
SG (1) SG52557A1 (sh)
SI (1) SI9210065B (sh)
SK (1) SK281801B6 (sh)
TN (1) TNSN92007A1 (sh)
UA (1) UA41267C2 (sh)
WO (1) WO1992013872A1 (sh)
YU (1) YU48892B (sh)
ZA (1) ZA92233B (sh)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
NZ259596A (en) * 1993-01-08 1997-04-24 Astra Ab Sugar-substituted glucocorticosteroid and use in medicaments specific to the colon or ileum
US5980949A (en) * 1994-10-03 1999-11-09 Astra Aktiebolag Formulation for inhalation
US5983956A (en) * 1994-10-03 1999-11-16 Astra Aktiebolag Formulation for inhalation
GB9423919D0 (en) * 1994-11-26 1995-01-11 Rhone Poulenc Rorer Ltd Chemical process
SE9700133D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
SE9700135D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
IT1291288B1 (it) * 1997-04-30 1999-01-07 Farmabios Srl Processo per la preparazione di 16,17 acetali di derivati pregnanici con controllo della distribuzione epimerica al c-22.
AU4093799A (en) 1998-05-22 1999-12-13 Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
GB0009607D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Medical compositions
GB0009592D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory combinations
HRP20010018A2 (en) 2001-01-09 2002-12-31 Pliva D D Novel anti-inflammatory compounds
GB0110411D0 (en) * 2001-04-27 2001-06-20 Astrazeneca Ab Chemical process
MXPA04002758A (es) * 2001-09-25 2004-06-29 Upjohn Co Transacetalizacion estereoselectiva de acetonido c-22 esteroidal.
RS20050008A (sr) 2002-07-08 2007-06-04 Pliva-Istraživački Institut D.O.O., Nova jedinjenja,kompozicije i metode za lečenje inflamatornih oboljenja i stanja
AU2003264917A1 (en) 2002-07-08 2004-01-23 Pliva - Istrazivacki Institut D.O.O. Hybrid molecules of macrolides with steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules
EP1562627A4 (en) * 2002-08-23 2006-11-02 Mclean Hospital Corp CORTICOSTEROID CONJUGATES AND ITS USES
TW200417371A (en) * 2003-02-21 2004-09-16 Upjohn Co A continuous process for the production of R-rofleponide
HRP20030324A2 (en) 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
HRP20030603A2 (en) 2003-07-25 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Substituted furochromene compounds of antiinflammatory action
HRP20030604A2 (en) 2003-07-25 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. Substituted furochromenes, preparation thereof andtheir antiinflammatory action
RU2253453C1 (ru) * 2004-03-15 2005-06-10 Общество с ограниченной ответственностью "ЮНАЛ" Противовоспалительная и антиаллергическая композиция
ES2337915T3 (es) 2004-10-27 2010-04-30 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Conjugados con adtividad antiinflamatoria.
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
EP1906960A4 (en) * 2005-07-11 2010-03-10 Astrazeneca Ab NEW COMBINATION 1
EP1945240B1 (en) 2005-09-16 2016-12-28 Raptor Pharmaceutical Inc Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
WO2008100560A2 (en) * 2007-02-14 2008-08-21 University Of Southern California Estrogen receptor modulators, associated pharmaceutical compositions and methods of use
TR201908314T4 (tr) 2009-02-20 2019-06-21 2 Bbb Medicines B V Glutatyon bazlı ilaç dağıtım sistemi.
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126375A (en) * 1964-03-24 Chioacyl
US3048581A (en) * 1960-04-25 1962-08-07 Olin Mathieson Acetals and ketals of 16, 17-dihydroxy steroids
US3357974A (en) * 1965-12-28 1967-12-12 Merck & Co Inc Processes for preparing 16alpha, 17alpha-acetals and ketals of 16alpha, 17alpha, 21-trihydroxy-delta4-pregnene-3, 20-diones
US3758686A (en) * 1971-12-07 1973-09-11 American Cyanamid Co Method of using steroid acetonides
SE378109B (sh) * 1972-05-19 1975-08-18 Bofors Ab
SE378110B (sh) * 1972-05-19 1975-08-18 Bofors Ab
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
US4749649A (en) * 1983-05-16 1988-06-07 The Upjohn Company Microbial Δ1-dehydrogenation process using a scavenger of toxic oxygen
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8403905D0 (sv) * 1984-07-30 1984-07-30 Draco Ab Liposomes and steroid esters
CN1060471A (zh) * 1985-04-04 1992-04-22 得拉科公司 新的16，17-缩醛取代雄甾烷-17β-酮类的制备方法
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
HU203562B (en) * 1989-03-09 1991-08-28 Richter Gedeon Vegyeszet Process for producing new steroide diols and pharmaceutical compositions containing them
HU203769B (en) * 1989-03-09 1991-09-30 Richter Gedeon Vegyeszet Process for producing new steroide derivatives and pharmaceutical compositions containing them
PL164294B1 (pl) * 1990-12-20 1994-07-29 Inst Farmaceutyczny Sposób otrzymywania diastereoizomeru /22R/-16a , 17a-butylidenodioksy-11 ß 21-dihydroksy-1,4-pregnadien-3,20-dionu PL
SE9100342D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids

Also Published As

Publication number Publication date
CN1058724C (zh) 2000-11-22
GR3030657T3 (en) 1999-10-29
WO1992013872A1 (en) 1992-08-20
PH31284A (en) 1998-07-06
RU2111212C1 (ru) 1998-05-20
FI933450A0 (fi) 1993-08-03
JPH06505232A (ja) 1994-06-16
IS3808A (is) 1992-08-05
IL100532A (en) 1996-05-14
SK79693A3 (en) 1994-03-09
ATE178611T1 (de) 1999-04-15
EP0570454B1 (en) 1999-04-07
SI9210065B (en) 2001-12-31
NO304073B1 (no) 1998-10-19
CN1034868C (zh) 1997-05-14
FI933450A7 (fi) 1993-08-03
EP0570454A1 (en) 1993-11-24
AU1230792A (en) 1992-09-07
MA22406A1 (fr) 1992-10-01
TNSN92007A1 (fr) 1993-06-08
HUT64973A (en) 1994-03-28
DZ1553A1 (fr) 2002-02-17
MX9200324A (es) 1992-09-01
PL170000B1 (pl) 1996-10-31
IL100532A0 (en) 1992-09-06
FI933450L (fi) 1993-08-03
HU9302244D0 (en) 1993-10-28
AP9200353A0 (en) 1992-01-31
UA41267C2 (uk) 2001-09-17
US5939409A (en) 1999-08-17
HK1010733A1 (en) 1999-06-25
ZA92233B (en) 1992-10-28
DK0570454T3 (da) 1999-10-18
KR100216720B1 (ko) 1999-10-01
PT100086B (pt) 1999-06-30
CA2103924A1 (en) 1992-08-05
HU218275B (en) 2000-07-28
SG52557A1 (en) 1998-09-28
NZ241210A (en) 1993-08-26
PT100086A (pt) 1994-05-31
EE03111B1 (et) 1998-08-17
YU48892B (sh) 2002-10-18
IE920166A1 (en) 1992-08-12
ES2133315T3 (es) 1999-09-16
IS1601B (is) 1996-10-18
AP366A (en) 1994-10-21
CN1140059A (zh) 1997-01-15
RO111195B1 (ro) 1996-07-30
SE9100341D0 (sv) 1991-02-04
US5674861A (en) 1997-10-07
AU661471B2 (en) 1995-07-27
NO932761D0 (no) 1993-08-02
NO932761L (no) 1993-08-02
BG97971A (bg) 1994-04-29
CZ149693A3 (en) 1994-03-16
SI9210065A (en) 1995-02-28
BG62211B1 (bg) 1999-05-31
CN1140178A (zh) 1997-01-15
CN1064079A (zh) 1992-09-02
CN1052155C (zh) 2000-05-10
DE69228870T2 (de) 1999-08-19
SK281801B6 (sk) 2001-08-06
CZ281685B6 (cs) 1996-12-11
DE69228870D1 (de) 1999-05-12

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