YU88902A - Supstituisani 1-aminoalkil laktami i njihova primena kao antagonista muskarinskih receptora - Google Patents

Supstituisani 1-aminoalkil laktami i njihova primena kao antagonista muskarinskih receptora

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Publication number
YU88902A
YU88902A YU88902A YUP88902A YU88902A YU 88902 A YU88902 A YU 88902A YU 88902 A YU88902 A YU 88902A YU P88902 A YUP88902 A YU P88902A YU 88902 A YU88902 A YU 88902A
Authority
YU
Yugoslavia
Prior art keywords
receptor antagonists
lactams
aminoalkyl
substituted
muscarinic receptor
Prior art date
Application number
YU88902A
Other languages
English (en)
Inventor
Charles Alois Dvorak
Lawrence Emerson Fisher
Keena Lynn Green
Ralph New Harris
Hans Maag
Anthony Prince
David Bruce Repke
Russel Stephen Stabler
Original Assignee
F. Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag. filed Critical F. Hoffmann-La Roche Ag.
Publication of YU88902A publication Critical patent/YU88902A/sh

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    • C07D207/26—2-Pyrrolidones
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Abstract

Ovaj pronalazak se odnosi na jedinjenja koja su obično antagonisti muskarinskih M2/M3 receptora i koji se predstavljeni Formulom (I) gde je jedan od X, Y, ili Z nezavisno -S-, -O-, -CH2- ili >NR6, ostali su CH2-; m je ceo broj od 0 do 3 uključiv, n je ceo broj od 1 do 6 uključiv; R4 je (C1-6)alkil; R5 je nezavisno u svakom pojavljivanju (C1-6)-alkil, (C1-6)-alkenil, (C1-6)-alkinil ili cikloalkil, i R1, R2 i R3 su vodonik ili specifični supstituenti. Ova jedinjenja su korisna za tretiranje oboljenja povezanih sa poremećajima glatke muskulature.[This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula (I) wherein one of X, Y or Z is independently -S-,-O- CH2- or >N-R6, the others are -CH2-; m is an integer from 0 to 3 inclusive; n is an integer from 1 to 6 inclusive; R4 is (C1-6)-alkyl; R5 is independently in each occurrence (C1-6)-alkyl, (C1-6)-alkenyl, (C1-6)- alkynyl or cycloalkyl; and R1, R2, and R3 are hydrogen or specified substituents. These compounds are useful for treating diseases associated with smooth muscle disorders.
YU88902A 2000-05-25 2001-05-16 Supstituisani 1-aminoalkil laktami i njihova primena kao antagonista muskarinskih receptora YU88902A (sh)

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