ZA200005378B - Medicinal compositions. - Google Patents

Medicinal compositions. Download PDF

Info

Publication number: ZA200005378B
Authority: ZA; South Africa
Prior art keywords: group; hydroxy; hydrogen atom; pharmaceutical composition; composition according
Prior art date: 1998-04-27

Application number

ZA200005378A

Other languages

English (en)

Inventor

Rinta Ibuki

Fumio Shimojo

Satoshi Ueda

Toshihiko Toyoda

Masayuki Yamanaka

Erika Yoshida

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-27

Filing date

2000-10-03

Publication date

2002-08-23

2000-10-03 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

2002-08-23 Publication of ZA200005378B publication Critical patent/ZA200005378B/en

Links

239000000203 mixture Substances 0.000 title claims description 25
-1 chloro, bromo, iodo Chemical group 0.000 claims description 79
150000001875 compounds Chemical class 0.000 claims description 43
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 35
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 30
239000008194 pharmaceutical composition Substances 0.000 claims description 30
125000000217 alkyl group Chemical group 0.000 claims description 26
239000003120 macrolide antibiotic agent Substances 0.000 claims description 26
125000003545 alkoxy group Chemical group 0.000 claims description 15
KSCKTBJJRVPGKM-UHFFFAOYSA-N octan-1-olate;titanium(4+) Chemical compound [Ti+4].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-] KSCKTBJJRVPGKM-UHFFFAOYSA-N 0.000 claims description 13
229940124532 absorption promoter Drugs 0.000 claims description 12
XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims description 12
229940075557 diethylene glycol monoethyl ether Drugs 0.000 claims description 12
238000004090 dissolution Methods 0.000 claims description 12
150000003839 salts Chemical class 0.000 claims description 11
125000001424 substituent group Chemical group 0.000 claims description 11
239000002562 thickening agent Substances 0.000 claims description 10
239000003937 drug carrier Substances 0.000 claims description 9
125000004432 carbon atom Chemical group C* 0.000 claims description 8
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
125000004043 oxo group Chemical group O=* 0.000 claims description 8
125000003118 aryl group Chemical group 0.000 claims description 7
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
229920002125 Sokalan® Polymers 0.000 claims description 6
125000003342 alkenyl group Chemical group 0.000 claims description 6
239000003795 chemical substances by application Substances 0.000 claims description 5
229910052760 oxygen Inorganic materials 0.000 claims description 5
229920000642 polymer Polymers 0.000 claims description 5
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 5
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 4
HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 claims description 4
239000002253 acid Substances 0.000 claims description 4
229920002678 cellulose Polymers 0.000 claims description 4
239000001913 cellulose Substances 0.000 claims description 4
229940031578 diisopropyl adipate Drugs 0.000 claims description 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 3
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims description 3
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
150000005690 diesters Chemical class 0.000 claims description 3
235000014113 dietary fatty acids Nutrition 0.000 claims description 3
125000003700 epoxy group Chemical group 0.000 claims description 3
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
239000000194 fatty acid Substances 0.000 claims description 3
229930195729 fatty acid Natural products 0.000 claims description 3
125000005553 heteroaryloxy group Chemical group 0.000 claims description 3
125000000623 heterocyclic group Chemical group 0.000 claims description 3
229910052739 hydrogen Inorganic materials 0.000 claims description 3
239000001257 hydrogen Substances 0.000 claims description 3
229910052757 nitrogen Inorganic materials 0.000 claims description 3
239000001301 oxygen Substances 0.000 claims description 3
125000004430 oxygen atom Chemical group O* 0.000 claims description 3
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
229910052717 sulfur Inorganic materials 0.000 claims description 3
239000011593 sulfur Substances 0.000 claims description 3
HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical group O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 2
125000004122 cyclic group Chemical group 0.000 claims description 2
150000002334 glycols Chemical class 0.000 claims description 2
125000005842 heteroatom Chemical group 0.000 claims description 2
229920006395 saturated elastomer Polymers 0.000 claims description 2
125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims description 2
CFZGEMKIQUVTCC-UHFFFAOYSA-N octacos-18-ene-2,3,10,16-tetrone Chemical compound CCCCCCCCCC=CCC(=O)CCCCCC(=O)CCCCCCC(=O)C(C)=O CFZGEMKIQUVTCC-UHFFFAOYSA-N 0.000 claims 1
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 33
QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 description 24
QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 description 23
201000004681 Psoriasis Diseases 0.000 description 15
125000002252 acyl group Chemical group 0.000 description 15
239000000126 substance Substances 0.000 description 13
229960002930 sirolimus Drugs 0.000 description 12
MTHSVFCYNBDYFN-UHFFFAOYSA-N anhydrous diethylene glycol Natural products OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 11
229910052799 carbon Inorganic materials 0.000 description 11
210000003491 skin Anatomy 0.000 description 11
238000010521 absorption reaction Methods 0.000 description 9
239000001863 hydroxypropyl cellulose Substances 0.000 description 9
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 9
229940071676 hydroxypropylcellulose Drugs 0.000 description 9
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 8
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 7
125000001931 aliphatic group Chemical group 0.000 description 6
ZDQSOHOQTUFQEM-PKUCKEGBSA-N ascomycin Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C\C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@@H](O)[C@H](OC)C1 ZDQSOHOQTUFQEM-PKUCKEGBSA-N 0.000 description 6
239000008280 blood Substances 0.000 description 6
210000004369 blood Anatomy 0.000 description 6
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 6
201000010099 disease Diseases 0.000 description 6
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 6
QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 5
239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 5
ZDQSOHOQTUFQEM-XCXYXIJFSA-N ascomycin Natural products CC[C@H]1C=C(C)C[C@@H](C)C[C@@H](OC)[C@H]2O[C@@](O)([C@@H](C)C[C@H]2OC)C(=O)C(=O)N3CCCC[C@@H]3C(=O)O[C@H]([C@H](C)[C@@H](O)CC1=O)C(=C[C@@H]4CC[C@@H](O)[C@H](C4)OC)C ZDQSOHOQTUFQEM-XCXYXIJFSA-N 0.000 description 5
235000010385 ascorbyl palmitate Nutrition 0.000 description 5
239000000499 gel Substances 0.000 description 5
210000001519 tissue Anatomy 0.000 description 5
238000011282 treatment Methods 0.000 description 5
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
125000005115 alkyl carbamoyl group Chemical group 0.000 description 4
125000005103 alkyl silyl group Chemical group 0.000 description 4
229940079593 drug Drugs 0.000 description 4
239000003814 drug Substances 0.000 description 4
230000001506 immunosuppresive effect Effects 0.000 description 4
230000014759 maintenance of location Effects 0.000 description 4
230000002265 prevention Effects 0.000 description 4
208000023275 Autoimmune disease Diseases 0.000 description 3
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
241001465754 Metazoa Species 0.000 description 3
239000002202 Polyethylene glycol Substances 0.000 description 3
239000002585 base Substances 0.000 description 3
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 3
235000010980 cellulose Nutrition 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
239000006071 cream Substances 0.000 description 3
239000002552 dosage form Substances 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
206010023332 keratitis Diseases 0.000 description 3
210000000056 organ Anatomy 0.000 description 3
230000000144 pharmacologic effect Effects 0.000 description 3
229920001223 polyethylene glycol Polymers 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
238000011321 prophylaxis Methods 0.000 description 3
NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 3
238000002560 therapeutic procedure Methods 0.000 description 3
238000002054 transplantation Methods 0.000 description 3
PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
BGRXBNZMPMGLQI-UHFFFAOYSA-N 2-octyldodecyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCC(CCCCCCCC)CCCCCCCCCC BGRXBNZMPMGLQI-UHFFFAOYSA-N 0.000 description 2
208000035473 Communicable disease Diseases 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
208000003556 Dry Eye Syndromes Diseases 0.000 description 2
206010013774 Dry eye Diseases 0.000 description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
206010060742 Endocrine ophthalmopathy Diseases 0.000 description 2
102000004190 Enzymes Human genes 0.000 description 2
108090000790 Enzymes Proteins 0.000 description 2
JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical class CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 2
241000700159 Rattus Species 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
241000187747 Streptomyces Species 0.000 description 2
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 2
125000004453 alkoxycarbonyl group Chemical group 0.000 description 2
150000005215 alkyl ethers Chemical class 0.000 description 2
230000000845 anti-microbial effect Effects 0.000 description 2
FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 2
MMKRHZKQPFCLLS-UHFFFAOYSA-N ethyl myristate Chemical compound CCCCCCCCCCCCCC(=O)OCC MMKRHZKQPFCLLS-UHFFFAOYSA-N 0.000 description 2
238000000855 fermentation Methods 0.000 description 2
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210000004209 hair Anatomy 0.000 description 2
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239000006210 lotion Substances 0.000 description 2
125000004092 methylthiomethyl group Chemical group [H]C([H])([H])SC([H])([H])* 0.000 description 2
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150000004682 monohydrates Chemical class 0.000 description 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
229940073665 octyldodecyl myristate Drugs 0.000 description 2
239000002674 ointment Substances 0.000 description 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 description 2
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 2
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125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
MIOPJNTWMNEORI-GMSGAONNSA-N (S)-camphorsulfonic acid Chemical compound C1C[C@@]2(CS(O)(=O)=O)C(=O)C[C@@H]1C2(C)C MIOPJNTWMNEORI-GMSGAONNSA-N 0.000 description 1
VYKNVAHOUNIVTQ-UHFFFAOYSA-N 1,2,2,3,3-pentamethylpiperidine Chemical class CN1CCCC(C)(C)C1(C)C VYKNVAHOUNIVTQ-UHFFFAOYSA-N 0.000 description 1
QMMJWQMCMRUYTG-UHFFFAOYSA-N 1,2,4,5-tetrachloro-3-(trifluoromethyl)benzene Chemical compound FC(F)(F)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl QMMJWQMCMRUYTG-UHFFFAOYSA-N 0.000 description 1
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
DHGBAFGZLVRESL-UHFFFAOYSA-N 14-methylpentadecyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC(C)C DHGBAFGZLVRESL-UHFFFAOYSA-N 0.000 description 1
LGEZTMRIZWCDLW-UHFFFAOYSA-N 14-methylpentadecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC(C)C LGEZTMRIZWCDLW-UHFFFAOYSA-N 0.000 description 1
YICVJSOYNBZJAK-UHFFFAOYSA-N 14-methylpentadecyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC(C)C YICVJSOYNBZJAK-UHFFFAOYSA-N 0.000 description 1
SAMYFBLRCRWESN-UHFFFAOYSA-N 16-methylheptadecyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCC(C)C SAMYFBLRCRWESN-UHFFFAOYSA-N 0.000 description 1
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GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Inorganic Chemistry (AREA)
Immunology (AREA)
Dermatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ZA200005378A 1998-04-27 2000-10-03 Medicinal compositions. ZA200005378B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP11727198		1998-04-27

Publications (1)

Publication Number	Publication Date
ZA200005378B true ZA200005378B (en)	2002-08-23

Family

ID=14707636

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200005378A ZA200005378B (en)	1998-04-27	2000-10-03	Medicinal compositions.

Country Status (24)

Country	Link
US (2)	US6673808B1 (de)
EP (1)	EP1074255B1 (de)
JP (1)	JP3732525B2 (de)
KR (1)	KR100406823B1 (de)
CN (1)	CN1161117C (de)
AR (1)	AR018330A1 (de)
AT (1)	ATE363275T1 (de)
AU (1)	AU749475B2 (de)
BR (1)	BR9910336A (de)
CA (1)	CA2326222C (de)
DE (1)	DE69936195T2 (de)
ES (1)	ES2284248T3 (de)
HK (1)	HK1038884B (de)
HU (1)	HUP0104452A3 (de)
ID (1)	ID29262A (de)
IL (1)	IL139210A (de)
NO (1)	NO20005399D0 (de)
NZ (1)	NZ507345A (de)
PL (1)	PL343627A1 (de)
RU (1)	RU2203058C2 (de)
TR (1)	TR200003108T2 (de)
TW (1)	TW565461B (de)
WO (1)	WO1999055332A1 (de)
ZA (1)	ZA200005378B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9826656D0 (en)	1998-12-03	1999-01-27	Novartis Ag	Organic compounds
US7063857B1 (en)	1999-04-30	2006-06-20	Sucampo Ag	Use of macrolide compounds for the treatment of dry eye
AU777915B2 (en) *	1999-04-30	2004-11-04	Sucampo Ag	Use of macrolide compounds for the treatment of dry eye
PL409579A1 (pl) *	2001-02-19	2015-03-02	Novartis Ag	Leczenie raka
GB0108498D0 (en) *	2001-04-04	2001-05-23	Novartis Ag	Organic Compounds
AUPR529701A0 (en) *	2001-05-28	2001-06-21	Fujisawa Pharmaceutical Co., Ltd.	Pharmaceutical composition
PE20030828A1 (es) *	2002-03-04	2003-11-04	Novartis Ag	Composicion oftalmica que comprende ascomicina
GB0218996D0 (en) *	2002-08-14	2002-09-25	Novartis Ag	Organic compounds
US7354574B2 (en)	2002-11-07	2008-04-08	Advanced Ocular Systems Limited	Treatment of ocular disease
US7083802B2 (en) *	2003-07-31	2006-08-01	Advanced Ocular Systems Limited	Treatment of ocular disease
US7083803B2 (en)	2003-09-19	2006-08-01	Advanced Ocular Systems Limited	Ocular solutions
US7087237B2 (en)	2003-09-19	2006-08-08	Advanced Ocular Systems Limited	Ocular solutions
CA2558676C (en)	2004-03-03	2019-04-16	Essentia Biosystems, Inc.	Compositions and methods for topical diagnostic and therapeutic transport
US9211248B2 (en)	2004-03-03	2015-12-15	Revance Therapeutics, Inc.	Compositions and methods for topical application and transdermal delivery of botulinum toxins
JP4579920B2 (ja) *	2004-06-24	2010-11-10	興和株式会社	アトルバスタチン外用剤組成物
SG160357A1 (en)	2005-03-03	2010-04-29	Revance Therapeutics Inc	Compositions and methods for topical application and transdermal delivery of botulinum toxins
RU2420280C2 (ru) *	2005-04-21	2011-06-10	Сантен Фармасьютикал Ко., Лтд	Терапевтическое средство против кератоконъюнктивального расстройства
AU2006270041B2 (en)	2005-07-18	2011-08-18	Minu, Llc	Enhanced ocular neuroprotection/neurostimulation
FR2900052B1 (fr) *	2006-04-19	2011-02-18	Galderma Sa	Composition comprenant au moins une phase aqueuse et au moins une phase grasse comprenant de l'ivermectine
CN101288643B (zh) *	2008-06-17	2012-11-14	杨喜鸿	含有他克莫司的凝胶剂组合物及其制备方法和药物应用
CN102176913B (zh) *	2008-10-08	2014-08-13	高田制药株式会社	外用的他克莫司制剂
GB0917817D0 (en)	2009-10-12	2009-11-25	Biotica Tech Ltd	Novel compounds and methods for their production
GB0917816D0 (en)	2009-10-12	2009-11-25	Biotica Tech Ltd	Novel compounds and methods for their production
JP2011102260A (ja) *	2009-11-11	2011-05-26	Takada Seiyaku Kk	タクロリムス外用剤
JP5674786B2 (ja) *	2010-07-23	2015-02-25	マルホ株式会社	タクロリムスを含有する水中油型クリーム状組成物
WO2012011192A1 (ja) *	2010-07-23	2012-01-26	マルホ株式会社	タクロリムスを含有する水中油型クリーム状組成物
CA2825786A1 (en) *	2011-01-31	2012-08-09	Osaka University	Externally-used drug for treating skin disorder and method for producing same
US20230056335A1 (en) *	2020-01-24	2023-02-23	Nobelpharma Co., Ltd.	Topical formulation containing rapamycin

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4454113A (en) *	1982-09-21	1984-06-12	Scm Corporation	Stabilization of oil and water emulsions using polyglycerol esters of fatty acids
US4894366A (en) *	1984-12-03	1990-01-16	Fujisawa Pharmaceutical Company, Ltd.	Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
PH26083A (en) *	1987-11-09	1992-02-06	Sandoz Ltd	11, 28-dioxa-4-azatricyclo [22.3.1.04.9) octacos-18-ene derivatives and pharmaceutical compositions containing them and method of use thereof
US5540931A (en) *	1989-03-03	1996-07-30	Charles W. Hewitt	Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
US4996193A (en) *	1989-03-03	1991-02-26	The Regents Of The University Of California	Combined topical and systemic method of administration of cyclosporine
US4973468A (en) *	1989-03-22	1990-11-27	Cygnus Research Corporation	Skin permeation enhancer compositions
DK0427680T3 (da) *	1989-11-09	1995-12-18	Sandoz Ltd	Heteroatom-holdige cykliske forbindelser
EP0594600A1 (de) *	1990-03-13	1994-05-04	FISONS plc	Immunosuppressive makrozyklische verbindungen
JPH05507915A (ja) *	1990-06-11	1993-11-11	藤沢薬品工業株式会社	特発性血小板減少性紫斑病およびバセドウ病治療薬製造のためのｆｋ５０６等のマクロライド化合物の用途
MY110418A (en) *	1990-07-02	1998-05-30	Novartis Ag	Heteroatoms-containing tricyclic compounds.
AU656145B2 (en) *	1990-09-04	1995-01-27	Astellas Pharma Inc.	Ointments containing tricyclic compound
EP0480623A1 (de) *	1990-10-11	1992-04-15	Merck & Co. Inc.	Halomakrolide und Derivate mit immunosuppressiver Wirkung
PH31204A (en) *	1990-11-02	1998-05-05	Fujisawa Pharmaceutical Co	Pharmaceutical composition.
TW213418B (de) *	1991-05-02	1993-09-21	Kuko Seiyaku Kk
US5252732A (en) *	1991-09-09	1993-10-12	Merck & Co., Inc.	D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
US5208241A (en) *	1991-09-09	1993-05-04	Merck & Co., Inc.	N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity
US5247076A (en) *	1991-09-09	1993-09-21	Merck & Co., Inc.	Imidazolidyl macrolides having immunosuppressive activity
JPH06128148A (ja) *	1992-04-30	1994-05-10	Dotsuto:Kk	皮膚外用剤
HUT66531A (en) *	1992-05-07	1994-12-28	Sandoz Ag	Heteroatoms-containing tricyclic compounds, pharmaceutical prepns contg. them and process for producing them
JP2523428B2 (ja) *	1992-12-04	1996-08-07	エスエス製薬株式会社	消炎鎮痛ゲル製剤
JPH06345646A (ja) *	1993-06-08	1994-12-20	Fujisawa Pharmaceut Co Ltd	ローション剤
ATE299017T1 (de) *	1994-10-26	2005-07-15	Novartis Pharma Gmbh	Arzneimittel
AR004480A1 (es) *	1995-04-06	1998-12-16	Amico Derin C D	Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen
ES2230571T3 (es)	1995-12-28	2005-05-01	Mitsubishi Pharma Corporation	`composicion farmaceutica destinada para la administracion topica que comprende el 2-amino-2-(2-(4-octilfenil)etil) propan-1,3-diol para el tratamiento de las enfermedades causadas por una alteracion inmunitaria.
CZ283516B6 (cs) *	1996-09-12	1998-04-15	Galena A.S.	Léčivé přípravky, zejména pro vnitřní aplikaci, ve formě samomikroemulgujících terapeutických systémů
TW450810B (en) *	1997-02-20	2001-08-21	Fujisawa Pharmaceutical Co	Macrolides antibiotic pharmaceutical composition for preventing and treating skin diseases
JP4221762B2 (ja) *	1997-04-11	2009-02-12	アステラス製薬株式会社	医薬組成物

1999
- 1999-04-26 AU AU35372/99A patent/AU749475B2/en not_active Ceased
- 1999-04-26 ID IDW20002464A patent/ID29262A/id unknown
- 1999-04-26 HU HU0104452A patent/HUP0104452A3/hu unknown
- 1999-04-26 AR ARP990101921A patent/AR018330A1/es unknown
- 1999-04-26 JP JP54808699A patent/JP3732525B2/ja not_active Expired - Fee Related
- 1999-04-26 EP EP99917179A patent/EP1074255B1/de not_active Expired - Lifetime
- 1999-04-26 KR KR10-2000-7011259A patent/KR100406823B1/ko not_active Expired - Fee Related
- 1999-04-26 PL PL99343627A patent/PL343627A1/xx not_active Application Discontinuation
- 1999-04-26 ES ES99917179T patent/ES2284248T3/es not_active Expired - Lifetime
- 1999-04-26 IL IL13921099A patent/IL139210A/xx not_active IP Right Cessation
- 1999-04-26 CA CA002326222A patent/CA2326222C/en not_active Expired - Fee Related
- 1999-04-26 NZ NZ507345A patent/NZ507345A/xx unknown
- 1999-04-26 AT AT99917179T patent/ATE363275T1/de not_active IP Right Cessation
- 1999-04-26 DE DE69936195T patent/DE69936195T2/de not_active Expired - Lifetime
- 1999-04-26 US US09/673,260 patent/US6673808B1/en not_active Expired - Fee Related
- 1999-04-26 CN CNB998079367A patent/CN1161117C/zh not_active Expired - Fee Related
- 1999-04-26 TR TR2000/03108T patent/TR200003108T2/xx unknown
- 1999-04-26 WO PCT/JP1999/002237 patent/WO1999055332A1/ja not_active Ceased
- 1999-04-26 HK HK02100502.9A patent/HK1038884B/zh not_active IP Right Cessation
- 1999-04-26 BR BR9910336-2A patent/BR9910336A/pt not_active IP Right Cessation
- 1999-04-26 RU RU2000129665/14A patent/RU2203058C2/ru not_active IP Right Cessation
- 1999-04-27 TW TW088106893A patent/TW565461B/zh active
2000
- 2000-10-03 ZA ZA200005378A patent/ZA200005378B/en unknown
- 2000-10-26 NO NO20005399A patent/NO20005399D0/no not_active Application Discontinuation
2001
- 2001-12-07 US US10/005,645 patent/US6586444B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1074255A4 (de)	2002-02-13
WO1999055332A8 (en)	2000-02-17
NO20005399L (no)	2000-10-26
CA2326222A1 (en)	1999-11-04
JP3732525B2 (ja)	2006-01-05
KR100406823B1 (ko)	2003-11-21
AU749475B2 (en)	2002-06-27
KR20010042589A (ko)	2001-05-25
IL139210A0 (en)	2001-11-25
CA2326222C (en)	2008-09-23
RU2203058C2 (ru)	2003-04-27
DE69936195D1 (de)	2007-07-12
AR018330A1 (es)	2001-11-14
BR9910336A (pt)	2001-09-25
DE69936195T2 (de)	2007-09-13
WO1999055332A1 (en)	1999-11-04
NO20005399D0 (no)	2000-10-26
EP1074255B1 (de)	2007-05-30
HK1038884B (zh)	2005-05-06
HK1038884A1 (en)	2002-04-04
HUP0104452A2 (hu)	2002-03-28
ID29262A (id)	2001-08-16
US20020061907A1 (en)	2002-05-23
US6586444B2 (en)	2003-07-01
TR200003108T2 (tr)	2001-02-21
ES2284248T3 (es)	2007-11-01
ATE363275T1 (de)	2007-06-15
CN1307475A (zh)	2001-08-08
HUP0104452A3 (en)	2004-05-28
IL139210A (en)	2005-11-20
TW565461B (en)	2003-12-11
EP1074255A1 (de)	2001-02-07
CN1161117C (zh)	2004-08-11
AU3537299A (en)	1999-11-16
NZ507345A (en)	2002-12-20
PL343627A1 (en)	2001-08-27
US6673808B1 (en)	2004-01-06

Publication	Publication Date	Title
AU749475B2 (en)	2002-06-27	Medicinal compositions
AU727337B2 (en)	2000-12-07	Pharmaceutical composition
JPWO1999055332A1 (ja)	2000-10-17	医薬組成物
EP0474126B1 (de)	1997-03-19	Tricyclische Verbindungen enthaltende Salben
CA2164838C (en)	2009-04-28	A lotion comprising a tricyclic macrolide
HK1000006B (en)	1997-10-03	Ointments containing tricyclic compound
IE902413A1 (en)	1991-06-19	Aqueous liquid composition for external use
EP0428169B1 (de)	1995-03-01	Wässrige flüssige Arzneizubereitungen
US6316473B1 (en)	2001-11-13	Two surfactant-containing medicinal composition
AU2003256068A1 (en)	2004-02-25	Pharmaceutical compositions comprising fk506 derivatives and the ir use for the treatment of allergic diseases
US20040220204A1 (en)	2004-11-04	Pharmaceutical composition comprising a tricyclic compound for the prevention or treatment of skin diseases
WO2000007594A1 (en)	2000-02-17	Use of il-2 inhibitors in the treatment of rheumatoid arthritis
CZ20003993A3 (cs)	2001-05-16	Farmaceutický prostředek
AU2002302969A1 (en)	2002-12-09	Pharmaceutical composition comprising a tricyclic compound for the prevention or treatment of skin diseases
MXPA99007451A (en)	2000-04-24	Pharmaceutical composition
MXPA00009949A (en)	2001-07-31	Medicinal compositions