ZA200205265B - A novel crystalline form of N-[4-[2-[2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]L-glutamic acid and process therefor. - Google Patents

A novel crystalline form of N-[4-[2-[2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]L-glutamic acid and process therefor.

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Publication number
ZA200205265B
ZA200205265B ZA200205265A ZA200205265A ZA200205265B ZA 200205265 B ZA200205265 B ZA 200205265B ZA 200205265 A ZA200205265 A ZA 200205265A ZA 200205265 A ZA200205265 A ZA 200205265A ZA 200205265 B ZA200205265 B ZA 200205265B
Authority
ZA
South Africa
Prior art keywords
pyrrolo
pyrimidin
dihydro
benzoyl
oxo
Prior art date
Application number
ZA200205265A
Other languages
English (en)
Inventor
Erik Christopher Chelius
Sharon Van Den Berghe Snorek
Susan Marie Reutzel-Edens
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22679017&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200205265(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA200205265B publication Critical patent/ZA200205265B/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
ZA200205265A 2000-02-25 2002-07-01 A novel crystalline form of N-[4-[2-[2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]L-glutamic acid and process therefor. ZA200205265B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18496400P 2000-02-25 2000-02-25

Publications (1)

Publication Number Publication Date
ZA200205265B true ZA200205265B (en) 2003-11-11

Family

ID=22679017

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200205265A ZA200205265B (en) 2000-02-25 2002-07-01 A novel crystalline form of N-[4-[2-[2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]L-glutamic acid and process therefor.

Country Status (35)

Country Link
US (1) US7138521B2 (fr)
EP (1) EP1259513B1 (fr)
JP (1) JP4846158B2 (fr)
KR (1) KR100744917B1 (fr)
CN (1) CN1183135C (fr)
AR (1) AR029471A1 (fr)
AT (1) ATE249462T1 (fr)
AU (1) AU777047B2 (fr)
BR (1) BR0108604A (fr)
CA (1) CA2400155C (fr)
CO (1) CO5261585A1 (fr)
CZ (1) CZ303772B6 (fr)
DE (1) DE60100750T2 (fr)
DK (1) DK1259513T3 (fr)
DZ (1) DZ3283A1 (fr)
EA (1) EA004684B1 (fr)
EG (1) EG24073A (fr)
ES (1) ES2206403T3 (fr)
HR (1) HRP20020701B1 (fr)
HU (1) HU229704B1 (fr)
IL (2) IL150480A0 (fr)
MX (1) MXPA02008242A (fr)
MY (1) MY124784A (fr)
NO (1) NO323422B1 (fr)
NZ (1) NZ519796A (fr)
PE (1) PE20011082A1 (fr)
PL (1) PL208061B1 (fr)
PT (1) PT1259513E (fr)
SI (1) SI1259513T1 (fr)
SK (1) SK287375B6 (fr)
SV (1) SV2002000321A (fr)
TW (1) TWI237024B (fr)
UA (1) UA72791C2 (fr)
WO (1) WO2001062760A2 (fr)
ZA (1) ZA200205265B (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100364993C (zh) * 2003-05-30 2008-01-30 江苏恒瑞医药股份有限公司 培美曲噻盐及其制备方法
CN100364994C (zh) * 2004-11-25 2008-01-30 重庆医药工业研究院有限责任公司 培美曲塞二钠的一种新晶型及其制备方法
US20070197568A1 (en) * 2005-11-04 2007-08-23 Paul Bunn Methods of using SAHA and Erlotinib for treating cancer
CA2627129A1 (fr) * 2005-11-04 2007-05-18 Merck & Co., Inc. Methodes d'utilisation de saha et de bortezomib pour traiter le cancer
KR101083230B1 (ko) 2006-08-14 2011-11-11 시코르, 인크. 페메트렉세드 이산의 동결 건조된 약학적 허용염의 제조 방법
US7994180B2 (en) * 2006-08-14 2011-08-09 Sicor Inc. Processes for preparing intermediates of pemetrexed
JP2008543975A (ja) 2006-08-14 2008-12-04 シコール インコーポレイティド 高度に純粋なペメトレキセド二酸およびその調製方法
EP2270012A1 (fr) * 2006-08-14 2011-01-05 Sicor, Inc. Forme cristalline de diacide de pemetrexed et son procédé de préparation
CN101528037A (zh) * 2006-11-03 2009-09-09 默克公司 使用saha和硼替佐米治疗多发性骨髓瘤的方法
BRPI0807939A2 (pt) 2007-04-03 2014-07-01 Reddys Lab Ltd Dr Formas sólidas de pemetrexed
CN101417998B (zh) * 2007-10-24 2012-10-24 重庆医药工业研究院有限责任公司 一种培美曲塞盐的纯化方法
US20090181990A1 (en) 2007-12-23 2009-07-16 Patel Nileshkumar S Stable amorphous form of pemetrexed disodium
WO2010028105A2 (fr) * 2008-09-08 2010-03-11 Dr. Reddy's Laboratories Ltd. Disodium de pemetrexed amorphe
WO2010030598A2 (fr) * 2008-09-11 2010-03-18 Dr. Reddy's Laboratories Limited Formulations pharmaceutiques comprenant du pemetrexed
CN101684121B (zh) * 2008-09-22 2013-04-03 重庆医药工业研究院有限责任公司 培美曲塞二酸的新晶型及其制备方法
CN102050825B (zh) * 2009-11-05 2014-12-17 上海创诺制药有限公司 制备培美曲塞二钠2.5水结晶的方法
EP2504341A1 (fr) 2009-11-24 2012-10-03 Azad Pharmaceutical Ingredients AG Nouvelle forme cristalline du pemetrexed disodique
CN102372719B (zh) * 2010-08-26 2013-10-30 齐鲁制药有限公司 培美曲塞二甲酯对甲苯磺酸盐晶型及其制备方法
KR101069128B1 (ko) * 2011-03-10 2011-09-30 건일제약 주식회사 페메트렉시드 또는 그의 염을 포함하는 항산화제-비함유 주사용 용액 형태의 약학적 제제의 제조방법
US9051322B2 (en) 2011-03-23 2015-06-09 Scinopharm Taiwan, Ltd. Process for the production of a pemetrexed salt
EP2688888B1 (fr) 2011-03-25 2017-06-14 Scinopharm Taiwan, Ltd. Procédé pour la production de disodium pémétrexed
ITRM20120398A1 (it) 2012-08-08 2014-02-09 Berlin Chemie Ag Procedimento di sintesi pemetrexed e suo sale di lisina.
CN102911176B (zh) * 2012-10-10 2015-07-22 德州德药制药有限公司 一种培美曲塞二钠的制备方法
WO2014060959A1 (fr) * 2012-10-17 2014-04-24 Shilpa Medicare Limited Procédé de préparation de dipotassium de pemetrexed cristallin
US20150359898A1 (en) 2013-02-06 2015-12-17 Cipla Limited Pemetrexed Complexes and Pharmaceutical Compositions Containing Pemetrexed Complexes
US20160051679A1 (en) 2013-04-12 2016-02-25 Actavis Group Ptc Ehf. Pemetrexed Formulation
KR101485243B1 (ko) 2013-05-08 2015-01-21 씨제이헬스케어 주식회사 안정화된 페메트렉시드 제제
JP6094388B2 (ja) * 2013-06-07 2017-03-15 ニプロ株式会社 ペメトレキセドを含む注射用組成物
US20160145260A1 (en) 2013-06-14 2016-05-26 Synthon B.V. Stable pemetrexed arginine salt and compositions comprising it
EP3021849B1 (fr) 2013-07-16 2019-10-09 Dr. Reddy's Laboratories Ltd. Nouvelles formes cristallines de sels de trométhamine de pemetrexed
DK3040074T3 (en) 2013-10-03 2018-10-08 Fujifilm Corp INJECTION PREPARATION AND METHOD OF PREPARING IT
NZ630292A (en) * 2013-11-25 2015-02-27 Shilpa Medicare Ltd Process for crystalline pemetrexed dipotassium salt
NZ630299A (en) 2014-06-30 2014-11-28 Shilpa Medicare Ltd Pemetrexed dipotassium formulations
CA3015436C (fr) 2014-10-30 2020-07-21 Scinopharm Taiwan, Ltd. Formes cristallines de diacide de pemetrexed et procedes de fabrication connexes
CN105566328B (zh) * 2014-11-06 2018-04-24 博瑞生物医药（苏州）股份有限公司 培美曲塞二酸多晶型的制备方法
ES2959975T3 (es) * 2017-10-10 2024-02-29 Sun Pharmaceutical Ind Ltd Forma de dosificación para infusión intravenosa de pemetrexed
JP7491572B2 (ja) 2018-02-07 2024-05-28 エル．イー．エー．エフ． ホールディングス グループ エルエルシー アルファポリグルタミン酸化ペメトレキセドおよびその使用
WO2019157145A1 (fr) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Compositions de pémétrexed polyglutamaté gamma et leurs utilisations
WO2025244944A1 (fr) * 2024-05-20 2025-11-27 Opna Bio SA Formes cristallines d'un agent

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO169490C (no) 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
KR0162654B1 (ko) 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
US5416211A (en) 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
WO1998008382A1 (fr) * 1996-08-30 1998-03-05 Eli Lilly And Company Antifoliques non classiques de pyrrolo[2,3-d]pyrimidine
ZA987550B (en) * 1997-09-26 2000-02-21 Lilly Co Eli Processes and intermediates useful to make antifolates.
WO1999016742A1 (fr) * 1997-09-26 1999-04-08 Eli Lilly And Company Procedes et intermediaires pour la production d'antifoliques
AU6890800A (en) * 1999-08-23 2001-03-19 Eli Lilly And Company A novel crystalline form of disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-D]- pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid salt and processes therefor

Also Published As

Publication number Publication date
WO2001062760A2 (fr) 2001-08-30
DK1259513T3 (da) 2004-01-12
NO20023974L (no) 2002-08-21
SK287375B6 (sk) 2010-08-09
DZ3283A1 (fr) 2001-08-30
PE20011082A1 (es) 2001-10-22
HRP20020701A2 (en) 2003-12-31
SV2002000321A (es) 2002-07-16
DE60100750T2 (de) 2004-07-29
HUP0204232A3 (en) 2006-01-30
HRP20020701B1 (en) 2011-02-28
KR20020075449A (ko) 2002-10-04
CN1183135C (zh) 2005-01-05
PL356423A1 (en) 2004-06-28
AR029471A1 (es) 2003-07-02
EG24073A (en) 2008-05-11
HU229704B1 (en) 2014-05-28
CZ20022875A3 (cs) 2003-02-12
SI1259513T1 (en) 2003-12-31
US7138521B2 (en) 2006-11-21
US20030216416A1 (en) 2003-11-20
ES2206403T3 (es) 2004-05-16
HUP0204232A2 (hu) 2003-04-28
AU777047B2 (en) 2004-09-30
PL208061B1 (pl) 2011-03-31
WO2001062760A3 (fr) 2001-12-06
JP2003530321A (ja) 2003-10-14
BR0108604A (pt) 2002-11-19
KR100744917B1 (ko) 2007-08-01
CN1406238A (zh) 2003-03-26
AU3445101A (en) 2001-09-03
ATE249462T1 (de) 2003-09-15
CZ303772B6 (cs) 2013-05-02
EP1259513B1 (fr) 2003-09-10
HK1051856A1 (en) 2003-08-22
JP4846158B2 (ja) 2011-12-28
UA72791C2 (uk) 2005-04-15
EP1259513A2 (fr) 2002-11-27
DE60100750D1 (de) 2003-10-16
IL150480A0 (en) 2002-12-01
CA2400155C (fr) 2009-09-15
PT1259513E (pt) 2004-02-27
NO20023974D0 (no) 2002-08-21
NZ519796A (en) 2003-01-31
CA2400155A1 (fr) 2001-08-30
CO5261585A1 (es) 2003-03-31
EA004684B1 (ru) 2004-06-24
SK11862002A3 (sk) 2003-01-09
MY124784A (en) 2006-07-31
EA200200905A1 (ru) 2003-02-27
NO323422B1 (no) 2007-04-30
TWI237024B (en) 2005-08-01
MXPA02008242A (es) 2002-11-29
IL150480A (en) 2007-12-03

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