DZ3283A1 - Nouvelle forme cristalline de l'acide n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutaminique et son procede de preparation - Google Patents

Nouvelle forme cristalline de l'acide n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutaminique et son procede de preparation

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Publication number
DZ3283A1
DZ3283A1 DZ013283A DZ013283A DZ3283A1 DZ 3283 A1 DZ3283 A1 DZ 3283A1 DZ 013283 A DZ013283 A DZ 013283A DZ 013283 A DZ013283 A DZ 013283A DZ 3283 A1 DZ3283 A1 DZ 3283A1
Authority
DZ
Algeria
Prior art keywords
glutaminique
pyrrolo
pyrimidin
dihydro
oxo
Prior art date
Application number
DZ013283A
Other languages
English (en)
Inventor
Erik Christopher Chelius
Susan Marie Reutzel-Edens
Den Berghe-Snorek Sharon Van
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22679017&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DZ3283(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DZ3283A1 publication Critical patent/DZ3283A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
DZ013283A 2000-02-25 2001-02-12 Nouvelle forme cristalline de l'acide n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutaminique et son procede de preparation DZ3283A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18496400P 2000-02-25 2000-02-25
PCT/US2001/001229 WO2001062760A2 (fr) 2000-02-25 2001-02-12 Nouvelle forme cristalline de n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-acide glutamique et procede correspondant

Publications (1)

Publication Number Publication Date
DZ3283A1 true DZ3283A1 (fr) 2001-08-30

Family

ID=22679017

Family Applications (1)

Application Number Title Priority Date Filing Date
DZ013283A DZ3283A1 (fr) 2000-02-25 2001-02-12 Nouvelle forme cristalline de l'acide n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutaminique et son procede de preparation

Country Status (35)

Country Link
US (1) US7138521B2 (fr)
EP (1) EP1259513B1 (fr)
JP (1) JP4846158B2 (fr)
KR (1) KR100744917B1 (fr)
CN (1) CN1183135C (fr)
AR (1) AR029471A1 (fr)
AT (1) ATE249462T1 (fr)
AU (1) AU777047B2 (fr)
BR (1) BR0108604A (fr)
CA (1) CA2400155C (fr)
CO (1) CO5261585A1 (fr)
CZ (1) CZ303772B6 (fr)
DE (1) DE60100750T2 (fr)
DK (1) DK1259513T3 (fr)
DZ (1) DZ3283A1 (fr)
EA (1) EA004684B1 (fr)
EG (1) EG24073A (fr)
ES (1) ES2206403T3 (fr)
HR (1) HRP20020701B1 (fr)
HU (1) HU229704B1 (fr)
IL (2) IL150480A0 (fr)
MX (1) MXPA02008242A (fr)
MY (1) MY124784A (fr)
NO (1) NO323422B1 (fr)
NZ (1) NZ519796A (fr)
PE (1) PE20011082A1 (fr)
PL (1) PL208061B1 (fr)
PT (1) PT1259513E (fr)
SI (1) SI1259513T1 (fr)
SK (1) SK287375B6 (fr)
SV (1) SV2002000321A (fr)
TW (1) TWI237024B (fr)
UA (1) UA72791C2 (fr)
WO (1) WO2001062760A2 (fr)
ZA (1) ZA200205265B (fr)

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CN100364994C (zh) * 2004-11-25 2008-01-30 重庆医药工业研究院有限责任公司 培美曲塞二钠的一种新晶型及其制备方法
JP2009514891A (ja) * 2005-11-04 2009-04-09 メルク エンド カムパニー インコーポレーテッド 癌を治療するためのｓａｈａ及びエルロチニブを用いる方法
CA2636596A1 (fr) * 2005-11-04 2007-05-18 James Pluda Traitement anticancereux au saha et au pemetrexed
EP1957497B1 (fr) * 2006-08-14 2015-09-30 Sicor, Inc. Procédés de préparation de produits intermédiaires de pemetrexed
ATE492547T1 (de) * 2006-08-14 2011-01-15 Sicor Inc Verfahren zur herstellung lipophiler pharmazeutisch akzeptabler salze aus pemetrexed- disäure
WO2008021405A1 (fr) * 2006-08-14 2008-02-21 Sicor Inc. Formes cristallines de diacide de pemetrexed et leurs procédés de préparation
KR20090052355A (ko) * 2006-08-14 2009-05-25 시코르, 인크. 순도가 높은 페메트렉세드 이산 및 이의 제조 방법
CN101528037A (zh) * 2006-11-03 2009-09-09 默克公司 使用saha和硼替佐米治疗多发性骨髓瘤的方法
BRPI0807939A2 (pt) * 2007-04-03 2014-07-01 Reddys Lab Ltd Dr Formas sólidas de pemetrexed
CN101417998B (zh) 2007-10-24 2012-10-24 重庆医药工业研究院有限责任公司 一种培美曲塞盐的纯化方法
EP2072518A1 (fr) 2007-12-23 2009-06-24 Sun Pharma Advanced Research Company Limited Forme amorphe stable de Pemextred disodium
EP2334685A4 (fr) * 2008-09-08 2011-10-26 Reddys Lab Ltd Dr Disodium de pemetrexed amorphe
WO2010030598A2 (fr) * 2008-09-11 2010-03-18 Dr. Reddy's Laboratories Limited Formulations pharmaceutiques comprenant du pemetrexed
CN101684121B (zh) * 2008-09-22 2013-04-03 重庆医药工业研究院有限责任公司 培美曲塞二酸的新晶型及其制备方法
CN102050825B (zh) * 2009-11-05 2014-12-17 上海创诺制药有限公司 制备培美曲塞二钠2.5水结晶的方法
WO2011064256A1 (fr) 2009-11-24 2011-06-03 Azad Pharmaceutical Ingredients Ag Nouvelle forme cristalline du pemetrexed disodique
CN102372719B (zh) * 2010-08-26 2013-10-30 齐鲁制药有限公司 培美曲塞二甲酯对甲苯磺酸盐晶型及其制备方法
KR101069128B1 (ko) * 2011-03-10 2011-09-30 건일제약 주식회사 페메트렉시드 또는 그의 염을 포함하는 항산화제-비함유 주사용 용액 형태의 약학적 제제의 제조방법
US9051322B2 (en) 2011-03-23 2015-06-09 Scinopharm Taiwan, Ltd. Process for the production of a pemetrexed salt
CA2827455C (fr) * 2011-03-25 2017-10-24 Scinopharm Taiwan Ltd Procede pour la production d'un sel de pemetrexed
ITRM20120398A1 (it) 2012-08-08 2014-02-09 Berlin Chemie Ag Procedimento di sintesi pemetrexed e suo sale di lisina.
CN102911176B (zh) * 2012-10-10 2015-07-22 德州德药制药有限公司 一种培美曲塞二钠的制备方法
WO2014060959A1 (fr) * 2012-10-17 2014-04-24 Shilpa Medicare Limited Procédé de préparation de dipotassium de pemetrexed cristallin
WO2014122460A2 (fr) 2013-02-06 2014-08-14 Cipla House Complexes de pémétrexed et compositions pharmaceutiques contenant des complexes de pémétrexed
US20160051679A1 (en) 2013-04-12 2016-02-25 Actavis Group Ptc Ehf. Pemetrexed Formulation
KR101485243B1 (ko) 2013-05-08 2015-01-21 씨제이헬스케어 주식회사 안정화된 페메트렉시드 제제
JP6094388B2 (ja) * 2013-06-07 2017-03-15 ニプロ株式会社 ペメトレキセドを含む注射用組成物
ES2657944T3 (es) 2013-06-14 2018-03-07 Synthon B.V. Sal estable de arginina de pemetrexed y composiciones que la comprenden
US9688682B2 (en) 2013-07-16 2017-06-27 Dr. Reddy's Laboratories Limited Crystalline forms of pemetrexed tromethamine salts
EP3040074B1 (fr) 2013-10-03 2018-07-25 Fujifilm Corporation Préparation pharmaceutique d'injection, et procédé de fabrication de celle-ci
NZ630292A (en) * 2013-11-25 2015-02-27 Shilpa Medicare Ltd Process for crystalline pemetrexed dipotassium salt
NZ630299A (en) 2014-06-30 2014-11-28 Shilpa Medicare Ltd Pemetrexed dipotassium formulations
CA2962383C (fr) * 2014-10-30 2019-10-08 Scinopharm Taiwan, Ltd. Formes cristallines du diacide de pemetrexed et leurs procedes de production
CN105566328B (zh) * 2014-11-06 2018-04-24 博瑞生物医药（苏州）股份有限公司 培美曲塞二酸多晶型的制备方法
EP3804686B1 (fr) * 2017-10-10 2023-08-30 Sun Pharmaceutical Industries Ltd Forme posologique de perfusion intraveineuse de pemetrexed
CN111954531A (zh) 2018-02-07 2020-11-17 L.E.A.F.控股集团公司 α聚谷氨酸化培美曲塞及其用途
EP3749311A4 (fr) 2018-02-07 2022-07-06 L.E.A.F Holdings Group LLC Compositions de pémétrexed polyglutamaté gamma et leurs utilisations
WO2025244944A1 (fr) * 2024-05-20 2025-11-27 Opna Bio SA Formes cristallines d'un agent

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NO169490C (no) 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
KR0162654B1 (ko) 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
US5416211A (en) 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
EP0923287A4 (fr) * 1996-08-30 2001-08-01 Lilly Co Eli Antifoliques non classiques de pyrrolo 2,3-d]pyrimidine
BR9812524A (pt) * 1997-09-26 2000-07-25 Lilly Co Eli Processos e intermediários utilizáveis para produzir antifolatos
ZA987550B (en) * 1997-09-26 2000-02-21 Lilly Co Eli Processes and intermediates useful to make antifolates.
EP1212325A2 (fr) * 1999-08-23 2002-06-12 Eli Lilly And Company Nouvelle forme cristalline de disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo 2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-l- sel d'acide glutamique et procedes de preparation

Also Published As

Publication number Publication date
CZ20022875A3 (cs) 2003-02-12
US7138521B2 (en) 2006-11-21
WO2001062760A3 (fr) 2001-12-06
MXPA02008242A (es) 2002-11-29
KR20020075449A (ko) 2002-10-04
ATE249462T1 (de) 2003-09-15
HUP0204232A2 (hu) 2003-04-28
EA004684B1 (ru) 2004-06-24
PL356423A1 (en) 2004-06-28
NO20023974L (no) 2002-08-21
AU3445101A (en) 2001-09-03
CN1406238A (zh) 2003-03-26
AU777047B2 (en) 2004-09-30
SI1259513T1 (en) 2003-12-31
HU229704B1 (en) 2014-05-28
IL150480A (en) 2007-12-03
HK1051856A1 (en) 2003-08-22
DE60100750T2 (de) 2004-07-29
TWI237024B (en) 2005-08-01
EP1259513A2 (fr) 2002-11-27
HUP0204232A3 (en) 2006-01-30
JP2003530321A (ja) 2003-10-14
US20030216416A1 (en) 2003-11-20
NZ519796A (en) 2003-01-31
ZA200205265B (en) 2003-11-11
SK11862002A3 (sk) 2003-01-09
MY124784A (en) 2006-07-31
EP1259513B1 (fr) 2003-09-10
EA200200905A1 (ru) 2003-02-27
BR0108604A (pt) 2002-11-19
PL208061B1 (pl) 2011-03-31
CA2400155A1 (fr) 2001-08-30
JP4846158B2 (ja) 2011-12-28
HRP20020701A2 (en) 2003-12-31
NO323422B1 (no) 2007-04-30
PT1259513E (pt) 2004-02-27
PE20011082A1 (es) 2001-10-22
NO20023974D0 (no) 2002-08-21
SK287375B6 (sk) 2010-08-09
UA72791C2 (uk) 2005-04-15
CO5261585A1 (es) 2003-03-31
HRP20020701B1 (en) 2011-02-28
ES2206403T3 (es) 2004-05-16
DK1259513T3 (da) 2004-01-12
IL150480A0 (en) 2002-12-01
CZ303772B6 (cs) 2013-05-02
AR029471A1 (es) 2003-07-02
DE60100750D1 (de) 2003-10-16
KR100744917B1 (ko) 2007-08-01
WO2001062760A2 (fr) 2001-08-30
SV2002000321A (es) 2002-07-16
EG24073A (en) 2008-05-11
CA2400155C (fr) 2009-09-15
CN1183135C (zh) 2005-01-05

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