NO323422B1 - Ny krystallinsk form av N-[4-[2-(2-amino-4,7-dihydro-4-okso-3H-pyrrolo[2,3-d]pyrimidin-5-yl)etyl]benzoyl]-L-glutaminsyre og fremgangsmate for fremstilling derav - Google Patents

Ny krystallinsk form av N-[4-[2-(2-amino-4,7-dihydro-4-okso-3H-pyrrolo[2,3-d]pyrimidin-5-yl)etyl]benzoyl]-L-glutaminsyre og fremgangsmate for fremstilling derav Download PDF

Info

Publication number: NO323422B1
Authority: NO; Norway
Prior art keywords: heptahydrate; pyrrolo; oxo; amino; dihydro
Prior art date: 2000-02-25

Application number

NO20023974A

Other languages

English (en)

Norwegian (no)

Other versions

NO20023974L (no

NO20023974D0 (no

Inventor

Erik Christopher Chelius

Susan Marie Reutzel-Edens

Sharon Van Den Berghe Snorek

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-25

Filing date

2002-08-21

Publication date

2007-04-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22679017&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO323422(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-08-21 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2002-08-21 Publication of NO20023974L publication Critical patent/NO20023974L/no

2002-08-21 Publication of NO20023974D0 publication Critical patent/NO20023974D0/no

2007-04-30 Publication of NO323422B1 publication Critical patent/NO323422B1/no

Links

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UANBXQTVHOIGGQ-LMOVPXPDSA-N diethyl (2s)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate;4-methylbenzenesulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1.C1=CC(C(=O)N[C@@H](CCC(=O)OCC)C(=O)OCC)=CC=C1CCC1=CNC2=C1C(=O)N=C(N)N2 UANBXQTVHOIGGQ-LMOVPXPDSA-N 0.000 title 1
239000013078 crystal Substances 0.000 claims description 50
150000004688 heptahydrates Chemical class 0.000 claims description 47
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical group CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 41
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 32
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IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 12
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 10
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125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 9
238000002441 X-ray diffraction Methods 0.000 claims description 8
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 8
150000003839 salts Chemical class 0.000 claims description 7
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 6
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-1 disodium N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d] Pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid salt Chemical class 0.000 claims description 3
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)

NO20023974A 2000-02-25 2002-08-21 Ny krystallinsk form av N-[4-[2-(2-amino-4,7-dihydro-4-okso-3H-pyrrolo[2,3-d]pyrimidin-5-yl)etyl]benzoyl]-L-glutaminsyre og fremgangsmate for fremstilling derav NO323422B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US18496400P	2000-02-25	2000-02-25
PCT/US2001/001229 WO2001062760A2 (fr)	2000-02-25	2001-02-12	Nouvelle forme cristalline de n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-acide glutamique et procede correspondant

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JP (1)	JP4846158B2 (fr)
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CN (1)	CN1183135C (fr)
AR (1)	AR029471A1 (fr)
AT (1)	ATE249462T1 (fr)
AU (1)	AU777047B2 (fr)
BR (1)	BR0108604A (fr)
CA (1)	CA2400155C (fr)
CO (1)	CO5261585A1 (fr)
CZ (1)	CZ303772B6 (fr)
DE (1)	DE60100750T2 (fr)
DK (1)	DK1259513T3 (fr)
DZ (1)	DZ3283A1 (fr)
EA (1)	EA004684B1 (fr)
EG (1)	EG24073A (fr)
ES (1)	ES2206403T3 (fr)
HR (1)	HRP20020701B1 (fr)
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IL (2)	IL150480A0 (fr)
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MY (1)	MY124784A (fr)
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NZ (1)	NZ519796A (fr)
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2001
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DZ3283A1 (fr)	2001-08-30
CZ20022875A3 (cs)	2003-02-12
US7138521B2 (en)	2006-11-21
WO2001062760A3 (fr)	2001-12-06
MXPA02008242A (es)	2002-11-29
KR20020075449A (ko)	2002-10-04
ATE249462T1 (de)	2003-09-15
HUP0204232A2 (hu)	2003-04-28
EA004684B1 (ru)	2004-06-24
PL356423A1 (en)	2004-06-28
NO20023974L (no)	2002-08-21
AU3445101A (en)	2001-09-03
CN1406238A (zh)	2003-03-26
AU777047B2 (en)	2004-09-30
SI1259513T1 (en)	2003-12-31
HU229704B1 (en)	2014-05-28
IL150480A (en)	2007-12-03
HK1051856A1 (en)	2003-08-22
DE60100750T2 (de)	2004-07-29
TWI237024B (en)	2005-08-01
EP1259513A2 (fr)	2002-11-27
HUP0204232A3 (en)	2006-01-30
JP2003530321A (ja)	2003-10-14
US20030216416A1 (en)	2003-11-20
NZ519796A (en)	2003-01-31
ZA200205265B (en)	2003-11-11
SK11862002A3 (sk)	2003-01-09
MY124784A (en)	2006-07-31
EP1259513B1 (fr)	2003-09-10
EA200200905A1 (ru)	2003-02-27
BR0108604A (pt)	2002-11-19
PL208061B1 (pl)	2011-03-31
CA2400155A1 (fr)	2001-08-30
JP4846158B2 (ja)	2011-12-28
HRP20020701A2 (en)	2003-12-31
PT1259513E (pt)	2004-02-27
PE20011082A1 (es)	2001-10-22
NO20023974D0 (no)	2002-08-21
SK287375B6 (sk)	2010-08-09
UA72791C2 (uk)	2005-04-15
CO5261585A1 (es)	2003-03-31
HRP20020701B1 (en)	2011-02-28
ES2206403T3 (es)	2004-05-16
DK1259513T3 (da)	2004-01-12
IL150480A0 (en)	2002-12-01
CZ303772B6 (cs)	2013-05-02
AR029471A1 (es)	2003-07-02
DE60100750D1 (de)	2003-10-16
KR100744917B1 (ko)	2007-08-01
WO2001062760A2 (fr)	2001-08-30
SV2002000321A (es)	2002-07-16
EG24073A (en)	2008-05-11
CA2400155C (fr)	2009-09-15
CN1183135C (zh)	2005-01-05

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Publication	Publication Date	Title
NO323422B1 (no)	2007-04-30	Ny krystallinsk form av N-[4-[2-(2-amino-4,7-dihydro-4-okso-3H-pyrrolo[2,3-d]pyrimidin-5-yl)etyl]benzoyl]-L-glutaminsyre og fremgangsmate for fremstilling derav
JP5665538B2 (ja)	2015-02-04	（１ｓ，２ｓ，３ｓ，４ｒ）−３−［（１ｓ）−１−アセチルアミノ−２−エチル−ブチル］−４−グアニジノ−２−ヒドロキシ−シクロペンチル−１−カルボン酸水和物及びその使用
NO326965B1 (no)	2009-03-23	a-form eller β-form-krystall av acetanilid-derivat og farmasoytisk preparat
RU2467012C2 (ru)	2012-11-20	Способ очистки стауроспорина и способ получения n-бензоилстауроспорина
GB2251791A (en)	1992-07-22	Stabilised sulphonamide compositions
NO326852B1 (no)	2009-03-02	Nye galeniske formuleringer av meloksicam for oral administrering, samt fremgangsmate for fremstilling derav.
AU2022290946A1 (en)	2024-01-25	Crystal form of tolebrutinib, preparation method therefor and use thereof
JP2025511217A (ja)	2025-04-15	メセンブリンの塩形態
WO2023138049A1 (fr)	2023-07-27	Composé de biflavone dirigé contre le virus de l'herpès simplex de type i, son procédé de préparation et son utilisation
EP0944612B1 (fr)	2001-09-05	Hydrate de n-(4-acetyl-1-piperazinyl)-4-fluorobenzamide
KR20010074473A (ko)	2001-08-04	형태 Ⅵ의 5,6-디클로로-2-(이소프로필아미노)-1-(β-Ｌ-리보푸라노실)-1Ｈ-벤즈이미다졸
CZ295578B6 (cs)	2005-08-17	Modifikovaná forma hydrochloridu R(-)-N-(4,4-di(3-methylthien-2-yl)but-3-enyl)nipekotové kyseliny, způsob její přípravy a použití a farmaceutické prostředky ji obsahující
CN100413500C (zh)	2008-08-27	一种预防或治疗骨质疏松症的药物及其制备方法和应用
HK1051856B (en)	2004-05-28	A novel crystalline form of n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo [2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and process therefor
US20250275939A1 (en)	2025-09-04	Co-crystals
WO2022237710A1 (fr)	2022-11-17	Forme cristalline d'un composé destiné au traitement de la grippe et son application
EP1355632B1 (fr)	2007-01-10	Base libre d'amlodipine
HK40112450A (zh)	2025-01-17	吡唑并[3，4-d]嘧啶化合物的固体形式