ZA200604620B - IP-10 antibodies and their uses - Google Patents

IP-10 antibodies and their uses Download PDF

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Publication number
ZA200604620B
ZA200604620B ZA200604620A ZA200604620A ZA200604620B ZA 200604620 B ZA200604620 B ZA 200604620B ZA 200604620 A ZA200604620 A ZA 200604620A ZA 200604620 A ZA200604620 A ZA 200604620A ZA 200604620 B ZA200604620 B ZA 200604620B
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ZA
South Africa
Prior art keywords
seq
variable region
antibody
chain variable
human
Prior art date
Application number
ZA200604620A
Other languages
English (en)
Inventor
Deshpande Shrikant
Huang Haichun
Srinivasan Mohan
Josephine M Cardarelli
Wang Changyu
Passmore David
Vangipuram S Rangan
Thomas E Lane
Hans S Keirstead
Michael T Liu
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Medarex Inc
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Publication of ZA200604620B publication Critical patent/ZA200604620B/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Medicinal Chemistry (AREA)
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  • Immunology (AREA)
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  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Oncology (AREA)
  • Communicable Diseases (AREA)
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
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  • Zoology (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
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  • Urology & Nephrology (AREA)
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ZA200604620A 2003-12-10 2004-12-10 IP-10 antibodies and their uses ZA200604620B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52918003P 2003-12-10 2003-12-10

Publications (1)

Publication Number Publication Date
ZA200604620B true ZA200604620B (en) 2007-10-31

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ID=34699950

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200604620A ZA200604620B (en) 2003-12-10 2004-12-10 IP-10 antibodies and their uses

Country Status (25)

Country Link
US (4) US20050191293A1 (fr)
EP (3) EP2865687A1 (fr)
JP (2) JP4942487B2 (fr)
KR (4) KR101374514B1 (fr)
CN (2) CN1889979B (fr)
AU (1) AU2004298492B2 (fr)
BR (1) BRPI0417429A (fr)
CA (1) CA2548338C (fr)
CY (2) CY1113096T1 (fr)
DK (2) DK2383295T3 (fr)
ES (2) ES2537163T3 (fr)
HK (1) HK1209759A1 (fr)
HR (2) HRP20120702T1 (fr)
HU (1) HUE025328T2 (fr)
IL (1) IL175855A (fr)
MX (1) MXPA06005941A (fr)
NO (1) NO342278B1 (fr)
NZ (1) NZ547499A (fr)
PL (2) PL2383295T3 (fr)
PT (2) PT2383295E (fr)
RS (1) RS53984B1 (fr)
RU (1) RU2486199C2 (fr)
SI (2) SI1691837T1 (fr)
WO (1) WO2005058815A2 (fr)
ZA (1) ZA200604620B (fr)

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NZ566395A (en) 2005-09-26 2012-03-30 Medarex Inc Human monoclonal antibodies to CD70
BRPI0619249A2 (pt) 2005-11-30 2011-09-20 Abbott Lab anticorpos anti-globulÈmeros-aß, frações que se ligam a antìgeno destes, hibridomas correspondentes, ácidos nucléicos, vetores, células hospedeiras, métodos de produzir os ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos de usar os ditos anticorpos
AU2013200177B2 (en) * 2005-11-30 2014-10-02 Abbvie Deutschland Gmbh & Co Kg Monoclonal antibodies against amyloid beta protein and uses thereof
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EP2009101B1 (fr) 2006-03-31 2017-10-25 Chugai Seiyaku Kabushiki Kaisha Procede de modification d'anticorps pour purifier un anticorps bispecifique
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EP2164508B1 (fr) 2007-06-04 2014-01-08 Rappaport Family Institute for Research in the Medical Sciences Agents destinés au traitement de maladies inflammatoires et leurs procédés d'utilisation
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