ZA200607995B - Compositions and method for control of insect infestation in plants - Google Patents
Compositions and method for control of insect infestation in plants Download PDFInfo
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- ZA200607995B ZA200607995B ZA2006/07995A ZA200607995A ZA200607995B ZA 200607995 B ZA200607995 B ZA 200607995B ZA 2006/07995 A ZA2006/07995 A ZA 2006/07995A ZA 200607995 A ZA200607995 A ZA 200607995A ZA 200607995 B ZA200607995 B ZA 200607995B
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- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
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- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
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- C—CHEMISTRY; METALLURGY
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- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
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| US60342104P | 2004-08-20 | 2004-08-20 | |
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| US66917505P | 2005-04-07 | 2005-04-07 | |
| PCT/US2005/011816 WO2005110068A2 (en) | 2004-04-09 | 2005-04-08 | Compositions and methods for control of insect infestations in plants |
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Families Citing this family (230)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9322031B2 (en) | 1999-05-06 | 2016-04-26 | Monsanto Technology Llc | Transgenic plants with enhanced agronomic traits |
| US20090044297A1 (en) * | 1999-05-06 | 2009-02-12 | Andersen Scott E | Transgenic plants with enhanced agronomic traits |
| US20090241217A9 (en) * | 2001-05-22 | 2009-09-24 | Jingrui Wu | Yield-improved transgenic plants |
| US7612194B2 (en) * | 2001-07-24 | 2009-11-03 | Monsanto Technology Llc | Nucleic acid sequences from Diabrotica virgifera virgifera LeConte and uses thereof |
| US20090049573A1 (en) * | 2002-10-02 | 2009-02-19 | Dotson Stanton B | Transgenic plants with enhanced agronomic traits |
| US20090183270A1 (en) | 2002-10-02 | 2009-07-16 | Adams Thomas R | Transgenic plants with enhanced agronomic traits |
| ATE430802T1 (de) | 2003-08-21 | 2009-05-15 | Monsanto Technology Llc | Fettsäuredesaturasen aus primula |
| PL1687435T3 (pl) * | 2003-11-17 | 2012-02-29 | Bayer Cropscience Nv | Odporność na owady z użyciem hamowania ekspresji genów |
| AU2005244258B2 (en) | 2004-04-09 | 2010-07-01 | Monsanto Technology Llc | Compositions and methods for control of insect infestations in plants |
| US20160230185A1 (en) | 2013-03-14 | 2016-08-11 | Monsanto Technology Llc | Compositions and methods for controlling diabrotica |
| US8404927B2 (en) * | 2004-12-21 | 2013-03-26 | Monsanto Technology Llc | Double-stranded RNA stabilized in planta |
| US20060200878A1 (en) | 2004-12-21 | 2006-09-07 | Linda Lutfiyya | Recombinant DNA constructs and methods for controlling gene expression |
| US8314290B2 (en) | 2004-12-21 | 2012-11-20 | Monsanto Technology Llc | Temporal regulation of gene expression by MicroRNAs |
| EP2500429A3 (en) * | 2005-05-31 | 2015-10-28 | Devgen N.V. | RNAi for the control of insects and arachnids |
| ATE548459T1 (de) | 2005-09-16 | 2012-03-15 | Monsanto Technology Llc | Verfahren zur genetischen kontrolle von insektenbefall bei pflanzen und zusammensetzungen |
| CA2622671C (en) | 2005-09-16 | 2020-12-22 | Devgen Nv | Methods for controlling pests using rnai |
| EP2281896A3 (en) | 2005-09-16 | 2012-04-11 | deVGen N.V. | Transgenic plant-based methods for plant insect pests using RNAi |
| EA023885B1 (ru) | 2005-10-13 | 2016-07-29 | МОНСАНТО ТЕКНОЛОДЖИ, ЭлЭлСи | Конструкция рекомбинантной днк для индуцирования стерильности в трансгенном растении, стерильные трансгенные растения и способы получения гибридных семян |
| CA2627795C (en) * | 2006-01-12 | 2019-01-22 | Devgen N.V. | Dsrna as insect control agent |
| US8906876B2 (en) | 2006-01-12 | 2014-12-09 | Devgen Nv | Methods for controlling pests using RNAi |
| EP2348115A3 (en) * | 2006-01-12 | 2012-01-18 | deVGen N.V. | Transgenic plant-based methods for plant pests using RNAi |
| CN101421406B (zh) | 2006-02-13 | 2016-08-31 | 孟山都技术有限公司 | 用于产生改变的种子油组成的核酸构建体和方法 |
| CN105385679B (zh) * | 2006-02-13 | 2020-05-26 | 孟山都技术有限公司 | 选择和稳定dsRNA构建体 |
| AR061685A1 (es) * | 2006-06-23 | 2008-09-17 | Monsanto Technology Llc | Plantas de cultivo transgenicas con mayor tolerancia al estres |
| WO2008027592A2 (en) | 2006-08-31 | 2008-03-06 | Monsanto Technology, Llc | Phased small rnas |
| EP2985353A1 (en) | 2006-10-12 | 2016-02-17 | Monsanto Technology LLC | Plant micrornas and methods of use thereof |
| CN101195821A (zh) | 2006-12-04 | 2008-06-11 | 中国科学院上海生命科学研究院 | 利用RNAi技术改良植物抗虫性的方法 |
| EP2115141A4 (en) * | 2007-02-20 | 2010-08-04 | Monsanto Technology Llc | miRNA FROM INVERTEBRATES |
| US8609936B2 (en) | 2007-04-27 | 2013-12-17 | Monsanto Technology Llc | Hemipteran-and coleopteran active toxin proteins from Bacillus thuringiensis |
| WO2008152008A2 (en) * | 2007-06-15 | 2008-12-18 | Basf Plant Science Gmbh | Compositions and methods of using rna interference for control of nematodes |
| US8097712B2 (en) | 2007-11-07 | 2012-01-17 | Beelogics Inc. | Compositions for conferring tolerance to viral disease in social insects, and the use thereof |
| US8847013B2 (en) * | 2008-01-17 | 2014-09-30 | Pioneer Hi Bred International Inc | Compositions and methods for the suppression of target polynucleotides from lepidoptera |
| US8367895B2 (en) * | 2008-01-17 | 2013-02-05 | Pioneer Hi-Bred International, Inc. | Compositions and methods for the suppression of target polynucleotides from the family aphididae |
| US20090188008A1 (en) * | 2008-01-17 | 2009-07-23 | Pioneer Hi-Bred International, Inc. | Compositions and methods for the suppression of target polynucleotides |
| US8809625B2 (en) * | 2008-01-17 | 2014-08-19 | Pioneer Hi-Bred International, Inc. | Compositions and methods for the suppression of target polynucleotides from Lygus |
| US8865668B2 (en) * | 2008-02-20 | 2014-10-21 | Devgen N.V. | Methods and compositions for increasing RNA interference |
| US8003335B2 (en) | 2008-04-30 | 2011-08-23 | Universite Paris-SUD11 | Levels of APRIL in serum and use in diagnostic methods |
| AU2009267007B2 (en) | 2008-07-01 | 2016-02-25 | Monsanto Technology, Llc | Recombinant DNA constructs and methods for modulating expression of a target gene |
| AR073237A1 (es) | 2008-08-29 | 2010-10-20 | Monsanto Technology Llc | Proteinas de bacillus thuringiensis que son toxinas activas contra hemipteros y coleopteros |
| US11414664B2 (en) * | 2008-12-18 | 2022-08-16 | Dicerna Pharmaceuticals, Inc. | Extended dicer substrate agents and methods for the specific inhibition of gene expression |
| US20100257634A1 (en) * | 2009-04-03 | 2010-10-07 | Venganza Inc. | Bioassay for gene silencing constructs |
| WO2010141294A1 (en) * | 2009-06-01 | 2010-12-09 | North Carolina State University | Insecticidal target genes identified from bug whole body and digestive system transcriptomes |
| EP3401404A1 (en) | 2009-08-28 | 2018-11-14 | E. I. du Pont de Nemours and Company | Compositions and methods to control insect pests |
| JP5396353B2 (ja) * | 2009-09-17 | 2014-01-22 | 日本碍子株式会社 | 静電チャック及びその製法 |
| WO2011040880A1 (en) | 2009-09-29 | 2011-04-07 | Temasek Life Sciences Laboratory Limited | Control of pests in plants |
| US8962584B2 (en) | 2009-10-14 | 2015-02-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Compositions for controlling Varroa mites in bees |
| US20110165561A1 (en) | 2009-12-31 | 2011-07-07 | Pioneer Hi-Bred International, Inc. | Direct and continuous root alone or root/shoot production from transgenic events derived from green regenerative tissues and its applications |
| US20110183369A1 (en) * | 2010-01-28 | 2011-07-28 | Monsanto Technology Llc | Plant infesting systems and methods |
| US8735560B1 (en) | 2010-03-02 | 2014-05-27 | Monsanto Technology Llc | Multiple domain lepidopteran active toxin proteins |
| CN102948425B (zh) * | 2010-03-05 | 2014-10-22 | 广州市锐博生物科技有限公司 | 一种生物农药和昆虫防治方法 |
| ES2641642T3 (es) | 2010-03-08 | 2017-11-10 | Monsanto Technology Llc | Moléculas de polinucleótido para regulación génica en plantas |
| KR101264527B1 (ko) * | 2010-03-19 | 2013-05-14 | 주식회사 엘지화학 | 파우치형 케이스 및 이를 포함하는 전지팩 |
| US8530440B2 (en) * | 2010-05-03 | 2013-09-10 | Board Of Regents Of The University Of Nebraska | dsRNA delivery composition and methods of use |
| US8872001B2 (en) | 2010-06-04 | 2014-10-28 | Pioneer Hi Bred International Inc | Compositions and methods for insecticidal control of stinkbugs |
| EP2618668B1 (en) | 2010-09-20 | 2016-09-14 | Wisconsin Alumni Research Foundation | Mosquitocidal xenorhabdus, lipopeptide and methods |
| EP2633048B1 (en) * | 2010-10-27 | 2019-07-31 | Devgen NV | Down-regulating gene expression in insect pests |
| CA2822958A1 (en) * | 2010-12-30 | 2012-07-05 | Dow Agrosciences Llc | Nucleic acid molecules that confer resistance to coleopteran pests |
| AP2013007005A0 (en) * | 2010-12-30 | 2013-07-31 | Dow Agrosciences Llc | Nucleic acid molecules that target the RHO1 small GTP-binding protein and confer resistance to coleopteran pests |
| EP3339440A1 (en) * | 2010-12-30 | 2018-06-27 | Dow AgroSciences LLC | Nucleic acid molecules that target the vacuolar atpase c subunit and confer resistance to coleopteran pests |
| EP2698379A4 (en) * | 2011-03-18 | 2015-04-29 | Shanghai Inst Biol Sciences | INSECTROSIVE PREPARATION AND METHODS BASED ON RNAI TECHNOLOGY |
| CN103562394B (zh) * | 2011-04-20 | 2019-09-03 | 德福根有限公司 | 在昆虫害虫中下调基因表达 |
| US8841272B2 (en) * | 2011-05-31 | 2014-09-23 | Kansas State University Research Foundation | Double-stranded RNA-based nanoparticles for insect gene silencing |
| CN102866220B (zh) * | 2011-07-08 | 2014-07-23 | 中国科学院大连化学物理研究所 | 一种基于化学衍生的飞蝗血淋巴代谢物的检测方法 |
| CN103687951B (zh) * | 2011-07-18 | 2019-08-02 | 德福根有限公司 | 对昆虫害虫具有抗性的植物 |
| BR112014003367A2 (pt) * | 2011-08-16 | 2017-03-01 | Syngenta Participations Ag | métodos e composições para introdução de dsrna exógeno em células de plantas |
| MX342856B (es) | 2011-09-13 | 2016-10-13 | Monsanto Technology Llc | Metodos y composiciones para el control de malezas. |
| UA116089C2 (uk) | 2011-09-13 | 2018-02-12 | Монсанто Текнолоджи Ллс | Спосіб та композиція для боротьби з бур'янами (варіанти) |
| US10760086B2 (en) | 2011-09-13 | 2020-09-01 | Monsanto Technology Llc | Methods and compositions for weed control |
| US10829828B2 (en) | 2011-09-13 | 2020-11-10 | Monsanto Technology Llc | Methods and compositions for weed control |
| US10806146B2 (en) | 2011-09-13 | 2020-10-20 | Monsanto Technology Llc | Methods and compositions for weed control |
| BR112014005958A2 (pt) | 2011-09-13 | 2020-10-13 | Monsanto Technology Llc | métodos e composições químicas agrícolas para controle de planta, método de redução de expressão de um gene accase em uma planta, cassete de expressão microbiana, método para fazer um polinucleotídeo, método de identificação de polinucleotídeos úteis na modulação de expressão do gene accase e composição herbicida |
| US9840715B1 (en) | 2011-09-13 | 2017-12-12 | Monsanto Technology Llc | Methods and compositions for delaying senescence and improving disease tolerance and yield in plants |
| CN103974967A (zh) | 2011-09-13 | 2014-08-06 | 孟山都技术公司 | 用于杂草控制的方法和组合物 |
| US9920326B1 (en) | 2011-09-14 | 2018-03-20 | Monsanto Technology Llc | Methods and compositions for increasing invertase activity in plants |
| US9534232B2 (en) | 2011-10-06 | 2017-01-03 | Dow Agrosciences Llc | Nucleic acid molecules that target RPS6 and confer resistance to coleopteran pests |
| AR088261A1 (es) * | 2011-10-06 | 2014-05-21 | Dow Agrosciences Llc | Moleculas de acido nucleico que se dirigen al gen pp1-87b y confieren resistencia a plagas de coleopteros |
| AR088262A1 (es) * | 2011-10-06 | 2014-05-21 | Dow Agrosciences Llc | Moleculas de acido nucleico que se dirigen a rpa70 y confieren resistencia a plagas de coleopteros |
| GB201202119D0 (en) * | 2012-02-08 | 2012-03-21 | Univ Swansea | Pest and pathogen control |
| BR112014024861B1 (pt) | 2012-04-06 | 2021-11-16 | Monsanto Technology Llc | Polipeptídeo inibidor de inseto, polinucleotídeo codificando o mesmo, célula hospedeira bacteriana, composição inibidora de inseto, mercadoria e métodos de controle de uma peste hemíptera e de produzir uma mercadoria |
| UY34752A (es) * | 2012-04-20 | 2013-11-29 | Futuragene Israel Ltd | Agentes para el control de la chinche del eucalipto |
| CN104508134A (zh) * | 2012-04-23 | 2015-04-08 | 富优基尼以色列股份有限公司 | 赤桉木虱防治剂 |
| UA126903C2 (uk) | 2012-05-08 | 2023-02-22 | Монсанто Текнолоджи Ллс | Об'єкт кукурудзи mon 87411 |
| US10240161B2 (en) * | 2012-05-24 | 2019-03-26 | A.B. Seeds Ltd. | Compositions and methods for silencing gene expression |
| US9657293B2 (en) * | 2012-06-22 | 2017-05-23 | Sygenta Participations Ag | Biological control of coleopteran pests |
| CA2886104A1 (en) * | 2012-09-20 | 2014-03-27 | E.I. Du Pont De Nemours And Company | Management of corn rootworm and other insect pests |
| US10004236B2 (en) * | 2012-09-24 | 2018-06-26 | Lincoln University | Biocontrol compositions |
| MX364070B (es) | 2012-10-18 | 2019-04-10 | Monsanto Technology Llc | Métodos y composiciones para el control de plagas vegetales. |
| DE102012110664A1 (de) * | 2012-11-07 | 2014-05-08 | Henkel Ag & Co. Kgaa | In Beschichtungsmitteln, Haftvermittlern oder Klebstoffen für oxidische Oberflächen einsetzbare Peptide |
| WO2014106837A2 (en) * | 2013-01-01 | 2014-07-10 | A. B. Seeds Ltd. | ISOLATED dsRNA MOLECULES AND METHODS OF USING SAME FOR SILENCING TARGET MOLECULES OF INTEREST |
| US10683505B2 (en) | 2013-01-01 | 2020-06-16 | Monsanto Technology Llc | Methods of introducing dsRNA to plant seeds for modulating gene expression |
| US10000767B2 (en) | 2013-01-28 | 2018-06-19 | Monsanto Technology Llc | Methods and compositions for plant pest control |
| EP2971185A4 (en) | 2013-03-13 | 2017-03-08 | Monsanto Technology LLC | Methods and compositions for weed control |
| BR112015022797A2 (pt) | 2013-03-13 | 2017-11-07 | Monsanto Technology Llc | método para controle de ervas daninhas, composição herbicida, cassete de expressão microbiano e método de produção de polinucleotídeo |
| WO2014153254A2 (en) * | 2013-03-14 | 2014-09-25 | Pioneer Hi-Bred International Inc. | Compositions and methods to control insect pests |
| US9920316B2 (en) * | 2013-03-14 | 2018-03-20 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
| US20140283211A1 (en) | 2013-03-14 | 2014-09-18 | Monsanto Technology Llc | Methods and Compositions for Plant Pest Control |
| US10568328B2 (en) | 2013-03-15 | 2020-02-25 | Monsanto Technology Llc | Methods and compositions for weed control |
| CA2901316A1 (en) | 2013-03-15 | 2014-09-25 | Pioneer Hi-Bred International, Inc. | Phi-4 polypeptides and methods for their use |
| WO2014182473A1 (en) | 2013-05-08 | 2014-11-13 | Monsanto Technology Llc | Compositions and methods for deploying a transgenic refuge seed blend |
| US9850496B2 (en) | 2013-07-19 | 2017-12-26 | Monsanto Technology Llc | Compositions and methods for controlling Leptinotarsa |
| RU2703498C2 (ru) * | 2013-07-19 | 2019-10-17 | Монсанто Текнолоджи Ллс | Композиции и способы борьбы с leptinotarsa |
| BR112016003225B1 (pt) | 2013-08-16 | 2022-10-25 | Pioneer Hi-Bred International, Inc. | Polipeptídeo pip-47, polipeptídeo pip-47 quimérico, composição, proteína de fusão, método para controlar uma população de inseto-praga, método para inibir o crescimento ou matar um inseto-praga, construto de dna, polinucleotídeo isolado, cassete de expressão, método de obtenção de uma planta transgênica e método para controlar infestação de inseto |
| BR122020001770B1 (pt) | 2013-09-13 | 2022-11-29 | Pioneer Hi-Bred International, Inc | Construto de dna, método de obtenção de planta transgênica, proteína de fusão, método para controlar uma população de praga de inseto, método para inibir o crescimento ou matar uma praga de inseto |
| US10329560B2 (en) | 2013-09-23 | 2019-06-25 | Georgia Tech Research Corporation | Targeting non-coding RNA for RNA interference |
| HUE070313T2 (hu) | 2013-11-04 | 2025-05-28 | Greenlight Biosciences Inc | Ízeltlábú paraziták és kártevõfertõzöttség szabályozására szolgáló készítmények és eljárások |
| CN104630275A (zh) * | 2013-11-12 | 2015-05-20 | 中国科学院上海生命科学研究院 | 一种通过灌溉防治害虫的RNAi技术及其应用 |
| CA2929703C (en) * | 2013-12-04 | 2022-05-10 | Stoller Enterprises, Inc. | Methods for applying diformylurea to crops |
| UA119253C2 (uk) | 2013-12-10 | 2019-05-27 | Біолоджикс, Інк. | Спосіб боротьби із вірусом у кліща varroa та у бджіл |
| BR102014031844A2 (pt) * | 2013-12-20 | 2015-10-06 | Dow Agrosciences Llc | ras oposto (rop) e moléculas de ácido nucleico relacionadas que conferem resistência a pragas de coleópteros e hemípteros |
| AU2015206585A1 (en) | 2014-01-15 | 2016-07-21 | Monsanto Technology Llc | Methods and compositions for weed control using EPSPS polynucleotides |
| CN106536545B (zh) | 2014-02-07 | 2026-03-03 | 先锋国际良种公司 | 杀昆虫蛋白及其使用方法 |
| BR112016018344A2 (pt) * | 2014-02-10 | 2017-08-08 | Ibex Bionomics Llc | Composição, métodos para tratamento e prevenção de uma infestação de moscas de estábulos, para biorremediação de água, para tratamento de brotos podres em palmeiras, para controlar e reduzir a infestação de moscas de estábulo, para controlar a produção de odor em águas residuais e para proteger plantas de arroz contra doenças fúngicas, agente biológico, uso de uma composição, e, amadurecedor ou estimulante de crescimento bioderivado |
| JP2017512070A (ja) | 2014-03-12 | 2017-05-18 | ザ ユニバーシティ オブ シドニー | 高等植物におけるｒｎａの生成 |
| CN103828721B (zh) * | 2014-03-20 | 2016-03-02 | 北京农学院 | 地衣芽孢杆菌在促进蓝莓组培苗生根或生长中的应用 |
| WO2015148976A1 (en) | 2014-03-28 | 2015-10-01 | Monsanto Technology Llc | Pesticidal toxin proteins active against coleopteran insects |
| BR112016022711A2 (pt) | 2014-04-01 | 2017-10-31 | Monsanto Technology Llc | composições e métodos para controle de pragas de inseto |
| EP3140406B1 (en) | 2014-05-07 | 2022-06-29 | Dow AgroSciences LLC | Dre4 nucleic acid molecules that confer resistance to coleopteran pests |
| US10988764B2 (en) | 2014-06-23 | 2021-04-27 | Monsanto Technology Llc | Compositions and methods for regulating gene expression via RNA interference |
| EP3161138A4 (en) | 2014-06-25 | 2017-12-06 | Monsanto Technology LLC | Methods and compositions for delivering nucleic acids to plant cells and regulating gene expression |
| CN104170557B (zh) * | 2014-07-24 | 2016-06-29 | 四川农业大学 | 一种促进中国樱桃种子快速高效萌发成苗的方法 |
| RU2021123470A (ru) * | 2014-07-29 | 2021-09-06 | Монсанто Текнолоджи Ллс | Композиции и способы борьбы с насекомыми-вредителями |
| WO2016044092A1 (en) * | 2014-09-17 | 2016-03-24 | Pioneer Hi Bred International Inc | Compositions and methods to control insect pests |
| BR112017007084A8 (pt) * | 2014-10-13 | 2023-02-07 | Dow Agrosciences Llc | Moléculas de ácido nucleico subunidade copi coatomer alfa que confere resistância a pragas de coleóptero e hemípteros |
| RU2017111804A (ru) * | 2014-10-13 | 2018-11-15 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Молекулы нуклеиновой кислоты субъединиц гамма коатомера copi, которые придают устойчивость к жесткокрылым и полужесткокрылым вредителям |
| CN113372421B (zh) | 2014-10-16 | 2024-08-06 | 先锋国际良种公司 | 杀昆虫蛋白及其使用方法 |
| US10487123B2 (en) | 2014-10-16 | 2019-11-26 | Monsanto Technology Llc | Chimeric insecticidal proteins toxic or inhibitory to lepidopteran pests |
| US10316329B2 (en) | 2014-10-16 | 2019-06-11 | Monsanto Technology Llc | Proteins toxic or inhibitory to lepidopteran insects |
| EP3517616A1 (en) | 2014-10-16 | 2019-07-31 | Monsanto Technology LLC | Lepidopteran-active cry1da1 amino acid sequence variant proteins |
| JP6626102B2 (ja) | 2014-10-16 | 2019-12-25 | モンサント テクノロジー エルエルシー | 鱗翅目害虫に有毒または阻害性の新規キメラ殺虫性タンパク質 |
| WO2016077624A1 (en) | 2014-11-12 | 2016-05-19 | Nmc, Inc. | Transgenic plants with engineered redox sensitive modulation of photosynthetic antenna complex pigments and methods for making the same |
| CN112626087B (zh) | 2014-11-20 | 2024-05-31 | 孟山都技术公司 | 新型昆虫抑制性蛋白 |
| TW201629221A (zh) * | 2014-12-16 | 2016-08-16 | 陶氏農業科學公司 | 以克魯拜爾基因（ＫＲＵＰＰＥＬ ＧＥＮＥ）之親代ＲＮＡ干擾（ＲＮＡｉ）抑制作用來控制半翅目害蟲之技術 |
| CN114075267B (zh) | 2015-01-15 | 2025-03-18 | 先锋国际良种公司 | 杀昆虫蛋白及其使用方法 |
| US20180000093A1 (en) * | 2015-01-16 | 2018-01-04 | Emekatech, Llc | Systems, methods and compositions for effective insect population suppression |
| JP6942632B2 (ja) | 2015-01-22 | 2021-09-29 | モンサント テクノロジー エルエルシー | Ｌｅｐｔｉｎｏｔａｒｓａ防除用組成物及びその方法 |
| US20180135048A1 (en) * | 2015-02-27 | 2018-05-17 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
| CA2977026A1 (en) | 2015-03-11 | 2016-09-15 | E.I. Du Pont De Nemours And Company | Insecticidal combinations of pip-72 and methods of use |
| CA2985198A1 (en) | 2015-05-19 | 2016-11-24 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
| EP3302062A4 (en) * | 2015-05-27 | 2018-10-31 | Dow AgroSciences LLC | Thread nucleic acid molecules that confer resistance to hemipteran pests |
| US10883103B2 (en) | 2015-06-02 | 2021-01-05 | Monsanto Technology Llc | Compositions and methods for delivery of a polynucleotide into a plant |
| EP3302030A4 (en) | 2015-06-03 | 2019-04-24 | Monsanto Technology LLC | METHOD AND COMPOSITIONS FOR INTRODUCING NUCLEIC ACIDS IN PLANTS |
| GB201510154D0 (en) * | 2015-06-11 | 2015-07-29 | Univ Swansea | Pest control system |
| EP3310803A1 (en) | 2015-06-16 | 2018-04-25 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
| JP6933641B2 (ja) | 2015-07-30 | 2021-09-08 | モンサント テクノロジー エルエルシー | 新規の昆虫阻害タンパク質 |
| BR112018002535A2 (pt) | 2015-08-06 | 2018-09-25 | Du Pont | polipeptídeo inseticida recombinante, polinucleotídeo recombinante, construto de dna, planta transgênica ou célula de planta, composição, proteína de fusão, método para controlar uma praga, método para inibir crescimento ou para exterminar uma população de pragas ou uma praga e uso do polipeptídeo |
| US10155960B2 (en) | 2015-08-27 | 2018-12-18 | Monsanto Technology Llc | Insect inhibitory proteins |
| BR112018005452A2 (pt) * | 2015-09-25 | 2018-10-09 | Dow Agrosciences Llc | moléculas de ácido nucleico de shibire/dinamina para controle de pragas coleópteras e hemípteras |
| KR20180056750A (ko) * | 2015-10-05 | 2018-05-29 | 신젠타 파티서페이션즈 아게 | 리보핵산의 생물학적 활성을 보존하는 방법 |
| AU2016339031B2 (en) | 2015-10-12 | 2021-03-04 | Droneseed Co. | Forestry information management systems and methods streamlined by automatic biometric data prioritization |
| EP3922100A1 (en) | 2015-10-12 | 2021-12-15 | Pioneer Hi-Bred International, Inc. | Biologicals and their use in plants |
| WO2017066041A2 (en) * | 2015-10-12 | 2017-04-20 | Dow Agrosciences Llc | Wupa nucleic acid molecules that confer resistance to coleopteran and hemipteran pests |
| US10212876B2 (en) | 2015-10-12 | 2019-02-26 | Droneseed Co. | Aerial deployment planting methods and systems |
| US20180223308A1 (en) * | 2015-11-02 | 2018-08-09 | Dow Agrosciences Llc | Rab5 nucleic acid molecules that confer resistance to coleopteran and hemipteran pests |
| BR112018011174A2 (pt) | 2015-11-30 | 2018-11-21 | Du Pont | polinucleotídeo recombinante, construto de dna, célula heteróloga, planta transgênica ou célula de planta, semente da planta transgênica, método para expressar um polinucleotídeo em uma planta e método para aprimorar a transcrição de um polinucleotídeo em uma célula hospedeira |
| EP3179251B1 (en) * | 2015-12-08 | 2019-03-06 | Agricultural Technology Research Institute | Cancer stem cell targeting peptides and use thereof |
| US11134675B2 (en) | 2015-12-14 | 2021-10-05 | Monsanto Technology Llc | Methods and compositions for delivery of polynucleotides |
| EP3389361A4 (en) | 2015-12-18 | 2019-09-11 | Dow Agrosciences LLC | RIBOSOME L40 NUCLEIC PROTEIN NUCLEIC ACID MOLECULES (RPL40) CONFERRING RESISTANCE TO HARMFUL CEREOPATERS AND HEMIPSES |
| CN108575091A (zh) | 2015-12-18 | 2018-09-25 | 先锋国际良种公司 | 杀昆虫蛋白及其使用方法 |
| CN109486812B (zh) * | 2016-01-04 | 2021-04-30 | 北京大北农生物技术有限公司 | 用于控制昆虫侵袭的核苷酸序列及其方法 |
| CN109312344A (zh) * | 2016-01-26 | 2019-02-05 | 孟山都技术公司 | 用于控制昆虫害虫的组合物和方法 |
| US10501755B2 (en) * | 2016-04-05 | 2019-12-10 | Dow Agrosciences Llc | FSH nucleic acid molecules to control insect pests |
| CA3018384A1 (en) | 2016-05-04 | 2017-11-09 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
| CA3023483C (en) | 2016-05-16 | 2024-01-16 | Danisco Us Inc. | Entomopathogenic products, metarhizium anisopliae or metarhizium robertsii |
| US20190343122A1 (en) * | 2016-05-27 | 2019-11-14 | Provivi, Inc. | Improved insect control strategies utilizing pheromones and rnai |
| CA3022858A1 (en) | 2016-06-16 | 2017-12-21 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
| US10612037B2 (en) | 2016-06-20 | 2020-04-07 | Monsanto Technology Llc | Insecticidal proteins toxic or inhibitory to hemipteran pests |
| BR112018076615A2 (pt) * | 2016-06-22 | 2019-04-24 | Dow Agrosciences Llc | moléculas de ácido nucleico de cactus para controle de pragas de coleópteros |
| UA127388C2 (uk) | 2016-06-24 | 2023-08-09 | Піонір Хай-Бред Інтернешнл, Інк. | Регуляторний елемент рослини і спосіб його застосування |
| EP3478052B1 (en) | 2016-07-01 | 2021-08-25 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins from plants and methods for their use |
| WO2018013333A1 (en) | 2016-07-12 | 2018-01-18 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
| US20180023076A1 (en) * | 2016-07-25 | 2018-01-25 | The United States Of America, As Represented By The Secretary Of Agriculture | Double strand rna delivery system for plant-sap-feeding insects |
| AR109205A1 (es) | 2016-08-05 | 2018-11-07 | Syngenta Participations Ag | Control de plagas de coleópteros utilizando moléculas de arn |
| AR109206A1 (es) * | 2016-08-05 | 2018-11-07 | Syngenta Participations Ag | Control de plagas de coleópteros utilizando moléculas de arn |
| WO2018065303A1 (en) * | 2016-10-05 | 2018-04-12 | Syngenta Participations Ag | Methods of preserving the biological activity of ribonucleic acids |
| CN107058466A (zh) * | 2016-10-20 | 2017-08-18 | 中国农业科学院植物保护研究所 | 玉米根萤叶甲特异性ss‑coi引物及检测方法和应用 |
| EP3535285B1 (en) | 2016-11-01 | 2022-04-06 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
| US12426568B2 (en) | 2016-12-06 | 2025-09-30 | Pebble Labs Inc. | System and methods for the biocontrol of plant pathogens |
| BR112019012339A2 (pt) | 2016-12-14 | 2019-11-26 | Pioneer Hi Bred Int | polipeptídeo inseticida recombinante, composição, construto de dna, célula hospedeira, planta transgênica, método para inibir o crescimento ou extermínio de uma praga de inseto ou população de praga, polipeptídeo ipd093 quimérico e proteína de fusão |
| US11213028B2 (en) | 2016-12-22 | 2022-01-04 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
| WO2018140214A1 (en) | 2017-01-24 | 2018-08-02 | Pioneer Hi-Bred International, Inc. | Nematicidal protein from pseudomonas |
| WO2018148001A1 (en) | 2017-02-08 | 2018-08-16 | Pioneer Hi-Bred International Inc | Insecticidal combinations of plant derived insecticidal proteins and methods for their use |
| EP3614838A1 (en) * | 2017-03-21 | 2020-03-04 | Dow AgroSciences LLC | Pre-mrna processing factor 19 (prp19) nucleic acid molecules to control insect pests |
| MX2019012986A (es) * | 2017-05-01 | 2020-08-06 | Donald Danforth Plant Science Center | Enfoque con arni para la protección de cultivos contra plagas. |
| RU2019140646A (ru) | 2017-05-11 | 2021-06-11 | Пайонир Хай-Бред Интернэшнл, Инк. | Инсектицидные белки и способы их применения |
| US20180334683A1 (en) * | 2017-05-18 | 2018-11-22 | Dow Agrosciences Llc | Structure specific recognition protein 1 (ssrp1) nucleic acid molecules to control insect pests |
| MX2020003414A (es) | 2017-10-02 | 2020-07-20 | Syngenta Participations Ag | Proteinas pesticidas modificadas y metodos para controlar las plagas de plantas. |
| US20200165626A1 (en) | 2017-10-13 | 2020-05-28 | Pioneer Hi-Bred International, Inc. | Virus-induced gene silencing technology for insect control in maize |
| GB201718701D0 (en) * | 2017-11-13 | 2017-12-27 | Syngenta Participations Ag | Improvements in or relating to gene silencing |
| GB201719680D0 (en) | 2017-11-27 | 2018-01-10 | Devgen Nv | Improvements in or relating to gene silencing |
| EP3740070B1 (en) | 2018-01-18 | 2024-10-16 | Pioneer Hi-Bred International Inc. | Alginate encapsulation of fungal microsclerotia |
| EP3759489A1 (en) | 2018-03-02 | 2021-01-06 | Pioneer Hi-Bred International, Inc. | Plant health assay |
| AU2019234562B2 (en) | 2018-03-14 | 2024-08-01 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins from plants and methods for their use |
| CA3092078A1 (en) | 2018-03-14 | 2019-09-19 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins from plants and methods for their use |
| WO2019200016A1 (en) | 2018-04-10 | 2019-10-17 | President And Fellows Of Harvard College | Aav vectors encoding clarin-1 or gjb2 and uses thereof |
| WO2019226508A1 (en) | 2018-05-22 | 2019-11-28 | Pioneer Hi-Bred International, Inc. | Plant regulatory elements and methods of use thereof |
| BR112021000759A2 (pt) | 2018-07-18 | 2021-04-13 | Plantarcbio Ltd. | Composições e métodos para mitigar a infestação de pestes |
| WO2020046701A1 (en) | 2018-08-29 | 2020-03-05 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
| EP3824084A4 (en) * | 2018-09-24 | 2021-12-22 | Orta Dogu Teknik Universitesi | MODIFIED AOX1 PROMOTER VARIANTS |
| US11470764B2 (en) * | 2018-11-06 | 2022-10-18 | Droneseed Co. | Wide base capsular planting systems and methods |
| AU2019380606B2 (en) | 2018-11-15 | 2026-04-23 | Quantum-Si Incorporated | Methods and compositions for protein sequencing |
| US20220015372A1 (en) | 2018-12-14 | 2022-01-20 | Pioneer Hi-Bred International, Inc. | Biologicals and their use in plants |
| CN109337884B9 (zh) * | 2018-12-21 | 2021-10-29 | 中国农业科学院北京畜牧兽医研究所 | 一种丙酮酸激酶基因及其应用 |
| EA202190969A1 (ru) | 2019-01-22 | 2021-10-18 | Монсанто Текнолоджи ЛЛК | Новые белки, ингибирующие активность насекомых |
| PH12021551717A1 (en) | 2019-02-20 | 2022-03-28 | Syngenta Crop Protection Ag | Engineered pesticidal proteins and methods of controlling plant pests |
| KR102934700B1 (ko) * | 2019-03-28 | 2026-03-09 | 더 제너럴 하스피탈 코포레이션 | 트랜스진 발현을 위한 조작된 아데노-연관 (aav) 벡터 |
| WO2020215149A1 (en) * | 2019-04-24 | 2020-10-29 | University Of Manitoba | Flea beetle-specific rnai-based pesticides |
| CN110117606A (zh) * | 2019-04-29 | 2019-08-13 | 贵州大学 | 一种马铃薯蚜虫效应蛋白Me10基因的重组载体和表达方法 |
| TWI906251B (zh) | 2020-02-04 | 2025-12-01 | 美商科迪華農業科技有限責任公司 | 具有殺有害生物效用之組成物及與其相關之方法 |
| CN116209756A (zh) | 2020-03-04 | 2023-06-02 | 旗舰先锋创新Vi有限责任公司 | 调控基因组的方法和组合物 |
| WO2021231791A2 (en) * | 2020-05-13 | 2021-11-18 | Greenlight Biosciences, Inc. | Rna-based control of lepidopteran pests |
| EP4143579A2 (en) * | 2020-05-20 | 2023-03-08 | Quantum-si Incorporated | Methods and compositions for protein sequencing |
| BR112022027035A2 (pt) | 2020-07-14 | 2023-04-11 | Pioneer Hi Bred Int | Proteínas inseticidas e métodos para uso das mesmas |
| TWI784298B (zh) * | 2020-08-06 | 2022-11-21 | 大江生醫股份有限公司 | 生物活性物質用於製備促進肌膚膠原蛋白質生成及提升肌膚膠原蛋白質密度的組合物的用途 |
| CN116096903A (zh) | 2020-08-10 | 2023-05-09 | 先锋国际良种公司 | 植物调节元件及其使用方法 |
| US12129287B2 (en) | 2020-09-14 | 2024-10-29 | President And Fellows Of Harvard College | Recombinant adeno associated virus encoding clarin-1 and uses thereof |
| CN116670155A (zh) | 2020-12-21 | 2023-08-29 | 孟山都技术公司 | 新型昆虫抑制性蛋白质 |
| UY39585A (es) | 2020-12-23 | 2022-07-29 | Monsanto Technology Llc | Proteínas que exhiben actividad inhibidora de insectos frente a plagas con importancia agrícola de plantas de cultivo y semillas |
| CN116848250A (zh) | 2020-12-31 | 2023-10-03 | 孟山都技术公司 | 新型昆虫抑制蛋白 |
| EP4314257A4 (en) * | 2021-04-01 | 2025-07-09 | Prime Medicine Inc | METHODS AND COMPOSITIONS FOR EDITING NUCLEOTIDE SEQUENCES |
| WO2023283103A1 (en) | 2021-07-08 | 2023-01-12 | Monsanto Technology Llc | Novel insect inhibitory proteins |
| US11807685B2 (en) * | 2021-08-05 | 2023-11-07 | The Uab Research Foundation | Anti-CD47 antibody and uses thereof |
| EP4396348A2 (en) | 2021-08-31 | 2024-07-10 | Nanosur LLC | High molecular weight modified dsrna compositions |
| AU2022343268A1 (en) | 2021-09-08 | 2024-03-28 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| TW202345696A (zh) | 2022-05-18 | 2023-12-01 | 美商科迪華農業科技有限責任公司 | 具有殺有害生物效用之組成物及與其相關的方法 |
| CN117025618B (zh) * | 2023-07-24 | 2024-07-05 | 西南大学 | 一种对番茄红螨高效致死的靶标基因及其应用 |
| WO2025038870A1 (en) * | 2023-08-16 | 2025-02-20 | Rnaissance Ag Llc | Double stranded rna methods and compositions for insecticide |
| CN117187278B (zh) * | 2023-10-17 | 2024-11-12 | 河北农业大学 | 一种用于防控蛴螬的dsHpVAA、dsRNA纳米复合物及其应用 |
| WO2025103765A1 (en) * | 2023-11-17 | 2025-05-22 | Novozymes A/S | Lytic polysaccharide monooxygenases and their use in detergent |
| US20250194603A1 (en) * | 2023-12-14 | 2025-06-19 | National Resources Institute | Compositions and methods for management of whitefly |
| WO2025221793A1 (en) * | 2024-04-16 | 2025-10-23 | Monsanto Technology Llc | Modified cas proteins for nuclear localization and editing activity in plants |
Family Cites Families (175)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3937813A (en) | 1974-02-20 | 1976-02-10 | Abbott Laboratories | Insecticidal compositions comprising mixtures of bacillus thuringiensis and chlordimeform |
| US4272417A (en) | 1979-05-22 | 1981-06-09 | Cargill, Incorporated | Stable protective seed coating |
| US4245432A (en) | 1979-07-25 | 1981-01-20 | Eastman Kodak Company | Seed coatings |
| US4339456A (en) | 1980-01-14 | 1982-07-13 | Gustafson, Inc. | Peanut seed treating |
| US4383391A (en) | 1981-09-21 | 1983-05-17 | Celanese Corporation | Seed coating composition based on carbamate pesticide and non-alkaline amorphous carbon |
| US4634587A (en) | 1982-07-09 | 1987-01-06 | Key Pharmaceuticals, Inc. | Sustained release quinidine dosage form |
| US4693977A (en) | 1982-08-23 | 1987-09-15 | Queen's University At Kingston | Enzyme immobilization for producing cephalosporin antibiotics |
| US4536475A (en) | 1982-10-05 | 1985-08-20 | Phytogen | Plant vector |
| US4876197A (en) | 1983-02-22 | 1989-10-24 | Chiron Corporation | Eukaryotic regulatable transcription |
| NL8300698A (nl) | 1983-02-24 | 1984-09-17 | Univ Leiden | Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten. |
| US4465017A (en) | 1983-03-09 | 1984-08-14 | Simmons John J | Seed coating machine |
| NZ207765A (en) | 1983-04-15 | 1987-03-06 | Lubrizol Genetics Inc | Plant expression of transferred dna(t-dna)from plasmids associated with agrobacterium sp |
| JPS59205983A (ja) | 1983-04-28 | 1984-11-21 | ジエネツクス・コ−ポレイシヨン | 異種遺伝子を原核微生物で発現させる方法 |
| US4735015A (en) | 1983-11-25 | 1988-04-05 | Basf Corporation | Seed protective coating |
| ATE102250T1 (de) | 1984-05-11 | 1994-03-15 | Chiron Corp | Erhoehte hefetranskription unter verwendung einer hybridkonstruktion der promotorregion. |
| US4880734A (en) | 1984-05-11 | 1989-11-14 | Chiron Corporation | Eukaryotic regulatable transcription |
| US4886937A (en) | 1985-05-20 | 1989-12-12 | North Carolina State University | Method for transforming pine |
| CA1293460C (en) | 1985-10-07 | 1991-12-24 | Brian Lee Sauer | Site-specific recombination of dna in yeast |
| US5453566A (en) | 1986-03-28 | 1995-09-26 | Calgene, Inc. | Antisense regulation of gene expression in plant/cells |
| US5107065A (en) | 1986-03-28 | 1992-04-21 | Calgene, Inc. | Anti-sense regulation of gene expression in plant cells |
| DE3616010A1 (de) | 1986-05-13 | 1987-11-19 | Bayer Ag | Verfahren zum beizen und/oder inkrustieren von saatgutkoernern |
| US5004863B2 (en) | 1986-12-03 | 2000-10-17 | Agracetus | Genetic engineering of cotton plants and lines |
| US5015580A (en) | 1987-07-29 | 1991-05-14 | Agracetus | Particle-mediated transformation of soybean plants and lines |
| DE3703584A1 (de) | 1987-02-06 | 1988-08-18 | Consortium Elektrochem Ind | Aldehyde und alkohole mit 3-methyl- oder 3,5-dimethylphenylgruppen, deren herstellung und verwendung als duftstoffe |
| CA1304020C (en) | 1987-03-23 | 1992-06-23 | Meher H. Irani | High level expression in yeast |
| TR27832A (tr) | 1987-04-29 | 1995-08-31 | Monsanto Co | Zararli ucucu hasarata mukavim bitkiler. |
| JPH01501660A (ja) | 1987-06-18 | 1989-06-08 | ユニシス・コーポレーシヨン | コンピユータ間通信制御装置及びその方法 |
| FR2618041B1 (fr) | 1987-07-16 | 1991-06-21 | Ceres Ets | Dispositif pour le traitement des semences |
| US4948734A (en) | 1987-08-12 | 1990-08-14 | Mycogen Corporation | Novel isolates of bacillus thuringiensis having activity against nematodes |
| EP0315447A3 (en) | 1987-11-06 | 1990-07-18 | Teijin Limited | Method of immunological measurement of human protein s and reagent and kit therefor |
| US5614395A (en) | 1988-03-08 | 1997-03-25 | Ciba-Geigy Corporation | Chemically regulatable and anti-pathogenic DNA sequences and uses thereof |
| US5789214A (en) | 1988-03-08 | 1998-08-04 | Novartis Finance Corporation | Method of inducing gene transcription in a plant |
| US5416011A (en) | 1988-07-22 | 1995-05-16 | Monsanto Company | Method for soybean transformation and regeneration |
| JPH0646887B2 (ja) | 1988-11-08 | 1994-06-22 | 矢崎総業株式会社 | 種子のゲル被覆装置 |
| US5300127A (en) | 1989-01-06 | 1994-04-05 | Agricultural Genetics Company Limited | Seed coatings |
| AU638438B2 (en) | 1989-02-24 | 1993-07-01 | Monsanto Technology Llc | Synthetic plant genes and method for preparation |
| US5231020A (en) | 1989-03-30 | 1993-07-27 | Dna Plant Technology Corporation | Genetic engineering of novel plant phenotypes |
| EP0400246A1 (en) | 1989-05-31 | 1990-12-05 | Plant Genetic Systems, N.V. | Prevention of Bt resistance development |
| US5501967A (en) | 1989-07-26 | 1996-03-26 | Mogen International, N.V./Rijksuniversiteit Te Leiden | Process for the site-directed integration of DNA into the genome of plants |
| US5550318A (en) | 1990-04-17 | 1996-08-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US7705215B1 (en) | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| WO1991010725A1 (en) | 1990-01-22 | 1991-07-25 | Dekalb Plant Genetics | Fertile transgenic corn plants |
| US5837848A (en) | 1990-03-16 | 1998-11-17 | Zeneca Limited | Root-specific promoter |
| US5639949A (en) | 1990-08-20 | 1997-06-17 | Ciba-Geigy Corporation | Genes for the synthesis of antipathogenic substances |
| US5633435A (en) | 1990-08-31 | 1997-05-27 | Monsanto Company | Glyphosate-tolerant 5-enolpyruvylshikimate-3-phosphate synthases |
| ES2260886T3 (es) | 1990-11-23 | 2006-11-01 | Bayer Bioscience N.V. | Procedimiento para transformar plantas monocotiledoneas. |
| ATE207126T1 (de) | 1991-05-15 | 2001-11-15 | Monsanto Technology Llc | Verfahren zur schöpfung einer transformierten reispflanze |
| CA2113643C (en) | 1991-07-19 | 2003-04-22 | Ikbal A. Akhtar | Seed film compositions |
| PL170837B1 (pl) | 1991-10-18 | 1997-01-31 | Monsanto Co | S rod ek g r zybobó j c zy PL PL PL PL PL PL |
| US5593874A (en) | 1992-03-19 | 1997-01-14 | Monsanto Company | Enhanced expression in plants |
| CA2094658A1 (en) | 1992-04-23 | 1993-10-24 | Martin Sumner-Smith | Intracellular delivery of biochemical agents |
| PL172710B1 (pl) | 1992-07-02 | 1997-11-28 | Hybridon Inc | Samostabilizujacy sie oligonukleotyd PL PL |
| ATE398679T1 (de) | 1992-07-07 | 2008-07-15 | Japan Tobacco Inc | Verfahren zur transformation einer monokotyledon pflanze |
| FI93687C (fi) | 1992-07-29 | 1995-05-26 | Novasso Oy | Menetelmä siementen päällystämiseksi |
| US5661103A (en) | 1992-11-05 | 1997-08-26 | Donlar Corporation | Seed treatment composition and method |
| US5527695A (en) | 1993-01-29 | 1996-06-18 | Purdue Research Foundation | Controlled modification of eukaryotic genomes |
| US6118047A (en) | 1993-08-25 | 2000-09-12 | Dekalb Genetic Corporation | Anthranilate synthase gene and method of use thereof for conferring tryptophan overproduction |
| US5629469A (en) | 1994-03-10 | 1997-05-13 | Sandoz Ltd. | Thiol protease inhibitor |
| US5882713A (en) | 1994-04-26 | 1999-03-16 | The United States Of America As Represented By The Secretary Of Agriculture | Non-separable compositions of starch and water-immiscible organic materials |
| US5662897A (en) | 1994-07-27 | 1997-09-02 | U. Of Ga Research Foundation | Insect viruses, sequences, insecticidal compositions and methods of use |
| US5631152A (en) | 1994-10-26 | 1997-05-20 | Monsanto Company | Rapid and efficient regeneration of transgenic plants |
| US5716837A (en) | 1995-02-10 | 1998-02-10 | Monsanto Company | Expression of sucrose phosphorylase in plants |
| US5580544A (en) | 1995-03-29 | 1996-12-03 | Uniroyal Chemical Company, Inc. | Paste formulation useful for seed treatment and foliar treatment of plants |
| JP3125847B2 (ja) | 1995-06-15 | 2001-01-22 | 矢崎総業株式会社 | ゲル被覆種子のゲル層易崩壊処理方法 |
| US5622003A (en) | 1995-07-11 | 1997-04-22 | Isp Investments Inc. | Seed coating containing Mn (NO3)2 ·6H2 O |
| US5693512A (en) | 1996-03-01 | 1997-12-02 | The Ohio State Research Foundation | Method for transforming plant tissue by sonication |
| US5876739A (en) | 1996-06-13 | 1999-03-02 | Novartis Ag | Insecticidal seed coating |
| US5849320A (en) | 1996-06-13 | 1998-12-15 | Novartis Corporation | Insecticidal seed coating |
| US5939356A (en) | 1996-06-21 | 1999-08-17 | Southwest Research Institute | Controlled release coated agricultural products |
| DE19631919C2 (de) | 1996-08-07 | 1998-07-16 | Deutsches Krebsforsch | Anti-Sinn-RNA mit Sekundärstruktur |
| US6603063B1 (en) * | 1999-05-07 | 2003-08-05 | Mycogen Corp. | Plants and cells transformed with a nucleic acid from Bacillus thuringiensis strain KB59A4-6 encoding a novel SUP toxin |
| US5942664A (en) | 1996-11-27 | 1999-08-24 | Ecogen, Inc. | Bacillus thuringiensis Cry1C compositions toxic to lepidopteran insects and methods for making Cry1C mutants |
| JP3185133B2 (ja) | 1997-02-13 | 2001-07-09 | タキイ種苗株式会社 | 造粒コーティング種子およびその製造方法 |
| IL132039A0 (en) | 1997-04-03 | 2001-03-19 | Novartis Ag | Plant pest control |
| GB9710475D0 (en) | 1997-05-21 | 1997-07-16 | Zeneca Ltd | Gene silencing |
| JP2001511358A (ja) | 1997-07-28 | 2001-08-14 | メディカル・バイオシステムズ・リミテッド | 核酸配列の解析 |
| US5891246A (en) | 1997-08-15 | 1999-04-06 | Gustafson, Inc. | Seed coating apparatus |
| US5879827A (en) | 1997-10-10 | 1999-03-09 | Minnesota Mining And Manufacturing Company | Catalyst for membrane electrode assembly and method of making |
| US20090077685A1 (en) | 1998-06-16 | 2009-03-19 | Buehler Robert E | Nucleic acid molecules and other molecules associated with plants |
| AUPP058797A0 (en) | 1997-11-28 | 1997-12-18 | Commonwealth Scientific And Industrial Research Organisation | Novel gene |
| US6037160A (en) | 1997-12-12 | 2000-03-14 | Heska Corporation | Flea epoxide hydrolase nucleic acid molecules, proteins and uses thereof |
| US6060594A (en) | 1997-12-18 | 2000-05-09 | Ecogen, Inc. | Nucleic acid segments encoding modified bacillus thuringiensis coleopteran-toxic crystal proteins |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| AU745472B2 (en) | 1998-01-09 | 2002-03-21 | Novartis Ag | Coating of polymers |
| AUPP135698A0 (en) | 1998-01-15 | 1998-02-05 | Commonwealth Scientific And Industrial Research Organisation | Insectical modalities |
| AUPP249298A0 (en) | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
| CN101818145A (zh) | 1998-03-20 | 2010-09-01 | 联邦科学和工业研究组织 | 控制基因表达 |
| US6433247B1 (en) | 1998-03-23 | 2002-08-13 | Devgen N.V. | Ballistic transformation of C. elegans |
| CN1202246C (zh) | 1998-04-08 | 2005-05-18 | 联邦科学和工业研究组织 | 获得修饰表型的方法和措施 |
| AR020078A1 (es) * | 1998-05-26 | 2002-04-10 | Syngenta Participations Ag | Metodo para alterar la expresion de un gen objetivo en una celula de planta |
| GB9827152D0 (en) | 1998-07-03 | 1999-02-03 | Devgen Nv | Characterisation of gene function using double stranded rna inhibition |
| CZ301915B6 (cs) | 1998-08-19 | 2010-07-28 | Monsanto Technology Llc | Rekombinantní molekula DNA, transformovaná bunka, rostlina a zpusob zlepšení genové exprese |
| US6506599B1 (en) | 1999-10-15 | 2003-01-14 | Tai-Wook Yoon | Method for culturing langerhans islets and islet autotransplantation islet regeneration |
| US6489542B1 (en) | 1998-11-04 | 2002-12-03 | Monsanto Technology Llc | Methods for transforming plants to express Cry2Ab δ-endotoxins targeted to the plastids |
| GB9826890D0 (en) | 1998-12-07 | 1999-01-27 | Devgen Nv | Method for screening compounds |
| WO2000042207A2 (en) | 1999-01-14 | 2000-07-20 | Monsanto Technology Llc | Soybean transformation method |
| US6417208B1 (en) | 1999-02-05 | 2002-07-09 | Albert Einstein College Of Medicine Of Yeshiva University | Method of identification of inhibitors of PDE1C |
| GB9906018D0 (en) | 1999-03-16 | 1999-05-12 | Devgen Nv | Expression of DNA or proteins in C.elegans |
| US6511824B1 (en) | 1999-03-17 | 2003-01-28 | Exelixis, Inc. | Nucleic acids and polypeptides of invertebrate TWIK channels and methods of use |
| US6703491B1 (en) | 1999-03-17 | 2004-03-09 | Exelixis, Inc. | Drosophila sequences |
| ATE327253T1 (de) | 1999-04-09 | 2006-06-15 | Heska Corp | Proteine und nukleinsäuremoleküle des kopfes, des nervenkords, der tieferen darmabschnitte und des malpighi-gefässes des flohs und ihre verwendungen |
| GB9908677D0 (en) | 1999-04-15 | 1999-06-09 | Devgen Nv | Compound assay |
| GB9908676D0 (en) | 1999-04-15 | 1999-06-09 | Devgen Nv | Method for screening compounds |
| US6555655B1 (en) | 1999-05-04 | 2003-04-29 | Monsanto Technology, Llc | Coleopteran-toxic polypeptide compositions and insect-resistant transgenic plants |
| US6551800B1 (en) * | 1999-10-26 | 2003-04-22 | The Board Of Regents, The University Texas System | Recombinant materials for production of a protein toxic to fire ants |
| GB9925459D0 (en) | 1999-10-27 | 1999-12-29 | Plant Bioscience Ltd | Gene silencing |
| US6326193B1 (en) * | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| AU2047001A (en) * | 1999-11-24 | 2001-06-04 | Dna Plant Technology Corporation | Methods of inhibiting plant parasitic nematodes and insect pests by expression of nematode and insect specific double-stranded rna in plants |
| GB9930691D0 (en) | 1999-12-24 | 2000-02-16 | Devgen Nv | Improvements relating to double-stranded RNA inhibition |
| RU2157644C1 (ru) | 2000-01-21 | 2000-10-20 | Авакян Юрий Арамович | Пищевой и кормовой продукт с повышенным содержанием балластных веществ и способ его получения |
| AU2001236839A1 (en) * | 2000-02-11 | 2001-08-20 | Metabolix, Inc. | Multi-gene expression constructs containing modified inteins |
| US20020053097A1 (en) | 2000-03-20 | 2002-05-02 | Susan Lindquist | Transgenic plants containing heat shock protein |
| EP1268856A2 (de) | 2000-04-07 | 2003-01-02 | Epigenomics AG | Detektion von snp's und cytosin-methylierungen |
| US20110131679A2 (en) | 2000-04-19 | 2011-06-02 | Thomas La Rosa | Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement |
| AU2001259260A1 (en) | 2000-05-15 | 2001-11-26 | Monsanto Technology Llc | Polypeptide composionns toxic to anthonomus insects, and use thereof |
| GB0012233D0 (en) | 2000-05-19 | 2000-07-12 | Devgen Nv | Vector constructs |
| AU2001263530A1 (en) | 2000-05-30 | 2001-12-11 | Pieter Lodewikus Steyn | An insect repellent and the preparation and use thereof |
| GB0014009D0 (en) | 2000-06-08 | 2000-08-02 | Devgen Nv | Compound screens relating to insulin deficiency or insulin resistance |
| GB0017224D0 (en) | 2000-07-14 | 2000-08-30 | Crocker John G | Hand and wrist support |
| JP2004518616A (ja) | 2000-08-11 | 2004-06-24 | ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア | 昆虫及び線虫のＢｔ毒素に対する抵抗性を遮断するための方法 |
| US20020048814A1 (en) | 2000-08-15 | 2002-04-25 | Dna Plant Technology Corporation | Methods of gene silencing using poly-dT sequences |
| US7109393B2 (en) | 2000-08-15 | 2006-09-19 | Mendel Biotechnology, Inc. | Methods of gene silencing using inverted repeat sequences |
| US6812339B1 (en) | 2000-09-08 | 2004-11-02 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
| US6586365B2 (en) | 2000-10-06 | 2003-07-01 | Monsanto Technology, Llc | Method for reducing pest damage to corn by treating transgenic corn seeds with clothianidin pesticide |
| US6660690B2 (en) | 2000-10-06 | 2003-12-09 | Monsanto Technology, L.L.C. | Seed treatment with combinations of insecticides |
| US6551962B1 (en) | 2000-10-06 | 2003-04-22 | Monsanto Technology Llc | Method for deploying a transgenic refuge |
| AU2002218457A1 (en) | 2000-10-18 | 2002-04-29 | Devgen N.V. | Methods for identifying pesticidal compounds |
| EP1210875A1 (en) | 2000-12-04 | 2002-06-05 | Aventis CropScience GmbH | Modulating gene expression in insects by using double-stranded RNA (dsRNA) |
| AU2002306849A1 (en) | 2001-03-21 | 2002-10-08 | Elitra Pharmaceuticals, Inc. | Identification of essential genes in microorganisms |
| AUPR621501A0 (en) | 2001-07-06 | 2001-08-02 | Commonwealth Scientific And Industrial Research Organisation | Delivery of ds rna |
| US7612194B2 (en) | 2001-07-24 | 2009-11-03 | Monsanto Technology Llc | Nucleic acid sequences from Diabrotica virgifera virgifera LeConte and uses thereof |
| US7230167B2 (en) * | 2001-08-31 | 2007-06-12 | Syngenta Participations Ag | Modified Cry3A toxins and nucleic acid sequences coding therefor |
| US6825398B2 (en) * | 2001-09-05 | 2004-11-30 | Monsanto Company | Seed specific 7Sα promoter for expressing genes in plants |
| WO2003031577A2 (en) | 2001-10-10 | 2003-04-17 | Heska Corporation | Flea head, nerve cord, hindgut and malpighian tubule nucleic acid molecules, proteins and uses thereof |
| US20030150017A1 (en) | 2001-11-07 | 2003-08-07 | Mesa Jose Ramon Botella | Method for facilitating pathogen resistance |
| US6766613B2 (en) | 2001-11-16 | 2004-07-27 | University Of Florida Research Foundation, Inc. | Materials and methods for controlling pests |
| US7314974B2 (en) | 2002-02-21 | 2008-01-01 | Monsanto Technology, Llc | Expression of microbial proteins in plants for production of plants with improved properties |
| CA2478904A1 (en) | 2002-03-14 | 2003-09-18 | Commonwealth Scientific And Industrial Research Organisation | Modified gene-silencing rna and uses thereof |
| US20040053876A1 (en) | 2002-03-26 | 2004-03-18 | The Regents Of The University Of Michigan | siRNAs and uses therof |
| AR039717A1 (es) | 2002-06-21 | 2005-03-09 | Monsanto Technology Llc | Construcciones de arn de intrones cadena doble y usos de las mismas |
| BR0312580A (pt) | 2002-07-10 | 2006-10-10 | Univ Kansas State | composições e métodos para controlar nematódeos parasitas |
| EP1532247A4 (en) * | 2002-07-29 | 2006-08-30 | Monsanto Technology Llc | PAVING THE EVENT PV-ZMIR13 (MON863) AND COMPOSITIONS AND METHODS FOR DETECTING THEREOF |
| US7205454B2 (en) | 2002-07-31 | 2007-04-17 | Bayer Bioscience N.V. | Corn root preferential promoters and uses thereof |
| US20040053289A1 (en) | 2002-09-09 | 2004-03-18 | The Regents Of The University Of California | Short interfering nucleic acid hybrids and methods thereof |
| US20040048261A1 (en) | 2002-09-11 | 2004-03-11 | Klaus Raming | Invertebrate choline transporter nucleic acids, polypeptides and uses thereof |
| CA2502649A1 (en) | 2002-10-18 | 2004-04-29 | Nucleonics Inc. | Double-stranded rna structures and constructs, and methods for generating and using the same |
| US7250496B2 (en) | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
| CN1412311A (zh) * | 2002-11-26 | 2003-04-23 | 西南农业大学 | 利用侵染相关基因的协同作用提高微生物杀虫效果的方法 |
| CN1750752A (zh) | 2003-02-19 | 2006-03-22 | 联邦科学和工业研究组织 | 使用短dsRNA序列在植物中进行有效的基因沉默 |
| CA2528162A1 (en) | 2003-06-04 | 2004-12-16 | The Government Of The United States As Represented By The Secretary Of T He Department Of Health And Human Services, Centers For Disease Control | Pni microarray and uses |
| CA2531400A1 (en) | 2003-07-07 | 2005-03-03 | Monsanto Technology, Llc | Insecticidal proteins secreted from bacillus thuringiensis and uses therefor |
| IL157538A0 (en) | 2003-08-21 | 2004-03-28 | Bar Ilan Res & Dev Company Ltd | Plant resistant to cytoplasm-feeding parasites |
| US7266831B2 (en) * | 2003-10-14 | 2007-09-04 | Byeong-Seon Bak | Insertion type compact disc case |
| PL1687435T3 (pl) | 2003-11-17 | 2012-02-29 | Bayer Cropscience Nv | Odporność na owady z użyciem hamowania ekspresji genów |
| ATE487372T1 (de) | 2003-12-16 | 2010-11-15 | Monsanto Technology Llc | Sekretiertes protein und genzusammensetzungen aus bacillus thuringiensis und deren verwendungen |
| CA2548484C (en) | 2003-12-23 | 2015-04-21 | Bayer Cropscience Sa | Method for modifying gene expression of a phytopathogenic fungus |
| US7622301B2 (en) | 2004-02-24 | 2009-11-24 | Basf Plant Science Gmbh | Compositions and methods using RNA interference for control of nematodes |
| CN101422167A (zh) | 2004-04-09 | 2009-05-06 | 孟山都技术有限公司 | 用于在植物中控制昆虫侵袭的组合物和方法 |
| AU2005244258B2 (en) | 2004-04-09 | 2010-07-01 | Monsanto Technology Llc | Compositions and methods for control of insect infestations in plants |
| WO2006070227A2 (en) | 2004-10-04 | 2006-07-06 | Devgen Nv | Method for down-regulating gene expression in fungi |
| MX2007004686A (es) | 2004-10-25 | 2007-06-14 | Devgen Nv | Moleculas de arn de multidominio que comprenden al menos un aptamero para suministrar arn de doble hebra a organismos nocivos. |
| US20100170000A9 (en) | 2004-10-25 | 2010-07-01 | Devgen Nv | Rna constructs |
| WO2006045591A2 (en) | 2004-10-25 | 2006-05-04 | Devgen N.V. | Method and constructs for delivering double stranded rna to pest organisms |
| US20060200878A1 (en) | 2004-12-21 | 2006-09-07 | Linda Lutfiyya | Recombinant DNA constructs and methods for controlling gene expression |
| US8404927B2 (en) | 2004-12-21 | 2013-03-26 | Monsanto Technology Llc | Double-stranded RNA stabilized in planta |
| US8030473B2 (en) | 2005-01-07 | 2011-10-04 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Method to trigger RNA interference |
| US8088976B2 (en) | 2005-02-24 | 2012-01-03 | Monsanto Technology Llc | Methods for genetic control of plant pest infestation and compositions thereof |
| EP2500429A3 (en) | 2005-05-31 | 2015-10-28 | Devgen N.V. | RNAi for the control of insects and arachnids |
| EP2281896A3 (en) | 2005-09-16 | 2012-04-11 | deVGen N.V. | Transgenic plant-based methods for plant insect pests using RNAi |
| CA2622671C (en) | 2005-09-16 | 2020-12-22 | Devgen Nv | Methods for controlling pests using rnai |
| ATE548459T1 (de) | 2005-09-16 | 2012-03-15 | Monsanto Technology Llc | Verfahren zur genetischen kontrolle von insektenbefall bei pflanzen und zusammensetzungen |
| CN105385679B (zh) | 2006-02-13 | 2020-05-26 | 孟山都技术有限公司 | 选择和稳定dsRNA构建体 |
| US7999148B2 (en) | 2006-02-16 | 2011-08-16 | Texas A&M University System | Cotton plant with seed-specific reduction in gossypol |
| AU2008286701B2 (en) | 2007-08-14 | 2015-02-12 | Commonwealth Scientific And Industrial Research Organisation | Improved gene silencing methods |
-
2005
- 2005-04-08 AU AU2005244258A patent/AU2005244258B2/en not_active Expired
- 2005-04-08 EP EP11183161A patent/EP2402441A1/en not_active Ceased
- 2005-04-08 PL PL07104762T patent/PL1818405T3/pl unknown
- 2005-04-08 WO PCT/US2005/011816 patent/WO2005110068A2/en not_active Ceased
- 2005-04-08 PT PT57771743T patent/PT1732379E/pt unknown
- 2005-04-08 US US11/547,764 patent/US8946510B2/en active Active
- 2005-04-08 ES ES05777174.3T patent/ES2439696T3/es not_active Expired - Lifetime
- 2005-04-08 PL PL05777174T patent/PL1732379T3/pl unknown
- 2005-04-08 MX MXPA06011694A patent/MXPA06011694A/es active IP Right Grant
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- 2005-04-08 ES ES07104762.5T patent/ES2547381T3/es not_active Expired - Lifetime
- 2005-04-08 CN CN201510472024.1A patent/CN105002208A/zh active Pending
- 2005-04-08 EP EP10185197.0A patent/EP2308971B1/en not_active Expired - Lifetime
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- 2005-04-08 US US11/102,026 patent/US20060021087A1/en not_active Abandoned
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2006
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2007
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2010
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2016
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2017
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2019
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