ZA200809787B - Method for preparing 4-[17ß-methoxy-17+--methoxymethyl-3-oxoestra-4,9-dien-11ß-yl]benzaldehyde (E)-oxime (asoprisnil) - Google Patents

Method for preparing 4-[17ß-methoxy-17+--methoxymethyl-3-oxoestra-4,9-dien-11ß-yl]benzaldehyde (E)-oxime (asoprisnil)

Info

Publication number
ZA200809787B
ZA200809787B ZA200809787A ZA200809787A ZA200809787B ZA 200809787 B ZA200809787 B ZA 200809787B ZA 200809787 A ZA200809787 A ZA 200809787A ZA 200809787 A ZA200809787 A ZA 200809787A ZA 200809787 B ZA200809787 B ZA 200809787B
Authority
ZA
South Africa
Prior art keywords
oxoestra
asoprisnil
dien
benzaldehyde
methoxymethyl
Prior art date
Application number
ZA200809787A
Other languages
English (en)
Inventor
Detlef Grawe
Sabine Gliesing
Hagen Gerecke
Peter Hoesel
Uwe Mueller
Thomas Michel
Robert Eilers
Uwe Knabe
Bernd Erhart
Michael Mosebach
David Voigtaender
Ulf Tilstam
Juergen Jacke
Klaus Bahl
Ulf Bohlmann
Dieter Wehmeier
Michael Sander
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of ZA200809787B publication Critical patent/ZA200809787B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)
ZA200809787A 2006-04-18 2008-11-17 Method for preparing 4-[17ß-methoxy-17+--methoxymethyl-3-oxoestra-4,9-dien-11ß-yl]benzaldehyde (E)-oxime (asoprisnil) ZA200809787B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102006018888A DE102006018888A1 (de) 2006-04-18 2006-04-18 Verfahren zur Herstellung von 4-[17beta-Methoxy-17alpha-methoxymethyl-3-oxoestra-4,9-dien-11beta-yl]benzaldehyd-(E)-oxims (Asoprisnil)

Publications (1)

Publication Number Publication Date
ZA200809787B true ZA200809787B (en) 2010-01-27

Family

ID=38536818

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200809787A ZA200809787B (en) 2006-04-18 2008-11-17 Method for preparing 4-[17ß-methoxy-17+--methoxymethyl-3-oxoestra-4,9-dien-11ß-yl]benzaldehyde (E)-oxime (asoprisnil)

Country Status (12)

Country Link
EP (1) EP2010555A2 (fr)
JP (1) JP2009534345A (fr)
KR (1) KR20080110629A (fr)
CN (1) CN101466724A (fr)
AU (1) AU2007237457A1 (fr)
BR (1) BRPI0710517A2 (fr)
CA (2) CA2839228A1 (fr)
DE (1) DE102006018888A1 (fr)
MX (2) MX2007000450A (fr)
RU (1) RU2008145098A (fr)
WO (1) WO2007118717A2 (fr)
ZA (1) ZA200809787B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108003210A (zh) * 2018-01-24 2018-05-08 四川理工学院 一种雌甾-4,9-二烯-3,17-二酮的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5183M (fr) * 1966-03-04 1967-06-19
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
DD296931A5 (de) * 1987-08-28 1991-12-19 Jenapharm Gmbh Jena,De Verfahren zur herstellung von 13 beta-alkyl-5(10),9(11)-gonadienderivaten
US4910191A (en) * 1988-06-28 1990-03-20 Merrell Dow Pharmaceuticals Inc. 19-substituted progesterone derivatives useful as 19-hydroxylase inhibitors
DE4332283A1 (de) * 1993-09-20 1995-04-13 Jenapharm Gmbh Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
EP1157996A1 (fr) * 2000-05-23 2001-11-28 JENAPHARM GmbH Nouveaux formes solides du mesoprogestin 11beta-(4E-(hxdroxyiminomethyl)-phenyl)-17alpha-methoxymethyl-17beta-methoxy-estra-4,9-dien-3-on
DE10056675A1 (de) * 2000-11-10 2002-05-16 Jenapharm Gmbh Verfahren zur Herstellung von 4-(17alpha-Methylsubstituierten 3-Oxoestra-4,9-dien-11ß-yl)-benzaldehyd-(1E oder 1Z)-oximen
DE10056676A1 (de) * 2000-11-10 2002-05-16 Jenapharm Gmbh Verfahren zur Herstellung von 4-/17alpha-substituierten-3-oxoestra-4,9-dien-11beta-yl)benzaldehyd-(1E oder 1Z)-oximen
JP4197890B2 (ja) * 2001-05-24 2008-12-17 興和創薬株式会社 第一級アリルアルコール類の酸化方法
DE10311092A1 (de) * 2003-03-07 2004-10-07 Schering Ag Verfahren zur Oxidation der 17-Hydroxylfunktion in Steroiden und die Verwendung von Trifluoressigsäure und Cyclohexanon zur Herstellung von steroidalen 17-Ketonen mittels Oppenauer Oxidation
DE102004021060A1 (de) * 2004-04-29 2005-11-24 Schering Ag Wiederfindung von Arzneistoffen im ppm-Bereich in Produktionsanlagen

Also Published As

Publication number Publication date
CN101466724A (zh) 2009-06-24
EP2010555A2 (fr) 2009-01-07
WO2007118717A2 (fr) 2007-10-25
KR20080110629A (ko) 2008-12-18
WO2007118717A3 (fr) 2008-04-24
BRPI0710517A2 (pt) 2011-08-16
RU2008145098A (ru) 2010-05-27
DE102006018888A1 (de) 2007-10-25
AU2007237457A1 (en) 2007-10-25
MX2008013336A (es) 2008-10-31
CA2648537C (fr) 2014-09-23
CA2648537A1 (fr) 2007-10-25
JP2009534345A (ja) 2009-09-24
MX2007000450A (es) 2009-02-11
CA2839228A1 (fr) 2007-10-25

Similar Documents

Publication Publication Date Title
ZA201000214B (en) Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives
EP2028172A4 (fr) Procédé de fabrication de 1,3,3,3-tétrafluoropropène
MX265618B (es) Metodo para preparar n-fenilpirazol-1-carboxamidas.
IL238437A0 (en) Method for preparing 3-aryl-5-trifluoromethyl-5,4-dihydro-isoxazoles
EP3301871B8 (fr) Procédé, dispositif et système pour la retransmission des paquets
PL2271606T3 (pl) Sposób wytwarzania 1,2,3,3,3-pentafluoropropenu-1
IL203428A (en) METHOD FOR PREPARING ANTI-COMPOSITION COMPOSITION
MX306717B (es) Proceso para preparar 2-amino-5-halobenzamidas 3-sustituidas.
ZA200907038B (en) Process for isomerising a (hydrohalo) fluoroalkene
IL188431A0 (en) Process for preparing 3-arylmethylthio-and 3-heteroarylmethylthio-4,5-dihydro-
IL203761A (en) Process for Preparation of Compounds 4 - Aminobut - 2 - Anabolic, Intermediate and Initial Compounds
GB2451099B (en) Support assembley for downhole tool, downhole tool and method
EG25311A (en) Process for preparing catalysts.
AU2008303007A1 (en) Protocol for characterizing rock, method for characterizing rock hardness and methods for use therewith
EP2114996B8 (fr) Procédé de préparation d'hypoallergènes
BRPI0720705A2 (pt) Método para preparar uma composição de espumação, e, composição de espumação
GB2440878B (en) Nibble de-skew method, apparatus and system
PL1718585T3 (pl) Sposób otrzymywania surowego 1,3-butadienu
AU2007287353A8 (en) Method for improving pharmacokinetics
GB2456999B (en) Method for preparing 2-deoxy-L-ribose
PL2069290T3 (pl) Sposób wytwarzania 3-(2,2,2-trimetylohydrazyno)propionianu w postaci dihydratu
IL179107A0 (en) Method for preparing n-piperidino-1,5-diphenylpyrazole-3-carboxamide derivatives
HU0700584D0 (en) Method for producing 6-hydroxymethyl-1,4-androstadiene-3,17-dion
PL2350108T3 (pl) C-glikozydy i sposoby wytwarzania c-glikozydów
GB2432233B (en) User-interface system, method & apparatus