ZA200900229B - Refolding of recombinant proteins - Google Patents

Refolding of recombinant proteins

Info

Publication number
ZA200900229B
ZA200900229B ZA200900229A ZA200900229A ZA200900229B ZA 200900229 B ZA200900229 B ZA 200900229B ZA 200900229 A ZA200900229 A ZA 200900229A ZA 200900229 A ZA200900229 A ZA 200900229A ZA 200900229 B ZA200900229 B ZA 200900229B
Authority
ZA
South Africa
Prior art keywords
refolding
recombinant proteins
recombinant
proteins
Prior art date
Application number
ZA200900229A
Other languages
English (en)
Inventor
Shelly Pizarro
Ailen Sanchez
Charles H Schmelzer
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ZA200900229B publication Critical patent/ZA200900229B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
ZA200900229A 2006-07-14 2007-07-13 Refolding of recombinant proteins ZA200900229B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83083106P 2006-07-14 2006-07-14

Publications (1)

Publication Number Publication Date
ZA200900229B true ZA200900229B (en) 2010-04-28

Family

ID=38722613

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200900229A ZA200900229B (en) 2006-07-14 2007-07-13 Refolding of recombinant proteins

Country Status (18)

Country Link
US (4) US20080125580A1 (fr)
EP (1) EP2041154B1 (fr)
JP (2) JP5566104B2 (fr)
KR (1) KR101520105B1 (fr)
CN (1) CN101506222B (fr)
AR (1) AR062069A1 (fr)
AU (1) AU2007272412B2 (fr)
BR (1) BRPI0713252C1 (fr)
CA (1) CA2656835C (fr)
IL (1) IL196004A (fr)
MX (1) MX2009000278A (fr)
MY (1) MY169472A (fr)
NZ (1) NZ573639A (fr)
RU (1) RU2439076C2 (fr)
SG (1) SG162834A1 (fr)
TW (1) TWI476207B (fr)
WO (1) WO2008008975A2 (fr)
ZA (1) ZA200900229B (fr)

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KR101063347B1 (ko) 2009-04-06 2011-09-07 인하대학교 산학협력단 이온성 액체를 이용한 이황화 결합을 포함하는 단백질의 재접힘 방법
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CN103492852B (zh) * 2011-04-28 2016-08-17 独立行政法人理化学研究所 生物材料的透明化方法、及其利用
EP2711682B1 (fr) 2011-05-20 2019-07-10 Riken Réactif de clarification pour des matières biologiques et son utilisation
CN102443055B (zh) * 2011-10-26 2017-07-28 浙江海正药业股份有限公司 一种重组人肿瘤坏死因子相关凋亡诱导配体的纯化工艺
RU2492177C2 (ru) * 2011-12-15 2013-09-10 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП ГосНИИгенетика) СПОСОБ ВЫДЕЛЕНИЯ И ОЧИСТКИ РЕКОМБИНАНТНОГО ГОРМОНА РОСТА ЧЕЛОВЕКА, СЕКРЕТИРУЕМОГО ДРОЖЖАМИ Saccharomyces cerevisiae
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CN103588871B (zh) * 2012-08-16 2016-08-03 深圳新鹏生物工程有限公司 一种rhTRAIL菌体的分离纯化方法
CA2894908C (fr) * 2012-12-20 2022-07-12 Medimmune, Llc Procedes de production d'immunoconjugues
US10065987B2 (en) * 2013-02-12 2018-09-04 Bristol-Myers Squibb Company High pH protein refolding methods
CN111973484A (zh) * 2013-03-12 2020-11-24 普莱玛疗法公司 包含螯合剂和碱的牙用组合物
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WO2015022883A1 (fr) 2013-08-14 2015-02-19 独立行政法人理化学研究所 Composition pour la préparation d'un biomatériau possédant une excellente propriété de transmission de la lumière, et son utilisation
CN103694339B (zh) * 2013-12-04 2017-10-13 珠海联邦制药股份有限公司 一种甘精胰岛素前体的复性方法
KR101651330B1 (ko) * 2014-07-28 2016-08-25 가톨릭대학교 산학협력단 세포투과성이 우수한 ｔａｔ－ａ２０ 융합단백질의 제조방법 및 이의 용도
US10301611B2 (en) 2014-11-18 2019-05-28 Merck Sharp & Dohme Corp. Process for refolding recombinant chymotrypsin
WO2016081289A1 (fr) 2014-11-18 2016-05-26 Merck Sharp & Dohme Corp. Procédé de préparation de trypsine recombinante
CN107108691B (zh) 2014-12-22 2021-06-29 Ucb生物制药私人有限公司 蛋白质制造方法
US20170362291A1 (en) * 2014-12-23 2017-12-21 Armo Biosciences, Inc. Methods of Improving Yield in Recombinant Protein Production
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CN106008702B (zh) * 2016-07-22 2019-11-26 江苏江山聚源生物技术有限公司 一种规模化分离纯化重组人源胶原蛋白的方法
MX2019013210A (es) 2017-05-05 2020-07-20 Trefoil Therapeutics Inc Factores de crecimiento recombinantes modificados de fibroblastos y usos terapéuticos de los mismos.
JP7282689B2 (ja) 2017-05-19 2023-05-29 カウンスィル オブ サイエンティフィック アンド インダストリアル リサーチ リフォールディングした組み換えヒト化ラニビズマブの製造方法
AU2020261942A1 (en) * 2019-04-24 2021-11-04 Tanvex Biopharma Usa, Inc. Process for preparing granulocyte-colony stimulating factor
CN116710568A (zh) * 2020-06-26 2023-09-05 特里福伊尔治疗公司 重组修饰成纤维细胞生长因子及其治疗用途
CN111848774B (zh) * 2020-08-05 2022-05-10 武汉海特生物制药股份有限公司 一种美曲普汀的制备方法
KR102534015B1 (ko) * 2021-01-27 2023-05-19 (재)씨젠의료재단 그람 음성균 유래 원형 단백질의 분리 방법
WO2023017540A1 (fr) * 2021-08-11 2023-02-16 Tata Institute For Genetics And Society Procédés de repliement d'une protéine recombinante solubilisée et leur mise en oeuvre

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Also Published As

Publication number Publication date
BRPI0713252B8 (pt) 2019-04-09
CA2656835A1 (fr) 2008-01-17
KR20090039772A (ko) 2009-04-22
WO2008008975A2 (fr) 2008-01-17
KR101520105B1 (ko) 2015-05-21
TW200813093A (en) 2008-03-16
RU2009105080A (ru) 2010-08-27
US9200030B2 (en) 2015-12-01
WO2008008975A3 (fr) 2008-04-10
US9994612B2 (en) 2018-06-12
NZ573639A (en) 2012-03-30
JP2009543882A (ja) 2009-12-10
MY169472A (en) 2019-04-12
AU2007272412B2 (en) 2013-11-07
CN101506222A (zh) 2009-08-12
US20080125580A1 (en) 2008-05-29
WO2008008975A8 (fr) 2008-10-16
IL196004A (en) 2014-06-30
BRPI0713252C1 (pt) 2021-05-25
CA2656835C (fr) 2017-12-19
CN101506222B (zh) 2013-10-02
US20160137690A1 (en) 2016-05-19
JP5566104B2 (ja) 2014-08-06
JP6120356B2 (ja) 2017-04-26
EP2041154B1 (fr) 2018-12-12
MX2009000278A (es) 2009-01-26
SG162834A1 (en) 2010-07-29
BRPI0713252B1 (pt) 2018-12-18
AR062069A1 (es) 2008-10-15
US20110294990A1 (en) 2011-12-01
TWI476207B (zh) 2015-03-11
EP2041154A2 (fr) 2009-04-01
AU2007272412A1 (en) 2008-01-17
IL196004A0 (en) 2011-08-01
RU2439076C2 (ru) 2012-01-10
US20130123474A1 (en) 2013-05-16
BRPI0713252A2 (pt) 2012-04-10
JP2013121362A (ja) 2013-06-20

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