ZA200901846B - Process for preparing N-alkyl naltrexone halides - Google Patents

Process for preparing N-alkyl naltrexone halides

Info

Publication number
ZA200901846B
ZA200901846B ZA200901846A ZA200901846A ZA200901846B ZA 200901846 B ZA200901846 B ZA 200901846B ZA 200901846 A ZA200901846 A ZA 200901846A ZA 200901846 A ZA200901846 A ZA 200901846A ZA 200901846 B ZA200901846 B ZA 200901846B
Authority
ZA
South Africa
Prior art keywords
halides
preparing
naltrexone
alkyl
alkyl naltrexone
Prior art date
Application number
ZA200901846A
Other languages
English (en)
Inventor
Alain Dlubala
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of ZA200901846B publication Critical patent/ZA200901846B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA200901846A 2006-09-21 2007-09-19 Process for preparing N-alkyl naltrexone halides ZA200901846B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0608286A FR2906252B1 (fr) 2006-09-21 2006-09-21 Procede de preparation d'halogenures de n-aklyl naltrexone

Publications (1)

Publication Number Publication Date
ZA200901846B true ZA200901846B (en) 2010-07-28

Family

ID=38016779

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200901846A ZA200901846B (en) 2006-09-21 2007-09-19 Process for preparing N-alkyl naltrexone halides

Country Status (35)

Country Link
US (2) US7645880B2 (no)
EP (1) EP2069362B1 (no)
JP (1) JP5214615B2 (no)
KR (1) KR101434693B1 (no)
CN (2) CN102225939A (no)
AR (1) AR062918A1 (no)
AU (1) AU2007298855B2 (no)
BR (1) BRPI0718440A2 (no)
CA (1) CA2663509C (no)
CL (1) CL2007002711A1 (no)
CO (1) CO6170362A2 (no)
CR (1) CR10660A (no)
DO (1) DOP2011000307A (no)
EA (1) EA015426B1 (no)
ES (1) ES2531093T3 (no)
FR (1) FR2906252B1 (no)
GT (1) GT200900060A (no)
HN (1) HN2009000503A (no)
IL (1) IL197402A (no)
JO (1) JO3023B1 (no)
MA (1) MA30793B1 (no)
ME (1) MEP10509A (no)
MX (1) MX2009003084A (no)
MY (1) MY148094A (no)
NI (1) NI200900035A (no)
NO (1) NO20091561L (no)
NZ (1) NZ575417A (no)
PE (1) PE20080867A1 (no)
SV (1) SV2009003192A (no)
TN (1) TN2009000080A1 (no)
TW (1) TWI465451B (no)
UA (1) UA96957C2 (no)
UY (1) UY30599A1 (no)
WO (1) WO2008034973A1 (no)
ZA (1) ZA200901846B (no)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009010550A (es) 2007-03-29 2009-12-14 Progenics Pharm Inc Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas.
WO2008138383A1 (de) * 2007-05-16 2008-11-20 Cilag Ag Verfahren zur herstellung von n-methylnaltrexonbromid
WO2009009292A2 (en) * 2007-07-11 2009-01-15 Mallinckrodt Inc. Crystalline forms of naltrexone methobromide
EP2019105A1 (en) * 2007-07-19 2009-01-28 Siegfried Ltd. Process for the preparation of quaternary n-alkyl morphine or morphinane alkaloid derivatives
CN102227433B (zh) * 2008-09-30 2015-01-07 马林克罗特有限公司 烷基化吗啡喃衍生物的仲胺基团的方法
CN102325777B (zh) * 2009-02-23 2015-08-12 马林克罗特公司 (+)-吗啡喃*n-氧化物及其制备方法
JP5784507B2 (ja) * 2009-02-23 2015-09-24 マリンクロッド エルエルシー （＋）−モルフィナニウム第四級塩およびその生成方法
US8563724B2 (en) * 2009-02-23 2013-10-22 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
AU2010239059B2 (en) 2009-04-24 2016-06-09 Brock University Processes for the preparation of morphinane and morphinone compounds
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CN101845047B (zh) * 2009-12-31 2011-12-07 南京臣功制药有限公司 一种溴甲基纳曲酮的制备方法
JO3209B1 (ar) * 2010-11-05 2018-03-08 H Lundbeck As طريقة لتصنيع نالتريكسون
US8580963B2 (en) 2010-11-05 2013-11-12 H. Lundbeck A/S Method for the manufacturing of naltrexone
AU2011325563B2 (en) 2010-11-05 2015-08-20 H. Lundbeck A/S Method for the manufacturing of naltrexone
US9029543B2 (en) 2011-04-05 2015-05-12 Alkermes, Inc. Process for the synthesis of quaternary amine compounds
KR20140063763A (ko) 2011-09-08 2014-05-27 말린크로트 엘엘씨 중간체를 단리하지 않는 알칼로이드의 제조 방법
CN103172640A (zh) * 2011-12-22 2013-06-26 天津康鸿医药科技发展有限公司 一种(r)-n-溴甲基纳曲酮的制备方法以及纳曲酮衍生物
US20140155608A1 (en) 2012-05-03 2014-06-05 H. Lundbeck A/S Method for the manufacturing of naltrexone
CN105985348B (zh) * 2015-02-12 2019-02-01 正大天晴药业集团股份有限公司 一种溴甲基纳曲酮的制备方法
CN106317064B (zh) * 2015-06-30 2018-06-19 北大方正集团有限公司 溴甲纳曲酮的制备方法
KR102201609B1 (ko) * 2019-04-19 2021-01-12 연성정밀화학(주) 날데메딘의 제조방법
CN111777617B (zh) * 2020-07-10 2025-06-06 华润三九医药股份有限公司 一种溴甲纳曲酮的精制方法
CA3194746A1 (en) 2020-10-06 2022-04-14 Tien-Li Lee Oral delayed burst formulation of low-dose naltrexone or naloxone used for|treating fibromyalgia and long covid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4176186A (en) * 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
US7285665B2 (en) * 2002-11-08 2007-10-23 Mallinckrodt Inc. Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
AR057325A1 (es) * 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos

Also Published As

Publication number Publication date
JP2010504308A (ja) 2010-02-12
FR2906252A1 (fr) 2008-03-28
MY148094A (en) 2013-02-28
WO2008034973A1 (fr) 2008-03-27
US20080214817A1 (en) 2008-09-04
IL197402A0 (en) 2009-12-24
EA015426B1 (ru) 2011-08-30
DOP2011000307A (es) 2011-10-31
US8288547B2 (en) 2012-10-16
CA2663509C (fr) 2014-03-18
UA96957C2 (ru) 2011-12-26
EP2069362B1 (fr) 2014-07-09
AU2007298855B2 (en) 2012-09-13
MA30793B1 (fr) 2009-10-01
CN101516892B (zh) 2012-06-20
US20100145051A1 (en) 2010-06-10
US7645880B2 (en) 2010-01-12
IL197402A (en) 2012-12-31
EA200970307A1 (ru) 2009-12-30
ES2531093T3 (es) 2015-03-10
BRPI0718440A2 (pt) 2013-11-19
ME00613B (me) 2011-12-20
CN101516892A (zh) 2009-08-26
PE20080867A1 (es) 2008-08-22
CL2007002711A1 (es) 2008-04-18
GT200900060A (es) 2011-01-04
NZ575417A (en) 2011-09-30
MX2009003084A (es) 2009-04-02
FR2906252B1 (fr) 2008-11-28
TW200821314A (en) 2008-05-16
KR101434693B1 (ko) 2014-08-27
JO3023B1 (ar) 2016-09-05
NI200900035A (es) 2010-01-26
KR20090057031A (ko) 2009-06-03
UY30599A1 (es) 2008-05-02
JP5214615B2 (ja) 2013-06-19
TN2009000080A1 (en) 2010-08-19
MEP10509A (en) 2011-12-20
TWI465451B (zh) 2014-12-21
SV2009003192A (es) 2009-10-27
CO6170362A2 (es) 2010-06-18
NO20091561L (no) 2009-06-16
CA2663509A1 (fr) 2008-03-27
AR062918A1 (es) 2008-12-17
EP2069362A1 (fr) 2009-06-17
AU2007298855A1 (en) 2008-03-27
CN102225939A (zh) 2011-10-26
HK1135389A1 (en) 2010-06-04
HN2009000503A (es) 2011-03-02
CR10660A (es) 2009-06-24

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