ZA201202018B - Susbtituted carbamolymenthlamino acetic acid derivatives as novel nep inhibitors - Google Patents

Susbtituted carbamolymenthlamino acetic acid derivatives as novel nep inhibitors

Info

Publication number
ZA201202018B
ZA201202018B ZA2012/02018A ZA201202018A ZA201202018B ZA 201202018 B ZA201202018 B ZA 201202018B ZA 2012/02018 A ZA2012/02018 A ZA 2012/02018A ZA 201202018 A ZA201202018 A ZA 201202018A ZA 201202018 B ZA201202018 B ZA 201202018B
Authority
ZA
South Africa
Prior art keywords
carbamolymenthlamino
susbtituted
acetic acid
acid derivatives
nep inhibitors
Prior art date
Application number
ZA2012/02018A
Other languages
English (en)
Inventor
Yuki Iwaki
Toshio Kawanami
Gary Michael Ksander
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ZA201202018B publication Critical patent/ZA201202018B/en

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms

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ZA2012/02018A 2009-11-20 2012-03-19 Susbtituted carbamolymenthlamino acetic acid derivatives as novel nep inhibitors ZA201202018B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26313709P 2009-11-20 2009-11-20
US35991410P 2010-06-30 2010-06-30
PCT/EP2010/067781 WO2011061271A1 (en) 2009-11-20 2010-11-18 Substituted carbamoylmethylamino acetic acid derivatives as novel nep inhibitors

Publications (1)

Publication Number Publication Date
ZA201202018B true ZA201202018B (en) 2012-11-28

Family

ID=43431937

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2012/02018A ZA201202018B (en) 2009-11-20 2012-03-19 Susbtituted carbamolymenthlamino acetic acid derivatives as novel nep inhibitors

Country Status (37)

Country Link
US (4) US8222286B2 (2)
EP (2) EP2501683B1 (2)
JP (2) JP5543609B2 (2)
KR (1) KR101460421B1 (2)
CN (1) CN102666493B (2)
AR (1) AR079061A1 (2)
AU (1) AU2010320930B2 (2)
BR (1) BR112012011977A2 (2)
CA (1) CA2780150C (2)
CL (1) CL2012001298A1 (2)
CO (1) CO6540001A2 (2)
CR (1) CR20120237A (2)
DK (1) DK2501683T3 (2)
EA (1) EA021479B1 (2)
EC (1) ECSP12011978A (2)
ES (2) ES2598961T3 (2)
GT (1) GT201200153A (2)
HN (1) HN2012001037A (2)
HR (1) HRP20140691T1 (2)
IL (1) IL219314A0 (2)
IN (1) IN2012DN02465A (2)
JO (1) JO2967B1 (2)
MA (1) MA33886B1 (2)
MX (1) MX2012005813A (2)
MY (1) MY158299A (2)
NZ (1) NZ599136A (2)
PE (1) PE20121311A1 (2)
PH (1) PH12012500519A1 (2)
PL (1) PL2501683T3 (2)
PT (1) PT2501683E (2)
RS (1) RS53422B (2)
SI (1) SI2501683T1 (2)
TN (1) TN2012000125A1 (2)
TW (1) TWI481598B (2)
UY (1) UY33044A (2)
WO (1) WO2011061271A1 (2)
ZA (1) ZA201202018B (2)

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CN103896796B (zh) * 2009-05-28 2016-04-27 诺华股份有限公司 作为脑啡肽酶抑制剂的取代的氨基丙酸衍生物
EP2435402B1 (en) 2009-05-28 2016-04-13 Novartis AG Substituted aminobutyric derivatives as neprilysin inhibitors
JO2967B1 (en) * 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
US8993631B2 (en) * 2010-11-16 2015-03-31 Novartis Ag Method of treating contrast-induced nephropathy
US8586536B2 (en) 2010-12-15 2013-11-19 Theravance, Inc. Neprilysin inhibitors
ES2548887T3 (es) 2010-12-15 2015-10-21 Theravance Biopharma R&D Ip, Llc Inhibidores de neprilisina
KR101854874B1 (ko) 2011-02-17 2018-05-04 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 네프릴리신 억제제로서 치환된 아미노부티릭 유도체
JP5959066B2 (ja) 2011-02-17 2016-08-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤としての置換アミノ酪酸誘導体
JP5959075B2 (ja) 2011-05-31 2016-08-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤
WO2012166389A1 (en) 2011-05-31 2012-12-06 Theravance, Inc. Neprilysin inhibitors
ES2653215T3 (es) 2011-05-31 2018-02-06 Theravance Biopharma R&D Ip, Llc Inhibidores de neprilisina
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
ES2609810T3 (es) 2012-05-31 2017-04-24 Theravance Biopharma R&D Ip, Llc Inhibidores de neprilisina donadores de óxido nítrico
CN104470521B (zh) 2012-06-08 2017-04-12 施万生物制药研发Ip有限责任公司 脑啡肽酶抑制剂
MX356260B (es) 2012-06-08 2018-05-21 Theravance Biopharma R&D Ip Llc Inhibidores de la neprilisina.
MX366149B (es) 2012-08-08 2019-06-28 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina.
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
CU24330B1 (es) 2013-02-14 2018-03-13 Novartis Ag Derivados del ácido 4-((1,1) bifenil-4-il)-3-(3-fosfonopropanamido) butanoico, activos como inhibidores de nep (endopeptidasa neutral)
US9102635B2 (en) * 2013-02-14 2015-08-11 Novartis Ag Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo efficacy
CA2902456A1 (en) 2013-03-05 2014-09-12 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
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DK2501683T3 (da) 2014-06-30
US8877786B2 (en) 2014-11-04
RS53422B (sr) 2014-12-31
US20140088165A1 (en) 2014-03-27
JO2967B1 (en) 2016-03-15
CA2780150A1 (en) 2011-05-26
EA021479B1 (ru) 2015-06-30
HRP20140691T1 (hr) 2014-10-24
WO2011061271A1 (en) 2011-05-26

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